A few years after Singapore was founded, Lady Sophia Raffles sponsored a school for girls started by the wife of a London Missionary Society (LMS) missionary. This and several other early attempts at female education by missionary women linked to LMS or the American Board of Commissioners for Foreign Missions (ABCFM) were largely forgotten by historians. Then there were girls’ schools operated by the Protestant Society for Promoting Female Education in the East (SPFEE) in Britian; the secular Singapore Institution founded by Sir Thomas Stamford Raffles; and the Catholic Convent of Holy Infant Jesus (CHIJ) linked to Sœurs de l’Enfant Jésus-Nicolas Barré (EJNB) in France, followed by others. As there were many pioneering schools and some better-known ones tend to overshadow others, recent studies often contain inconsistent information as to which were the earliest schools, when they started, and who and which organisations were involved. This article uses primary sources from several archives to reconstruct the stories of the first Western-style girls’ schools on the island to hopefully clarify matters and close some knowledge gaps for readers interested in the history of female education in the early decades of colonial Singapore.

Timely blood cultures (BCx) are required by SEP-1. The recent BCx bottle shortage necessitated enhanced BCx stewardship. At two hospitals during the shortage, SEP-1 metric compliance declined related to BCx utilization. Review of cases where BCx were not obtained demonstrated most BCx were safely avoided without demonstrable patient harm.

This paper examines the prescription stimulant shortage in the United States, a crisis that has intensified since the FDA’s 2022 announcement of an Adderall shortage. The regulatory, systemic, and societal factors driving the shortage are analyzed — including the surge in attention-deficit/hyperactivity disorder (ADHD) diagnoses, expanded use of telehealth services, and disproportionate impact of the shortage on marginalized communities. It’s argued that existing health inequities are exacerbated by barriers to medication access as current regulatory frameworks are ill-equipped to address the growing demand for prescription stimulants, causing substantial harm to patients. A series of reforms are proposed — including modernizing the DEA’s quota system, strengthening interagency collaboration between the DEA, FDA, and HHS, and diversifying pharmaceutical supply chains to enhance resilience. These reforms aim to balance the dual imperatives of preventing misuse and ensuring equitable access to medications for patients with legitimate medical needs. By offering a comprehensive analysis of the prescription stimulant shortage and actionable policy recommendations, this paper seeks to inform regulatory reform, foster a more adaptive, patient-centered approach to ADHD care, and provide a roadmap for addressing one of the most pressing healthcare challenges of our time.

This article argues that the global Business and Human Rights movement demonstrates a push towards a human-rights type of sustainable corporation, reconciling economic development and human rights. It explains the necessity for and significance of a definition of a sustainable corporation at the intersection of traditional international human rights and sustainable development instruments. It argues, inter alia, that an internationally recognised definition of a sustainable corporation can settle fundamental questions and create a minimal framework for meaningful discourse on corporate accountability for human rights, climate change and the environment. It identifies difficulties of defining a sustainable corporation such as the integration problem. It suggests ‘direct human rights obligation’ as a minimally sufficient normative criterion for the definitional correctness of a sustainable corporation. The suggested definition of sustainable corporation requires taking a normative position which makes the term ‘essentially contested’ resulting in discursive and behavioural norm contestation in the search for definitional determinacy and consensus within the divide between international and domestic law.

This study presents the control of an omnidirectional automated guided vehicle (AGV) with mecanum wheels using a hybrid optimization algorithm that combines a modified A* algorithm and the dynamic window approach (ADWA-HO). The method ensures efficient and precise navigation in both static and dynamic environments. The modified A* algorithm generates global paths, removes redundant nodes, and refines trajectories to improve efficiency and smoothness. At the same time, the dynamic window approach (DWA) enables real-time local path planning and obstacle avoidance. By evaluating the AGV’s motion commands in real time, ADWA-HO selects optimal velocity commands within a dynamically updated window, thereby reducing route conflicts and ensuring stable movement. Compared with benchmark methods including dynamic A* (D*), artificial potential field (APF), DWA, probabilistic roadmap (PRM) & rapidly exploring random tree (RRT) fusion, and PRM & DWA fusion, the proposed ADWA-HO achieves improvements in average path length of 28.10%, 22.95%, 21.16%, 17.35%, and 10.71% and in average motion time of 23.48%, 17.85%, 15.47%, 11.86%, and 7.53% on both Map 1 and Map 2, respectively. The difference between simulation and real-world experiments is limited to 5.35% in path length and 4.38% in motion time, confirming the method’s practical reliability. Furthermore, the algorithm achieves lower standard deviation in both metrics, indicating higher consistency of performance. This work also introduces a novel map-building strategy based on geometric and semantic data modules, which enhances the adaptability of real-world AGV deployment.

This article discusses the official discourse that appeared in Macau’s Portuguese-language media and the documentaries that were shot there by Portuguese filmmakers in the 1960s and 1970s, especially focusing on the productions that followed the 123 Incident and which largely functioned as a response to it. These riots occurred in December 1966, when Chinese residents of Macau used Cultural Revolution-like protests to contest what they viewed as an inefficient and unfair Portuguese administration. They had a long-lasting and deep impact, weakening Portuguese colonial rule and increasing the influence of the People’s Republic of China (PRC) and local Maoists in Macau. In an attempt to counter the image-damage caused by the incident and legitimise Portuguese sovereignty in the territory during what was its worst crisis in the post-war period, Portuguese official discourse and these films came to promote Macau as a site of ‘miraculous’ development and modernisation that had as its basis Luso-Chinese partnership. Furthermore, Macau was advocated as an exemplary case of good neighbourhood policy towards the PRC and of coexistence at all levels, particularly ethnically and politically. This, it was suggested, made it a unique place and a model for the world in a time of cold war.

A general way to represent stochastic differential equations (SDEs) on smooth manifolds is based on the Schwartz morphism. In this manuscript, we are interested in SDEs on a smooth manifold $M$ that are driven by p-dimensional Wiener process $W_t \in \mathbb{R}^p$ and time $t$. In terms of the Schwartz morphism, such an SDE is represented by a Schwartz morphism that morphs the semimartingale $(t,W_t)\in\mathbb{R}^{p+1}$ into a semimartingale on the manifold $M$. We show that it is possible to construct such Schwartz morphisms using special maps that we call diffusion generators. We show that one of the ways to construct a diffusion generator is by considering the flow of differential equations. One particular case is the construction of diffusion generators using Lagrangian vector fields. Using the diffusion generator approach, we also give the extended Itô formula (also known as generalized Itô formula or Itô–Wentzell formula) for SDEs on manifolds.

Collaborative governance among multiple stakeholders is typically essential for conserving complex social-ecological systems. Mexico’s ‘biocultural landscapes’ – a territorial governance initiative – may be seen as pioneering models to promote this. However, actual outcomes depend on the initial conditions, institutional design, leadership and details of the collaborative process. We used a mixed-methods approach combining social network analysis and semi-structured interviews to analyse the structure of the collaboration network within Mexico’s Sierra Occidental Biocultural Landscape (SOBL). Our findings revealed a sparse, low-reciprocity network dominated by a few public managers, indicating potential power imbalances and challenges to building trust. Stakeholder interviews showed misalignments with theoretical collaborative governance including power imbalances, limited inclusiveness and a lack of trust among participants. While the SOBL has achieved collaborative results, such as the community forest fire brigades and the development of land management plans, achieving its full potential as a model for biocultural conservation requires addressing power dynamics and building a more equitable governance structure.

We exploit U.S. states’ staggered adoption of Universal Demand (UD) laws to study how the risk of shareholder lawsuits affects insider trading. UD laws, which make it harder for shareholders to bring derivative lawsuits against directors and officers, lead to more profitable insider trades, especially sales. This effect is stronger among smaller firms and firms with lower institutional monitoring. After UD laws, the timing of insiders’ trades also appears more opportunistic and riskier, for example, sales increase before negative earnings surprises. Overall, our study offers clean evidence that the threat of shareholder litigation deters opportunistic insider trading.

The emergence of the so-called gig economy has reshaped the labor market and, potentially, the politics of the safety net. Much of the American welfare state is based on a traditional model of employment, excluding most gig workers from benefits like subsidized employer-provided health insurance and unemployment insurance. Despite these trends, there is little research on how these changes might affect politics. Are gig workers likely to become a relevant constituency on social welfare and other issues? To address this, we conducted a unique online survey examining policy attitudes and political behaviors among gig workers compared with traditional workers. Our findings indicate that people who view gig work as their “main job” tend to lack access to traditional social insurance and employer-provided benefits, as expected, and rely more on means-tested assistance programs (e.g., food stamps). Consequently, gig workers exhibit higher support than traditional workers for expanding social welfare programs, and are more engaged on issues that affect gig workers. In terms of participation, gig workers are less likely to vote but more likely to engage in nonvoting political activities like protest than traditional workers. This study contributes to the understanding of social welfare politics in the new era of the labor market and highlights a growing constituency for expanding the safety net.

The European Radiation Dosimetry Group (EURADOS) and the WHO’s Radiation Emergency Medical Preparedness and Assistance Network (REMPAN) have collaborated to review best practices for managing radionuclide intakes through wounds. Rapid response and decisions on wound decontamination, tissue excision, and chelation therapy are based on measurements of the exposed individual and preliminary dose assessments using reasonable default assumptions. The goal is to minimize exposure, prevent tissue reactions, and reduce the risk of stochastic effects.

The management of a contaminated wound is always case-specific, but some general procedures typically apply for a proper evaluation of the contamination case. Medical doctors (surgeons and toxicologists) and internal dosimetrists should work together in the management of the contaminated wound case, with internal dosimetrists providing expert advice to aid clinical decision-making and communication with the patient and his/her family. The ISO standard 20031:2020 provides guidelines on the monitoring and dosimetry for internal exposures due to wound contamination with radionuclides. The Clinical Decision Guide was proposed by the National Council on Radiation Protection and Measurements in its Report 161 to assist physicians in making treatment decisions for individuals with internal radionuclide intakes. Best practices for medical treatment, based on previous experience, are presented here.