Men with diabetes frequently experience spermatogenic dysfunction, which is the most significant sign that diabetes has harmed their ability to reproduce. The effect of various doses of the hydro-alcoholic extract of Nerium oleander leaves on the pituitary–gonadal axis, sperm motility and number, antioxidant system, changes in testicular tissue structure, and spermatogenesis in healthy and diabetic rats has been examined in the current study. Eighty male rats that had been streptozotocin-induced diabetic and healthy were divided into eight groups: (1) control, (2) Nerium (50 mg/kg), (3) Nerium (100 mg/kg), (4) Nerium (200 mg/kg), (5) DM (6) DM+Nerium (50 mg/kg), (7) DM+Nerium (100 mg/kg) and (8) DM+Nerium (200 mg/kg) and were administered orally for 48 days consecutive. Following the studies, analysis of the testicular tissues’ antioxidant capacity as well as sperm parameters, Johnsen’s scoring and morphometric evaluation, histology, biochemical and stereology studies were performed.

The outcomes showed that Nerium 50 and 100 mg/kg considerably enhanced the testicular morphology, sperm parameters, and reproductive organs to varying degrees in diabetic rats. After Nerium 50 mg/kg administration, glutathione peroxidase (GPX) and catalase (CAT) levels in the testicular tissue were increased whereas malondialdehyde (MDA) levels were markedly decreased. Nerium may help protect against diabetic-induced spermatogenic dysfunction in male rats by enhancing the activities of antioxidant enzymes in lower dosages.

We develop methods for testing factor models when the weights in portfolios of factors and test assets can vary with lagged information. We derive and evaluate consistent standard errors and finite sample bias adjustments for unconditional maximum squared Sharpe ratios and their differences. Bias adjustment using a second-order approximation performs well. We derive optimal zero-beta rates for models with dynamically trading portfolios. Factor models’ Sharpe ratios are larger but standard test asset portfolios’ maximum Sharpe ratios are larger still when there is dynamic trading. As a result, most of the popular factor models are rejected.

Brazil et al. [‘Maximal subgroups of infinite symmetric groups’, Proc. Lond. Math. Soc. (3) 68(1) (1994), 77–111] provided a new family of maximal subgroups of the symmetric group $G(X)$ defined on an infinite set X. It is easy to see that, in this case, $G(X)$ contains subsemigroups that are not groups, but nothing is known about nongroup maximal subsemigroups of $G(X)$. We provide infinitely many examples of such semigroups.

Imagine a student reading Odysseus’ Cretan tale at Odyssey 19.172–84. When faced by a string of unfamiliar names – in addition to ‘native Cretans’, there are Achaeans, Cydonians and Dorians, as well as the individuals Minos, Deucalion, Idomeneus and the speaker, Aethon (Odysseus in disguise) –, they use their digital edition to find out more about each of these people and their places of origin. A personal name opens an online encyclopaedia entry, while clicking on a place launches an emerging world beyond the single text – an online atlas that provides information about the place's toponymy, form and exact location as well as links to other resources (textual and archaeological, ancient and modern) about this place, including those to which our student has contributed. The year? 2023 (Figure 1).1

In many theories of electoral accountability, voters learn about an incumbent’s quality by observing public goods outcomes. But empirical findings are mixed, suggesting that increasing the visibility of these outcomes only sometimes improves accountability. I reconcile these heterogeneous findings by highlighting bureaucrats’ role in the production of public goods. In a simple model of electoral accountability involving a voter, a politician, and a bureaucrat, I show that accountability relationships yield distinct empirical implications at different levels of bureaucratic quality. To illustrate how this model rationalizes otherwise mixed or heterogeneous results, I develop a new research design—a theoretically structured meta-study—to synthesize existing findings. Meta-study evidence on the accountability of Brazilian mayors suggests that a common model of electoral accountability that allows for variation in bureaucratic quality predicts observed heterogeneity in politician and voter behavior and beliefs across multiple studies with distinct samples, treatments, and outcomes.

Recent years have seen a flourishing of everyday experimentations with the category of religion: the “spiritual but not religious,” “religionless” Christians, and many more. Why is there such proliferation of popular experimentation with—and often distancing from—the category of religion? This article explores two such cases of experimentation, a religion-disavowing evangelical Christian brotherhood in Mexico and a Masonic lodge in Switzerland, and shows how, in these two cases, disavowing religion is in part a response to problems associated with a founding principle of liberalism, the separation of private conscience from public citizenship. Subjects of liberal separation are vulnerable to feelings of cloistered conscience and hollow citizenship, problems that are inherent to liberal separation, as evidenced by Freemasonry’s age-old experimentations. These problems are also, however, exacerbated by dwindling popular faith in the institutions of religion and liberal democracy, as evidenced by contemporary evangelical trends of which the Christian brotherhood is exemplary. Such experimentations can be distinguished between those that collapse conscience and citizenship and those that defend the separation while still looking for indirect connections. This contrast is also highlighted by the comparison of religion-disavowing evangelical Christians and Freemasonry.

This article studies the association between the characteristics of individuals’ social networks and expectations of career advancement, including pay raises and job promotions. The literature has extensively documented the role of social capital as a determinant of labour market outcomes. However, the formation of expectations constitutes another critical path by which social ties may affect work through their influence on individual motivation and behaviour. This study attempts to explain the relationship between social capital and career-related expectations and empirically assesses these associations by employing data from a survey administered to a representative sample of the Spanish population. Our findings suggest that the ability to mobilise network resources is positively linked with both measures of career advancement. However, access to the upper class is only positively associated with expecting a pay rise. Additionally, for non-employed individuals, higher mobilisation is positively associated with the expectation of an increase in income.

A 12-year-old female with pulmonary artery stenosis developed pseudoaneurysms due to septic embolism, requiring close follow-up.

One of the key responsibilities of public institutions in liberal democracies is to formulate recommendations for decision makers. However, public institutions realize that decision makers will often partly ignore their recommendations. This situation of “partial compliance” with recommendations raises a number of philosophical issues for institutions. Based on an analysis of 570 recommendations drawn from 40 Quebec public-sector documents and reports, we identify two issues surrounding the structure of public-policy recommendations.

Every countable group G can be embedded in a finitely generated group $G^*$ that is hopfian and complete, that is, $G^*$ has trivial centre and every epimorphism $G^*\to G^*$ is an inner automorphism. Every finite subgroup of $G^*$ is conjugate to a finite subgroup of G. If G has a finite presentation (respectively, a finite classifying space), then so does $G^*$. Our construction of $G^*$ relies on the existence of closed hyperbolic 3-manifolds that are asymmetric and non-Haken.

The Minoan settlement of Myrtos–Pyrgos on the south coast of Crete has produced five seals (and one unfinished seal), 11 seal impressions on clay vessels, two roundels and one nodulus, as well as two Linear A tablets and two inscriptions on clay vessels. Dating between Early Minoan II and Late Minoan IB, these documents form valuable evidence for the development of sealing, marking and writing practices at a small but important rural settlement, including a penchant for using antique seals for stamping jars. They contribute too to understanding the regional hierarchical and, probably, political cultures of Crete throughout this long period, especially in the late Protopalatial phase of Middle Minoan IIB, when there seems to have been a special relationship with Malia on the north coast, and again in Late Minoan IB, when there was a relationship with Knossos. Finally, the paper discusses a pithos fragment from Tel Haror in Israel, which appears to have an inscription in Cretan Hieroglyphic or Linear A, and may well have been a product of Myrtos or nearby.