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The aim of the study was to evaluate calcium anacardate (CAn), associated or not with citric acid (CAc) in laying hen diets on performance, egg quality, serum biochemical profile, serum lipid peroxidation (TBARS) and catalase (CAT) in reproductive tissue. A total of 432 laying hens from 63 to 74 weeks of age, were distributed in nine diets: Control; 0.25% CAn; 0.25% of CAn associated with 0.25% CAc; 0.50% CAn; 0.50% CAn associated with 0.25% CAc; 0.50% CAn associated with 0.50% CAc; 0.75% of CAn; 0.75% CAn associated with 0.25% CAc; 0.75% CAn associated with 0.50% CAc. There was no effect of CAn or CAc on laying hen performance. Yolk colour showed greater pigmentation for 0.75% CAn and its associations with CAc (0.25% and 0.50%). Lower egg yolk oxidation was observed for an isolated dose of 0.75% CAn. Higher values of TBARs were observed in eggs from birds fed control diet; 0.25% CAn; 0.50% CAn associated with 25% CAc and 0.75% CAn associated with 0.25 and 0.50% CAc. Dietary inclusion of CAn (0.75%) and its association with CAc (0.50% CAn with 0.50 CAc) for late-phase laying hens reduce serum peroxidation. CAn from 0.50% associated with CAc increases catalase in magnum. The addition of 0.75% CAn increases yolk pigmentation, reduces lipid oxidation in the yolk and blood plasma and increases CAT activity in the magnum in late-stage laying hens. These benefits can also be obtained with the combination of 0.50% CAn and 0.50% CAc.
Despite the destruction it inevitably engenders and the opposition it often elicits, war remains a near-human universal. There is almost no society, across time or place, that has not experienced some form of violent conflict, whether internally or against its neighbors or adversaries. The most common explanations for the causes of war and conflict tend to center around social and material factors, such as conflicts over resources, territory, or regime type. Certainly, these factors play a role in many conflicts, but they cannot alone explain every war. Other arguments, however, drawn from evolutionary psychology and biological anthropology, based on fundamental aspects of human nature with regard to male coalitionary psychology, do posit specific sources for conflict that provide an underlying platform for its emergence and can help explain its wide variety across time and space. A comprehensive and accurate understanding of the nature of war must include these considerations.
To elucidate the attenuation mechanism of wall-bounded turbulence due to heavy small particles, we conduct direct numerical simulations (DNS) of turbulent channel flow laden with finite-size solid particles. When particles cannot follow the swirling motions of wall-attached vortices, vortex rings are created around the particles. These particle-induced vortices lead to additional energy dissipation, reducing the turbulent energy production from the mean flow. This mechanism results in the attenuation of turbulent kinetic energy, which is more significant when the Stokes number of particles is larger or particle size is smaller under the condition that the volume fraction of particles is fixed. Moreover, we propose a method to quantitatively predict the degree of turbulence attenuation without using DNS data by estimating the additional energy dissipation rate in terms of particle properties.
The “home–field” dichotomy has long been a core assumption of fieldwork in political science. As in other social science disciplines, political scientists rely on these categories to contextualize our research within particular time–space nexuses and to separate our personal lives and private dwellings and institutions from our sources, participants, and broader research environments. Although the spatial, temporal, and emotional divisions between our “homes” and “fields” have always been arbitrary, they are increasingly blurred when we use remote and online methods for research, especially for qualitative studies. This article problematizes the home–field dichotomy within the context of remote and online political science field research. We contend that the overlap of our homes and fields in digital fieldwork poses different challenges for our professional boundaries than offline research, particularly in terms of separating our personal and research lives, mitigating risk, and protecting our mental health. Given the growing use of remote and online methods, we argue that the discipline of political science must account more seriously for the muddling of our homes and fields to support rigorous, transparent, and ethical empirical research.
Ventricular assist devices, such as the HeartMate 3, are routinely used to support patents with failing ventricular function. However, extrinsic obstruction of the outflow graft has been identified as a complication associated with the HeartMate 3. We report a case of a patient with transposition of the great arteries (d-TGA), status post-Mustard procedure with severe systemic (right) ventricular dysfunction who developed extrinsic obstruction of theoutflow graft, 6 years after implant, leading to a significant reduction in HeartMate 3 flow. This patient required the placement of multiple stents to fully address the diffuse stenosis of the outflow graft. This case underscores the technical challenges involved in managing extrinsic obstruction of theoutflow graft in patients with this anatomy and highlights the importance of a tailored, multidisciplinary approach. It emphasises the need for careful planning around stent overlap, outflow graft angulation, and catheter and wire positioning in the context of complex anatomical and device-related interactions.
For both Hegel and Badiou, love is one vehicle through which the transition from substance to subject concretely occurs, despite their respective conceptions of this transition differing drastically. Although (amicably) critical of Hegel’s Logic, Badiou—the first systematic continental philosopher since Hegel—never expressly reproaches Hegel’s conception of love, as outlined in both the Logic and the Realphilosophie lectures, but it is not Hegelian love which Badiou champions. His possible criticisms of Hegelian love can only be discerned through his explicit critiques of the Logic, in which he faults Hegel’s denial of absolute difference. Given that Badiouian love is conceived precisely as the subjective experience of absolute difference, his critique of Hegel must play a more significant role in his conceptual rehabilitation of love than is immediately evident. This paper teases out Badiou’s critique of Hegel and examines what it illuminates regarding his conception of love, as well as Hegel’s. I conclude that Badiou’s conception highlights an aspect of Hegelian love which Hegel himself does not sufficiently emphasize, but it remains too one-sided on its own and thus forces one to continue to decide in favour of Hegel.
The impact of chronic pain and opioid use on cognitive decline and mild cognitive impairment (MCI) is unclear. We investigated these associations in early older adulthood, considering different definitions of chronic pain.
Methods:
Men in the Vietnam Era Twin Study of Aging (VETSA; n = 1,042) underwent cognitive testing and medical history interviews at average ages 56, 62, and 68. Chronic pain was defined using pain intensity and interference ratings from the SF-36 over 2 or 3 waves (categorized as mild versus moderate-to-severe). Opioid use was determined by self-reported medication use. Amnestic and non-amnestic MCI were assessed using the Jak-Bondi approach. Mixed models and Cox proportional hazards models were used to assess associations of pain and opioid use with cognitive decline and risk for MCI.
Results:
Moderate-to-severe, but not mild, chronic pain intensity (β = −.10) and interference (β = −.23) were associated with greater declines in executive function. Moderate-to-severe chronic pain intensity (HR = 1.75) and interference (HR = 3.31) were associated with a higher risk of non-amnestic MCI. Opioid use was associated with a faster decline in verbal fluency (β = −.18) and a higher risk of amnestic MCI (HR = 1.99). There were no significant interactions between chronic pain and opioid use on cognitive decline or MCI risk (all p-values > .05).
Discussion:
Moderate-to-severe chronic pain intensity and interference related to executive function decline and greater risk of non-amnestic MCI; while opioid use related to verbal fluency decline and greater risk of amnestic MCI. Lowering chronic pain severity while reducing opioid exposure may help clinicians mitigate later cognitive decline and dementia risk.
The immune-modified Glasgow Prognostic Score, encompassing C-reactive protein, serum albumin, and lymphocyte count, is a valuable prognostic tool for head and neck squamous cell carcinoma. We aimed to assess the utility of immune-modified Glasgow Prognostic Score in predicting the treatment response to nivolumab in patients with head and neck squamous cell carcinoma.
Methods
Seventy-six patients with head and neck squamous cell carcinoma treated with nivolumab were included in this study. The imGPS was assessed before the initial nivolumab dose and four weeks after immune-modified Glasgow Prognostic Score.
Results
Multivariable analysis identified four weeks after immune-modified Glasgow Prognostic Score as an adverse prognostic factor for progression-free and overall survival. The best overall response was significantly associated with four weeks after immune-modified Glasgow Prognostic Score. Remarkably, all patients with four weeks after immune-modified Glasgow Prognostic Score = 3 and 8 (80.0%) of 10 patients with four weeks after immune-modified Glasgow Prognostic Score = 2 experienced progressive disease.
Conclusion
The immune-modified Glasgow Prognostic Score proves valuable for predicting prognosis in patients with head and neck squamous cell carcinoma undergoing nivolumab treatment, particularly excelling in identifying individuals unlikely to respond to nivolumab.
A clay from Weslatiya that is widely used in Tunisian ceramic production has abundant reserves but generates significant waste, posing environmental concerns if not handled appropriately. This study explores the valorization of this local clay by incorporating ceramic waste (chamotte) and quartz sand to produce eco-friendly materials, in line with sustainability and circular economy principles. X-ray diffraction and scanning electron microscopy analyses reveal that incorporating chamotte at levels exceeding 15% by weight improves the material’s properties. The Young’s modulus of the composite increases to 80 GPa, more than 2.5 times that of the basic clay. Chamotte can replace up to 30% of quartz sand without significantly affecting densification or porosity while preserving structural integrity. This approach offers flexibility in terms of material composition, enhancing performance and promoting sustainability by reusing waste materials for high-performance ceramics in industrial applications.
Recognizing the distributed nature of agency in human–AI interactions, this article proposes a framework for examining the power dynamics that undergird the use of generative AI (GenAI) for language learning. Drawing on Darvin and Norton’s model of investment, it adopts a critical sociomaterial lens to cast a light on the entanglement of bodies, objects and discourse in these interactions, while highlighting how issues of positioning, access to resources, and ideological reproduction emerge from this perspective. Human agency both interacts with and is constrained or amplified by the functionalities of GenAI. To invest in agentive GenAI practices that enable meaningful learning and the achievement of their own intentions, learners must not only recognize the power of GenAI to steer interactions and promote specific ways of thinking, but also resist fully delegating the production of meaning and texts to technology. Cultivating critical digital literacies that recognize how power operates in human-AI interactions is integral to fostering reflexive, inclusive and equitable language learning and teaching in the age of GenAI.
During the first half of the nineteenth century, Mid-Atlantic States expanded guardianship to include habitual drunkards. Legislators in Pennsylvania, New York, and New Jersey empowered courts to put habitual drunkards under guardianship, a legal status that stripped them of their rights to own property, enter into contracts, make wills, and, in some states, even vote. Amid the dramatic nineteenth-century expansion of male suffrage, the habitual drunkard signified a masculine failure of self-government that disqualified propertied men from the privileges of full citizenship. The struggle to define habitual drunkenness, detect the habitual drunkard, and put him under guardianship transformed the courtroom into an arena for contesting the thresholds of compulsion, policing respectable manhood, and drawing the borders of full citizenship in the nineteenth-century United States.
During the COVID-19 pandemic, the United States Centers for Disease Control and Prevention provided strategies, such as extended use and reuse, to preserve N95 filtering facepiece respirators (FFR). We aimed to assess the prevalence of N95 FFR contamination with SARS-CoV-2 among healthcare personnel (HCP) in the Emergency Department (ED).
Design:
Real-world, prospective, multicenter cohort study. N95 FFR contamination (primary outcome) was measured by real-time quantitative polymerase chain reaction. Multiple logistic regression was used to assess factors associated with contamination.
Setting:
Six academic medical centers.
Participants:
ED HCP who practiced N95 FFR reuse and extended use during the COVID-19 pandemic between April 2021 and July 2022.
Primary exposure:
Total number of COVID-19-positive patients treated.
Results:
Two-hundred forty-five N95 FFRs were tested. Forty-four N95 FFRs (18.0%, 95% CI 13.4, 23.3) were contaminated with SARS-CoV-2 RNA. The number of patients seen with COVID-19 was associated with N95 FFR contamination (adjusted odds ratio, 2.3 [95% CI 1.5, 3.6]). Wearing either surgical masks or face shields over FFRs was not associated with FFR contamination, and FFR contamination prevalence was high when using these adjuncts [face shields: 25% (16/64), surgical masks: 22% (23/107)].
Conclusions:
Exposure to patients with known COVID-19 was independently associated with N95 FFR contamination. Face shields and overlying surgical masks were not associated with N95 FFR contamination. N95 FFR reuse and extended use should be avoided due to the increased risk of contact exposure from contaminated FFRs.
Inspired by the need to theoretically understand the naturally occurring interactions between internal waves and mesoscale phenomena in the ocean, we derive a novel model equation from the primitive rotational Euler equations using the multi-scale asymptotic expansion method. By applying the classic balance $\epsilon =\mu ^2$ between nonlinearity (measured by $\epsilon$) and dispersion (measured by $\mu$), along with the assumption that variations in the transverse direction are of order $\mu$, which is smaller than those in the propagation direction, we arrive at terms from the classic Kadomtsev–Petviashvili equation. However, when incorporating background shear currents in two horizontal dimensions and accounting for Earth’s rotation, we introduce three additional terms that, to the best of the authors’ knowledge, have not been addressed in the previous literature. Theoretical analyses and numerical results indicate that these three terms contribute to a tendency for propagation in the transverse direction and an overall variation in wave amplitudes. The specific effects of these terms can be estimated qualitatively based on the signs of the coefficients for each term and the characteristics of the initial waves. Finally, the potential shortcomings of this proposed equation are illuminated.
Bentonite is mined globally for use in commercial and industrial applications. In these applications, smectite content and composition are the paramount factors of the bentonite material and control its properties. As bentonite composition and properties can vary significantly over a large mining district or within a single mine, quality control is required including: mineral composition, especially smectite content; cation exchange capacity (CEC); exchangeable cation composition; and smectite crystallochemical features. Differences in bentonite composition locally or over a spatial area stem from the different geological settings present throughout bentonitization. The study aims were to: (1) determine the layer charge (LC) variation of dioctahedral smectite over the Bavarian mining district and within individual mines in the area; and (2) assess the error in smectite content calculations based on CEC data resulting from the actual range of experimentally determined LC values. This information has been missing in the scientific literature, as previous LC methods were laborious or subject to assumptions, making a comprehensive study over a large spatial area impractical. This study employed the use of the recently developed efficient and precise spectroscopic ‘O-D method’, which enabled the LC measurement of 40 samples from eight mines in the Bavarian bentonite mining district, covering an area of 250 km2, within the North Alpine Foreland Basin. Results showed LC values calibrated against the alkylammonium method (LC (AAM)) generally ranged between 0.29 and 0.30 eq per formula unit (FU), with only 10% of samples showing LC values >0.31 eq/FU. This narrow LC range has positive implications for the accuracy of determining smectite content calculated from CEC data, during routine quality control of Bavarian and other bentonites. The average error of the CEC-based smectite contents resulting from LC variations was, on average, ±3 wt.%.
This longitudinal survey examined the effect of the National Healthcare Safety Network’s (NHSN) recently updated Clostridioides difficile test method definition on reporting of hospital-onset C. difficile. Among six hospitals with ≥ 5 years of data available, the updated NHSN definition was associated with improved concordance between predicted versus reported cases.