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For both Hegel and Badiou, love is one vehicle through which the transition from substance to subject concretely occurs, despite their respective conceptions of this transition differing drastically. Although (amicably) critical of Hegel’s Logic, Badiou—the first systematic continental philosopher since Hegel—never expressly reproaches Hegel’s conception of love, as outlined in both the Logic and the Realphilosophie lectures, but it is not Hegelian love which Badiou champions. His possible criticisms of Hegelian love can only be discerned through his explicit critiques of the Logic, in which he faults Hegel’s denial of absolute difference. Given that Badiouian love is conceived precisely as the subjective experience of absolute difference, his critique of Hegel must play a more significant role in his conceptual rehabilitation of love than is immediately evident. This paper teases out Badiou’s critique of Hegel and examines what it illuminates regarding his conception of love, as well as Hegel’s. I conclude that Badiou’s conception highlights an aspect of Hegelian love which Hegel himself does not sufficiently emphasize, but it remains too one-sided on its own and thus forces one to continue to decide in favour of Hegel.
The impact of chronic pain and opioid use on cognitive decline and mild cognitive impairment (MCI) is unclear. We investigated these associations in early older adulthood, considering different definitions of chronic pain.
Methods:
Men in the Vietnam Era Twin Study of Aging (VETSA; n = 1,042) underwent cognitive testing and medical history interviews at average ages 56, 62, and 68. Chronic pain was defined using pain intensity and interference ratings from the SF-36 over 2 or 3 waves (categorized as mild versus moderate-to-severe). Opioid use was determined by self-reported medication use. Amnestic and non-amnestic MCI were assessed using the Jak-Bondi approach. Mixed models and Cox proportional hazards models were used to assess associations of pain and opioid use with cognitive decline and risk for MCI.
Results:
Moderate-to-severe, but not mild, chronic pain intensity (β = −.10) and interference (β = −.23) were associated with greater declines in executive function. Moderate-to-severe chronic pain intensity (HR = 1.75) and interference (HR = 3.31) were associated with a higher risk of non-amnestic MCI. Opioid use was associated with a faster decline in verbal fluency (β = −.18) and a higher risk of amnestic MCI (HR = 1.99). There were no significant interactions between chronic pain and opioid use on cognitive decline or MCI risk (all p-values > .05).
Discussion:
Moderate-to-severe chronic pain intensity and interference related to executive function decline and greater risk of non-amnestic MCI; while opioid use related to verbal fluency decline and greater risk of amnestic MCI. Lowering chronic pain severity while reducing opioid exposure may help clinicians mitigate later cognitive decline and dementia risk.
The immune-modified Glasgow Prognostic Score, encompassing C-reactive protein, serum albumin, and lymphocyte count, is a valuable prognostic tool for head and neck squamous cell carcinoma. We aimed to assess the utility of immune-modified Glasgow Prognostic Score in predicting the treatment response to nivolumab in patients with head and neck squamous cell carcinoma.
Methods
Seventy-six patients with head and neck squamous cell carcinoma treated with nivolumab were included in this study. The imGPS was assessed before the initial nivolumab dose and four weeks after immune-modified Glasgow Prognostic Score.
Results
Multivariable analysis identified four weeks after immune-modified Glasgow Prognostic Score as an adverse prognostic factor for progression-free and overall survival. The best overall response was significantly associated with four weeks after immune-modified Glasgow Prognostic Score. Remarkably, all patients with four weeks after immune-modified Glasgow Prognostic Score = 3 and 8 (80.0%) of 10 patients with four weeks after immune-modified Glasgow Prognostic Score = 2 experienced progressive disease.
Conclusion
The immune-modified Glasgow Prognostic Score proves valuable for predicting prognosis in patients with head and neck squamous cell carcinoma undergoing nivolumab treatment, particularly excelling in identifying individuals unlikely to respond to nivolumab.
A clay from Weslatiya that is widely used in Tunisian ceramic production has abundant reserves but generates significant waste, posing environmental concerns if not handled appropriately. This study explores the valorization of this local clay by incorporating ceramic waste (chamotte) and quartz sand to produce eco-friendly materials, in line with sustainability and circular economy principles. X-ray diffraction and scanning electron microscopy analyses reveal that incorporating chamotte at levels exceeding 15% by weight improves the material’s properties. The Young’s modulus of the composite increases to 80 GPa, more than 2.5 times that of the basic clay. Chamotte can replace up to 30% of quartz sand without significantly affecting densification or porosity while preserving structural integrity. This approach offers flexibility in terms of material composition, enhancing performance and promoting sustainability by reusing waste materials for high-performance ceramics in industrial applications.
Recognizing the distributed nature of agency in human–AI interactions, this article proposes a framework for examining the power dynamics that undergird the use of generative AI (GenAI) for language learning. Drawing on Darvin and Norton’s model of investment, it adopts a critical sociomaterial lens to cast a light on the entanglement of bodies, objects and discourse in these interactions, while highlighting how issues of positioning, access to resources, and ideological reproduction emerge from this perspective. Human agency both interacts with and is constrained or amplified by the functionalities of GenAI. To invest in agentive GenAI practices that enable meaningful learning and the achievement of their own intentions, learners must not only recognize the power of GenAI to steer interactions and promote specific ways of thinking, but also resist fully delegating the production of meaning and texts to technology. Cultivating critical digital literacies that recognize how power operates in human-AI interactions is integral to fostering reflexive, inclusive and equitable language learning and teaching in the age of GenAI.
During the first half of the nineteenth century, Mid-Atlantic States expanded guardianship to include habitual drunkards. Legislators in Pennsylvania, New York, and New Jersey empowered courts to put habitual drunkards under guardianship, a legal status that stripped them of their rights to own property, enter into contracts, make wills, and, in some states, even vote. Amid the dramatic nineteenth-century expansion of male suffrage, the habitual drunkard signified a masculine failure of self-government that disqualified propertied men from the privileges of full citizenship. The struggle to define habitual drunkenness, detect the habitual drunkard, and put him under guardianship transformed the courtroom into an arena for contesting the thresholds of compulsion, policing respectable manhood, and drawing the borders of full citizenship in the nineteenth-century United States.
During the COVID-19 pandemic, the United States Centers for Disease Control and Prevention provided strategies, such as extended use and reuse, to preserve N95 filtering facepiece respirators (FFR). We aimed to assess the prevalence of N95 FFR contamination with SARS-CoV-2 among healthcare personnel (HCP) in the Emergency Department (ED).
Design:
Real-world, prospective, multicenter cohort study. N95 FFR contamination (primary outcome) was measured by real-time quantitative polymerase chain reaction. Multiple logistic regression was used to assess factors associated with contamination.
Setting:
Six academic medical centers.
Participants:
ED HCP who practiced N95 FFR reuse and extended use during the COVID-19 pandemic between April 2021 and July 2022.
Primary exposure:
Total number of COVID-19-positive patients treated.
Results:
Two-hundred forty-five N95 FFRs were tested. Forty-four N95 FFRs (18.0%, 95% CI 13.4, 23.3) were contaminated with SARS-CoV-2 RNA. The number of patients seen with COVID-19 was associated with N95 FFR contamination (adjusted odds ratio, 2.3 [95% CI 1.5, 3.6]). Wearing either surgical masks or face shields over FFRs was not associated with FFR contamination, and FFR contamination prevalence was high when using these adjuncts [face shields: 25% (16/64), surgical masks: 22% (23/107)].
Conclusions:
Exposure to patients with known COVID-19 was independently associated with N95 FFR contamination. Face shields and overlying surgical masks were not associated with N95 FFR contamination. N95 FFR reuse and extended use should be avoided due to the increased risk of contact exposure from contaminated FFRs.
Inspired by the need to theoretically understand the naturally occurring interactions between internal waves and mesoscale phenomena in the ocean, we derive a novel model equation from the primitive rotational Euler equations using the multi-scale asymptotic expansion method. By applying the classic balance $\epsilon =\mu ^2$ between nonlinearity (measured by $\epsilon$) and dispersion (measured by $\mu$), along with the assumption that variations in the transverse direction are of order $\mu$, which is smaller than those in the propagation direction, we arrive at terms from the classic Kadomtsev–Petviashvili equation. However, when incorporating background shear currents in two horizontal dimensions and accounting for Earth’s rotation, we introduce three additional terms that, to the best of the authors’ knowledge, have not been addressed in the previous literature. Theoretical analyses and numerical results indicate that these three terms contribute to a tendency for propagation in the transverse direction and an overall variation in wave amplitudes. The specific effects of these terms can be estimated qualitatively based on the signs of the coefficients for each term and the characteristics of the initial waves. Finally, the potential shortcomings of this proposed equation are illuminated.
Bentonite is mined globally for use in commercial and industrial applications. In these applications, smectite content and composition are the paramount factors of the bentonite material and control its properties. As bentonite composition and properties can vary significantly over a large mining district or within a single mine, quality control is required including: mineral composition, especially smectite content; cation exchange capacity (CEC); exchangeable cation composition; and smectite crystallochemical features. Differences in bentonite composition locally or over a spatial area stem from the different geological settings present throughout bentonitization. The study aims were to: (1) determine the layer charge (LC) variation of dioctahedral smectite over the Bavarian mining district and within individual mines in the area; and (2) assess the error in smectite content calculations based on CEC data resulting from the actual range of experimentally determined LC values. This information has been missing in the scientific literature, as previous LC methods were laborious or subject to assumptions, making a comprehensive study over a large spatial area impractical. This study employed the use of the recently developed efficient and precise spectroscopic ‘O-D method’, which enabled the LC measurement of 40 samples from eight mines in the Bavarian bentonite mining district, covering an area of 250 km2, within the North Alpine Foreland Basin. Results showed LC values calibrated against the alkylammonium method (LC (AAM)) generally ranged between 0.29 and 0.30 eq per formula unit (FU), with only 10% of samples showing LC values >0.31 eq/FU. This narrow LC range has positive implications for the accuracy of determining smectite content calculated from CEC data, during routine quality control of Bavarian and other bentonites. The average error of the CEC-based smectite contents resulting from LC variations was, on average, ±3 wt.%.
This longitudinal survey examined the effect of the National Healthcare Safety Network’s (NHSN) recently updated Clostridioides difficile test method definition on reporting of hospital-onset C. difficile. Among six hospitals with ≥ 5 years of data available, the updated NHSN definition was associated with improved concordance between predicted versus reported cases.
We present the case of a patient with bilateral vocal fold paralysis following extensive surgical repair of congenital cardiac abnormalities and the management of the subsequent airway compromise with primary endoscopic anterior–posterior cricoid split.
Methods
Review of our management of a patient with bilateral vocal fold paralysis using anterior–posterior cricoid split and literature search of alternative management options for patients with bilateral vocal fold paralysis.
Results
Our newborn patient developed stridor and respiratory failure following surgery for multiple cardiac malformations. Flexible fiberoptic laryngoscopy revealed bilateral vocal fold paralysis, and the patient was intubated for airway protection. We addressed the bilateral vocal fold paralysis with primary endoscopic anterior–posterior cricoid split to avoid tracheostomy, successfully extubating to room air 13 days later. The patient regained nearly total function of both folds and, at two-year follow-up, was asymptomatic from an airway, voice, sleep and swallowing perspective.
Conclusions
APCS was effective in managing bilateral vocal fold paralysis-associated respiratory failure and avoiding tracheostomy, with long-term follow-up demonstrating symptom resolution and bilateral recovery of laryngeal mobility.
We apply a synthesis review to revisit the concept, measurement, and operationalisation of social inclusion and exclusion in the context of comparative social policy, integrating the vast literature on the concepts, with the aim of elucidating a clearer understanding of the concepts for use by scholars and policymakers around the planet. In turn, we outline the conceptual development of the concepts, how they have been operationalised through social policy, and how they have been measured at the national and individual levels. Through our review, we identify limitations in extant conceptualisation and measurement approaches and suggest directions for refining conceptual and measurement frameworks to enhance their utility in social inclusion policy, emphasising the concepts’ multidimensional, multilevel, dynamic, and relational essence and highlighting their connection to related concepts such as social capital, social integration, and social citizenship.
We give a notion of boundary pair $(\mathcal{B}_-,\mathcal{B}_+)$ for measured groupoids which generalizes the one introduced by Bader and Furman [BF14] for locally compact groups. In the case of a semidirect groupoid $\mathcal{G}=\Gamma \ltimes X$ obtained by a probability measure preserving action $\Gamma \curvearrowright X$ of a locally compact group, we show that a boundary pair is exactly $(B_- \times X, B_+ \times X)$, where $(B_-,B_+)$ is a boundary pair for $\Gamma$. For any measured groupoid $(\mathcal{G},\nu )$, we prove that the Poisson boundaries associated to the Markov operators generated by a probability measure equivalent to $\nu$ provide other examples of our definition. Following Bader and Furman [BF], we define algebraic representability for an ergodic groupoid $(\mathcal{G},\nu )$. In this way, given any measurable representation $\rho \,:\,\mathcal{G} \rightarrow H$ into the $\kappa$-points of an algebraic $\kappa$-group $\mathbf{H}$, we obtain $\rho$-equivariant maps $\mathcal{B}_\pm \rightarrow H/L_\pm$, where $L_\pm =\mathbf{L}_\pm (\kappa )$ for some $\kappa$-subgroups $\mathbf{L}_\pm \lt \mathbf{H}$. In the particular case when $\kappa =\mathbb{R}$ and $\rho$ is Zariski dense, we show that $L_\pm$ must be minimal parabolic subgroups.
Executive dysfunction is prevalent in early stroke and can predict long-term outcomes. Impairments can be subtle and undetected in cognitive stroke screens. To better assess executive functions, this study introduced a novel sentence completion test, which assesses multiple executive processes in <5 minutes (Brief Executive Language Screen – Sentence Completion; BELS-SC). The aim was to determine construct, convergent and divergent validity, sensitivity and specificity of the BELS-SC, and to explore differences between left and right hemisphere stroke patients (LHS and RHS, respectively) on the BELS-SC and standard executive function tests.
Method:
Eighty-eight acute/early sub-acute stroke patients and 116 age-matched healthy controls were included.
Results:
Principal Component Analysis (PCA) suggested four to five factors of the BELS-SC: Initiation, Selection, Inhibition (with strategy loading on Inhibition), Inhibition Response Time, and Semantic Retrieval Response Time. The BELS-SC had good sensitivity (.84) but poorer specificity (.66) differentiating controls and stroke, and good sensitivity (.83) and specificity (.80) differentiating executive function impaired versus executive function intact groups. BELS-SC Initiation and Inhibition subtests demonstrated convergent and divergent validity with corresponding Hayling subtests. LHS and RHS showed impairment across initiation, selection, inhibition and strategy; however, greatest deficits were shown by RHS on Inhibition items requiring suppression of one dominant response. More patients were impaired on BELS-SC than other executive function tests.
Conclusions:
The BELS-SC demonstrated convergent, divergent, and construct validity, good sensitivity and specificity, taps multiple executive processes, and provides insight into strategy. Use in early stroke may aid in targeted and timely cognitive rehabilitation.
Neurodegenerative diseases (NDDs) are a group of complex disorders marked by pathophysiological mechanisms involving protein aggregation, mitochondrial dysfunction, oxidative stress and neuroinflammation. Irrespective of extensive research advances, NDDs have become a serious global concern and persist as a major therapeutic challenge. In recent years, microRNAs (miRNAs), a class of small non-coding RNAs, have established a pivotal role in combating NDDs. The altered expression of miRNAs is reported to be associated with the progression of various NDDs. This review aims to discuss miRNA biogenesis; dysregulation in NDDs, specifically Alzheimer’s disease, Parkinson’s disease (PD) and amyotrophic lateral sclerosis; their potential as biomarkers; and promising therapeutic targets. Additionally, there are various emerging technologies discussed that are advanced approaches to enhance miRNA-based diagnostics and therapeutics.