Marine organisms account for more than half of the global biodiversity and have proven to be a rich source of pharmacologically active compounds. Turkey has an extensive coastline hosting a diverse marine ecosystem. This paper describes the phytochemical prospection based on chromatographic profiles of extracts, fractions, and sub-fractions from Turkish organisms. In addition, the samples were evaluated for their antioxidant, anticholinesterasic, and antibacterial activities. According to the chromatographic profiles, terpenes were identified in most samples, with the exception of Dictyonella incisa. Alkaloids were detected in Ascidiella aspersa, Eunicella cavolini, Halocynthia papillosa, Limaria hians, Microcosmus polymorphus, and D. incisa. The phenolic carboxylic acids were detected in all the samples, and the results for polyphenols were similar. The extract of P. clavata showed antioxidant activity in both models evaluated, whereas the remaining samples were positive only in the bioautographic assay. With regard to AChE inhibition, D. incisa fraction showed potent activity (%I ˃ 90%), while the sub- fractions were moderate (%I ˃ 45%). In the antibacterial assay, the same samples from D. incisa have shown activity against both Gram-negative and Gram-positive bacteria. On the other hand, the present study opens up avenues for future research on D. incisa by aligning alkaloids and neuroprotective effects, taking into account that inhibition of AChE is a therapeutic strategy in the treatment of Alzheimer’s disease.

Since the mid-2010s, conflicts at UNESCO over the interpretation of Japanese colonial rule and wartime actions in the first half of the twentieth century in Japan, South Korea, and China have been fierce. Contested nominations include the Meiji Industrial Revolution Sites for the World Heritage List (Japan), the Documents of Nanjing Massacre for the Memory of the World (MoW) Register (China), and two still pending applications on the Documents on the Comfort Women (South Korean and Japanese NGOs). This paper examines the recent “heritage war” negotiations at UNESCO as they unfolded in a changing political, economic, and security environment. Linking World Heritage and MoW nominations together for a holistic analysis, this paper clarifies the interests of State actors and of various non-State actors, such as NGOs, experts, and the UNESCO secretariat. We discuss the prospects for these contested nominations and recommend further involvement of non-State actors to ensure more constructive and inclusive heritage interpretation to enable a more comprehensive understanding of history.

The study investigated the effects of replacing maize with enzyme-supplemented Dried Date Fruit Pulp (DDFP) in the diets of broiler chickens. 576-day-old commercial broiler chicks (Arbor Acre Plus) were randomly selected and distributed into 8 treatment groups of 72 birds each. Each treatment was divided into six replicates of 12 birds on a weight-equalisation basis. The treatments consisted of 4 levels of DDFP (0, 100, 200 and 300 g/kg) and 2 levels of enzyme supplementation (with or without). The data obtained were subjected to an Analysis of Variance in a 4 × 2 factorial arrangement. Birds fed 300 g/kg DDFP recorded the least weight gain (971 g) and final weight (1013 g) across the treatments at the starter phase, while there were no significant (P > 0.05) differences in the final weight, weight gain, feed intake and feed conversion ratio of birds fed with DDFP and maize-based diets at the finisher phase. DDFP inclusion reduced the experimental birds’ feeding cost (NGN/kg) and cost/kg weight gain (NGN/kg WG). Enzyme supplementation increased serum protein and glucose concentrations. Reduced (P < 0.05) EE and CF digestibility coefficients were seen in birds fed 30% DDFP at the finisher phase. Carcass indices, ileal digesta viscosity and caecal total bacteria were not negatively influenced. It was concluded that DDFP could replace up to 200 g/kg maize in broiler chicken diets at the starter phase and up to 300 g/kg at the finisher phase without any deleterious effects on health and performance.

Five specimens of the rare alpheid shrimp Betaeus levifrons Vinogradov, 1950 were collected from the burrows of the mud-shrimp Upogebia major (De Haan, 1841) in Akkeshi and Usu Bays, along the Pacific coast of Hokkaido, Japan. As B. levifrons has been previously only reported from the Russian coast of the Sea of Japan, the Hokkaido specimens represent the first record of this species from the western Pacific coast as well as a new to the Japanese fauna. Ovigerous females of B. levifrons were recorded for the first time based on specimens. This study provides additional data on this species, including its distribution, colour variation, and DNA sequences of the mitochondrial 16S rRNA and cytochrome c oxidase subunit I barcoding regions. Lastly, we revised the available data on the symbiotic fauna of U. major.

This review highlights the importance of dietary fibres (DF) intake and its interconnection with the gut microbiome and psychological well-being, while also exploring the effects of existing DF interventions on these aspects in adults. The gut microbiota is a complex and diverse ecosystem in which microbial species interact, influencing the human host. DF are heterogeneous, requiring different microbial species to degrade the complex DF structures. Emerging evidence suggests that microbial fermentation of DF produces short-chain fatty acids (SCFA), which may play a role in regulating psychological well-being by affecting neurotransmitter levels, including serotonin. The effectiveness of DF interventions depends on factors such as baseline gut microbiota composition, the dosage and the source of DF consumed. Although the gut microbiota of adults is relatively stable, studies have shown that the abundance of the species in the gut microbiota can change within 24 h of an intervention and may return to baseline following the termination of DF intervention. This review underscores the need for larger and well-powered dietary clinical trials incorporating longitudinal biological sample collections, advanced sequencing and omic techniques (including novel dietary biomarkers and microbial metabolites), validated subjective questionnaires and dietary records. Furthermore, mechanistic studies driven by clinical observations are crucial to understanding gut microbiota function and its underlying biological pathways, informing targeted dietary interventions.

There has been a renewed focus on improving mental health outcomes and experiences for women with the publication of ‘Embedding Women’s Mental Health in Sharing the Vision’, but much needs to be done to translate this policy into tangible improvements in delivered care. Historical biases in medical education and practice, as well as in research, have led to serious deficiencies in how illnesses are diagnosed and managed in women. This is not solely observed in mental health, and andronormative perspectives and gender blindness are widespread throughout medicine. Trauma informed practices should be adopted in all healthcare settings that treat women. Consideration also needs to be given to reproductive life stage in psychotropic prescribing beyond concerns of the risk of teratogenicity. Medical education and training should play a central role in increasing gender awareness among healthcare professionals. Combining top-down policy initiatives with bottom-up education and training is required to meaningfully integrate gender awareness into mental healthcare and address historical shortcomings in care for women. Implementing gender-sensitive practices is an important step toward delivering more individualised, patient-centred mental health services.

We analyze the effects of different pay-as-you-go public pension systems on financial imbalance, rate of return, and inequality of heterogeneous generations in terms of gender and education. We include aspects that are relevant for developing countries such as labor informality and payment of an old-age and social benefit. We introduce a new mixed system that combines components of the defined benefit (DB) and the defined contribution (DC) systems. Results show the new mixed system represents a compromise between the DB and DC systems and that a scheme (inspired in the German system) exhibits the highest rates of return and horizontal equity.

This article contends that the humanitarianism that developed in Europe in the 1930s and 1940s and, in particular, because of the Spanish Civil War, was shaped by a transnational network that was fundamentally female. Within this network, women with diverse political experiences converged; however, suffragism, pacifism and anti-fascism occupied a central place. Humanitarianism became for them a favourable space from which to intervene politically. To demonstrate this, we focus on the CAEERF, an aid organisation formed in 1939 in response to the arrival of Spanish refugees in France. It was created, led by and composed mainly of women from different backgrounds. The first part of this article concerns anti-fascist and humanitarian women’s networks that emerged during the Spanish Civil War. The second traces the journey of the British Quaker Edith Mary Pye, the driving force behind the CAEERF. The third and fourth parts discuss its creation and the work that it carried out on the ground.

Metarhizium guizhouense (Clavicipitaceae) is an insect pathogen employed as a mycoinsecticide against many insect pests worldwide. In this study, for the first time in a laboratory setting, the pathogenicity of the M. guizhouense isolate PSUM04 was evaluated against the coffee berry borer, Hypothenemus hampei (Coleoptera: Curculionidae: Scolytinae). Following the exposure (1 × 109 spores/mL) of H. hampei to M. guizhouense PSUM04, morpho-histopathological changes and numbers of apoptotic cells via the TUNEL (terminal deoxynucleotidyl transferase (TdT), dUTP (deoxyuridine triphosphate) nick-end labelling) assay in H. hampei were evaluated at 12-hour intervals until 144 hours after exposure. The external morphology of H. hampei underwent drastic changes from 24 to 144 hours post-exposure accompanied by the degeneration of integument and adipose tissues. The semi-quantitative analytical score of TUNEL-positive cells showed a slight increase at 12 hours after exposure and a significant increase in TUNEL-positive apoptotic cells at 48 hours after exposure. These results suggest a series of tissue alterations of H. hampei during its process of infection with a strain of M. guizhouense, highlighting the pathogen’s potential as a biological control agent in natural settings.

While the plague of Provence is the most studied outbreak of the disease in early modern Europe, there is little in the extensive historiography on this topic about fears of the cross-species transmission of disease which re-emerged in the early eighteenth century because of events in southwestern France. Concerns about the interplay between cattle murrains and human plague resurfaced in the early eighteenth century because the plague of Provence followed an outbreak of cattle disease which swept across Europe and killed tens of thousands of animals. This article focuses on the debate about the spread of contagious diseases between species which occurred in Britain during this time. Links between the health of animals and that of humans became objects of heated discussion especially following the issuing of the 1721 Quarantine Act, which was designed to prevent the plague currently ravaging southwestern France from taking hold in Britain. It then considers the different beliefs regarding contagion and the transmission of diseases between different species during the plague of Provence. While focusing on the richly documented and highly revealing discussions in early eighteenth-century Britain about the interplay between plague in cattle and plague in humans, it also utilises materials from earlier centuries to examine more fully how early modern populations understood the relationship between plague in humans and cattle murrains.

A type of signal-interference fourth-order dual-band bandpass filter (BPF) with multiple out-of-band transmission zeros (TZs) is reported. A second-order dual-band BPF block is firstly discussed, which is composed of two microstrip-to-slotline vertical transitions that are back-to-back connected by means of an in-parallel asymmetrical microstrip-line-based closed loop. It exhibits spectrally symmetrical passbands regarding the design frequency fD and three TZs at the inter-band region. Subsequently, by using stepped-impedance-line segments at the longest path of the transversal signal-interference closed loop, its dual-band BPF counterpart with second-order spectrally asymmetrical dual passbands is presented. Next, in order to increase the filter order as well as the number of out-of-band TZs for augmented stopband attenuation, a fourth-order dual-band BPF circuit is conceived. To this aim, two Y-shaped stepped-impedance microstrip stubs are loaded at the input and output ports of the previously devised second-order frequency-symmetrical dual-band BPF block. The RF operational principles of all these dual-band BPFs are detailed through their associated transmission-line-based equivalent circuits. Moreover, for experimental-demonstration purposes, a 1.154-/2.818-GHz two-layer microstrip proof-of-concept prototype of a fourth-order sharp-rejection dual-band BPF is designed, simulated, and characterized. It features inter-band power-rejection levels higher than 28.68 dB and lower-/upper-stopband attenuation levels above 40.92 dB from DC to 4.64 GHz.

Compulsory voting (CV) has been common in Latin America. While research on its effects is burgeoning, little is known about its origins. This article seeks to start filling the gap by focusing on the adoption of CV in democratising polities. It proposes an explanation that rests on two implications of what this institution can reasonably be expected to do, i.e. increase turnout. The first logic suggests that CV was established to curb electoral malfeasance. The second, in turn, posits that it was introduced for damage limitation to those who held power. These hypotheses are tested against alternatives through a comparative historical study of three South American countries.

Kant claims that we must Believe (or have faith, Glaube) in the attainability of our ultimate moral end – the Highest Good – and that God exists. According to a strand of orthodoxy, this claim rests on a rational principle, called Attainability: one can rationally will an end only if one thinks that it is attainable. However, this orthodox view faces four prominent objections concerning (1) acting as if, (2) the modal content of Beliefs, (3) approximation, and (4) withholding belief about Attainability. I show that Attainability should be read as a principle of willing simpliciter and that these objections do not withstand critical scrutiny. Kant’s critics, therefore, will need either to sharpen their objections or seek alternatives elsewhere.

Single ventricle patients undergoing comprehensive stage II palliation have higher incidence of severe acute kidney injury compared to the bidirectional Glenn palliation; however, the optimal method for early detection remains unknown. Several urinary biomarkers are increased in other patient populations with postoperative kidney injury. We explored the kinetics of these biomarkers in this high-risk population.

We conducted prospective, observational study of 20 patients with single ventricle physiology who underwent second stage palliation (July 2019–December 2021). Acute kidney injury was defined by Kidney Diseases Improving Global Guidelines, based on peak serum creatinine value and urine output. Urine samples were collected pre-operatively and at 1-, 6-, and 24-hours post-surgery. Urinary biomarkers neutrophil gelatinase-associated lipocalin, interleukin-18, liver fatty acid-binding protein, kidney injury molecule-1, and cystatin C were quantified by enzyme linked immunosorbent assay, normalised to urinary creatinine, and shown as median [interquartile range].

Four patients (50%) undergoing comprehensive stage II and 1 patient (8%) undergoing bidirectional Glenn palliation developed stage ≥ 2 acute kidney injury. Comprehensive stage II compared to bidirectional Glenn group had higher median neutrophil gelatinase-associated lipocalin (1769 [1309–1961] versus 91[18–1120] ng/mg) and liver fatty acid-binding protein (12,836 [5016–19798] versus 1272 [220–5172] ng/mg) that peaked 1-hour post-surgery. Kidney injury molecule-1 was significantly greater at 1-, 6-, and 24-hours (greatest) post-surgery in comprehensive stage II than bidirectional Glenn (24h: 11[9–23]) versus 2 [1–6] ng/mg).

Elevated urinary neutrophil gelatinase-associated lipocalin, liver fatty acid-binding protein, and kidney injury molecule-1 may be useful biomarkers for early detection of acute kidney injury in children following comprehensive stage II palliation.

We give a short proof of the anticyclotomic analogue of the “strong” main conjecture of Kurihara on Fitting ideals of Selmer groups for elliptic curves with good ordinary reduction under mild hypotheses. More precisely, we completely determine the initial Fitting ideal of Selmer groups over finite subextensions of an imaginary quadratic field in its anticyclotomic $\mathbb {Z}_p$-extension in terms of Bertolini–Darmon’s theta elements.

Despite Hegel’s great admiration for Schiller and Schiller’s influence on Hegel’s philosophy of art, Hegel rarely praises Schiller’s tragedies and is indeed often critical of Schiller’s dramatic works. These criticisms for the most part concern characters who fail to live up to Hegel’s criteria for tragic heroes, as they vacillate, come to an unheroic demise, or are inwardly conflicted about their aims or actions. Despite these criticisms, this article argues that some of Schiller’s tragic heroines are nonetheless beautiful by Hegel’s own lights. Using Schiller’s Mary Stuart (1800) and The Maid of Orleans (1801), I argue that a deep spiritual beauty is exemplified in Schiller’s Joan of Arc and Mary Stuart, who overcome an inner conflict to achieve spiritual reconciliation, affording us the experience of Hegel’s ideal. Schiller’s tragic heroines present the beautiful triumph of an individual’s subjective freedom over great spiritual conflict, which is Hegel’s definition of artistic beauty. It is hoped that this article offers a new perspective not only on Hegel’s philosophy of art, but also on the power and beauty of Schiller’s tragic heroines.