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Artificial sweeteners are used to reduce energy intake, but studies suggest that consumption during pregnancy may impact the offspring’s risk of overweight. In this longitudinal cohort study, we aimed to examine the association between consumption of artificially sweetened or sugar-sweetened beverages during pregnancy and offspring overweight from birth to 18 years in the Danish National Birth Cohort. A total of 101 042 pregnancies were enrolled in the Danish National Birth Cohort from 1996 to 2002. Follow-up was conducted throughout pregnancy, childhood and adolescence. Additionally, 72 821 women completed an FFQ during pregnancy, reporting intake of beverages sweetened with artificial sweeteners or sugar. Offspring height and weight were obtained during childhood and adolescence. Multivariate logistic regression was performed to estimate the OR for overweight concerning maternal beverage consumption. Analyses were adjusted for risk factors for childhood overweight, including maternal age, pre-pregnancy BMI, physical activity and smoking in pregnancy, healthy eating index, paternal BMI, socio-economic status and duration of breastfeeding. We found increased odds of overweight in 7-, 11-, 14- and 18-year-old offspring whose mothers reported drinking ≥ 1 artificially sweetened beverage daily during pregnancy compared with no consumption (18 years: adjusted OR 1·26 (95 % CI 1·12, 1·42)). We found decreased adjusted odds of overweight in 11- and 18-year-old offspring whose mothers reported drinking ≥ 1 sugar-sweetened beverage daily during pregnancy compared with no consumption. We found that consumption of artificially sweetened beverages during pregnancy was associated with an increased risk of overweight in childhood and adolescence after adjustment for risk factors for childhood overweight.
Detrimental impacts of early ecological adversity on children’s development are known, but our understanding of their mechanisms and factors contributing to multifinality of developmental trajectories triggered by adversity is incomplete. We examined longitudinal pathways from ecological adversity parents experienced when children were infants, measured as a cumulative index of fine-grained scores on several ecological risks, to children’s future self-regulation (SR) in 200 U.S. Midwestern community families (96 girls). Parents’ observed power-assertive styles were modeled as mediators, and their negative internal working models (IWMs) of the child, coded from interviews – as moderators. Both were assessed twice, at 16 months and at 3 years, to inform our understanding of their developmental timing. Children’s SR was reported by parents and observed at 4.5 years. Path analyses revealed moderated mediation in mother-child relationships: A path from higher early ecological adversity to elevated power assertion to children’s poorer SR was significant only for mothers with highly negative IWMs of the child. Maternal negative IWMs assessed early, at 16 months, moderated the link between ecological adversity and power assertion. Once elevated, maternal power assertion was stable through age 3 and not moderated by IWM at age 3. There were no significant effects in father-child relationships.
To evaluate the outcomes of patients with single ventricle physiology supported with extracorporeal membrane oxygenation as a bridge to first-stage palliation.
Methods:
This was a retrospective registry-based study. Data from the Extracorporeal Life Support Organization registry were used to identify single ventricle physiology patients supported with extracorporeal membrane oxygenation prior to palliation from 2016 to 2021. Descriptive statistics and multivariate analyses for associations with mortality were conducted.
Results:
Primary outcome was death before hospital discharge. Patient characteristics including demographics and associated complications were evaluated as secondary outcomes. Sixty-five patients met inclusion criteria. Survival to discharge was 42%. Twenty-four (37%) patients died while on extracorporeal membrane oxygenation. There was no significant difference in demographics between survivors and non-survivors. Non-survivors had a significantly longer median duration on extracorporeal membrane oxygenation compared to survivors, 99-hrs [IQR (Interquartile Range), 160, 300] vs. 59-hrs [43, 124] (p<0.001). Multivariate analysis demonstrated extracorporeal membrane oxygenation duration (adjusted-OR [Odds Ratio] 1.01, 95% CI [Confidence Interval] 0.98, 0.99; p = 0.03) and requiring renal replacement therapy (42% vs. 19%; p = 0.04) were associated with mortality prior to discharge.
Conclusions:
Clinicians managing decompensated patients with single ventricle physiology may consider extracorporeal membrane oxygenation as a bridge to palliation. Survival to discharge was 42%. Evidence of renal injury and longer extracorporeal membrane oxygenation durations were associated with mortality. These data may be used to guide providers and to counsel families. However, more data are needed to refine indications and assess associations related to outcomes and decision-making.
This History of Education Society Presidential Address considers Blackfoot education and how psychologist Abraham Maslow attempted to make sense of it after his six-week stay at the Siksika reserve in 1938. Maslow encountered an educated, secure people at Siksika, who had a fully formed system of education grounded in reverence for children, stories, ceremonies, songs, language, humor, land, and connection, all of which had been tested over millennia. Though he might not have been able to interpret what he was seeing and hearing as fully as would a member of the Blackfoot community, what he experienced stuck with him, and can be read as the basis for the theories he presented as the hierarchy of needs and self-actualization. As Maslow learned, Blackfoot history is an education history, which Blackfoot Elders sought to document and keep for generations not yet born.
Aphis gossypii Glover (Hemiptera: Aphididae) is a significant pest of Capsicum annuum (Solanales: Solanaceae) and exhibits intraspecific differentiation within populations. To investigate the adaptability of Hap3 and Hap17 A. gossypii to various C. annuum varieties, including ‘Lvzhou101’ (LZ), ‘Lashen’ (LA), ‘Saierweilvtianjiao’ (SE), ‘Haimaihongri’ (HM), ‘Chaotianjiao’ (CT), and ‘Luosijiangjun’ (LS), we employed life tables to analyse growth and population parameters post-feeding and conducted petri dish host choice experiments to assess the host plant preference of A. gossypii. Survival rates of A. gossypii varied significantly across C. annuum varieties. Notably, Hap3 and Hap17 thrived on ‘LZ’ but failed to establish populations on ‘LA’. The net reproductive rate (R0), average generation time (T), and intrinsic rate of increase (rm) differed markedly between Hap3 and Hap17 across C. annuum varieties. Feeding on ‘LZ’ resulted in a significantly higher R0 value (26.49) for Hap3 relative to other varieties. The T (7.60 days) and rm (0.27) values for Hap3 on ‘SE’ were superior to those observed on other C. annuum varieties. These findings indicate that ‘SE’ is the optimal host for Hap3 growth, while ‘LZ’ best supports Hap17. Both haplotypes exhibited the lowest adaptability to ‘LA’. Therefore, the utilisation capacity of A. gossypii populations on C. annuum demonstrates differentiation, and the resistance levels among C. annuum varieties to A. gossypii vary. This differentiation can inform targeted management strategies for aphid infestations on pepper crops.
Low-inertia pulsatile flows in highly distensible viscoelastic vessels exist in many biological and engineering systems. However, many existing works focus on inertial pulsatile flows in vessels with small deformations. As such, here we study the dynamics of a viscoelastic tube at large deformation conveying low-Reynolds-number oscillatory flow using a fully coupled fluid–structure interaction computational model. We focus on a detailed study of the effect of wall (solid) viscosity and oscillation frequency on tube deformation, flow rate, phase shift and hysteresis, as well as the underlying flow physics. We find that the general behaviour is dominated by an elastic flow surge during inflation and a squeezing effect during deflation. When increasing the oscillation frequency, the maximum inlet flow rate increases and tube distention decreases, whereas increasing solid viscosity causes both to decrease. As the oscillation frequency approaches either $0$ (quasi-steady inflation cycle) or $\infty$ (steady flow), the behaviours of tubes with different solid viscosities converge. Our results suggest that deformation and flow rate are most affected in the intermediate range of solid viscosity and oscillation frequency. Phase shifts of deformation and flow rate with respect to the imposed pressure are analysed. We predict that the phase shifts vary throughout the oscillation; while the deformation always lags the imposed pressure, the flow rate may either lead or lag depending on the parameter values. As such, the flow rate shows hysteresis behaviour that traces either a clockwise or counterclockwise curve, or a mix of both, in the pressure–flow rate space. This directional change in hysteresis is fully characterised here in the appropriate parameter space. Furthermore, the hysteresis direction is shown to be predicted by the signs of the flow rate phase shifts at the crest and trough of the oscillation. A distinct change in the tube dynamics is also observed at high solid viscosity which leads to global or ‘whole-tube’ motion that is absent in purely elastic tubes.
We use data on Latino children in the United States who have been randomly assigned calculation tests in English or Spanish to check for the so-called bilingual advantage, the notion that knowing more than one language improves individuals’ other cognitive skills. After controlling for different characteristics of children and their parents, as well as children's time in the US, we find a bilingual advantage among children who read or write in English and Spanish but not for those who only speak or understand both languages. In particular, bilingual readers or writers perform one-fourth to one-third of a standard deviation better than monolingual children, equal to learning gains of an additional school year. Applying the Oster test, we find that selection on unobservables would need to be 3–4 times stronger than selection on observables to explain away our results. The bilingual advantage is stronger among children in two-parent households with siblings and for those at the upper end of the ability distribution.
To examine if the current taught undergraduate psychiatry syllabus at an Irish University relates to what doctors in psychiatry consider to be clinically relevant and important.
Methods:
Doctors of different clinical grades were invited to rate their views on 216 items on a 10-point Likert scale ranging from ‘0 = not relevant’ to ‘10 = very relevant’. Participants were invited to comment on topics that should be excluded or included in a new syllabus. Thematic analysis was conducted on this free-text to identify particular themes.
Results:
The doctors surveyed rated that knowledge of diagnostic criteria was important for medical students. This knowledge attained high scores across all disorders with particularly high scores for a number of disorders including major depressive disorder (mean = 9.64 (SD = 0.86)), schizophrenia (mean = 9.55 (SD = 0.95)) and attention deficit hyperactivity disorder (Attention Deficit Hyperactivity Disorder (ADHD); mean = 9.26 (SD = 1.40)). Lower scores were noted for less frequently utilised management strategies (transcranial magnetic stimulation (mean = 4.97 (SD = 2.60)), an awareness of the difference in criteria for use disorder and dependence from psychoactive substances (mean = 5.56 (SD = 2.26)), and some theories pertaining to psychotherapy (i.e. Freud’s drive theory (mean = 4.59 (SD = 2.42)).
Conclusions:
This study highlights the importance of an undergraduate programme that is broad based, practical and relevant to student’s future medical practice. An emphasis on diagnosis and management of major psychiatry disorders, and knowledge of the interface between mental health services, other medical specialities and support services was also deemed important.
We present an agent-based model to study how the structure of a scientific network could affect the public uptake of science and how this impact is influenced by scientific uncertainty and affinity bias. For unbiased agents, a highly connected scientific network decreases the probability that the public favors the correct theory. For biased agents, however, a moderately connected scientific network causes the public to favor the correct theory more often. This results from the competition between the scarcity of information (for poorly connected agents) and the spread of misleading information (for highly connected agents). Adding more scientists strengthens both effects.
Three popular objections to reductionism about color, experience as of impossible colors, the unary/binary distinction, and structural mismatch, are issues just, I argue, for the (probably default) version of reductionism according to which colors reduce to sets of surface spectral reflectances. They are not problems for the version on which colors are dispositions to reflect coarse-grained intensities of light are—what in colorimetry are called “object colors.” This article sets out to demonstrate the virtues of the latter reductionism.
This article defends informed preference satisfaction theories of welfare against the most influential objections put forward in the economic and philosophy of science literatures. The article explicates and addresses in turn: the objection from inner rational agents; the objection from unfeasible preference reconstruction; the objection from dubious normative commitments; the objection from conceptual ambiguity; and the objection from conceptual replacement. My defence does not exclude that preference satisfaction theories of welfare face significant conceptual and practical challenges. Still, if correct, it demonstrates that philosophers/welfare economists are justified in relying on specific versions of such theories, namely informed preference satisfaction theories.
Total anomalous pulmonary venous return is a rare CHD that may present in the neonatal period with signs of congestive cardiac failure. First-line treatment is corrective surgery in the first months of life. The authors report the case of a 2-month-old infant with non-obstructive total anomalous pulmonary venous return submitted to a two-stage hybrid repair, involving cardiac surgery and interventional cardiology.
This case report discusses a 1-year-old female with severe growth retardation and multiple congenital anomalies, including a large patent ductus arteriosus and interrupted inferior vena cava. Successful percutaneous patent ductus arteriosus closure was achieved via the azygos venous route, overcoming anatomical challenges and highlighting the importance of individualized procedural strategies in complex cases.
Is gender violence considered a part of advancing Indigenous self-determination in Alaska? What are the key jurisdictional, institutional, infrastructural, and community level challenges in combating violence against Alaska Native women? Few studies have considered the relationship between gender violence and Alaska Native sovereignty. I address this gap by employing the theory of relational Indigenous self-determination and drawing on research interviews with Indigenous women in Alaska and analyzing the data in light of two recent legislative changes: the 2022 reauthorization of the Violence Against Women Act, and the legislation that formally recognizes Alaska Native tribes in the state of Alaska. The findings demonstrate that persistent questions about Alaska Native jurisdiction stemming from the 1971 Alaska Native Claims Settlement Act (ANCSA) limit considering violence against Indigenous women and Indigenous self-determination as issues that need to be addressed in tandem.
We use recent advances in polynomial diffusion processes to develop a continuous-time joint mortality model for the actuarial valuation and risk analysis of life insurance liabilities. The model considers the stochastic nature of future mortality improvements and introduces a common subordinator for the marginal survival processes, resulting in a nontrivial dependence structure between the survival of pairs of individuals. Polynomial diffusion processes can be used to derive closed-form formulae for standard actuarial quantities. The model fits well with a classic dataset provided by a Canadian insurer and can be used to evaluate products issued to multiple lives, as shown through numerical applications.