To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
A time-domain model of an ice shelf interacting with ocean water in a finite domain is developed, which combines Kirchhoff–Love plate theory with the shallow-water wave equations. In particular, the domain is divided into an open-water region and a region in which the ocean is covered by an ice shelf. Boundary conditions, together with continuity conditions at the ice–water interface, lead to a nonlinear matrix eigenvalue problem, which is solved numerically to obtain the natural modes and frequencies of the system. These form the basis for reconstructing the transient response to wave forcing using a spectral method. Simulations show how wave packets excite multiple modes and generate interference patterns through boundary reflections. Since the method solves the initial value problem in a geometry containing both an open-ocean region and an ice-shelf-covered region, it provides a foundation for simulating sequential break-up of ice shelves due to wave-induced mechanical stresses, and contributes to broader efforts to model ice shelf disintegration under ocean forcing.
We investigate uniqueness of solution to the heat equation with a density $\rho$ on complete, non-compact weighted Riemannian manifolds of infinite volume. Our main goal is to identify sufficient conditions under which the solution $u$ vanishes identically, assuming that $u$ belongs to a certain weighted Lebesgue space with exponential or polynomial weight, $L^p_{\phi}$. We distinguish between the cases $p \gt 1$ and $p = 1$ which required stronger assumptions on the manifold and the density function $\rho$. We develop a unified method based on a conformal transformation of the metric, which allows us to reduce the problem to a standard heat equation on a suitably weighted manifold. In addition, we construct explicit counterexamples on model manifolds which demonstrate optimality of our assumptions on the density $\rho$.
Following the pivotal work of Sevastyanov (1957), who considered branching processes with homogeneous Poisson immigration, much has been done to understand the behaviour of such processes under different types of branching and immigration mechanisms. Recently, the case where the times of immigration are generated by a non-homogeneous Poisson process has been considered in depth. In this work, we demonstrate how we can use the framework of point processes in order to go beyond the Poisson process. As an illustration, we show how to transfer techniques from the case of Poisson immigration to the case where it is spanned by a determinantal point process.
This paper introduces an overlapping generations model to explore the interplay between economic growth, the environment, and endogenous technology adoption. Considering an economy with physical capital and publicly funded human capital, the analytical framework extends Prieur and Bréchet (2013, Macroeconomic Dynamics 17, 1135–1157) by incorporating the endogenous technology choice mechanism from Umezuki and Yokoo (2019, Journal of Economic Dynamics & Control 100, 164–175). The analysis focuses on how the choice of capital-intensive technologies impacts environmental dynamics. The model reveals complex equilibrium dynamics, driven by a core trade-off between individuals’ resource allocation on consumption versus environmental protection and firms’ technology decisions.
Constant-force mechanisms (CFMs) are attractive for mechanical energy storage owing to their distinctive force–displacement characteristics, particularly under conditions with limited external load capacity and restricted space. However, conventional CFMs often suffer from short constant-force strokes and inefficient space utilization, which hinder their broader application. To address these limitations, this study exploits the buckling of compliant beams and increases the structural degrees of freedom by adopting a less constrained configuration, which extends the constant-force stroke and space utilization while reducing the required external load, thus improving energy storage efficiency for the same stored elastic energy. A novel catapult was developed through NSGA-II multi-objective optimization, achieving a high energy-to-cost ratio and an extended constant-force stroke. This work presents an effective design approach for motion mechanisms that demand high energy-storage efficiency and high-power output.
The pandemic crisis introduced an unprecedented supply-side shock that was global in scope. Despite historically high levels of prior sovereign debt and low bond yields, macroeconomic policy responses included monetised fiscal expansions of extraordinary magnitude. Conventional theory suggests that the combination of supply contractions with such expansions is inflationary, yet central bank discourse during the pandemic expressed little concern about inflation. Our theoretical analysis suggests the presence of strong inflation forces at the time, likely offset by continuing pessimism shocks, consumption constraints and expectations management. In prominent advanced countries over more than a century, monetised fiscal expansions are shown to have preceded inflation surges, most strongly following signature episodes like WWII.
Ocrelizumab (OCR) and rituximab (RTX) are anti-CD20 monoclonal antibodies (CD20Mabs) used in the treatment of relapsing multiple sclerosis (RMS). While both are effective at reducing relapses and new MRI lesions in clinical trials, real-world data on discontinuation rates and reasons for stopping therapy are limited.
Methods:
This observational retrospective chart review included patients from two MS clinics in British Columbia, Canada. RMS patients treated with at least one infusion of OCR or RTX between January 2017 and March 2023 were included. Primary outcomes were reasons for discontinuation and discontinuation rates, with a secondary outcome of time to discontinuation.
Results:
In total, 881 RMS patients were included, with 478 on OCR and 403 on RTX. A total of 16.9% of patients on OCR and 14.9% on RTX discontinued therapy over 1643 and 694 patient-years, respectively (p = 0.46). Reasons for discontinuation included: side effects (33.3%), insurance coverage (17.0%) and clinical or radiological disease activity (11.3%). Discontinuation rates at 12, 24 and 36 months were 3.5%, 8.2% and 12.5% for OCR, and 6.4%, 14.8% and 22.2% for RTX, respectively (p = 0.0089). Median time to discontinuation was 21 months on OCR and 11.5 months on RTX (p < 0.0001). On Cox regression analysis, treatment with RTX was the only variable associated with discontinuation (hazard ratio 1.72, 95% CI 1.20–2.45).
Conclusion:
Discontinuation rates of CD20Mabs were low, and the most common reason for stopping was side effects. Although not designed for comparison, our study suggests RMS patients may persist longer on OCR than RTX.
Equilibrium shapes of hollow vortices with surface tension in a corner geometry are obtained by solving a free-boundary problem. Using the integral hodograph method, we derive the complex velocity potential in an auxiliary parameter plane, which includes the velocity magnitude along the free surface. A singular integral equation for the velocity magnitude is obtained by applying the dynamic boundary condition. Numerical solutions to this equation reveal a wave quantisation phenomenon on the boundary of the hollow vortex due to the surface tension. The number of waves allocated on the free surface is arbitrary, starting from some minimal value depending on the strain-to-circulation ratio, the corner angle and the surface tension. In the limiting case of zero surface tension, the solution is obtained analytically and shown to agree with previous studies based on alternative mathematical formulations. These findings provide the first known equilibrium configurations of hollow vortices with surface tension in the presence of solid boundaries.
To assess the efficacy of intranasal cryotherapy to treat chronic rhinitis refractory to medical therapy.
Methods
An evaluation was performed for all patients (n = 36) with chronic rhinitis refractory to medical treatment who underwent intranasal cryotherapy between 2022 and 2024 at this centre. The primary outcome measures were changes in validated pre- and post-operative scoring systems (Total Nasal Symptom Score, Sino-Nasal Outcome Test 22 (SNOT-22), Nasal Obstruction Symptom Evaluation and peak inspiratory nasal flow).
Results
Objective scoring pre- and post-procedure showed statistically significant improvement across all measures (p < 0.001): mean Total Nasal Symptom Score (12 hours) 8.4 to 5.3, Total Nasal Symptom Score (2 weeks) 9.2 to 5.9, SNOT-22 56 to 31, Nasal Obstruction Symptom Evaluation 57.5 to 28.5 and peak inspiratory nasal flow 98 to 138 l/min.
Conclusion
This is the only dataset for patients receiving intranasal cryotherapy in the UK to date and follows patients over a two-year period. The results support the ongoing use of intranasal cryotherapy for sustained treatment of refractory chronic rhinitis.
Crop wild relatives represent an essential reservoir of untapped genetic diversity for crop improvement. Despite sesame (Sesamum indicum L.) being an important oilseed crop, its wild relatives remain underutilized for characterization and breeding efforts. To comprehensively assess their potential, a field evaluation was conducted during the kharif seasons of 2022 and 2023 on 53 accessions belonging to seven wild, three S. indicum accessions, and three cultivated species. Thirty-four agro-morphological traits (18 qualitative, 16 quantitative) were characterized under field conditions. Substantial variability was observed across key traits, including plant height, branching patterns, leaf morphology, corolla structure and pigmentation, capsule size and shape, seed characteristics, and yield-contributing attributes. Multivariate analyses revealed significant clustering patterns, and several traits, notably capsule width, capsule length, corolla length, seed area and test weight, exhibited high heritability. Importantly, certain wild accessions such as IC621506 and IC557250 (early maturity), IC409053, IC204658, IC208661 and IC208662 (greater capsule number), and IC208661, IC208662 and IC409053 (superior seed yield per plant) outperformed cultivated sesame species. These novel accessions constitute valuable genetic resources for broadening the cultivated gene pool and enhancing breeding strategies. This study provides the first comprehensive characterization of morphological diversity in wild sesame species, underscoring their potential utility in developing high-yielding, resilient varieties that can address future agricultural challenges.
This study aimed to evaluate the microclimatic conditions of natural shading provided by Ipês (Handroanthus heptaphyllus [Vell.] Mattos), and of an artificial shading structure characterized by the combination of an aluminized net on the outside and a black polypropylene net on the inside. In addition, their effects were analysed with respect to the physiological and behavioural responses of Holstein cows kept at pasture in a tropical climate. Two paddocks were used, one with trees and the other with trees and an artificial shade structure. Eight multiparous cows were evaluated over 20 non-consecutive days and selected according to their predominant coat colour: four with predominantly white coats and four with predominantly black coats. The experimental days were classified as very hot, with radiation above 625 Wm−2; and hot days, with radiation between 300 and 625 Wm−2. The mean radiant temperature (°C), the radiant heat load (Wm−2) and the black globe humidity index were calculated. The mean radiant temperature for artificial shading was lower for all days (P < 0.05), with values below 30°C during daylight hours. The radiant heat load was lower under the artificial shading structure regardless of the day (P < 0.05), with values below 470 Wm−2. When compared microclimatically with natural shading, artificial shading was more efficient (P < 0.05) in reducing mean radiant temperature and radiant heat load. Although behavioural variation (P < 0.05) was observed, these results were related to the difference in coat pattern. Animals with predominantly black coats grazed in the early morning hours and sought protection as thermal comfort levels rose.
The question of how digital health is regulated has become increasingly important within debates on technology, inequality and global health. While digital health is frequently celebrated for its capacity to expand access, build resilient systems and advance equity, scholars have raised critical concerns about its role in reproducing asymmetries of power. The potential for reproducing rather than curbing inequality is particularly relevant for the Global South. This Special Issue of the International Journal of Law in Context interrogates the ways in which digital health infrastructures, regulatory frameworks and transnational data flows are constitutive of coloniality and neoliberal capitalism. Bringing together socio-legal, feminist and decolonial perspectives, the contributions examine regulation as a terrain in which vulnerabilities, exclusions and structural inequalities are reinforced. Against the celebratory rhetoric of innovation, this collection situates regulation as a key site for understanding the entanglement of digital health with broader histories of coloniality and capitalism.
In this research, a hierarchical dynamic and kinematic modeling framework is proposed for a wheeled-legged manipulator (WLM), explicitly incorporating wheel slip and skid effects through the Gibbs–Appell formulation. Unlike traditional Lagrangian methods that depend on constraint multipliers, the proposed approach unifies the platform and manipulator dynamics while substantially reducing computational complexity. This integration enables efficient handling of nonholonomic constraints without compromising physical fidelity and offers a clear separation between subsystems, allowing the effects of wheel-ground interactions to be analyzed independently from manipulator motions. The proposed formulation is validated through a combination of MATLAB/Webots simulations and laboratory experiments conducted under both dry and wet (soapy ceramic) surface conditions. Experimental results indicate end-effector position deviations of 8–10.5% primarily due to wheel slip and initial joint torque discrepancies of 6.5–20% that progressively diminish as steady-state motion is reached. Comparative evaluation against a conventional Lagrangian model highlights the computational advantage of the Gibbs–Appell formulation, demonstrating reduced assembly time and fewer symbolic differentiation operations. Furthermore, a sensitivity analysis on friction coefficients and slip ratios confirms the robustness of the model to variations in surface conditions. Beyond accurate dynamic prediction, the hierarchical structure enables modular real-time implementation, supporting controller design, trajectory planning, and fault detection. Overall, the results demonstrate that the Gibbs–Appell-based hierarchical modeling framework combines analytical rigor with computational efficiency, providing a robust foundation for control and optimization in advanced wheeled-legged robotic manipulators.
We use direct numerical simulations to investigate fluid–solid interactions in suspensions of rigid fibres settling under gravity in a quiescent fluid. The solid-to-fluid density ratio is $\mathcal{O}(100)$, while the Galileo number ($ \textit{Ga}$) and fibre concentration ($n\ell_{\kern-1.5pt f}^3$) are varied over the ranges $ \textit{Ga} \in [180, 900]$ and $n\ell_{\kern-1.5pt f}^3 \in [0.36, 23.15]$; $\ell_{\kern-1.5pt f}$ denotes the fibre length and $n$ the number density. At high $ \textit{Ga}$ and/or low $n\ell_{\kern-1.5pt f}^3$, fibres cluster into gravity-aligned streamers with elevated concentrations and enhanced settling velocities, disrupting the flow homogeneity. As $ \textit{Ga}$ increases and/or $n\ell_{\kern-1.5pt f}^3$ decreases, the fluid-phase kinetic energy rises and the energy spectrum broadens, reflecting enhanced small-scale activity. The flow anisotropy is assessed by decomposing the energy spectrum into components aligned with and transverse to gravity. Vertical fluctuations are primarily driven by fluid–solid interactions, while transverse ones are maintained by pressure–strain effects that promote isotropy. With increasing $ \textit{Ga}$, nonlinear interactions become more prominent, producing a net forward energy cascade toward smaller scales, punctuated by localised backscatter events. Analysis of the local velocity gradient tensor reveals distinct flow topologies: at low $ \textit{Ga}$, the flow is dominated by axisymmetric compression and two-dimensional straining; at high $ \textit{Ga}$, regions of high fibre concentration are governed by two-dimensional strain, while voids are associated with axisymmetric extension. The fluid motion is predominantly extensional rather than rotational.