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We investigated associations between ‘healthy dietary pattern’ scores, at ages 36, 43, 53 and 60–64 years, and body composition at age 60–64 years among participants from the MRC National Survey of Health and Development (NSHD). Principal component analyses of dietary data (food diaries) at age 60–64 years were used to calculate diet scores (healthy dietary pattern scores) at each age. Higher scores indicated healthier diets (higher consumption of fruit, vegetables and wholegrain bread). Linear regression was used to investigate associations between diet scores at each age and height-adjusted dual-energy X-ray absorptiometry-measured fat and lean mass measures at age 60–64 years. Analyses, adjusting for sex and other potential confounders (age, smoking history, physical activity and occupational class), were implemented among 692 men and women. At age 43, 53 and 60–64 years, higher diet scores were associated with lower fat mass index (FMI) and android:gynoid fat mass ratio; for example, in fully adjusted analyses, a standard deviation (sd) increase in diet score at age 60–64 years was associated with an SD difference in mean FMI of −0·18 (95 % CI: −0·25, −0·10). In conditional analyses, higher diet scores at ages 43, 53 and 60–64 years (than expected from diet scores at younger ages) were associated with lower FMI and android:gynoid fat mass ratio in fully adjusted analyses. Diet scores at age 36 years had weaker associations with the outcomes considered. No associations regarding appendicular lean mass index were robust after full adjustment. This suggests that improvements in diet through adulthood are linked to beneficial effects on adiposity in older age.
Evidence is largely limited regarding the extent to which abnormal behavioural profiles, including physical inactivity, sedentary behaviour and inadequate sleep duration, impact long-term health conditions in individuals with pre-existing depression.
Aims
To investigate the associations between accelerometer-derived daily movement behaviours and mortality in individuals with pre-existing depression.
Method
Between 2013 and 2015, a total of 10 914 individuals with pre-existing depression were identified from the UK Biobank through multiple sources including self-reported symptoms, records of antidepressant usage and diagnostic recording based on the 10th Revision of the International Classification of Diseases (ICD-10) codes F32–F33. These participants were subsequently followed up until 2021. Wrist-worn accelerometers were used for objective measurement of sleep duration, sedentary behaviour, moderate-to-vigorous physical activity (MVPA) and light physical activity (LPA) over a span of seven consecutive days.
Results
During a median follow-up of 6.9 years, 434 deaths occurred among individuals with pre-existing depression. We observed a U-shaped association between sleep duration and mortality in individuals with pre-existing depression, with the lowest risk occurring at approximately 9 h/day. Both MVPA and LPA exhibited an L-shaped pattern in relation to mortality, indicating that engaging in higher levels of physical activity was associated with lower risk of mortality in individuals with pre-existing depression, but the beneficial effect reached a plateau after 50 min/day for MVPA and 350 min/day for LPA. We found a positive association between sedentary time and mortality, and the risk apparently increased above 8 h/day. Moreover, substituting 1 hour/day of sedentary time with LPA or MVPA was significantly associated with a 12% (hazard ratio: 0.88, 95% CI: 0.83–0.94) and 24% (hazard ratio: 0.76, 95% CI: 0.61–0.94) lower risk of mortality, respectively.
Conclusions
Our study found the beneficial effect of adequate sleep duration, high levels of physical activity and short sedentary time on risk of mortality among individuals with pre-existing depression.
İstanbul was the only one of the capital cities of the defeated Central Powers to suffer a military occupation for almost five years between 1918 and 1923. The question posed in this Postscript is whether occupied Istanbul resembled cities within the orbit of the British and French empires of the time? The tentative answer we propose is that Istanbul was a cosmopolitan city turned into a colonial outpost of the British and French empires. Within this context, aspects of the cultural life of Istanbul took on a number of political colourations, examined by the authors whose essays precede the Postscript.
We solve the non-discounted, finite-horizon optimal stopping problem of a Gauss–Markov bridge by using a time-space transformation approach. The associated optimal stopping boundary is proved to be Lipschitz continuous on any closed interval that excludes the horizon, and it is characterized by the unique solution of an integral equation. A Picard iteration algorithm is discussed and implemented to exemplify the numerical computation and geometry of the optimal stopping boundary for some illustrative cases.
The ocellated shrimp goby, Tomiyamichthys russus was recorded from peninsular India based on a single specimen from Royapuram Fishing Harbour (13°07′24.49′′ N; 80°17′52.20′′E), Chennai, Southeast coast of India. The specimen was identified as the ocellated shrimp goby, T. russus by identification characteristics such as crosswise rows of small orange spots surrounded by minute dull black circles in the post-orbital and pre-dorsal region; posterior area of the gill membrane orange; operculum with pale violet traces. The morphometric characteristics were compared with the previous reports of ocellated shrimp goby. The present finding is the documentation of rare ocellated shrimp goby from the peninsular Indian coast.
This report outlines a 9-year-old Thai boy with acute myocarditis due to rhinovirus infection, manifesting complete heart block. Despite aggressive treatment, including pulse methylprednisolone and temporary pacing, his condition remained unstable. He gradually improved over five days in the paediatric cardiac ICU and continued recovery over six months. This underscores the need for comprehensive treatment and follow-up in paediatric myocarditis.
In 2005, Enzo Traverso argued that a very problematic trend was affecting German memory culture and scholarship about Nazism. Echoing an alarm raised earlier by Timothy Mason, the scholar contended that at least since the 1980s there had been a progressive ‘disparition de la notion de “fascism” du champ historiographique’ (disappearance of the concept of ‘fascism’ from historiography) (p.94). The phenomenon observed by Traverso has found concrete materialisation in the EU's politics of memory developed throughout the twenty-first century. As Filippo Focardi argues in his work Nel cantiere della memoria (2020), the EU memory discourse has been shaped around a totalitarian paradigm centred on the memorialisation of Nazi and Communist crimes, in which the notion of a general form of fascism finds little space, and Italian Fascism only exists as a marginal epiphenomenon. This situation has begun to change in recent years as the growing success of far-right movements across the globe has brought international attention to the concept of fascism. Many Italian scholars, who have never ceased to study fascism, are now directing their efforts towards the international arena to contribute to a discussion that seems to have acquired particular significance for the understanding of our time.
This article discusses illusions of ‘three hands’ in the circle of Joachim and the Mendelssohns, arguing that manifestations of ‘three hands’ at play created an aesthetic both in dialogue with the Golden Age of Virtuosity, and going beyond it. Though techniques alluding to three hands or multiple performing bodies diminished sharply in popularity after 1830–50, violin and piano music from the later nineteenth and twentieth centuries remained highly virtuosic and often ‘unplayable’ in other ways. The difference between before and after the half-century mark is that later examples tended not to celebrate so overtly such special effects, because doing so would revive the no-longer-tenable principle of ‘virtuosity as a reward in itself’. Rather, double-stop harmonics, left-hand pizzicato, three-hand techniques and their related sleights of hand were largely escorted off the stage into a pedagogical realm. As this article shows, Joachim helped to exorcise the spectre of Paganini, and to sweep effectively out the door the residual confetti of the Golden Age of Virtuosity. Following in the footsteps of Mendelssohn, Joachim did so with Clara Schumann, viewing himself, Clara Schumann (and, we might add, Brahms) as a cohort of artists seeking to reverse the tawdry display of virtuosity. It was precisely Joachim's acute historicist perception, solidified during the 1850s, that allowed his musical aesthetics to turn so sharply from his openness to, tolerance and acceptance of dazzling violinistic tricks in the 1840s, to their absolute rejection in his later career.
Net zero as a policy for reducing atmospheric carbon emissions is relatively straightforward; however, the implementation of that policy is not, particularly in difficult-to-measure sectors such as agriculture. As strategies to reduce emissions are explored, multiple uncertainties in measuring these emissions are confronted. In this paper, we use the example of a coffee supply chain in Peru to illustrate the magnitude of potential variability in emissions accounting results, which represent a necessary first step in moving towards net zero. We show that scope boundaries and emissions factors chosen for carbon calculations significantly alter emissions outcomes and can result in discrepancies of over 77 million kg CO2e when scaled to a medium-size coffee trader. Net zero targets and efforts to reduce emissions may be over- or understated depending on subjective decisions that cause significant differences in emissions results. Although framework guidance exists, it is apparent that a greater set of micro-level agreements is needed for calculating the emissions of lesser-studied sectors, such as agricultural supply chains. This process is imperative to focus efforts on reducing emissions and on moving from net zero as a mere policy to action and implementation.
This Participatory Action Research (PAR) investigates the integration of informal music learning in Macau’s educational context, guided by the Model of Generative Change (Ball, 2009). Engaging the participating college students (N = 41), this study explores how learners perceive the formal–informal learning continuum (Folkestad, 2006) through the four stages of informal learning experiences: awakening, agency, advocacy and efficacy (Ball, 2009). Through multiple data collection methods and qualitative analysis, students experienced (a) autonomous learning, (b) joyful peer learning, (c) creative exploration and skill development and (d) resilience through challenges. Moreover, the study highlights the stages of awakening, introspection and critique from the students’ perspectives. Notably, a subset of students, predominantly those with prior formal instrumental training, expressed critiques concerning informal learning, predominantly regarding its perceived lack of systematic structure and foundational skills. These insights suggest a need to further embed informal music learning in Macau to foster a dynamic change towards generativity and a ‘multileveled cultural world’ (Law & Ho, 2015). The implications point to a broader pedagogical shift that values diverse learning experiences, which may enhance the development of a more adaptable, innovative and well-rounded musical skill set within the student population in Macau.
Hoarding disorder (HD) is primarily characterised by difficulties with discarding possessions. Evidence-based psychological interventions such as CBT have been found to be of benefit to people with HD. However, people with HD may receive a psychosocial intervention provided by other professions such as social workers or a multi-disciplinary team before receiving psychological therapy, if at all.
Objectives:
The aim of this systematic review is to evaluate psychosocial interventions for HD.
Method:
Searches were conducted on three databases (PsycInfo; MEDLINE; Embase) and grey literature, and the search strategy was designed to capture psychosocial interventions for adults with HD.
Results:
Studies (n=5) were included where the outcome was related to a psychosocial factors, such as fire safety, tenancy preservation and QoL. These psychosocial interventions show improvements in those with HD, with effect sizes ranging from d=0.86 to d=1.41.
Conclusions:
Despite the limited research on psychosocial interventions for HD, this systematic review suggests it is a promising area for further research in this area.
Key learning aims
(1) To identify what psychosocial interventions are available for people experiencing hoarding difficulties.
(2) To identify how available psychosocial interventions for hoarding difficulties are delivered and by whom.
(3) To examine the effectiveness of psychosocial interventions for people experiencing hoarding difficulties.
Understanding interfacial instability in a coflow system has relevance in the effective manipulation of small objects in microfluidic applications. We experimentally elucidate interfacial instability in stratified coflow systems of Newtonian and viscoelastic fluid streams in microfluidic confinements. By performing a linear stability analysis, we derive equations that describe the complex wave speed and the dispersion relationship between wavenumber and angular frequency, thus categorizing the behaviour of the systems into two main regimes: stable (with a flat interface) and unstable (with either a wavy interface or droplet formation). We characterize the regimes in terms of the capillary numbers of the phases in a comprehensive regime plot. We decipher the dependence of interfacial instability on fluidic parameters by decoupling the physics into viscous and elastic components. Remarkably, our findings reveal that elastic stratification can both stabilize and destabilize the flow, depending on the fluid and flow parameters. We also examine droplet formation, which is important for microfluidic applications. Our findings suggest that adjusting the viscous and elastic properties of the fluids can control the transition between wavy and droplet-forming unstable regimes. Our investigation uncovers the physics behind the instability involved in interfacial flows of Newtonian and viscoelastic fluids in general, and the unexplored behaviour of interfacial waves in stratified liquid systems. The present study can lead to a better understanding of the manipulation of small objects and production of droplets in microfluidic coflow systems.
This study presents the design and realization of a dual-port multiple-input–multiple-output (MIMO) filtering antenna system. The device shows good response in the frequency rage 1 (4.1 to 7.125 GHZ) frequency band, which handles most of the cellular mobile communication traffic. First, the single element ultra-wideband (UWB) filtenna is designed by combining a UWB antenna and a band-reject filter (BRF) where the antenna works in the frequency range from 1 to 11 GHz and the BRF is rejecting the frequency range of 3–3.42 GHz with 3.2 GHz as its resonant frequency. Finally, the proposed two-port MIMO filtenna combines two single element UWB filtennas in antiparallel manner which shows impedance bandwidth from 2.59 to 7.1 GHz with a band notch from 3 to 3.42 GHz. The structure is built on cost-efficient FR4 substrate (εr = 4.4, tanδ = 0.02) of dimensions 0.68${{\boldsymbol{\lambda }}_{\boldsymbol{c}}}$×0.27${{\boldsymbol{\lambda }}_{\boldsymbol{c}}}$×0.01${{\boldsymbol{\lambda }}_{\boldsymbol{c}}}$ (mm3), which is compact in size and utilizes a defected ground structure for further miniaturization. The proposed design is simulated using Ansys HFSS software, and after fabrication, it is measured, and the output shows good results for the proposed application. The designed antenna system is suitable for fifth-generation (5G) wideband systems.
The incidence of Kawasaki Disease has a peak in the winter months with a trough in late summer/early fall. Environmental/exposure factors have been associated with a time-varying incidence. These factors were altered during the COVID-19 pandemic. The study was performed through the International Kawasaki Disease Registry. Data from patients diagnosed with acute Kawasaki Disease and Multiple Inflammatory Syndrome-Children were obtained. Guideline case definitions were used to confirm site diagnosis. Enrollment was from 1/2020 to 7/2023. The number of patients was plotted over time. The patients/month were tabulated for the anticipated peak Kawasaki Disease season (December–April) and non-peak season (May–November). Data were available for 1975 patients from 11 large North American sites with verified complete data and uninterrupted site reporting. The diagnosis criteria were met for 531 Kawasaki Disease and 907 Multiple Inflammatory Syndrome-Children patients. For Multiple Inflammatory Syndrome-Children there were peaks in January of 2021 and 2022. For Kawasaki Disease, 2020 began (January–March) with a seasonal peak (peak 26, mean 21) with a subsequent fall in the number of cases/month (mean 11). After the onset of the pandemic (April 2020), there was no clear seasonal Kawasaki Disease variation (December–April mean 12 cases/month and May–November mean 10 cases/month). During the pandemic, the prevalence of Kawasaki Disease decreased and the usual seasonality was abolished. This may represent the impact of pandemic public health measures in altering environmental/exposure aetiologic factors contributing to the incidence of Kawasaki Disease.
The self-generated magnetic field in three-dimensional (3-D) single-mode ablative Rayleigh–Taylor instability (ARTI) relevant to the acceleration phase of a direct-drive inertial confinement fusion (ICF) implosion is investigated. It is found that stronger magnetic fields up to a few thousand teslas can be generated by 3-D ARTI rather than by its two-dimensional (2-D) counterpart. The Nernst effects significantly alter the magnetic field convection and amplify the magnetic fields. The magnetic field of thousands of teslas yields the Hall parameter of the order of unity, leading to profound magnetized heat flux modification. While the magnetic field significantly accelerates the bubble growth in the short-wavelength 2-D modes through modifying the heat fluxes, the magnetic field mostly accelerates the spike growth but has little influence on the bubble growth in 3-D ARTI. The accelerated growth of spikes in 3-D ARTI is expected to enhance material mixing and degrade ICF implosion performance. This work is focused on a regime relevant to direct-drive ICF parameters at the National Ignition Facility, and it also covers a range of key parameters that are relevant to other ICF designs and hydrodynamic/astrophysical scenarios.