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Ideas about morphological complexity have been used to classify languages and to link complexity to language age and social structure. Creoles and sign languages are often framed as younger and structurally simpler than other languages. Concurrently, sign language morphology has been described as paradoxical, as both simple and complex. This paper is a critical examination of claims about morphological complexity and its relationship to language age and social structure. We show that the theoretical and empirical foundations of claims that sign language morphology is paradoxical are flawed. Specifically, argumentation and evidence supporting analogies between creole and sign language complexity adopt theoretically contested and ideologically problematic assumptions about creoles and uncritically apply them to sign languages. We identify four flaws in argumentation: (i) use of limited morphological data to generate claims about global complexity, (ii) association of binary language categories with categorical complexity differences, (iii) use of language age to motivate predictions about morphological complexity, and (iv) extrapolating from creole complexity to sign language complexity. Based on these flaws, we develop nine theoretical and practical recommendations for working with morphological complexity and discuss uncritical cross-disciplinary transfer of ideas.
Prognostic discussions are critical in the care of patients with advanced lymphoma, given the disease’s complexity, rapidly evolving treatments, and shifting potential for cure. However, previous research has paid limited attention to how these discussions unfold from both patient and clinician perspectives, particularly in the context of early conversations. The current study sought to identify key experiences that inform improvements in clinician communication and patient understanding of prognosis for patients with advanced lymphoma.
Methods
We conducted a qualitative study from July 2023 to June 2024 with 19 patients diagnosed with advanced lymphoma and 3 oncologists. Semi-structured interview transcripts were analyzed using thematic content analysis, and emergent themes were identified through consensus among a trained coding team.
Results
Two primary themes emerged. First, patients recalled early prognostic conversations as highly focused on curative intent. Second, oncologists cited incomplete diagnostic data and concerns about overwhelming patients as reasons for limiting early discussions, often delaying deeper prognostic conversations. Clinicians reported tension between maintaining patient hope and providing comprehensive information about disease trajectory and treatment uncertainty.
Significance of Results
Findings highlight a need for communication strategies that balance hope with realism in early prognostic discussions for patients with advanced lymphoma. Oncologists may benefit from structured, evidence-based guidance to manage information delivery over time, particularly in the face of diagnostic ambiguity. Future research should prioritize inclusive sampling and explore timing and content of ongoing prognostic discussions to better support informed decision-making and goal-concordant care.
Commemorations of the Confederacy remain pervasive throughout the Southern U.S. Historians have long established that many of these symbols were erected during the Jim Crow era to reinforce white political dominance in public spaces. Yet, little is known about how these enduring symbols shape perceptions among people of different racial identities today. This study examines Confederate monuments where they are most prominently placed: courthouse grounds. Using an original survey experiment of Black, white, and Latino Southerners, it investigates whether the presence of a Confederate monument in front of a courthouse influences feelings of personal safety and welcomeness, as well as perceptions of the fairness of the court system. Findings reveal that a Confederate monument made Black and Latino Southerners feel less safe and welcome at the courthouse and led Black Southerners to perceive the court system as less fair toward people like them. In contrast, Confederate monuments had no overall effect on white Southerners’ perceptions of courthouses or the judicial system. These results underscore the role of contentious symbols in reinforcing inequalities in public spaces.
Bone and tissue fractions, obtained in 2017 following hip replacement surgery on a healthy Caucasian male, born in 1944, reflect in their 14C concentrations the integrated effect of the lifetime metabolic uptake and replacement of atmospheric bomb 14C at different tissue-specific turnover rates. The 14C content of hair and nails reflects recent carbon uptake. The 14C values in healthy cartilage and bone collagen/apatite correspond to those of the “local” atmosphere during the 2005–2009 Northern Hemisphere growing seasons, while those from damaged areas of the femur head correspond to the atmosphere in 2013–2014. A simple bone growth and regeneration model used in combination with the NH atmospheric 14C concentrations indicates remodelling rates around 9% per year in the healthy bone and a doubling to tripling in the damaged area depending on the model chosen. The differences in 14C concentration observed in the fractions provide both a caveat for sample selection for the 14C dating of archaeological bones and an indication of its potential in forensics and as a diagnostic tool for turnover rates in medical studies.
Repetitive negative thinking (RNT) in major depressive disorder (MDD) involves a persistent focus on negative self-related experiences. Resting-state fMRI shows that the functional connectivity (FC) between the anterior insula and the superior temporal sulcus is associated with RNT intensity. This study examines how insular FC patterns differ between resting state and RNT induction in MDD and healthy control (HC) participants.
Methods
Forty-one individuals with MDD and 28 HCs (total n = 69) underwent resting-state and RNT-induction fMRI scans. Seed-to-whole brain analysis using insular subregions as seeds was performed.
Results
No diagnosis-by-run interaction effects were observed across insular subregions. MDD participants showed greater FC between the bilateral anterior, middle, and posterior insular regions and the cerebellum (z = 4.31–6.15). During RNT induction, both MDD and HC participants demonstrated increased FC between bilateral anterior/middle insula and prefrontal cortices, parietal lobes, posterior cingulate cortex (PCC), and medial temporal gyrus, encompassing the STS (z = 4.47–8.31). In exploratory correlation analyses, higher trait RNT was associated with increased FC between the right dorsal anterior/middle insula and the PCC, middle temporal gyrus, and orbital frontal gyrus in MDD participants (z = 4.31–6.15). Greater state RNT was linked to increased FC in similar insular regions, as well as the bilateral angular gyrus and right middle temporal gyrus (z = 4.47–8.31).
Conclusions
Hyperconnectivity in insula subregions during active rumination, especially involving the default mode network and salience network, supports theories of heightened self-focused and negative emotional processing in depression. These findings emphasize the neural basis of RNT when actively elicited in MDD.
A popular method to perform adversarial attacks on neural networks is the so-called fast gradient sign method and its iterative variant. In this paper, we interpret this method as an explicit Euler discretization of a differential inclusion, where we also show convergence of the discretization to the associated gradient flow. To do so, we consider the concept of $p$-curves of maximal slope in the case $p=\infty$. We prove existence of $\infty$-curves of maximum slope and derive an alternative characterization via differential inclusions. Furthermore, we also consider Wasserstein gradient flows for potential energies, where we show that curves in the Wasserstein space can be characterized by a representing measure on the space of curves in the underlying Banach space, which fulfil the differential inclusion. The application of our theory to the finite-dimensional setting is twofold: On the one hand, we show that a whole class of normalized gradient descent methods (in particular, signed gradient descent) converge, up to subsequences, to the flow when sending the step size to zero. On the other hand, in the distributional setting, we show that the inner optimization task of adversarial training objective can be characterized via $\infty$-curves of maximum slope on an appropriate optimal transport space.
In the context of urban traffic control, traffic signal optimisation is the problem of determining the optimal green length for each signal in a set of traffic signals. The literature has effectively tackled such a problem, mostly with automated planning techniques leveraging the PDDL + language and solvers. However, such language has limitations when it comes to specifying optimisation statements and computing optimal plans. In this paper, we provide an alternative solution to the traffic signal optimisation problem based on Constraint Answer Set Programming (CASP). We devise an encoding in a CASP language, which is then solved by means of clingcon 3, a system extending the well-known ASP solver clingo. We performed experiments on real historical data from the town of Huddersfield in the UK, comparing our approach to the PDDL+ model that obtained the best results for the considered benchmark. The results showed the potential of our approach for tackling the traffic signal optimisation problem and improving the solution quality of the PDDL + plans.
Stress could increase delay discounting in subjects with bulimia nervosa and alcohol use disorder (AUD), meaning that the short-term benefits of coping through eating or drinking outweigh the long-term negative consequences. Therefore, this study explores differences in delay discounting between patients and healthy controls, the impact of stress on food and alcohol delay discounting and associated changes in brain activity.
Method
A total of 102 female participants (AUD, 27; bulimia nervosa, 25; healthy controls, 50) underwent repeated functional magnetic resonance imaging scanning. Initially, all participants performed a monetary delay discounting task (DDT), followed by a food or alcohol DDT before and after stress induction. Specifically, those with bulimia nervosa completed a food DDT, those with AUD completed an alcohol DDT and healthy controls were randomly allocated to one or either DDT.
Results
Participants with AUD, but not healthy controls, displayed a higher discounting of alcohol after stress. Healthy controls, but not those with bulimia nervosa, had nominally higher discounting rates of food following stress, although not significant following multiple testing correction. Participants with AUD displayed a lower activity of the right supplementary motor area while discounting alcohol after stress. Healthy controls showed a lower activity of the frontal cortex and a higher activity of the motor cortex while discounting food after stress, while those with bulimia nervosa displayed a higher activity of the occipital cortex.
Conclusions
The results suggest that, in subjects with AUD, stress induces neurobiological changes that cause them to prefer more immediately available alcohol. However, the results observed in participants with bulimia nervosa suggest a more complex relation between stress and food.
The rapid advancement of 3D bioprinting is transforming possibilities in tissue engineering and personalised medicine, offering innovative solutions to critical biomedical challenges such as organ shortages and the need for precise 3D cellular models. To fully unlock the potential of this technology, anoptimised and comprehensive workflow is essential.
Methods
This review provides a systematic examination of the bioprinting process, covering key steps from medical image acquisition to the validation of bioprinted structures. The analysis includes biomaterial and cell type selection, conversion of DICOM images into 3D-printable models, and slicing techniques.
Results
Key factors influencing the precision, viability, and clinical relevance of bioprinted tissues are identified. Comparisons between planar and non-planar slicing algorithms highlight their impact on scaffold integrity. The review also discusses advancements in algorithm development, bioprinter technology, and biomaterial optimisation, emphasising their role in enhancing reproducibility and functionality.
Conclusions
This structured review offers actionable insights for researchers and practitioners aiming to refine bioprinting workflows. By integrating improvements across imaging, modelling, and material selection, 3D bioprinting can more effectively support the development of clinically relevant constructs, advancing regenerative medicine and personalisedhealthcare.
Auditory verbal hallucinations are a common phenomenon in the general population, with many people without psychological issues reporting the experience. In the ‘White Christmas’ method to induce auditory hallucinations, participants are told that they will be played a portion of the song ‘White Christmas’ and are asked to report when they hear it. Participants are presented only with stochastic noise; still, a large proportion of participants report hearing the song. The experiments reported here investigate how masking relationships modulate verbal hallucinations in the White-Christmas effect. Specifically, we tested how the effect is modulated by different kinds of maskers (multi-talker babble versus spectrally matched speech-shaped stochastic noise) and different kinds of expectation of the speech being masked (expecting a ‘normal’ modal voice versus a whispered voice behind the masking). The White Christmas effect was replicated, and the rate of verbal hallucinations was higher for multi-talker babble than for spectrally-matched speech-shaped stochastic noise. In addition, a trend for a higher rate of hallucination for whispered voices was found. These results confirm the role of masking relations in the White Christmas effect and reinforce the similarity between the White Christmas effect and continuity illusions such as phoneme restoration.
Dignity Therapy (DT) helps reframe and give meaning to the illness process of the terminally ill individual. This study aims to evaluate the effect of DT on meaning in life scores and, additionally, to assess how much DT can alleviate physical and emotional symptoms in cancer patients undergoing palliative care.
Methods
This was a before-and-after clinical trial, involving the recruitment of 30 patients hospitalized in a palliative care unit, who filled out the Edmonton Symptom Assessment Scale (ESAS) and the Meaning in Life Scale (MiLS) both before and after the implementation of DT.
Results
Of the 40 patients invited to participate in the study, DT was completed by 30 (75%) participants: 22 (73%) women and 8 (27%) men. Eighteen (60%) patients died during hospitalization, while 12 (40%) were discharged. When analyzing the factors correlated with the MiLS scores, a positive association was identified between the emotional and physical domains of the ESAS, and a negative association with the total ESAS score, spiritual ESAS score, male gender, higher educational level, and a cancer diagnosis duration (>6 years).
Significance of results
DT contributed to clinically relevant improvement, albeit not statistically significant, observed in emotional and spiritual well-being, as well as in the meaning of life. This underscores the importance of considering DT for palliative care patients nearing death.
In this article, the authors contend that three blades, archaeometrically identified as made of obsidian from the Nemrut Dağ source in eastern Anatolia, were recovered from bona fide archaeological contexts at two sites in Poland. This is supported by somewhat contentious contextual evidence, which is thoroughly reviewed. If the findspots are accepted as genuine, these artefacts would mark the furthest western distribution of Nemrut Dağ obsidian, approximately 2200 km away from the source, more than three times the previously recorded western distribution of this material. The known history of recovery and curation of these artefacts, their techno-typological features, and their raw material source (based on EDXRF analysis) are assessed, and an interpretation of this unusual material is offered.
Dacus frontalis (Diptera:Tephritidae), is an emerging pest that causes damage to fruit in Africa and now represent a threat to Cucurbitaceae production in Europe. Understanding interactions between D. frontalis and host plants is important to improve pest management and prevent their invasions in areas where this pest is not yet established. In this study, female preference and larval performance of D. frontalis with regard to wild and cultivated Cucurbitaceae species at different stages of fruit maturity (green, intermediate, and ripe) were examined. Host plant quality, species, and fruit maturity play a major role in oviposition preference under both choice and no-choice conditions. They also influence larval performance (larval survival, development time, and pupal weight). Larval survival rates differed significantly between fruit species and different stage of fruit maturity, ranging from 0.2% to 0.7% in the case of ripe melon and green Bitter apple, respectively. Larval performance was higher in fruit with low soluble sugar, such as green bitter apple. Results revealed that D. frontalis has distinct ovipositional preferences for the cucurbitaceous host plants tested, with a clear preference for cultivated fruit compared with wild fruit. In cultivated cucurbitaceous fruit, the highest number of eggs was laid on the oviposition device containing green cucumber (48 eggs/female) and the lowest on that containing green melon fruit, where there was no oviposition. Females of D. frontalis were able to choose fruit for oviposition that promoted high larval performance, such as cucumber, pumpkin, zucchini, and watermelon particularly at the green stage. This behaviour reveals a positive preference–performance relationship. Predicting the interactions between exotic insects and their potential host plants is important for preventing invasions using Pest Risk Analyses and associated quarantine procedures.
We examine hidden orders usage by algorithmic traders (ATs) and nonATs. ATs extensively use hidden orders but of smaller size than nonATs, who are the primary contributors to hidden volume. ATs’ relative share of hidden volume decreases with volatility, adverse selection costs, and the relative tick-size. Proprietary ATs (HFTs), who differ from agency ATs (AATs) in their information sets and potential gains from trade, hide orders to reduce competition for liquidity provision, whereas AATs use hidden orders to conceal information in their more informed orders and manage picking-off risk. Finally, superior technology provides limited benefit for hidden order execution.
To examine the potential role of computerized clinical decision support systems (CDSS) in antimicrobial stewardship (AMS) and to identify significant challenges concerning their effectiveness and implementation.
Design:
Narrative review.
Setting and methods:
This review is based on existing literature regarding CDSS in AMS across various healthcare environments, such as hospitals and primary care facilities. The systems evaluated include both stand-alone tools and those integrated into electronic health records (EHR), featuring expert rule-based logic and new machine learning (ML) models. CDSS capabilities include prescribing guidance, alerts, resistance prediction, and de-escalation protocols.
Results:
CDSS are intended to aid in antimicrobial prescribing by integrating clinical guidelines with data specific to each patient. Despite their theoretical potential, their effectiveness is often hindered by inconsistent incorporation into clinical practices, low user engagement, and inadequate design. Many systems are reactive, not well-suited to user needs, or lack transparency in their recommendations. Evaluating these systems is challenging due to varied outcomes, poor methodological quality of studies, and the complexity of attributing causality in intricate care settings. Barriers to implementation include alert fatigue, perceived time constraints, poor fit with existing workflows, and resistance to change. Instances like the COMPASS trial demonstrate the disconnect between design and practical application, underscoring the necessity for user-focused development, clear reasoning, and a balanced approach between mandatory and advisory elements.
Conclusions:
CDSS have the potential to improve antimicrobial use, but widespread impact is hindered by evaluation and implementation challenges. Realizing their value requires better integration, usability, and rigorous research frameworks tailored to complex healthcare settings.
Despite the clear divisions in current archaeological theories, in the last 30 years a ‘new consensus’ is emerging; this is the recognition that materials can actively shape human behaviour and cognition. While this recognition offers major opportunities for explaining changes in the archaeological record without just succumbing to individual simplistic models – such as migration or diffusion, or acculturation or convergence – there is still a need to formulate a framework that allows schematising this new consensus into our classifications and analyses of archaeological materials. Our paper aims to take a first step in this direction by formalising some mechanisms through which human behaviour and cognition can be modified by the material world. Operating at the interstices between theories about material engagement, cognition, and practice, three mechanisms of transformation are formalised, i.e., visual enchantment, mechanical degradation and obtrusion. As a further step to integrate these mechanisms, we stress the need to factor in human expectations, the changing states of materials and contingent situations into our schematisations and reconstructions of human–material relations.
Partial correctness of imperative or functional programming divides in logic programming into two notions. Correctness means that all answers of the program are compatible with the specification. Completeness means that the program produces all the answers required by the specifications. We also consider semi-completeness – completeness for those queries for which the program does not diverge. This paper presents an approach to systematically construct provably correct and semi-complete logic programs, for a given specification. Normal programs are considered, under Kunen’s 3-valued completion semantics (of negation as finite failure) and the well-founded semantics (of negation as possibly infinite failure). The approach is declarative, it abstracts from details of operational semantics, like, for example, the form of the selected literals (“procedure calls”) during the computation. The proposed method is simple and can be used (maybe informally) in actual everyday programming.