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Inequality has increased over recent decades in many advanced industrial democracies, but taxes have rarely become more progressive. One possible explanation for the lack of a policy response is that, despite rising inequality, voters support higher taxes on incomes weakly, if at all. Using original representative surveys in Austria and Germany, we elicit voters’ preferences over the progressivity of income tax policy and examine whether exposing them to accurate information about inequality affects those preferences. Voters, we find first, express an abstract preference for progressivity but concretely support tax plans that are only somewhat more progressive than the status quo in Austria and less progressive than the status quo in Germany. Second, we find evidence that certain kinds of information about inequality moderately increase progressive tax preferences in Germany; however, we find no equivalent effects in Austria. While information on inequality does seem able to affect tax policy views in certain contexts, it seems unlikely that lack of this information can fully account for the lack of rising redistribution through the income tax system in the face of increasing inequality.
The purpose of this study is to examine the existing literature on end-of-life dream experiences and bucket list fulfillments among terminally ill individuals receiving hospice and/or palliative care.
Methods
A scoping review registered on Open Science Framework was conducted in accordance with the guidelines for Scoping reviews (PRISMA-ScR). An electronic search of literature was generated from EBSCO databases published until June 2024. Studies were included if they described and evaluated the effects of bucket lists and/or end-of-life wish fulfillment.
Results
This review identified 2,234 studies, and 11 of these were included in the review. Four major themes were established using thematic content analysis: (1) impact on holistic well-being, (2) role of family in wish fulfillment, (3) cultivation of gratitude, and (4) collaborative leadership in wish fulfillment. In wish fulfillment, the results significantly pointed to the need for more intricate evaluation among patients and interventions that cover beyond the physical aspect.
Significance of results
Palliative and hospice care settings should work toward securing sustainable funding for structured wish-fulfillment programs to address existing accessibility gaps and further enhance the holistic nature of care in these settings. Wish-fulfillment interventions represent a powerful tool in enhancing dignity and holistic experiences for terminally ill patients. Future research efforts could strengthen programs ensuring every individual is able to achieve a sense of peace, fulfillment, and closure during their care trajectory.
Given a family of pairs over a smooth curve whose general fiber is a log Calabi–Yau pair in a fixed bounded family, suppose there exists a divisor on the family whose restriction on a general fiber is ample with bounded volume. We show that if the total space of the family has relatively trivial log canonical divisor and the special fiber has slc singularities, then every irreducible component of the special fiber is birationally bounded.
Negami found an elegant splitting formula for the Tutte polynomial. We present an analogue of this for Bollobás and Riordan’s ribbon graph polynomial, and for the transition polynomial. From this we deduce a splitting formula for the Jones polynomial.
We consider the question of when a Jacobian of a curve of genus $2g$ admits a $(2,2)$-isogeny to a product of two polarized dimension g abelian varieties. We find that one of them must be a Jacobian itself and, if the associated curve is hyperelliptic, so is the other.
For $g=2,$ this allows us to describe $(2,2)$-decomposable genus $4$ Jacobians in terms of Prym varieties. We describe the locus of such genus $4$ curves in terms of the geometry of the Igusa quartic threefold. We also explain how our characterization relates to Prym varieties of unramified double covers of plane quartic curves, and we describe this Prym map in terms of $6$ and $7$ points in $\mathbb {P}^3$.
We also investigate which genus $4$ Jacobians admit a $2$-isogeny to the square of a genus $2$ Jacobian and give a full description of the hyperelliptic ones. While most of the families we find are of the expected dimension $1$, we also find a family of unexpectedly high dimension $2$.
Although life stressors are known risk factors for suicide, the specific stressor types that most strongly precipitate suicidal outcomes, and on what timescale, remain poorly understood. Based on existing theory, we investigated whether objectively rated interpersonal stressors, especially social and targeted rejection stressors, are proximally associated with increased likelihood of suicidal ideation and behavior.
Method
Using an objectively rated contextual threat interview to assess stressful life events, and a timeline followback procedure for assessing suicide-related outcomes, we examined how the severity of four types of acute life events (i.e. non-interpersonal, interpersonal without social rejection, social rejection without targeted rejection, and targeted rejection) were temporally associated with the likelihood of same-day and next-day suicidal ideation and behavior over 16 months in 143 young adults (Mage = 25.27, SD = 4.65) with recent suicidal ideation or behavior.
Results
After controlling for prior-day suicidal ideation and non-interpersonal stressors, daily within-person increases in interpersonal stressor severity were related to higher odds of same-day (but not next-day) suicidal ideation. Additionally, greater increases in targeted rejection severity were uniquely related to increased likelihood of both same-day and next-day suicidal behavior after controlling for prior-day suicidal behavior and other types of stressors.
Conclusions
Interpersonal stressors are strong, proximal risk factors for suicidal ideation and behavior, and these effects are particularly strong for targeted rejection life events. Clinicians should thus assess recent interpersonal and, especially, targeted rejection stressors when evaluating acute suicide risk, and may reduce such risk by helping patients stabilize and strengthen their social relationships.
This article provides new exploratory information on child support amounts expected for non-resident fathers of children living with low-income, unemployed mothers in Colombia, Finland, Peru, the United States, and Uruguay. Using vignette data obtained through extensive interviews with judicial and social service personnel and child support experts, we investigated whether child support is expected and its amount when single mothers are unemployed, considering four different levels of earnings for fathers. In all countries but Finland, child support is expected when the father has only temporary employment. For the lowest income fathers, child support expectations in Colombia, Peru, and Uruguay are similar or higher than the United States and higher in Finland. In all countries except Colombia, child support expectations are higher when father’s income is higher. We discuss implications for policy and future research.
Real-world evidence (RWE) is increasingly used to assess and make regulatory decisions on health technologies. However, its application in healthcare payer decision-making is less well-known.
Objectives
The objectives of this study were to (i) review the recent literature on how RWE has been used by healthcare payers, (ii) highlight barriers that limit the use of RWE in payer decision making, and (iii) explore how RWE has been used in various funding arrangements between payers and manufacturers. The benefits of utilizing RWE are also discussed.
Methods
A scoping review was conducted on articles published between 2014 and 2025 in PubMed (Medline), OVID EMBASE, Cochrane Library, and ProQuest Dissertations and Theses Global. Eligible articles were those written in English that discussed the use of real-world evidence among healthcare payers/decision-makers for health technology reimbursement decisions.
Results
Nineteen articles were selected for full-text review based on the inclusion criteria. The review highlighted payers’ interest in incorporating RWE into funding and reimbursement decisions to address uncertainty in the performance of new health technologies. However, a lack of standards for collecting, analyzing, and reporting RWE limits its use. Little is known about how RWE is used in reimbursement decisions since contractual arrangements between payers and manufacturers are confidential.
Conclusions
Although payers are interested in using RWE to inform funding and reimbursement decisions, there are concerns regarding the scientific rigor used to generate such evidence. Having more insight into the contractual arrangements between payers and manufacturers would help to better understand how RWE informs these agreements.
This article traces the visual culture of human genetic engineering over the past decade, focusing on the CRISPR genome editing technology. We argue that the representations surrounding CRISPR exemplify, and to an extent define, this visual culture. We examine the history of CRISPR, particularly its human applications from 2012 to 2022, through a periodization that includes the CRISPR craze, gene therapy initiatives, the He Jiankui controversy and clinical trials. Employing an expanded interpretation of intermediality within science communication, this work addresses the role of figuration across the relationships between specialist science reporting and the mainstream press and between traditional and social media. Using a mixed-methods approach combining visual and social-media analysis, the article presents an empirical analysis of three key figures – the double helix, the scientist and the human subject – and their roles across the discussed phases. The study concludes by articulating the stabilizing, amplifying and affective functions of intermedial figuration within science communication.
The evolution of a rotationally symmetric surface by a linear combination of its radii of curvature is considered. It is known that if the coefficients form certain integer ratios the flow is smooth and can be integrated explicitly. In this paper the non-integer case is considered for certain values of the coefficients and with mild analytic restrictions on the initial surface.
We prove that if the focal points at the north and south poles on the initial surface coincide, the flow converges to a round sphere. Otherwise the flow converges to a non-round Hopf sphere. Conditions on the fall-off of the astigmatism at the poles of the initial surface are also given that ensure the convergence of the flow.
The proof uses the spectral theory of singular Sturm-Liouville operators to construct an eigenbasis for an appropriate space in which the evolution is shown to converge.
The rate at which psychosis drugs can be reduced in dose remains unclear. Anecdotal reports exist of people experiencing worsening of mental state before their next dose of long-acting injectable antipsychotic. No research has previously explored this phenomenon, but understanding this may advise on the rate of receptor occupancy change that provokes the emergence of psychotic symptoms.
Aims
Exploring the relationship between psychotic symptoms and variations in plasma concentration (and calculated receptor occupancy) of long-acting injectable antipsychotics.
Method
This longitudinal study monitored mental state variation within dosing cycles of people taking depot flupentixol and zuclopenthixol. The Positive and Negative Syndrome Scale (PANSS) monitored global mental state changes, and was stratified into domains according to a five-factor model. Plasma assays at maximal and minimal concentrations allowed prediction of striatal D2 occupancy from published data. We examined correlations between receptor occupancy and the emergence of psychotic symptoms.
Results
Preliminary results from ten participants with psychotic disorders suggest that global mental state deterioration may correlate with increased rate of D2 occupancy reduction. Increased rate of D2 occupancy reduction led to deterioration in ‘positive’ (r = 0.637 [CI: 0.013, 0.904], P = 0.047) and ‘resistance’ (r = 0.726 [CI: 0.177, 0.930], P = 0.018) PANSS clinical domains at minimal concentrations. PANSS score differences were not related to absolute reduction in D2 occupancy.
Conclusions
Our novel observational study design has been demonstrated to be feasible and practicable. Faster reductions in D2 occupancy may increase the risk of increased positive psychotic symptoms and irritability. Slower reductions may minimise this effect. Further recruitment is required before this can be confirmed.
The multi-agent path finding (MAPF) problem aims to find plans for multiple agents in an environment within a given time, such that the agents do not collide with each other or obstacles. Motivated by the execution and monitoring of these plans, we study dynamic MAPF (D-MAPF) problem, which allows changes such as agents entering/leaving the environment or obstacles being removed/moved. Considering the requirements of real-world applications in warehouses with the presence of humans, we introduce (1) a general definition for D-MAPF (applicable to variations of D-MAPF), (2) a new framework to solve D-MAPF (utilizing multi-shot computation and allowing different methods to solve D-MAPF), and (3) a new answer set programming-based method to solve D-MAPF (combining advantages of replanning and repairing methods, with a novel concept of tunnels to specify where agents can move). We have illustrated the strengths and weaknesses of this method by experimental evaluations, from the perspectives of computational performance and quality of solutions.
Immunomodulatory effects of psychotropic agents used to treat severe mental disorders (SMDs) have been suggested. We investigated associations between immune marker levels and antipsychotic- (AP), antidepressant- (AD), and mood stabilizing agents (MS) use in SMDs.
Methods
We included 1215 participants with SMDs (777 with schizophrenia spectrum disorders and 438 with bipolar disorders). Circulating levels of 45 immune markers were determined by enzyme-immunoassay or immunoturbidimetry and analyzed for associations with use, doses, and serum concentrations of AP, AD, and MS. Extensive adjustments for potential confounders were performed. Immune marker levels of 1008 healthy controls served as a reference.
Results
AP use was significantly associated with higher plasma levels of beta defensin 2 (BD-2) (β = 0.094, p = 0.8E-4), AD use with higher serum levels of CRP (β = 0.072, p = 0.8E-3), and MS use with higher plasma levels of soluble interleukin 2 receptor (sIL-2R) (β = 0.063, p = 0.9E-4). These findings were paralleled by positive associations with psychotropic agent dose and serum concentrations: AP dose was associated with BD-2 levels (β = 0.045, p = 2.3E-4), AD dose with CRP levels (β = 0.039, p = 0.001), MS dose with sIL-2R levels (β = 0.048, p = 0.001), and serum concentration of AD was nominally positively associated with CRP (β = 0.072, p = 0.002).
Conclusions
The findings suggest that AP and MS use affect pathways involved in immune homeostasis and inflammatory regulation in individuals with SMDs, while AD use augments low-grade systemic inflammation reflected by CRP.
The months following psychiatric hospitalization are associated with heightened suicide risk among adolescents. Better characterizing predictors of trajectories of suicidal ideation (SI) post-discharge is critical.
Method
We examined trajectories of SI over 18 months post-discharge and emotional processing variables (recognition, reactivity, and regulation) as predictors using a multi-method approach. Participants were 180 adolescents recruited from a pediatric psychiatric inpatient unit, assessed during hospitalization and 3, 6, 12, and 18-months post-discharge. At each time-point, participants reported on SI; at baseline, they completed measures of emotion dysregulation, reactivity, and a behavioral task measuring facial emotion recognition.
Results
A three-group model best fits the data (Chronic SI, Declining SI, and Subthreshold SI groups). The Chronic SI group, compared to the Declining SI group, had greater difficulty identifying children’s sad facial expressions. The Declining SI group compared to the Subthreshold SI group reported greater overall emotion dysregulation and difficulties engaging in goal-directed behavior. No other emotional processing variable was significantly associated with specific SI trajectories.
Conclusions
The findings suggest that difficulties in properly identifying peer emotions may be predictive of resolution of severe SI post-discharge. Furthermore, the results suggest that emotion regulation may be an important target for discharge planning.
This article was submitted to the ‘The Legacy of Giovanni Sartori’ symposium on IPSR/RISP – Italian Political Science Review. The goal of this note is to suggest an alternative approach to the of party family. The literature agrees that individual party families should be ideologically distinct and cohesive but maintains a broad understanding of ‘ideology’. This comes with conceptual and operational complications, including rarely explicit definitions of party family and frequently inconclusive empirical evidence. Instead, I suggest that the historically rooted ideological distinctiveness and uniqueness of party families should be conceived at the issue level. Accordingly, an alternative conceptualisation of party family is proposed: groups of parties whose patterns of issue salience ideologically reflect their historical origins. Importantly, this approach revolves around the identification of party families’ core issues, based on their cleavage/historical origins. Parties belonging to a party family will be the most consistent emphasizers of their core issues within their party system. This note provides a first discussion of how this alternative approach may provide party family scholars with greater clarity, both conceptually and in proposed empirical applications.
This article analyses the agony column ‘Voi e il cinema’, launched in November 1938 in Cine illustrato, one of the most popular film magazines of the time. ‘Voi e il cinema’ invited readers to share their acting aspirations, but also to send in photographs of themselves that might contain the defining feature of a diva: photogenicity. The magazine was flooded with images of ‘ordinary young Italian women’ that created an intermediate visual grammar. Focusing on both the photographs and the editors’ responses, the article reveals how shared consumption practices redefined the relationship between public and private space. It also highlights the distance of the readers’ self-representations from Fascist models and sheds light on the role of American star culture in creating the ‘modern’ subject. Although they were not politically opposed to Fascist models, the photographs reveal a strong desire for social change and the perception of such change, particularly in relation to traditional female roles.