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Researchers interested in dyadic processes increasingly collect intensive longitudinal data (ILD), with the longitudinal actor–partner interdependence model (L-APIM) being a popular modeling approach. However, due to non-compliance and the use of conditional questions, ILD are almost always incomplete. These missing data issues become more prominent in dyadic studies, because partners often miss different measurement occasions or disagree about features that trigger conditional questions. Large amounts of missing data challenge the L-APIM’s estimation performance. Specifically, we found that non-convergence occurred when applying the L-APIM to pre-existing dyadic diary data with a lot of missing values. Using a simulation study, we systematically examined the performance of the L-APIM in dyadic ILD with missing values. Consistent with our illustrative data, we found that non-convergence often occurred in conditions with small sample sizes, while the fixed within-person actor and partner effects were well estimated when analyses did converge. Additionally, considering potential convergence failures with the L-APIM, we investigated 31 alternative models and evaluated their performance on simulated and empirical data, showing that multiple alternatives may alleviate the convergence problems. Overall, when the L-APIM fails to converge, we recommend fitting multiple alternative models to check the robustness of the results.
Common mental disorders (CMDs) are significant causes of work disability. Low socioeconomic status (SES) is a known risk factor for CMDs and work disability, one possible reason being poorer treatment adherence. We aimed to study the realization of pharmacological treatment and antidepressant adherence in patients with CMDs 3 years before and 3 years after being granted a disability pension (DP) and the role of SES in this. We also studied whether antidepressant adherence is associated with return to work (RTW) after a temporary DP.
Methods
Information on all persons granted a DP due to CMD between 2010 and 2012 in Finland (n = 12,388) was retrieved from national registers, which included medical, socioeconomic, and sociodemographic information of the subjects. We used the PRE2DUP method to estimate drug use periods and regression analyses to study associations between SES, taking medications, and RTW.
Results
Prevalence of taking antidepressants increased towards the DP grant and decreased thereafter, but 14.6% of subjects did not take antidepressants or antipsychotics at all during the study period. Of SES factors, only income was positively associated with antidepressant adherence, lasting over a year. Antidepressant adherence was not associated with RTW.
Conclusions
An alarming result was the absence of recommended medication in fewer than every seventh patient estimated to be disabled due to pharmacologically treatable psychiatric disorders. Contrary to expectations, SES had only a minor predictive role in antidepressant adherence in this patient group. Contrary to taking antidepressants, rehabilitation was associated with RTW. The results adduced the importance of CMD treatment optimization regardless of SES.
The making of the Passeio Público, Lisbon’s first public garden, is filled with contradictions, advances and setbacks. By looking at the long-term history of this green infrastructure, from its inception in 1764 until the inauguration of the boulevard built on its footprint in 1886, and considering the various technical-scientific, artistic, economic, social and political factors, this article demonstrates that the so-called public garden of the ancién régime was in fact made by the Liberals. Political issues and the Liberals’ narration of events were primarily responsible for the disappearance of the Passeio Público.
The tendency to dismiss history in favour of close reading by twentieth-century British critics has cast a long shadow over critical practice. Yet the tendency to revere a formalist, a-historical, even a-political critical method primarily for its own sake seems to be singularly strong in English studies. This somewhat self-isolating tendency has not, for example, appeared as a noteworthy part of critical practice in comparative literature. Of course, the two fields have built up over time a mutual suspicion of each other’s critical methods, though it wasn’t just about the necessity of multilingualism but also about the value of history.
Late-life depression (LLD) arises from a complex interplay among biological, psychological, and social factors. Biologically, three main hypotheses have been proposed to explain the distinct clinical features of LLD. The vascular hypothesis supports vascular-related white matter changes in the development of LLD, while the neurodegenerative hypothesis suggests that LLD might be a prodrome of neurodegenerative diseases. The inflammatory hypothesis, which is the main focus of this review, posits that heightened inflammation underlies LLD directly or indirectly through neurodegenerative and microvascular alterations.
Methods:
This is a non-systematic review on the role played by inflammation in the pathophysiology of LLD and the related opportunities to define biomarkers and therapeutic targets. We searched PubMed from January 2010 through March 2025 for relevant English-language studies.
Results:
Patients with LLD have elevated circulating levels of inflammatory biomarkers (e.g., C-reactive protein and interleukin-6) as well as evidence of neuroinflammation. Although the exact origin of this inflammatory profile remains unclear, it is thought to be exacerbated by immune cell senescence and the presence of physical comorbidities, including cardiovascular and metabolic diseases. Pharmacological (e.g., selective serotonin receptor inhibitors) and non-pharmacological (e.g., diet, physical interventions) approaches for LLD seem to exert their therapeutic effect, at least in part, through inflammation-related mechanisms.
Conclusion:
Recognizing the unique features of LLD compared to depression in other periods of life is an important step toward its proper management. More specifically, understanding the role of inflammation in LLD holds both theoretical and practical implications, including anti-inflammatory or immune-based strategies as potential therapeutic interventions.
A new form of human–machine collaborative capabilities has been called to complement traditional capabilities to ensure higher but more responsible performance. We reviewed the extant literature on leadership in the artificial intelligence context to identify the leaders’ essential artificial intelligence-driven capabilities and synthesize the systematic review findings into an integrated conceptual framework to highlight how artificial intelligence-driven organizations could lead more responsibly. We conducted the systematic review and thematic analysis based on 37 papers identified from Emerald Insight, EBSCOhost Business Source Complete, and ScienceDirect databases. We found organizational leaders require technical, adaptive, and transformational capabilities to lead in an artificial intelligence-driven disruptive organizational environment. Our findings contribute to dynamic managerial capability and responsible leadership for performance theories by showing how these three uncovered capabilities enable organizational leaders to deploy dynamic managerial capabilities – sensing, seizing and reconfiguring more responsibly.
Nd-Hf isotope evolution in arc magmas has been widely used to trace the advance and retreat of subduction zones over time. However, the reliability of this method has been questioned. One way to assess its validity is by comparing it with LaN/YbN or Sr/Yb ratios, which are well-established proxies for crustal thickness. In this study, we present new Nd-Hf isotopic data from the Permian to Triassic Hangay Batholith in the western Mongol-Okhotsk Orogen (Hangay Mountains), to evaluate the role of Nd-Hf isotopes in tracing crustal thickness variations along convergent plate boundaries. Our results show that granitoids from the Hangay Batholith likely originated from partial melting of crustal materials, with a possible mantle contribution. These granitoids have moderate εNd(t) and εHf(t) values, with no significant shift from Permian to Triassic, which contrasts with the continuous crustal thickening indicated by LaN/YbN ratios. This inconsistency between Nd-Hf isotope evolution and crustal thickness variation is likely due to the heterogeneous crustal architecture in this accretionary orogen. Our findings highlight the need for caution when linking Hf and Nd isotope evolution with extensional and contractional tectonics.
This article examines the legal framework for offshore CO2 sequestration in South Korea, paying particular attention to how to ensure the protection of the marine environment from CO2 sequestration in sub-seabed geological formations. It analyses the relevant international regulatory framework, including the 1982 United Nations Convention on the Law of the Sea, the 1972 London Convention and the 1996 London Protocol. It then examines the Korean national legal framework relating to offshore CO2 sequestration. In the absence of detailed regulations on the process of CO2 sequestration in sub-seabed geological formations in South Korea, the article suggests detailed regulations regarding site selection, assessment of potential risks, monitoring and long-term liability to ensure environmental safety and security from offshore CO2 sequestration, which should comply with the 1996 Protocol and relevant guidelines. The development of detailed Korean national regulations ensuring compliance with international rules and standards could serve as best practices driving offshore CCS in the Asia-Pacific region.
This article examines the everyday experiences of the Egyptian minority in Milan, Italy, focusing on challenges arising from the lack of formal recognition for their religious affiliations—Islam and Coptic Orthodoxy—which are central to their ethnic identity. Drawing on Talal Asad’s notion of recognition, Edward Said’s critique of Orientalism, and Nelson Maldonado-Torres’ coloniality framework, it critiques how European policies conflate secularization with security, marginalizing non-European communities. Italy’s legal system highlights this tension: while de jure constitutional protections guarantee religious freedom, de facto bureaucratic and political barriers exclude minority faiths from equal standing. Egyptian migrants must navigate this imbalance, where theoretical rights rarely translate into practical access, forcing them to continually adapt their religious and ethnic identities in a marginalizing society. The article shows how religious invisibility sustains marginalization, contrasting Europe’s multicultural ideals with exclusionary practices. It reveals how colonial legacies shape migrant experiences and restrict rights.
We investigate the dynamics of a pair of rigid rotating helices in a viscous fluid, as a model for bacterial flagellar bundle and a prototype of microfluidic pumps. Combining experiments with hydrodynamic modelling, we examine how spacing and phase difference between the two helices affect their torque, flow field and fluid transport capacity at low Reynolds numbers. Hydrodynamic coupling reduces the torque when the helices rotate in phase at constant angular speed, but increases the torque when they rotate out of phase. We identify a critical phase difference, at which the hydrodynamic coupling vanishes despite the close spacing between the helices. A simple model, based on the flow characteristics and positioning of a single helix, is constructed, which quantitatively predicts the torque of the helical pair in both unbounded and confined systems. Finally, we show the influence of spacing and phase difference on the axial flux and the pump efficiency of the helices. Our findings shed light on the function of bacterial flagella and provide design principles for efficient low-Reynolds-number pumps.
This review article summarizes the history of amoebic dysentery (entamoebiasis) caused by Entamoeba histolytica. Initially, Entamoeba species were thought to be the most primitive extant eukaryotes, but more recent research revealed that they emerged relatively late in evolutionary history. Paleoparasitological data suggest that E. histolytica has been a parasite of humans since ancient times and was probably spread throughout the world by man during early human migration. By the end of the 19th century, it was established that E. histolytica was the etiological agent of amoebic dysentery and liver abscess. The issue over pathogenic and non-pathogenic strains of E. histolytica was resolved in the 1980s by the discovery of the morphologically indistinguishable harmless sister species Entamoeba dispar. Being mainly a disease of tropical and subtropical low-income countries, entamoebiasis cases have increased among travellers and immigrants arriving from endemic regions in recent years.
Climate impacts and risk, within and across cities, are distributed highly unequally. Cities located in low latitudes are more vulnerable to climate risk and impacts than in high latitudes, due to the large proportion of informal settlements relative to the housing stock and more frequent extremes. According to EM-DAT, about 60% of environmental disasters in cities relate to riverine floods. Riverine floods and heatwaves cause about 33% of deaths in cities. However, cold-waves and droughts impact most people in cities (42% and 39% of all people, respectively). Human vulnerability intersects with hazardous, underserved communities. Frequently affected groups include women, single parents, and low-income elderly. Responses to climatic events are conditioned by the informality of social fabric and institutions, and by inequitable distribution of impacts, decision-making, and outcomes. To ensure climate-resilient development, adaptation and mitigation actions must include the broader urban context of informality and equity and justice principles. This title is also available as open access on Cambridge Core.
To illustrate how a partnership between an academic medical center and a public health department successfully responded to a large tuberculosis (TB) exposure at a community daycare center.
Setting:
A multidisciplinary team rapidly established a dedicated TB Exposure Clinic to evaluate and screen exposed children requiring window prophylaxis.
Patients:
The exposure affected 592 individuals, including 359 children under five—those at highest risk for severe disease.
Interventions:
Given the vulnerability of young children to TB infection, timely evaluation and initiation of window prophylaxis were prioritized.
Results:
Over two days, 162 children were assessed for TB window prophylaxis, and 110 additional children underwent TB screening.
Conclusions:
By leveraging clinical expertise, interdisciplinary collaboration, and informatics infrastructure, the TB Exposure Clinic delivered rapid, comprehensive care while minimizing disruption to local healthcare systems. This model underscores the essential role of academic medical centers in supporting public health responses.
Do populist governments bend their economic policies to the preferences of bondholders? Populist governments should be a “least likely” case for the market discipline hypothesis. Populist parties typically run on platforms that scapegoat wealthy elites as “enemies of the people” and hence should be more resistant to changing policy positions in the face of market pressure, given their reluctance to alienate their base. Employing most-different case studies of the Five Star Movement/Lega coalition in Italy and Viktor Orbán’s government in Hungary, we find that populists do bend to market pressure but that this “disciplining effect” does not stem primarily from foreign investors. Rather, it was the inaction of domestic investors in bond auctions that caused these governments to reverse course on headline economic policies. Because domestic investors served as both governments’ “buyers of last resort,” they needed to maintain their favor amidst foreign capital flight.
Housing scarcity is a widespread social and economic problem. Prior studies have attributed this scarcity to local control over land use, which has been seen as making policy makers more responsive to small electorates. Challenging this argument, we suggest that smaller jurisdictions have stronger incentives and greater capacity to raise tax revenue by building housing. Therefore, expanding the electorate that policy makers are responsive to could lead to a more restrictive housing policy. To explore this question empirically, we study a reform that consolidated some Danish municipalities, increasing the size of their jurisdiction. Using a difference-in-differences design, we find that consolidated municipalities issue fewer permits and complete less housing than smaller jurisdictions. Our study thus shows that politicians permitted more housing when they were accountable to a smaller electorate. This upends conventional wisdom and suggests that local control need not be at odds with more liberal land use policy.
Hospitalized patients are commonly discharged to skilled nursing facilities (SNFs) on outpatient parenteral antimicrobial therapy (OPAT). In this study, 101 patients discharged to a SNF on OPAT required considerable post-hospital care coordination and experienced high readmission and mortality rates within 90 days, contributing to literature characterizing OPAT patients in other settings.
Life-history traits such as dispersal affect population attributes like gene flow, which can have consequences for speciation and extinction rates over macroevolutionary timescales. Here we use the Cheilostomatida, a monophyletic order of marine bryozoans, to test whether a life-history trait, larval brooding, affected the origination and extinction rates of genera throughout their fossil record. Cheilostome lineages that brood their larvae have shorter larval dispersal distances than non-brooding lineages, which has led to the hypothesis that the evolution of larval brooding decreased gene flow, increased origination, and drove their Cretaceous diversification. Brooding cheilostomes are far more diverse than non-brooding cheilostomes today, but it remains to be shown that brooding lineages have a higher origination rate than non-brooders. We fit time-varying Pradel seniority capture–mark–recapture models to look at the effect of brooding on origination and extinction rates during the Cretaceous cheilostome diversification, the Cretaceous/Paleogene mass extinction and recovery, and through the Cenozoic. Our results support the hypothesis that brooding affects origination rate, but only in the Cenomanian to Campanian. Extinction rates do not differ between brooding and non-brooding genera, and there is no regime shift specific to the Cretaceous/Paleogene mass extinction. Our work illustrates the importance of using fossil occurrences and time-varying models, which can detect interval-specific diversification differentials.
Mixing-induced reactions play an important role in a wide range of porous media processes. Recent advances have shown that fluid flow through porous media leads to chaotic advection at the pore scale. However, how this impacts Darcy-scale reaction rates is unknown. Here, we measure the reaction rates in steady mixing fronts using a chemiluminescence reaction in index-matched three-dimensional porous media. We consider two common mixing scenarios for reacting species, flowing either in parallel in a uniform flow or towards each other in a converging flow. We study the reactive properties of these fronts for a range of Péclet numbers. In both scenarios, we find that the reaction rates significantly depart from the prediction of hydrodynamic dispersion models, which obey different scaling laws. We attribute this departure to incomplete mixing effects at the pore scale, and propose a mechanistic model describing the pore-scale deformations of the front triggered by chaotic advection and their impact on the reaction kinetics. The model shows good agreement with the effective Darcy-scale reaction kinetics observed in both uniform and converging flows, opening new perspectives for upscaling reactive transport in porous media.
Portable medical equipment (PME) is inconsistently cleaned and disinfected, resulting in contamination that increases the risk of healthcare-associated infections. A virtual reality PME cleaning and disinfection training module was designed and tested at multiple healthcare facilities. Barriers identified during an initial phase led to improvements in the second phase.