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There is an urgent need to address the poor quality of mental healthcare and human rights violations within mental health systems and communities. To achieve this, efforts must focus on changing the attitudes that perpetuate stigma and discrimination against individuals with mental health conditions, as well as psychosocial, intellectual and cognitive disabilities. The World Health Organization (WHO) QualityRights e-training on mental health, recovery and community inclusion is tackling these issues in several countries; however, its global impact has yet to be evaluated.
Aims
This study aims to assess the changes in attitudes following the completion of the WHO QualityRights e-training in countries worldwide.
Method
Data from 3026 participants were analysed in this pre-post intervention study. Changes in scores on the WHO QualityRights Attitudes questionnaire were evaluated with the paired t-test and Wilcoxon signed-rank test.
Results
The mean differences from baseline to post-training on the WHO QualityRights Attitudes questionnaire were 9.91 (95% CI 9.58–10.24, d = 1.07) for the total sample, 8.95 (95% CI 8.59–9.31, d = 0.99) for the high-income countries sample; and 12.75 (95% CI 12.03–13.47, d = 1.33) for the low- and middle-income countries sample. These findings indicate that participants, after completing the e-training, showed a decrease in negative attitudes toward individuals with mental health conditions and psychosocial, intellectual and cognitive disabilities.
Conclusions
This study suggests that the WHO QualityRights e-training has a positive, large effect in reducing negative attitudes toward individuals with mental health conditions and psychosocial, intellectual and cognitive disabilities, and can contribute to reduced stigma and greater alignment with rights-based approaches. These findings support the scale-up of the WHO QualityRights e-training programme.
Horseweed [Erigeron canadensis L.; syn.: Conyza canadensis (L.) Cronquist (2n = 18), family: Asteraceae] is known as one of the 10 most troublesome and most commonly occurring weeds in 12 categories of broadleaf crops, fruits, and vegetables and is present in 2,540 counties across the United States. Wide phenotypic plasticity coupled with highly adaptive traits and reported allelopathy might have resulted in its rapid spread and extensive presence across the United States, presumably by altering the composition of local plant community. This study for the first time revealed the allelopathic effect of E. canadensis leaf aqueous extract (10%) on seed germination and seedling growth of seven common weeds, namely, Palmer amaranth (Amaranthus palmeri S. Watson), smooth pigweed (Amaranthus hybridus L.), prickly sida (Sida spinosa L.), and pitted morningglory (Ipomoea lacunosa L.), which are native to North America, and non-native lambsquarters (Chenopodium album L.), curly dock (Rumex crispus L.), and barnyardgrass [Echinochloa crus-galli (L.) P. Beauv.]. Erigeron canadensis aqueous extract significantly (P < 0.05) reduced the seed germination and seedling growth of A. hybridus, A. palmeri, R. crispus, and S. spinosa, but showed nonsignificant impacts on I. lacunosa, C. album, and E. crus-galli. Based on synthetical allelopathic effects (SE < 0), the order of inhibition from highest to lowest was as follows: A. hybridus (−0.580), R. crispus (−0.464), A. palmeri (−0.409), S. spinosa (−0.248), C. album (−0.143), I. lacunosa (−0.035), and E. crus-galli (0.009). Liquid chromatography of the E. canadensis aqueous extract identified a total of 38 compounds with previously known allelopathy, including piperidine, choline, 4-hydroxybenzaldehyde, acetonecyanohydrin, gallic acid, 2-furoic acid, genistein, and gentisic acid. The current study, utilizing a petri dish bioassay, explains E. canadensis’s invasive potential and mechanisms for affecting the succession of commonly occurring native and non-native weed species in the southern United States. These results establish a solid foundation for understanding the mechanisms driving the successful invasion of E. canadensis in its native range and provide a valuable theoretical framework for early-warning systems assessing ecological risks.
Demographic transitions, societal changes, and evolving population health needs are placing increasing pressure on healthcare systems, necessitating ongoing reforms. Primary health care (PHC) is a foundational component of Universal Health Coverage (UHC) and sustainable health systems. Many countries have undertaken PHC reforms aimed at improving population health. This review explores the objectives, implementation mechanisms, challenges, and outcomes of these reforms.
Methods:
We conducted a systematic review of studies sourced from five databases (PubMed, Scopus, Proquest, Embase, and Science Direct), applying the World Health Organization’s Health Systems Framework for deductive content analysis. The PRISMA guidelines were followed to ensure transparency and rigour in summarizing the published literature.
Results:
A total of 147 types of interventions were identified, with most targeting service delivery and financing. Key reform objectives included expanding access to care, improving financing and payment systems, scaling up family physician programmes, increasing government health expenditure, leveraging private sector capacities, and strengthening the PHC workforce. These interventions resulted in expanded public health coverage, enhanced access to PHC, increased utilization of services among low-income populations, broader social insurance coverage, and improved service quality, contributing to better community health outcomes.
Conclusion:
The success of PHC reforms depends on their alignment with political, social, and cultural contexts, as well as consideration of the social determinants of health. Strong governmental support, managerial stability, decentralization, and regional capacity building are essential for sustainable implementation. Reforms should be gradual, supported by accurate forecasting, adequate and sustainable resources, and evidence-based strategies, drawing on international experiences.
W. E. B. Du Bois is credited with debunking the social Darwinism pervasive in turn-of-the-century social and political theory, exposing the environmental causes of black disadvantage and undercutting claims regarding “inborn” racial deficits. This, however, misses the constructive role that Darwinism played in his account of racial advancement. This article shows how Darwinism, eugenics, and race science shaped Du Bois’s conceptualizations of race and of racial uplift. Darwinism, I argue, informed his analysis of the harms that slavery and segregation visited on black Americans. It also influenced his defense of democratic equality: setting aside its other virtues, democracy would remove “artificial” constraints on the competitive struggle, enabling the best of white and black races to succeed. It was, then, eugenically advantageous. Against the common view that Du Bois rejected social Darwinism and eugenics, I demonstrate that their relationship was far more ambivalent and that his racial politics appealed to them.
We analyse the pressure-driven radial flow of a shear-thinning fluid between two parallel plates. Complex fluid rheology may significantly affect the hydrodynamic features of such non-Newtonian flows, which remain not fully understood, compared with Newtonian flows. We describe the shear-thinning rheology using the Ellis model and present a theoretical framework for calculating the pressure distribution and the flow rate–pressure drop relation. We first derive a closed-form expression for the pressure gradient, which allows us to obtain semi-analytical expressions for the pressure, velocity and flow rate–pressure drop relation. Specifically, we provide the corresponding asymptotic solutions for small and large values of the dimensionless flow rates. We further elucidate the entrance length required for the radial velocity of a shear-thinning fluid to reach its fully developed form, showing that this length approximates the Newtonian low-Reynolds-number value at low shear rates, but may strongly depend on the fluid’s shear-thinning rheology and exceed the Newtonian value at high shear rates. We validate our theoretical results with finite-element numerical simulations and find excellent agreement. Furthermore, we compare our semi-analytical, asymptotic and finite-element simulation results for the pressure distribution with the experimental measurements of Laurencena & Williams (Trans. Soc. Rheol. vol. 18, 1974, pp. 331–355), showing good agreement. Our theoretical results using the Ellis model capture the interplay between the shear-thinning and the zero-shear-rate effects on the pressure drop, which cannot be explained using a simple power-law model, highlighting the importance of using an adequate constitutive model to accurately describe non-Newtonian flows of shear-thinning fluids.
Purple nutsedge is a competitive and persistent perennial weed in the agronomic and horticultural cropping systems of the southeastern United States. Its management is a challenge during the growing season due to its ability to propagate vegetatively through underground rhizomes and tubers. Therefore, effective herbicide programs are needed that can check the spread of purple nutsedge and protect crop yields. Greenhouse experiments were conducted in 2024 to evaluate the response of purple nutsedge at two different growth stages (10 to 15 cm and 15 to 20 cm heights) to herbicides currently labeled for use in Mississippi cropping systems. Herbicides tested were glyphosate at 1,260 g ai ha–1, glufosinate at 672 g ai ha–1, bentazon at 1,680 g ai ha–1, halosulfuron at 69.5 g ai ha–1, and trifloxysulfuron at 6.9 g ai ha–1. Glyphosate was the most effective herbicide against purple nutsedge, providing >90% control, followed by halosulfuron, which provided 70% to 90% control at both growth stages. New shoot emergence was highest when glufosinate and bentazon were applied, and no new shoots emerged when glyphosate and halosulfuron were applied. More new shoots were observed when glufosinate and bentazon were applied when plants were 15 to 20 cm high compared to 10 to 15 cm. Shoot regrowth at 21 d after cutting the aboveground shoots indicated similar trends. A reduction of >90% in shoot and root biomass was observed when glyphosate, halosulfuron, and trifloxysulfuron were applied, whereas glufosinate and bentazon applications resulted in 50% less biomass reduction. Overall, herbicide efficacy against purple nutsedge was greater when plants were treated at the recommended height of 10 to 15 cm rather than 15 to 20 cm. The study results indicated that both herbicide mode of action and application timing are important for better purple nutsedge management in cropping systems.
The European Union is a world leader in nanotechnology environmental, health and safety (EHS) risk regulation, and since its policy integration has been increasingly active in promoting international coordination and cooperation on nanotechnology risk governance. What affects its ability to influence nanotechnology risk regulation and governance internationally? This analysis focuses on the European Union (EU) level arguing that the EU’s scientific and regulatory capacities have significant explanatory power. Empirically, the article examines three cases of EU influence in key areas of international nanotechnology risk regulation and governance – nanosafety research for regulatory purpose, science diplomacy, and multilateral risk governance, following its integrated policy.
Redroot pigweed (Amaranthus retroflexus L.) is among the most troublesome weeds in the Intermountain West affecting corn (Zea mays L.) production and contributing to significant yield losses, in addition to losses caused by water stress. Improvements in agricultural technology such as use of drought-tolerant (DT) corn hybrids has helped minimize the impact of water stress on corn yields. However, it is not known how the use of hybrids affects the interactions between weeds and corn. This work evaluated the competitive effects of A. retroflexus on DT and drought-susceptible (DS) corn hybrids exposed to optimal and reduced irrigation levels in a semi-controlled study. The semi-controlled environment was established in a rainout shelter with corn maintained at a density of 66,482 plants ha−1 and A. retroflexus varied at densities of 0, 33,241, and 66,482 plants ha−1 that were then provided either optimal or reduced irrigation (100% and 50%). We observed a 45% reduction in the shoot biomass of DS corn under reduced irrigation, while the shoot biomass of DT corn remained the same under both irrigation levels in Season 1. In Season 2, both hybrids experienced a decrease in shoot biomass under reduced irrigation. Amaranthus retroflexus exhibited an 80% increase in shoot biomass when growing with DS corn exposed to reduced irrigation, compared with its growth with DS corn exposed to optimal irrigation. Conversely, DT corn negatively impacted A. retroflexus shoot biomass under reduced irrigation, resulting in only a 9% difference between the reduced and optimally irrigated plots. These findings suggest that DT corn may mitigate water stress while also providing the additional benefit of improved competition against weeds, effectively suppressing their growth in water-stressed environments.
Ethnicity and race are vital for understanding representation, yet individual-level data are often unavailable. Recent methodological advances have allowed researchers to impute racial and ethnic classifications based on publicly available information, but predictions vary in their accuracy and can introduce statistical biases in downstream analyses. We provide an overview of common estimation methods, including Bayesian approaches and machine learning techniques that use names or images as inputs. We propose and test a hybrid approach that combines surname-based Bayesian estimation with the use of publicly available images in a convolutional neural network. We find that the proposed approach not only reduces statistical bias in downstream analyses but also improves accuracy in a sample of over 16,000 local elected officials. We conclude with a discussion of caveats and describe settings where the hybrid approach is especially suitable.
Widespread resistance to selective postemergence herbicides has led to increased use of preemergence herbicides to control rigid ryegrass (Lolium rigidum Gaudin), the major weed of southern Australian cropping systems. Seeds of L. rigidum are dormant at maturity, leading to staggered germination across the growing season and avoidance of pre-sowing knockdown herbicides by the later-germinating cohorts. Although it is well known that this selects for higher seed dormancy in intensively cropped areas, there is less information on whether dormant seeds respond differently to preemergence herbicides applied at sowing. To address this, seeds of field-collected L. rigidum populations were divided into dormant and nondormant (afterripened) subsamples and treated with sublethal rates of three preemergence herbicides in order to monitor seedling emergence and seed persistence over 6 mo. The presence of prosulfocarb and pyroxasulfone eliminated the nearly 4-fold increase in seedling emergence that typically results from afterripening, while trifluralin was partially inhibitory. In all treatments, the proportion of viable seeds remaining in the soil after 6 mo was negligible (≤3% of the viable seeds originally sown) for both the dormant and nondormant seeds. Application of radiolabeled herbicides to soil and seeds showed that the herbicides persisted in the seed tissue for longer than in the bulk soil. Therefore, the presence of dormant L. rigidum seeds in the soil seedbank is unlikely to result in cohorts that can avoid preemergence herbicides.
This article examines the theology of Katherine Parr, sixth and surviving wife of Henry VIII, through a close reading of her mature work, The Lamentation of a Sinner. In particular, I treat Parr’s theological use of the epistle to the Romans to inform and structure her doctrine of the work of Christ within The Lamentation. I argue that Parr follows the structure of Romans in her opening lament over sin, her central discussion of the cross of Christ, and her application of this theology to the Christian lives of the people of England’s church. I also posit Parr’s use of several overlapping motifs for Christ’s work within The Lamentation’s treatment of the atonement and its relationship to the Protestant understanding of justification by faith.
Breaches of international law have consequences. Under the Articles on the Responsibility of States for Internationally Wrongful Acts, the international responsibility of a state triggered by its internationally wrongful acts entails specific legal consequences, including the obligation to provide “full reparation” for the injury caused.1 However, obtaining reparations in the current international legal system often proves difficult. Existing international courts and tribunals often lack the jurisdiction to provide full reparations, especially when there are multiple and complex violations that caused injuries to numerous and diverse parties. International claims commissions can be effective instruments to provide reparations in such circumstances, including in post-conflict and other complex situations. Indeed, international claims commissions can fill the vacuum that exists between breaches and reparations due for serious violations. Their flexibility is a unique feature that can provide the missing procedural bridge between international law violations and reparation.
To describe antimicrobial prescribing practices in 4 hospitals in Guatemala to guide the development of an ongoing antimicrobial stewardship (AS) project.
Design:
A cross-sectional mixed methodologies descriptive study design.
Participants and setting
Practicing physicians from 4 hospitals (2 tertiary public hospitals and 2 specialty referral hospitals) within Guatemala City.
Methods:
All participants responded to a survey to ascertain 3 key areas of antimicrobial prescription practices: identify key players, communication among key players, and perceptions and behaviors regarding antimicrobial prescribing. A subset of respondents participated in semi-structured interviews to further explore experiences with AS team dynamics and communication.
Results:
One hundred and ten participants completed the survey (n = 110/145, 75.8%), and 79 completed the interview (n = 79/110, 71.8%). Antimicrobial prescribing is led by physicians who are responsible for maintaining communication with infectious disease physicians. The limited role of the pharmacist and the more predominant role of the microbiologist in antimicrobial selection were notable despite similar levels of training. Efficient communication about prescribing was perceived primarily among physicians, although existing hierarchies within the healthcare system negatively influenced decision-making strategies. Participants reported difficulty in choosing an antibiotic and indicated a preference for broad-spectrum antimicrobial use.
Conclusions:
The existing structure between physicians in hospitals facilitates antimicrobial prescribing practices. However, optimization of antimicrobial use may occur if multidisciplinary teams participate in antimicrobial selection activities. The results of this study provide valuable insight and can be used as a starting point toward the implementation of effective AS strategies within Guatemala and other similar countries in Central America and the Caribbean.
On January 20, 2025, President Donald Trump issued a presidential memorandum that mandated all federal employees return to in-person work full time. Implementation guidance from the Office of Personnel Management (OPM) required rapid policy revisions. The order marks a sharp departure from prior federal telework policies, including longstanding efforts to expand flexible work as a tool for recruitment, retention, productivity, and inclusion. Contrary to claims that in-person work boosts efficiency, research shows remote work generally has no adverse impact on productivity and supports performance in both public and private sectors. The return-to-office mandate is likely to lead to turnover, particularly among highly skilled workers, creating risks of brain drain and diminished capacity to compete with the private sector for talent. It also threatens diversity, equity, and inclusion (DEI) efforts by disproportionately burdening women, caregivers, individuals with disabilities, workers of color, and LGBTQ+ employees. These changes, alongside parallel executive actions undermining DEI programs, reflect a broader return to traditional, centralized models of work built on outdated “ideal worker” norms. These changes have the potential to negatively reshape federal employment for years to come.
On what basis may the International Criminal Court (“ICC”) exercise its jurisdiction over States that have withdrawn from the Rome Statute? Is it enough that the alleged crimes occurred before the State withdrew from the treaty? When acting proprio motu, does the Prosecutor have to seek authorization from a Pre-Trial Chamber before they are allowed to proceed with the criminal investigation post-State withdrawal? This issue has received only cursory attention from the ICC and the academic community but the lack of clarity around the Court’s post-withdrawal jurisdiction is a serious concern, and not only for States that have withdrawn their membership (such as the Philippines). It is important because, as things stand, and given what the Court has said so far, States parties cannot be sure of the parameters of the Court’s temporal jurisdiction, nor of the legal effects of a State’s withdrawal.
Reparations aim to rectify historical harms by compensating victims, or their descendants. Even when such harms have a transnational aspect, as with the case for climate change reparations, they often stem from entrenched domestic political stalemates. In a common pattern, vested interest groups oppose reforms that, although supported by majorities and beneficial to society as a whole, threaten their own material interest. Such groups hold a mobilization advantage that allows them to effectively obstruct change. Left unresolved, these domestic stalemates can compound harm over time in a way that eventually forms the basis of demands for reparations.
Although unconditional cash transfers (UCTs) were an important government intervention during the COVID-19 crisis worldwide, research covering UCTs’ impact on compliance with public health recommendations, at an individual level, remains limited to low-income countries. This study assesses the association between UCTs’ reception and compliance with public health recommendations in the United States. Longitudinal data from the Understanding Coronavirus in America panel are applied to difference-in-differences models to estimate how Economic Impact Payments’ reception, associated with the CARES Act 2020, impacted a variety of pandemic health behaviours. UCTs’ reception was associated with increased uptake of explicitly costly health behaviours, such as facemasks, but not with increased compliance amongst behaviours more generally. Moreover, results document stronger effects amongst poorer households. These findings have theoretical implications for how government transfers impact individual behaviour during periods of crisis and for the direction of future research.
Magnetostratigraphy, palynology and ammonite biochronology of the Staithes S-20 core are used in an integrated evaluation of the late Norian to early Hettangian successions in Britain. The polarity patterns of the Blue Anchor and Westbury formations differ from their counterparts in SW England, indicating younger and older ages, respectively, for those units in NE England. Magnetostratigraphy indicates an underlying Sevatian age hiatus coeval with the D5 disconformity of the German Keuper. The miospore succession from S-20 is divisible into zones like those from the St Audrie’s Bay section in SW England. Using magnetic susceptibility datasets for the earliest Hettangian chronozones from S-20, Lavernock, St Audrie’s Bay and Lyme Regis, a new method is used to derive a TimeOpt-based astrochronology for the earliest Hettangian. This is anchored to radioisotopic dates from Peru correlated into British sections using carbon isotope excursions. A brief reverse magnetozone in the basal Cotham Member in the Staithes S-20 core and the astrochronological evaluation demonstrate that CAMP volcanics are coeval with the end-Triassic extinction in UK sections. An eco-plant model assessment of the miospores indicates greater proportions of eurythermic and europhyte floras, suggesting stronger seasonality in palaeoclimate was probably a key factor in the end-Triassic extinction.
Misinformation has emerged as a key threat worldwide, with scholars frequently highlighting the role of partisan motivated reasoning in misinformation belief. Yet the mechanisms enabling the endorsement of misinformation may differ in contexts where other identities are salient. This study explores whether religion drives the endorsement of misinformation in India. Using original data, we first show that individuals with high levels of religiosity and religious polarization endorse significantly higher levels of misinformation. Next, to understand the causal mechanisms through which religion operates, we field an experiment where corrections rely on religious messaging, and/or manipulate perceptions of religious ingroup identity. We find that corrections including religious frames (1) reduce the endorsement of misinformation; (2) are sometimes more effective than standard corrections; and (3) work beyond the specific story corrected. These findings highlight the religious roots of belief formation and provide hope that social identities can be marshalled to counter misinformation.
This study longitudinally examined associations between parent and peer relationships, childhood maltreatment, and adolescents’ psychopathology. We expected lower perceived parental relationship quality to predict greater symptomatology and higher perceived friendship quality to buffer this association, with greater buffering effects for maltreated participants. We assessed 545 participants (295 maltreated, 250 non-maltreated; 60.2% male; 52.8% Black, 27.5% White, 12.8% Bi-racial, 13.4% Latin@) across two timepoints (Wave 1, Mage = 13.8 years, Wave 2,Mage = 16.2 years). Department of Human Services records indicated maltreatment status prior to Wave 1. Adolescents self-reported Wave 1 parental relationship and friendship quality and Wave 2 internalizing/externalizing symptoms. Parental relationship quality did not predict psychopathology, and this association did not differ by maltreatment status. We found a significant three-way interaction between maternal relationship quality, maltreatment, and friendship quality on internalizing (β = .10, p = .037) and externalizing (β = .12, p = .010) symptoms. For non-maltreated adolescents, parental relationships and friendship quality differentially predicted symptomatology. Maltreated adolescents with low maternal relationship and friendship quality exhibited the most symptoms, whereas those with low maternal relationship quality and high friendship quality exhibited the least. Findings invite inquiry into parent and peer relationships’ differential roles in adolescents’ psychopathology.