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We consider the hypergraph Turán problem of determining $ex(n, S^d)$, the maximum number of facets in a $d$-dimensional simplicial complex on $n$ vertices that does not contain a simplicial $d$-sphere (a homeomorph of $S^d$) as a subcomplex. We show that if there is an affirmative answer to a question of Gromov about sphere enumeration in high dimensions, then $ex(n, S^d) \geq \Omega (n^{d + 1 - (d + 1)/(2^{d + 1} - 2)})$. Furthermore, this lower bound holds unconditionally for 2-LC (locally constructible) spheres, which includes all shellable spheres and therefore all polytopes. We also prove an upper bound on $ex(n, S^d)$ of $O(n^{d + 1 - 1/2^{d - 1}})$ using a simple induction argument. We conjecture that the upper bound can be improved to match the conditional lower bound.
We investigated the interactive effects of bilingualism and sleep on executive functioning at the behavioral level. We conducted two experiments using two independent samples of bilingual young adults, the Flanker task to assess executive performance, the Pittsburg Sleep Quality Index to measure retrospective sleep quality over a one-month period and the Insomnia Severity Index to assess insomnia-related symptoms. In Experiment 1, we registered bilingualism effects on executive performance in poor, but not in good sleepers. In Experiment 2, the magnitude of bilingual effects increased with increasing severity of insomnia symptoms. We conclude that when poor sleep quality and insomnia negatively affect cognitive resources, bilingualism-related cognitive effects emerge more prominently. This suggests higher degrees of bilingualism may compensate detrimental effects of poor sleep quality and insomnia on executive functioning. We suggest that cognitive research in bilingualism and sleep could benefit from controlling for interindividual variability in sleep quality and vice versa.
Educational experience of children with CHD is often adversely impacted by factors such as medical burden, social and school functioning challenges. It is, therefore, vitally important that adequate support is provided at an early stage in order to facilitate better educational outcomes for this cohort. The role of the teacher is pivotal in supporting the overall healthy development of a child with CHD. Thus, it is important to understand how we can also support teachers to provide optimal support to this cohort. This systematic scoping review aimed to offer a comprehensive understanding of existing research in this area and identify any knowledge gaps.
Methods:
The methodological framework for scoping reviews developed by Arksey and O’Malley (2005) was employed.
Findings:
Children with CHD face educational challenges in cognitive, psychomotor, behavioural, and affective domains and also with school attendance. The main challenges for teachers include a lack of information around CHD and how it affects the individual child. Building a strong relationship and having frequent communication between the teacher/ parent/ child were considered key in alleviating anxiety and promoting a supportive environment.
Conclusions:
Children with CHD often require additional support from educational professionals in the classroom. Teachers of children with CHD would benefit from condition-specific training, updated on a regular basis.
Shared decision-making (SDM) is a collaborative process between clinicians and service users to select treatment, guided by evidence and service user preferences. SDM has clinical, economic, and ethical benefits compared to clinician-led decision-making; yet, implementation remains challenging. An important knowledge gap is the influence of culture on implementation. Cultural impacts on service user decision-making preferences have been documented, but little is known about how culture impacts clinician preferences. This study examined associations between country-level cultural characteristics and decision-making preferences of psychiatrists in routine care settings across Europe.
Methods
We analysed data from 751 psychiatrists and trainees in 38 European countries, who completed the Clinical Decision-Making Style–Staff (CDMS-S) scale. Country-level Hofstede cultural dimensions were linked to CDMS-S scores using univariate and multivariate regression models. Mixed-effects models were used to account for country-level clustering and controlling for professional and economic variables.
Results
In univariate analyses, all six dimensions were associated with SDM preferences. However, only three remained significant in mixed-effects models. Higher levels of Indulgence and Individualism were associated with stronger preferences for SDM, while higher Power Distance was associated with more clinician-led decision-making. These associations did not remain significant in fully adjusted multivariate models, suggesting professional and systematic factors mediate cultural influences.
Conclusions
Indulgence, Individualism, and Power Distance are associated with psychiatrists’ decision-making preferences across Europe. Culturally sensitive SDM interventions should address not only clinician attitudes but also healthcare structures and patient expectations. Findings offer an empirical foundation for tailoring SDM training and policy to diverse cultural contexts within European psychiatry.
Functional disorders (FDs) are associated with internalizing disorders (IDs). Studies investigating the nature of these associations over time are limited. We tested the direction of causation between measures of IDs (major depressive disorder [MDD], generalized anxiety disorder [GAD]) and FDs (fibromyalgia [FM] and myalgic encephalomyelitis/chronic fatigue syndrome [ME/CFS]) measured across two waves of longitudinal data (N = 108,034 and N = 73,590).
Methods
The Lifelines Cohort Study is a large prospective population-based cohort study in the northeast of the Netherlands. We tested competing causal models for the longitudinal association between IDs and FDs and, to follow-up results from the model with all IDs and FDs, tested the direction of causation between MDD and FM.
Results
FDs were more stable over time than IDs. Initial model comparisons support a bidirectional relationship between most IDs and FDs. Follow-up analyses support a unidirectional model where FM predicts MDD over time (β = 0.14, 95% confidence interval = [0.11, 0.18]), but not vice versa.
Conclusions
The cross-time associations between ME/CFS, MDD, and GAD appear bidirectional (causal in both directions). Our results are consistent with, but not demonstrative of, a causal relationship from FM to MDD. The consequences of specific FDs vary, underscoring the value of studying these conditions as distinct constructs.
In 2025, the United States raised tariffs to rates not seen for more than a century. These tariffs were not part of a carefully designed industrial strategy. Instead, the second Trump administration distanced itself from existing industrial policy initiatives and indicated a desire to roll back government-funded subsidies for businesses. This article examines the rationale behind the United States’ pivot from subsidies to tariffs and explores implications for trade partners and multilateral institutions.
Digital eXtended Reality technologies enable users to view and interact with spaces and objects in three dimensions (3D), thus supporting a variety of potential innovative embodied applications in archaeology. Here, we review the Apple Vision Pro as a Mixed/Augmented Reality (MR/AR) headset to determine where it might fit within current archaeological practice. Our interest in this device spans primary field data collection, in situ visual–spatial interpretation, and public education and tourism. Overall, we find that although it makes certain advances on prior eXtended Reality hardware, it does not yet represent a significant enough shift forward to have a major impact on archaeology. However, we do plan to continue our field experiments with this technology to push its limits and to prepare for future improvements to this product and its competitors.
We focus on the wake of a cylinder placed in uniform flow and forced to rotate periodically at subcritical Reynolds numbers, i.e. for Reynolds numbers smaller than 47 calculated based on the incoming flow velocity and the cylinder diameter, where vortices are not shed in the wake of a fixed cylinder. We show that in the near wake, the imposed periodic rotation causes the Föppl vortices (the symmetric steady vortices that are formed right behind a fixed cylinder within the Reynolds number range of $5\lt {Re}\lt 47$) to appear only momentarily during each rotation cycle until they disappear at higher rotation rates. In the far wake, vortices can be induced for certain values of rotation rate, $\alpha$, and rotation frequency, $f$. The shedding of these vortices in the wake results in a periodic lift force that acts on the cylinder. We have defined a new parameter $\omega /(f\alpha )\equiv 1/F$, where $\omega$ is the angular velocity of the cylinder, which is significant in describing the system. For any values of angular velocity and the frequency of change in the rotation direction, the wake pattern remains the same if the value of $1/F$ stays constant. Subsequently, the fluctuating lift coefficient and the average drag coefficient peak at the same value of $1/F$ for any value of $\omega /f\equiv \alpha /F$. The Reynolds number for the onset of shedding decreases with increasing rotation rate at a constant $\alpha /F$. We have observed shedding at Reynolds numbers as low as ${Re}=1$ for higher rotation rates.
Emerging infectious diseases pose threats to wildlife, particularly in geographically isolated populations where hosts may lack prior exposure and immunity. Seabirds inhabiting remote islands in the southwest Atlantic and Southern Ocean, including threatened albatrosses and petrels, are increasingly affected by infectious pathogens. However, baseline data on vector-borne infections in these species remain scarce. This study assessed the presence of vector-borne haemosporidian parasites (Plasmodium, Haemoproteus and Leucocytozoon) and bacterial pathogens (Borrelia burgdorferi sensu lato, Anaplasma and Ehrlichia) in albatrosses and petrels, providing insights into disease prevalence and potential threats to these populations. We analysed blood and tissue samples from 269 individuals of 5 albatross and 12 petrel species, collected over an 11-year period (2013–2023) from South Georgia and multiple sites along the Brazilian coastline. Molecular assays, including nested Polymerase Chain Reaction (PCR), were used for pathogen screening. Blood smears from birds sampled in South Georgia were also examined for haemoparasites via light microscopy. We found no molecular or microscopy evidence of infection with haemosporidian parasites, Borrelia, Anaplasma or Ehrlichia in any of the samples. These findings suggest that vector-borne pathogens are either absent or at low prevalence, possibly because of limited vector presence, natural resistance or historical isolation from infection. Continuous monitoring is critical given current environmental changes and risks of pathogen introduction via climate-driven shifts in vector distribution. Our study establishes an essential baseline for future disease surveillance, prevention and mitigation in albatrosses and petrels, underscoring the importance of long-term monitoring to detect emerging pathogens in vulnerable seabird populations.
A simple view about “now” is that it picks out the time of the speech act in which it is used. A major advantage of this view is that it incorporates a semantical claim about reference in the larger framework of speech acts. However, the view cannot account for uses of “now” in so-called “answering machine” cases of speech acts, where we lack both clear intuitions and a widely accepted metaphysical view about their temporal locations. I first show that this problem is not limited to indexicals and answering machines. I then propose a different token-reflexive, speech act-friendly view: that speakers set detonation conditions for tokens of “now”, which, when the conditions are met, pick out the time of their detonation.
Many scholars now contend that the wall separating church and state has been effectively dismantled. One of the strongest pieces of evidence used to make this argument is the transfer of over five million taxpayer dollars to churches during Covid-19. But who exactly received this money? When the wall separating church and state came crashing down, as some assert, was there an ambush of religious actors seeking to collect federal funds? Or did we see many religious actors maintain their distance? What distinguishes one group from the other? This research note examines the behavior of religious congregations during Covid-19 with regard to the Paycheck Protection Program (PPP). We compare a sample of 2020 and 2021 PPP congregation recipients with the 2020 US Religious Census to note which denominations are over- and under-represented and then test the hypotheses suggested by the existing literature on faith-based organizations and government funding.
Over the last two decades, there have been significant investments designed to advance clinical and translational research (CTR) with an emphasis on supporting early career investigators and building a cadre of skilled researchers. Despite the investments, there are no comprehensive measurement tools to track individual-level progress along the research continuum as supports are put in place.
Objective:
The Researcher Investment Tool (RIT) is a novel tool that was created to provide a consistent approach for measuring individual-level changes in the research career trajectory of investigators receiving support from CTR programs.
Methods:
The RIT is a 90-item questionnaire, with eight domains and four sub-domains, designed to measure a researcher’s experiences and perceptions. Several rounds of testing were conducted to assess the tool’s face and content validity as well as the internal consistency and test-retest reliability.
Results:
Psychometric testing revealed strong content validity and good internal consistency with Cronbach’s alpha coefficients ranging from 0.85 to 0.97 across all domains. Test-retest reliability results also revealed stability in the domain measures over time with Pearson’s correlation coefficients ranging from 0.70 to 0.98 for all but one domain (.53).
Conclusions:
This novel RIT may be useful to evaluators when measuring the impact of investments designed to support early career clinical and translational researchers.
We establish a one-to-one correspondence between Kähler metrics in a given conformal class and parallel sections of a certain vector bundle with conformally invariant connection, where the parallel sections satisfy a set of non-linear algebraic constraints that we describe. The vector bundle captures 2-form prolongations and is isomorphic to $\Lambda^3(\mathcal{T})$, where ${\mathcal{T}}$ is the tractor bundle of conformal geometry, but the resulting connection differs from the normal tractor connection by curvature terms.
Our analysis leads to a set of obstructions for a Riemannian metric to be conformal to a Kähler metric. In particular, we find an explicit algebraic condition for a Weyl tensor which must hold if there exists a conformal Killing–Yano tensor, which is a necessary condition for a metric to be conformal to Kähler. This gives an invariant characterization of algebraically special Riemannian metrics of type D in dimensions higher than four.
QuickSelect (also known as Find), introduced by Hoare ((1961) Commun. ACM4 321–322.), is a randomized algorithm for selecting a specified order statistic from an input sequence of $n$ objects, or rather their identifying labels usually known as keys. The keys can be numeric or symbol strings, or indeed any labels drawn from a given linearly ordered set. We discuss various ways in which the cost of comparing two keys can be measured, and we can measure the efficiency of the algorithm by the total cost of such comparisons.
We define and discuss a closely related algorithm known as QuickVal and a natural probabilistic model for the input to this algorithm; QuickVal searches (almost surely unsuccessfully) for a specified population quantile $\alpha \in [0, 1]$ in an input sample of size $n$. Call the total cost of comparisons for this algorithm $S_n$. We discuss a natural way to define the random variables $S_1, S_2, \ldots$ on a common probability space. For a general class of cost functions, Fill and Nakama ((2013) Adv. Appl. Probab.45 425–450.) proved under mild assumptions that the scaled cost $S_n / n$ of QuickVal converges in $L^p$ and almost surely to a limit random variable $S$. For a general cost function, we consider what we term the QuickVal residual:
\begin{equation*} \rho _n \,{:\!=}\, \frac {S_n}n - S. \end{equation*}
The residual is of natural interest, especially in light of the previous analogous work on the sorting algorithm QuickSort (Bindjeme and Fill (2012) 23rd International Meeting on Probabilistic, Combinatorial, and Asymptotic Methods for the Analysis of Algorithms (AofA'12), Discrete Mathematics, and Theoretical Computer Science Proceedings, AQ, Association: Discrete Mathematics and Theoretical Computer Science, Nancy, pp. 339–348; Neininger (2015) Random Struct. Algorithms46 346–361; Fuchs (2015) Random Struct. Algorithms46 677–687; Grübel and Kabluchko (2016) Ann. Appl. Probab.26 3659–3698; Sulzbach (2017) Random Struct. Algorithms50 493–508). In the case $\alpha = 0$ of QuickMin with unit cost per key-comparison, we are able to calculate–àla Bindjeme and Fill for QuickSort (Bindjeme and Fill (2012) 23rd International Meeting on Probabilistic, Combinatorial, and Asymptotic Methods for the Analysis of Algorithms (AofA'12), Discrete Mathematics and Theoretical Computer Science Proceedings, AQ, Association: Discrete Mathematics and Theoretical Computer Science, Nancy, pp. 339–348.)–the exact (and asymptotic) $L^2$-norm of the residual. We take the result as motivation for the scaling factor $\sqrt {n}$ for the QuickVal residual for general population quantiles and for general cost. We then prove in general (under mild conditions on the cost function) that $\sqrt {n}\,\rho _n$ converges in law to a scale mixture of centered Gaussians, and we also prove convergence of moments.
Narratives of Sino-Middle Eastern Futures attempts to discern the future trajectory and endpoint of Sino-Middle Eastern relations – are we on the precipice of a post-American Chinese hegemony in the region? Or are we reaching the outer limits of what is feasible within what are essentially transactional ties? Drawing on a wide range of multilingual sources from 2010 to 2023, and based on a framework of thin constructivism, the Element delves into the Saudi, Syrian and Chinese elite narratives regarding the Middle Eastern regional order and China's envisaged place within it. By centering local perspectives, it offers insights into how these actors –with diverse positionalities in the region (vis-à-vis the United States) and different national capabilities– are debating the future of China in the Middle East, and what the juxtaposition of their multiple narratives mean for where things are headed. This title is also available as Open Access on Cambridge Core.
This Element provides an argumentative introduction to the doctrines of karma and rebirth in Hinduism. It explains how various Hindu texts, traditions, and figures have understood the philosophical nuances of karma and rebirth. It also acquaints readers with some of the most important academic debates about these doctrines. The Element's primary argumentative aim is to defend the rationality of accepting the truth of karma and rebirth through a critical examination of an array of arguments for and against these doctrines. It concludes by highlighting the relevance of karma and rebirth to contemporary philosophical debates on a variety of issues. This title is also available as open access on Cambridge Core.
This Element addresses a range of pressing challenges and crises by introducing readers to the Maya struggle for land and self-determination in Belize, a former British colony situated in the Caribbean and Central America. In addition to foregrounding environmental relations, the text provides deeper understandings of Qʼeqchiʼ and Mopan Maya people's dynamic conceptions and collective defence of community and territory. To do so, the authors centre the voices, worldviews, and experiences of Maya leaders, youth, and organisers who are engaged in frontline resistance and mobilisations against institutionalised racism and contemporary forms of dispossession. Broadly, the content offers an example of how Indigenous communities are reckoning with the legacies of empire whilst confronting the structural violence and threats to land and life posed by the driving forces of capital accumulation, neoliberal development, and coloniality of the state. Ultimately, this Element illustrates the realities, repercussions, and transformative potential of grassroots movement-building 'from below.' This title is also available as open access on Cambridge Core.
Cancer patients often suffer from refractory symptoms near death. The use of sedatives aims to relieve suffering caused by these symptoms. The practice varies broadly. The aim of this study was to evaluate the role and trends of midazolam use in cancer patients dying in a university hospital oncology ward.
Methods
The study population of this retrospective registry-based study consists of patients who died in a university hospital oncology ward in Eastern Finland in 2010–2018 (n = 639). Information about treatment decisions, midazolam use, and background factors were gathered.
Results
During the study period, 14.7 % of the patients dying in the ward received midazolam with sedative intent prior to death. 4.7 % (n = 30) of the whole study population had continuous infusion and the rest of the midazolam use was one or multiple single doses. Documented discussion of possible palliative sedation (PS) use was found in almost one third of all patients. Out of those, eventually receiving midazolam with sedative intent, two thirds had had this discussion. The most common symptoms leading to midazolam were dyspnea, pain, and delirium. In continuous use the median midazolam infusion rate was 4.0 mg/h. The continuous infusion started median of 23.25 h and multiple single doses 19 h before death. If only one dose of midazolam was needed, it was given median of 30 minutes prior to death and the most common symptom was dyspnea. Those who received midazolam were more likely to be younger (p = 0.003) and had had a palliative outpatient clinic visit (p = 0.045).
Significance of results
This is the first study to report the trends and practices of midazolam use for refractory symptoms in Finland. Midazolam was used for approximately every 7th dying cancer patient. Applying midazolam was supported by a history of palliative clinic visits and younger age.
Eimeria species, the causative agents of avian coccidiosis, are major pathogens in poultry, resulting in substantial economic losses and welfare concerns worldwide. Understanding their complex life cycle, including different developmental stages and host interactions, is essential for advancing control strategies. Traditional cultivation systems, such as primary cell cultures and immortalised cell lines, have provided valuable insights, but they present limitations in supporting complete parasite development, host–pathogen interactions and immune response evaluation. Recent advances in intestinal organoids offer a promising alternative for Eimeria research. Initially developed in human models, intestinal organoids have been successfully adapted to avian systems, replicating the architecture, cellular diversity and physiological functions of the chicken gut epithelium. These 3D models provide now a physiologically relevant platform for studying parasite development, host–pathogen interactions, immune responses and drug screening in vitro. Complementary tools, such as intestinal explants, could further enhance the experimental repertory available for investigating Eimeria species. Additionally, insights from studies on related apicomplexan parasites support the translational value of these systems. These innovative systems could support significant advances in Eimeria cultivation, enabling more robust and ethical research while reducing the use of experimental animals.