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Emerging infectious diseases pose threats to wildlife, particularly in geographically isolated populations where hosts may lack prior exposure and immunity. Seabirds inhabiting remote islands in the southwest Atlantic and Southern Ocean, including threatened albatrosses and petrels, are increasingly affected by infectious pathogens. However, baseline data on vector-borne infections in these species remain scarce. This study assessed the presence of vector-borne haemosporidian parasites (Plasmodium, Haemoproteus and Leucocytozoon) and bacterial pathogens (Borrelia burgdorferi sensu lato, Anaplasma and Ehrlichia) in albatrosses and petrels, providing insights into disease prevalence and potential threats to these populations. We analysed blood and tissue samples from 269 individuals of 5 albatross and 12 petrel species, collected over an 11-year period (2013–2023) from South Georgia and multiple sites along the Brazilian coastline. Molecular assays, including nested Polymerase Chain Reaction (PCR), were used for pathogen screening. Blood smears from birds sampled in South Georgia were also examined for haemoparasites via light microscopy. We found no molecular or microscopy evidence of infection with haemosporidian parasites, Borrelia, Anaplasma or Ehrlichia in any of the samples. These findings suggest that vector-borne pathogens are either absent or at low prevalence, possibly because of limited vector presence, natural resistance or historical isolation from infection. Continuous monitoring is critical given current environmental changes and risks of pathogen introduction via climate-driven shifts in vector distribution. Our study establishes an essential baseline for future disease surveillance, prevention and mitigation in albatrosses and petrels, underscoring the importance of long-term monitoring to detect emerging pathogens in vulnerable seabird populations.
A simple view about “now” is that it picks out the time of the speech act in which it is used. A major advantage of this view is that it incorporates a semantical claim about reference in the larger framework of speech acts. However, the view cannot account for uses of “now” in so-called “answering machine” cases of speech acts, where we lack both clear intuitions and a widely accepted metaphysical view about their temporal locations. I first show that this problem is not limited to indexicals and answering machines. I then propose a different token-reflexive, speech act-friendly view: that speakers set detonation conditions for tokens of “now”, which, when the conditions are met, pick out the time of their detonation.
Many scholars now contend that the wall separating church and state has been effectively dismantled. One of the strongest pieces of evidence used to make this argument is the transfer of over five million taxpayer dollars to churches during Covid-19. But who exactly received this money? When the wall separating church and state came crashing down, as some assert, was there an ambush of religious actors seeking to collect federal funds? Or did we see many religious actors maintain their distance? What distinguishes one group from the other? This research note examines the behavior of religious congregations during Covid-19 with regard to the Paycheck Protection Program (PPP). We compare a sample of 2020 and 2021 PPP congregation recipients with the 2020 US Religious Census to note which denominations are over- and under-represented and then test the hypotheses suggested by the existing literature on faith-based organizations and government funding.
Over the last two decades, there have been significant investments designed to advance clinical and translational research (CTR) with an emphasis on supporting early career investigators and building a cadre of skilled researchers. Despite the investments, there are no comprehensive measurement tools to track individual-level progress along the research continuum as supports are put in place.
Objective:
The Researcher Investment Tool (RIT) is a novel tool that was created to provide a consistent approach for measuring individual-level changes in the research career trajectory of investigators receiving support from CTR programs.
Methods:
The RIT is a 90-item questionnaire, with eight domains and four sub-domains, designed to measure a researcher’s experiences and perceptions. Several rounds of testing were conducted to assess the tool’s face and content validity as well as the internal consistency and test-retest reliability.
Results:
Psychometric testing revealed strong content validity and good internal consistency with Cronbach’s alpha coefficients ranging from 0.85 to 0.97 across all domains. Test-retest reliability results also revealed stability in the domain measures over time with Pearson’s correlation coefficients ranging from 0.70 to 0.98 for all but one domain (.53).
Conclusions:
This novel RIT may be useful to evaluators when measuring the impact of investments designed to support early career clinical and translational researchers.
We establish a one-to-one correspondence between Kähler metrics in a given conformal class and parallel sections of a certain vector bundle with conformally invariant connection, where the parallel sections satisfy a set of non-linear algebraic constraints that we describe. The vector bundle captures 2-form prolongations and is isomorphic to $\Lambda^3(\mathcal{T})$, where ${\mathcal{T}}$ is the tractor bundle of conformal geometry, but the resulting connection differs from the normal tractor connection by curvature terms.
Our analysis leads to a set of obstructions for a Riemannian metric to be conformal to a Kähler metric. In particular, we find an explicit algebraic condition for a Weyl tensor which must hold if there exists a conformal Killing–Yano tensor, which is a necessary condition for a metric to be conformal to Kähler. This gives an invariant characterization of algebraically special Riemannian metrics of type D in dimensions higher than four.
QuickSelect (also known as Find), introduced by Hoare ((1961) Commun. ACM4 321–322.), is a randomized algorithm for selecting a specified order statistic from an input sequence of $n$ objects, or rather their identifying labels usually known as keys. The keys can be numeric or symbol strings, or indeed any labels drawn from a given linearly ordered set. We discuss various ways in which the cost of comparing two keys can be measured, and we can measure the efficiency of the algorithm by the total cost of such comparisons.
We define and discuss a closely related algorithm known as QuickVal and a natural probabilistic model for the input to this algorithm; QuickVal searches (almost surely unsuccessfully) for a specified population quantile $\alpha \in [0, 1]$ in an input sample of size $n$. Call the total cost of comparisons for this algorithm $S_n$. We discuss a natural way to define the random variables $S_1, S_2, \ldots$ on a common probability space. For a general class of cost functions, Fill and Nakama ((2013) Adv. Appl. Probab.45 425–450.) proved under mild assumptions that the scaled cost $S_n / n$ of QuickVal converges in $L^p$ and almost surely to a limit random variable $S$. For a general cost function, we consider what we term the QuickVal residual:
\begin{equation*} \rho _n \,{:\!=}\, \frac {S_n}n - S. \end{equation*}
The residual is of natural interest, especially in light of the previous analogous work on the sorting algorithm QuickSort (Bindjeme and Fill (2012) 23rd International Meeting on Probabilistic, Combinatorial, and Asymptotic Methods for the Analysis of Algorithms (AofA'12), Discrete Mathematics, and Theoretical Computer Science Proceedings, AQ, Association: Discrete Mathematics and Theoretical Computer Science, Nancy, pp. 339–348; Neininger (2015) Random Struct. Algorithms46 346–361; Fuchs (2015) Random Struct. Algorithms46 677–687; Grübel and Kabluchko (2016) Ann. Appl. Probab.26 3659–3698; Sulzbach (2017) Random Struct. Algorithms50 493–508). In the case $\alpha = 0$ of QuickMin with unit cost per key-comparison, we are able to calculate–àla Bindjeme and Fill for QuickSort (Bindjeme and Fill (2012) 23rd International Meeting on Probabilistic, Combinatorial, and Asymptotic Methods for the Analysis of Algorithms (AofA'12), Discrete Mathematics and Theoretical Computer Science Proceedings, AQ, Association: Discrete Mathematics and Theoretical Computer Science, Nancy, pp. 339–348.)–the exact (and asymptotic) $L^2$-norm of the residual. We take the result as motivation for the scaling factor $\sqrt {n}$ for the QuickVal residual for general population quantiles and for general cost. We then prove in general (under mild conditions on the cost function) that $\sqrt {n}\,\rho _n$ converges in law to a scale mixture of centered Gaussians, and we also prove convergence of moments.
Narratives of Sino-Middle Eastern Futures attempts to discern the future trajectory and endpoint of Sino-Middle Eastern relations – are we on the precipice of a post-American Chinese hegemony in the region? Or are we reaching the outer limits of what is feasible within what are essentially transactional ties? Drawing on a wide range of multilingual sources from 2010 to 2023, and based on a framework of thin constructivism, the Element delves into the Saudi, Syrian and Chinese elite narratives regarding the Middle Eastern regional order and China's envisaged place within it. By centering local perspectives, it offers insights into how these actors –with diverse positionalities in the region (vis-à-vis the United States) and different national capabilities– are debating the future of China in the Middle East, and what the juxtaposition of their multiple narratives mean for where things are headed. This title is also available as Open Access on Cambridge Core.
This Element provides an argumentative introduction to the doctrines of karma and rebirth in Hinduism. It explains how various Hindu texts, traditions, and figures have understood the philosophical nuances of karma and rebirth. It also acquaints readers with some of the most important academic debates about these doctrines. The Element's primary argumentative aim is to defend the rationality of accepting the truth of karma and rebirth through a critical examination of an array of arguments for and against these doctrines. It concludes by highlighting the relevance of karma and rebirth to contemporary philosophical debates on a variety of issues. This title is also available as open access on Cambridge Core.
This Element addresses a range of pressing challenges and crises by introducing readers to the Maya struggle for land and self-determination in Belize, a former British colony situated in the Caribbean and Central America. In addition to foregrounding environmental relations, the text provides deeper understandings of Qʼeqchiʼ and Mopan Maya people's dynamic conceptions and collective defence of community and territory. To do so, the authors centre the voices, worldviews, and experiences of Maya leaders, youth, and organisers who are engaged in frontline resistance and mobilisations against institutionalised racism and contemporary forms of dispossession. Broadly, the content offers an example of how Indigenous communities are reckoning with the legacies of empire whilst confronting the structural violence and threats to land and life posed by the driving forces of capital accumulation, neoliberal development, and coloniality of the state. Ultimately, this Element illustrates the realities, repercussions, and transformative potential of grassroots movement-building 'from below.' This title is also available as open access on Cambridge Core.
Cancer patients often suffer from refractory symptoms near death. The use of sedatives aims to relieve suffering caused by these symptoms. The practice varies broadly. The aim of this study was to evaluate the role and trends of midazolam use in cancer patients dying in a university hospital oncology ward.
Methods
The study population of this retrospective registry-based study consists of patients who died in a university hospital oncology ward in Eastern Finland in 2010–2018 (n = 639). Information about treatment decisions, midazolam use, and background factors were gathered.
Results
During the study period, 14.7 % of the patients dying in the ward received midazolam with sedative intent prior to death. 4.7 % (n = 30) of the whole study population had continuous infusion and the rest of the midazolam use was one or multiple single doses. Documented discussion of possible palliative sedation (PS) use was found in almost one third of all patients. Out of those, eventually receiving midazolam with sedative intent, two thirds had had this discussion. The most common symptoms leading to midazolam were dyspnea, pain, and delirium. In continuous use the median midazolam infusion rate was 4.0 mg/h. The continuous infusion started median of 23.25 h and multiple single doses 19 h before death. If only one dose of midazolam was needed, it was given median of 30 minutes prior to death and the most common symptom was dyspnea. Those who received midazolam were more likely to be younger (p = 0.003) and had had a palliative outpatient clinic visit (p = 0.045).
Significance of results
This is the first study to report the trends and practices of midazolam use for refractory symptoms in Finland. Midazolam was used for approximately every 7th dying cancer patient. Applying midazolam was supported by a history of palliative clinic visits and younger age.
Eimeria species, the causative agents of avian coccidiosis, are major pathogens in poultry, resulting in substantial economic losses and welfare concerns worldwide. Understanding their complex life cycle, including different developmental stages and host interactions, is essential for advancing control strategies. Traditional cultivation systems, such as primary cell cultures and immortalised cell lines, have provided valuable insights, but they present limitations in supporting complete parasite development, host–pathogen interactions and immune response evaluation. Recent advances in intestinal organoids offer a promising alternative for Eimeria research. Initially developed in human models, intestinal organoids have been successfully adapted to avian systems, replicating the architecture, cellular diversity and physiological functions of the chicken gut epithelium. These 3D models provide now a physiologically relevant platform for studying parasite development, host–pathogen interactions, immune responses and drug screening in vitro. Complementary tools, such as intestinal explants, could further enhance the experimental repertory available for investigating Eimeria species. Additionally, insights from studies on related apicomplexan parasites support the translational value of these systems. These innovative systems could support significant advances in Eimeria cultivation, enabling more robust and ethical research while reducing the use of experimental animals.
The interaction of a solitary wave and a slowly varying mean background or flow for the Serre-Green-Naghdi (SGN) equations is studied using Whitham modulation theory. The exact form of the three SGN-Whitham modulation equations – two for the mean horizontal velocity and depth decoupled from one for the solitary wave amplitude field – is obtained in the solitary wave limit. Although the three equations are not diagonalizable, the restriction of the full system to simple waves for the mean equations is diagonalized in terms of Riemann invariants. The Riemann invariants are used to analytically describe the head-on and overtaking interactions of a solitary wave with a rarefaction wave and dispersive shock wave (DSW), leading to scenarios of solitary wave trapping or transmission by the mean flow. The analytical results for overtaking interactions prove that a simpler, approximate approach based on the DSW fitting method is accurate to the second order in solitary wave amplitude, beyond the first order accurate Korteweg-de Vries approximation. The analytical results also accurately predict the SGN DSW’s solitary wave edge amplitude and speed. The analytical results are favourably compared with corresponding numerical solutions of the full SGN equations. Because the SGN equations model the bi-directional propagation of strongly nonlinear, long gravity waves over a flat bottom, the analysis presented here describes large amplitudesolitary wave-mean flow interactions in shallow water waves.
Stroke is a devastating disease, but the disability due to stroke can be avoided or reduced through timely access to treatment and care. This study surveyed all designated stroke centres across Canada to better understand the national acute stroke treatment landscape.
Methods:
An online survey designed to obtain information on each stroke hospital’s designation level, most responsible physician for acute reperfusion treatment decision-making, availability of stroke coordinators, stroke research activity and level of transition to tenecteplase for intravenous thrombolysis was distributed to stroke centres in Canada via a network of stroke administrators and physician leads from each province. The survey responses were collated and audited for completeness and accuracy, and final responses were analysed using descriptive statistics and graphical distributions as appropriate.
Results:
There are a total of 205 designated stroke centres in Canada; 13.2% (n = 27) are endovascular thrombectomy (EVT) capable (n = 26 provide 24/7 access), while the rest provide thrombolysis alone, comprising primary stroke centres (n = 70, 34.1%) and thrombolysis-ready centres (n = 108, 52.7%). The presence of neurologists in the thrombolysis-capable centres is minimal, although compensated for by a high use of telestroke in making thrombolysis decisions. Participation rate in stroke clinical trials was heavily restricted to the EVT-capable centres. There were variabilities among provinces in the availability of stroke coordinators.
Conclusion:
The acute ischaemic stroke landscape in Canada is variable between provinces, presenting unique opportunities for collaboration. There is a need for greater availability of stroke neurologists and stroke coordinators and for diversifying site participation in clinical trials.
The composition of phosgenite (ideal formula Pb2(CO3)Cl2, sp. gr. P4/mbm with a ≈ 8.15 and c ≈ 8.87 Å) from Monteponi Mine, Iglesias, Sardinia, Italy, its crystal structure and its high-T behaviour up to the onset of decomposition were investigated by a series of chemical analytical and diffraction techniques, including single-crystal X-ray (data collected at 293 K) and neutron diffraction (at 293 and 20 K), in situ high-T powder X-ray diffraction (XRD) and thermogravimetric analysis. Concentrations of >65 elements were measured. The empirical mineralogical formula of phosgenite, obtained by the multi-analytical approach used in this study, is almost identical to the ideal one, with only a few elements measured above the detection limit: Σ(Na2O+K2O+CaO+SiO2) = 0.11 wt.%. The concentration of other industrially relevant elements is insignificant. X-ray and neutron refinements, based on data collected at room T, confirm the previously reported general structural model of phosgenite, while providing a full description of the displacement parameters of all the atomic sites. The building unit of the crystal structure of phosgenite is represented by a Pb-polyhedron, in which Pb is coordinated by 5Cl + 4O (coordination number CN = 9), forming a monocapped square antiprism. The combination of face-sharing Pb-polyhedra generates dense layers parallel to (001), which are connected by (edge-sharing) CO3-groups to form the crystalline edifice. Low-T neutron diffraction data show evidence of a temperature-mediated phase transition towards a lower symmetry (space group P$\bar 4$), with a modest distortion of the building units of the structure. A tentative description of the low-T mechanisms, at the atomic scale, that can lead to the phase transition is provided.
The high-T behaviour of phosgenite proves this mineral is stable at least up to 523 K, at which the first evidence of transformation (with the coexistence of phosgenite + Pb2O2Cl, and probably an amorphous phase) takes place. The XRD pattern at 548 K unveils a more complex scenario, with coexisting: phosgenite (dominant) + Pb2O2Cl (minor) + mendipite [Pb3O2Cl2] (minor) + Pb5O2Cl6 (subordinate) (+ amorphous phase). This phase composition is preserved up to 648 K, after which phosgenite is no longer preserved, and the stable compounds are: mendipite [Pb3O2Cl2] (dominant), Pb2O2Cl (subordinate) + Pb5O2Cl6 (subordinate) + kutnohorite-type [Ca(Mn,Mg,Fe2+)(CO3)2] (likely, very minor) (+ amorphous phase). The same assemblage is observed up to 698 and back to 298 K after a decrease in T, showing an irreversible transformation of the pristine material. Therefore, the irreversible temperature-induced degradation of phosgenite is substantially governed by a decarbonation process.
The Kruskal–Friedman theorem asserts: in any infinite sequence of finite trees with ordinal labels, some tree can be embedded into a later one, by an embedding that respects a certain gap condition. This strengthening of the original Kruskal theorem has been proved by I. Kříž (Ann. Math. 1989), in confirmation of a conjecture due to H. Friedman, who had established the result for finitely many labels. It provides one of the strongest mathematical examples for the independence phenomenon from Gödel’s theorems. The gap condition is particularly relevant due to its connection with the graph minor theorem of N. Robertson and P. Seymour. In the present article, we consider a uniform version of the Kruskal–Friedman theorem, which extends the result from trees to general recursive data types. Our main theorem shows that this uniform version is equivalent both to $\Pi ^1_1$-transfinite recursion and to a minimal bad sequence principle of Kříž, over the base theory $\mathsf {RCA_0}$ from reverse mathematics. This sheds new light on the role of infinity in finite combinatorics.
We developed a clinical care pathway for the detection and management of frailty for older adults living in long-term care (LTC) homes.
Methods
We utilized a modified Delphi with residents of LTC homes experiencing frailty, their caregivers, and care providers. The pathway was created using existing literature and input from key LTC experts.
Findings
Fifty-two panelists completed round one of the Delphi, and 55.8% of these respondents completed round two. Both rounds had high agreement and ratings. We added six new statements following analysis of round two, and 15 statements were modified/updated to reflect panelist feedback. The final pathway included 28 statements and promotes a resident-centered approach that highlights caregiver involvement and inter-professional teamwork to identify and manage frailty, as well as initiate palliative care earlier.
Conclusion
Implementing this pathway will allow health care providers to adopt screening measures and adapt care to a resident’s frailty severity.
We prove that the mapping class group is not an h-cobordism invariant of high-dimensional manifolds by exhibiting h-cobordant manifolds whose mapping class groups have different cardinalities. In order to do so, we introduce a moduli space of ‘h-block’ bundles and understand its difference with the moduli space of ordinary block bundles.