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Participatory Design – an iterative, flexible design process that closely involves stakeholders, often end users – is growing in use across design disciplines. As more practitioners use Participatory Design (PD), it has become less rigidly defined, with stakeholders engaged to varying degrees through disjointed techniques. This ambiguity can be counterproductive when discussing PD processes. We performed a systematic literature review that builds shared, foundational knowledge of PD processes and techniques while also summarizing the state of PD research in the field, as a first step in supporting richer understandings of how best to equitably engage with stakeholders. We found that a majority of PD literature examined specific case studies of PD, with the design of intangible systems representing the most common design context. Stakeholders most often participated throughout multiple stages of a design process, recruited in a variety of ways, and engaged in several of the 14 specific participatory techniques identified. Our findings also identify leverage points for creators of PD processes and how the leverage points impact design equity, including: (1) emergent versus predetermined processes; (2) direct versus indirect participation; (3) early versus late participation; (4) one time versus iterative participation; and (5) singular versus multiple PD techniques.
Weight suppression represents the difference between highest and current body weight and predicts maintenance of bulimia nervosa and related syndromes (BN-S). This study tested a biobehavioral model of binge-eating severity in which greater weight suppression links to reduced leptin, which links to reduced glucagon-like peptide 1 (GLP-1) release, which links to both decreased reward satiation and increased reward valuation, which link, respectively, to excessive food intake and loss of control while eating – the defining features of DSM-5 binge-eating episodes.
Methods
Women (N = 399) who met DSM-5 criteria for bulimia nervosa or another eating disorder with binge eating (n = 321) or had no lifetime eating disorder symptoms (n = 78) participated in a multi-visit protocol, including structured clinical interviews, height, weight, weight history, percent body fat, fasting leptin, post-prandial GLP-1 response to a fixed meal, and self-report and behavioral assessments of food reward satiation (ad lib meal) and food and nonfood reward valuation (progressive ratio tasks).
Results
A structural equation model (SEM) demonstrated excellent fit to data with significant pathways from greater weight suppression to lower leptin, to blunted GLP-1 response, to lower reward satiation, to larger eating/binge-eating episode size, with significant indirect paths through leptin, GLP-1, and reward satiation. SEM with paths via reward valuation to loss of control eating demonstrated inadequate fit.
Conclusions
Findings specifically link reduced GLP-1 response to severity of binge-episode size and support weight history assessment in eating disorders, DSM-5 over ICD-11 criteria for binge eating, and may inform future clinical trials of GLP-1 agonists for BN-S.
What can we learn about organizational ethics from studying cemeteries as organizational/organized manifestations of our mutual, embodied vulnerability? How does, and how should, the ethico-political imperative of death and the deceased materialize in the cemeterial space? With reference to a comparative analysis of two island cemeteries, Venice’s San Michele and New York’s Hart Island, this paper makes three contributions to the emerging literature on organizational ethics of life and death. First, it makes an empirical contribution based on an organizational study of two “resting places” that highlights the importance of understanding organizational life and death with reference to ethics. Second, it makes a theoretical contribution to scholarship on the organization of death and on grieving as embedded in a politics and ethics of recognition. Third, the paper shows how our desire to be recognized as valid, viable subjects comes to be organized, and situated, in ways that perpetuate precarity and vulnerability, a point that is illustrated with reference to cemeteries as ethically significant organizational settings.
Major depressive disorder (MDD) is a leading cause of disability worldwide. Investigating early-stage alterations in cerebral intrinsic activity among drug-naive patients may enhance our understanding of MDD’s neurobiological mechanisms and contribute to early diagnosis and intervention.
Aims
To examine alterations in the amplitude of low-frequency fluctuation (ALFF) in first-episode, drug-naive MDD individuals and explore associations between ALFF changes and clinical parameters, including depression severity and illness duration.
Method
A total of 30 first-episode, drug-naive MDD individuals (mean illness duration 14 weeks) and 52 healthy controls were included in this study. Resting-state functional magnetic resonance imaging was used to obtain whole-brain ALFF measurements. Voxel-based ALFF maps were compared between MDD and healthy control groups using a two-sample t-test. Simple regression analysis was performed to assess associations between ALFF and clinical measures, including Hamilton Rating Scale for Depression (HAMD) scores and illness duration.
Results
MDD individuals exhibited significantly increased ALFF in the dorsal anterior cingulate cortex and vermal subregion V3 of the cerebellum. Additionally, ALFF in the right dorsolateral prefrontal cortex was negatively correlated with HAMD scores (r = –0.591, P < 0.001). However, no significant association was found between ALFF and illness duration.
Conclusions
This study demonstrates early-stage ALFF alterations in drug-naive MDD patients, particularly in brain regions implicated in cognitive and emotional regulation. These findings suggest potential neuroimaging biomarkers for the early diagnosis and intervention of MDD.
Heating, Ventilation, and Air Conditioning (HVAC) systems are major energy consumers in buildings, challenging the balance between efficiency and occupant comfort. While prior research explored generative AI for HVAC control in simulations, real-world validation remained scarce. This study addresses this gap by designing, deploying, and evaluating “Office-in-the-Loop,” a novel cyber-physical system leveraging generative AI within an operational office setting. Capitalizing on multimodal foundation models and Agentic AI, our system integrates real-time environmental sensor data (temperature, occupancy, etc.), occupants’ subjective thermal comfort feedback, and historical context as input prompts for the generative AI to dynamically predict optimal HVAC temperature setpoints. Extensive real-world experiments demonstrate significant energy savings (up to 47.92%) while simultaneously improving comfort (up to 26.36%) compared to baseline operation. Regression analysis confirmed the robustness of our approach against confounding variables like outdoor conditions and occupancy levels. Furthermore, we introduce Data-Driven Reasoning using Agentic AI, finding that prompting the AI for data-grounded rationales significantly enhances prediction stability and enables the inference of system dynamics and cost functions, bypassing the need for traditional reinforcement learning paradigms. This work bridges simulation and reality, showcasing generative AI’s potential for efficient, comfortable building environments and indicating future scalability to large systems like data centers.
With the widespread democratic decline and the rise of autocratic regimes, global humanitarian assistance efforts have often fallen short of expectations. Historical humanitarian assistance efforts have changed, becoming less effective, or disappearing. Given the direction that global health crisis risks are taking today, it is crucial that diplomatic, structural, logistical, security, and operational questions be asked and appropriate global solutions sought for the future management of pandemics and climate change crises.
Let g be an element of a group G. For a positive integer n, let $R_n(g)$ be the subgroup generated by all commutators $[\ldots [[g,x],x],\ldots ,x]$ over $x\in G$, where x is repeated n times. Similarly, $L_n(g)$ is defined as the subgroup generated by all commutators $[\ldots [[x,g],g],\ldots ,g]$, where $x\in G$ and g is repeated n times. In the literature, there are several results showing that certain properties of groups with small subgroups $R_n(g)$ or $L_n(g)$ are close to those of Engel groups. The present article deals with orderable groups in which, for some $n\geq 1$, the subgroups $R_n(g)$ are polycyclic. Let $h\geq 0$, $n>0$ be integers and G be an orderable group in which $R_n(g)$ is polycyclic with Hirsch length at most h for every $g\in G$. It is proved that there are $(h,n)$-bounded numbers $h^*$ and $c^*$ such that G has a finitely generated normal nilpotent subgroup N with $h(N)\leq h^*$ and $G/N$ nilpotent of class at most $c^*$. The analogue of this theorem for $L_n(g)$ was established in 2018 by Shumyatsky [‘Orderable groups with Engel-like conditions’, J. Algebra499 (2018), 313–320].
Political scientists regularly rely on a selection-on-observables assumption to identify causal effects of interest. Once a causal effect has been identified in this way, a wide variety of estimators can, in principle, be used to consistently estimate the effect of interest. While these estimators are all justified by appeals to the same causal identification assumptions, they often differ greatly in how they make use of the data at hand. For instance, methods based on regression rely on an explicit model of the outcome variable but do not explicitly model the treatment assignment process, whereas methods based on propensity scores explicitly model the treatment assignment process but do not explicitly model the outcome variable. Understanding the tradeoffs between estimation methods is complicated by these seemingly fundamental differences. In this paper we seek to rectify this problem. We do so by clarifying how most estimators of causal effects that are justified by an appeal to a selection-on-observables assumption are all special cases of a general weighting estimator. We then explain how this commonality provides for diagnostics that allow for meaningful comparisons across estimation methods—even when the methods are seemingly very different. We illustrate these ideas with two applied examples.
This essay takes as its point of departure the so-called ‘Verdi A’, 432Hz. From the late 1860s through to the 1880s, the opera composer was intensely preoccupied with the question of tuning, weighing in several times on the matter of where A should sit. Verdi was concerned for the strain that high tunings should place on singers’ voices. He advocated on multiple occasions for global acceptance of an A well below 440, and sent Arrigo Boito to argue in favour of A=432 at the Congresso dei Musicisti Italiani, held in Milan on 16–21 June 1881. In the 1880s, Italy remained one of the only nations in Europe that had not adopted equal temperament wholesale for fixed-tone instruments; as in the case of its spoken languages during this same period, and the locations of its A, temperament varied by region, with the southern part of the peninsula clinging to meantones. This article argues that ‘Verdi tuning’ represents the end point of a number of longer shifts in the conceptualization of musical sound, particularly in the Italian context: from temperament to tuning (accordatura); from relative conceptions of musical pitch to an absolute one; from local and regional variations towards a standardized system; from an older notion of all-encompassing nature to a presumed separation between nature and culture. Tracing this history through the Italian long nineteenth century will involve concentrating on what this article calls music-adjacent sound: that is, interrogative play with musical pitch; sound experiments from musical materials and operatic voices; instrument tuning by ear; listening for overtones; legislating preferred ratios and (eventually) frequencies for musical use; and constructing a theory of music that draws together these means of sounding. Music-adjacent sound is where the conditions for music-making were and still are established. This article argues that an attention to these sonic and nearly musical moments can demonstrate how listening and the musical imagination were cultivated outside the boundaries of any work or performance.
In this editorial, we draw insights from a special collection of peer-reviewed papers investigating how new data sources and technology can enhance peace. The collection examines local and global practices that strive towards positive peace through the responsible use of frontier technologies. In particular, the articles of the collection illustrate how advanced techniques—including machine learning, network analysis, specialised text classifiers, and large-scale predictive analytics—can deepen our understanding of conflict dynamics by revealing subtle interdependencies and patterns. Others assess innovative approaches reinterpreting peace as a relational phenomenon. Collectively, they assess ethical, technical, and governance challenges while advocating balanced frameworks that ensure accountability alongside innovation. The collection offers a practical roadmap for integrating technical tools into peacebuilding to foster resilient societies and non-violent conflict transformations.
Would you prioritize assembling a group of more competent individuals or a more diverse group? According to the well-known Diversity-Trumps-Ability Theorem (DTA), when two groups of similar size are compared, the more diverse group generally outperforms the more competent group. Despite considerable criticism regarding the DTA’s mathematical rigor, it has sparked substantial interdisciplinary discussion. While most research on the DTA focuses on its implications within specific fields or on empirical simulations to test its validity, we aim to establish precise conditions under which diversity indeed surpasses ability in a particular decision-making context: voting. To this end, we integrate the DTA into a voting model inspired by the Condorcet Jury Theorem (CJT) and model diversity based on the classic dependency model in the CJT literature, namely the influence of an opinion leader.
Historically, it has been proposed that functional neurological symptoms occur more frequently on the left side of the body due to a distinct body representation and emotional processing of the right hemisphere, yet objective imaging data to support this are lacking. We aimed to investigate whether patients with acute left-sided symptoms (right hemisphere) suspected of having a minor stroke are more likely to show negative diffusion-weighted imaging (DWI) compared to those with right-sided symptoms.
Methods:
Data are from the SpecTRA (Spectrometry for Transient Ischemic Attack Rapid Assessment) multicenter prospective cohort study conducted between 2013 and 2017. Patients with mild persistent unilateral hemiparesis and/or hemisensory symptoms (National Institute of Health Stroke Scale ≤ 3) and available DWI were included. The primary outcome was the proportion of patients with a negative DWI.
Results:
Of 1731 patients, 584 (30.8%) were included. Of these, 310 (53.1%) patients presented with left-sided symptoms and 274 (46.9%) with right-sided symptoms. Overall, 214 (36.6%) patients had a negative DWI, 126 (58.9%) with left-sided symptoms and 88 (41.1%) with right-sided symptoms: risk ratio (RR) 1.27 (95% CI = 1.02–1.57). Left-sided hemiparesis was associated with negative DWI (RR 1.42 [95% CI = 1.08–1.87]), while left-sided hemisensory symptoms were not (RR 1.11 [95% CI = 0.87–1.41]). There was no effect modification by age or sex on this association (Pinteraction 0.787 and 0.057, respectively).
Conclusions:
Unilateral left-sided neurological symptoms were more frequently associated with negative DWI compared to right-sided symptoms in suspected minor stroke patients. This observation is exploratory, as the final diagnosis in DWI-negative cases was not established.
First-year postpartum depression is a common mental health problem among first-time mothers. A younger age of pregnancy often compounds the challenge due to underlying factors such as poverty and limited educational achievement. This study aimed to examine the minimal number of interpersonal supporters during pregnancy associated with lower levels of postpartum depressive symptoms among first-time mothers.
Methods
We obtained data from the population-based Mother–Infant/Newborn Tokyo Cohort (MINT cohort) in four municipalities in Tokyo on 429 first-time mothers who responded to two waves of surveys (early pregnancy and one month postpartum). They completed self-report measures of interpersonal support using one item from the Social Support Questionnaire and depressive symptoms using the Edinburgh Postnatal Depression Scale. Segmented regression analyses were conducted to determine the threshold at which the strength of the association changed between the number of interpersonal supporters and postpartum depressive symptoms, with adjustment for depressive symptoms in pregnancy. This analysis was also conducted with the sample stratified into young mothers (≤ 25 years) and older mothers (≥ 26 years).
Results
In the overall sample, postpartum depressive symptoms were found to be lower among individuals with more than 3.0 supportive individuals (prepartum). Among young mothers, this threshold was higher, with lower symptom levels observed among those with at least 5.3 supporters. Only 22.9% of young first-time mothers had this level of interpersonal support, compared to 54.8% of all first-time mothers.
Conclusions
Our results suggest that having four or more interpersonal supporters in early pregnancy is associated with lower levels of postpartum depressive symptoms among first-time mothers. Additionally, among young mothers, having six or more supporters was associated with lower postpartum depressive symptoms. These findings suggest that tailored strategies to increase supporters around first-time pregnant women might be beneficial depending on their age.
Numerous studies show that women are less likely than men to express attitudes and opinions about politics. To explore the origins of this gender gap, we use data from a series of surveys of the general public and international relations scholars in the United States between 2014 and 2023. These data show that the gender gap in political expression exists, even among knowledge elites; female IR scholars say they don’t know the answer to survey questions at higher rates than their male colleagues. We also find that differences in political knowledge explain a significant part of the gap in political expression; the highly educated female scholars we surveyed were less likely than women in the general public to say they didn’t know the answer to survey questions. At the same time, factors other than knowledge, including confidence, also matter. Our public opinion survey shows that women select extreme answers, such as “strongly agree/disagree” rather than simply “agree/disagree,” at lower rates than men. Despite high levels of education among the female scholars we surveyed, they too are more hesitant than their male counterparts to select extreme answers. These findings have important implications for civic participation as well as for the recognition of women’s expertise within the academy and society more broadly.
This paper examines how, in politically polarized contexts, people reconstruct the biographies of contested memorialized figures to challenge or reproduce dualistic metanarratives of national history. We analyze two sites of recent controversy in Scotland and Lithuania which have been engaged in struggles over how to memorialize individuals who, at various points in their lives, engaged in acts of both anti-imperial resistance and collaboration in those same empires’ systems of oppression. Their moral liminality—a term we employ to refer to the transgression of moral categories—blurs the boundaries between perpetrators and victims of imperial violence, calling into question binary frameworks underpinning broader national narratives. Based on a comparative media analysis of debates over the legacies of David Livingstone and Jonas Noreika, we find that though some people in both Scotland and Lithuania have embraced these figures’ moral liminality, others have, instead, suppressed aspects of their biographies to uphold traditional distinctions between national “heroes” and foreign “villains.” We argue that such moral binaries are either blurred or reproduced through the manipulation of three aspects of liminal figures’ biographical records: their agency, motives, and social impact.
The boom in survey experiments in international relations has allowed researchers to make causal inferences on longstanding foreign policy debates such as democratic peace, and audience costs. However, most of these experiments rely on mass samples, whereas foreign policy is arguably more technocratically driven. We probe the validity of generalizing from mass to elite preferences by exploring preferences of ordinary U.S. citizens and foreign policy experts (employees of the U.S. Department of State) in two identical conjoint experiments on democratic peace. We find that experts are not only more opposed to military actions against other democracies than members of the public—but also that overall preferences about the matters of war and peace are stronger among foreign policy professionals.
We investigated the effects of body mass, geographic range size, the within-range richness of host assemblages (diversity field) and the habitat breadth of small mammalian hosts from 6 biogeographic realms on the species richness of their flea and gamasid mite faunas. We also tested whether the probability of between-host ectoparasite sharing is related to host phylogenetic relatedness, trait similarity or geographic distance/environmental dissimilarity between their ranges. We asked whether the effects of host-associated determinants of ectoparasite richness and the probability of ectoparasite sharing differ between (1) biogeographic realms and (2) fleas and mites. Whenever significant effects of host body mass on ectoparasite richness were found, they were negative, whereas the significant effects of geographic range size, diversity field and habitat breadth were positive. The occurrence of each determinant’s effects on ectoparasite species richness differed (1) within fleas or mites between realms and (2) between fleas and mites within a realm. In all realms, the probability of a flea or a mite species being shared between hosts decreased with a decrease in the hosts’ phylogenetic relatedness, trait similarity, geographic distance between ranges or environmental similarity. The probabilities of an ectoparasite species being shared between hosts were most strongly related to the hosts’ trait similarity and were least related to the environmental similarity. We conclude that caution is needed in making judgements about the generality of macroecological patterns related to parasites based on the investigations of these patterns in limited numbers of localities and when pooling data on various taxa.