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This article appraises cultural understanding and controversies regarding hikikomori (prolonged social withdrawal), with reference to research over the past 20 years. Initially viewed as a uniquely Japanese phenomenon, hikikomori is now recognised globally, prompting a re-evaluation of its cultural, psychological and socioeconomic demographics. A revision in lifestyle after the COVID-19 pandemic and ongoing technological advancements – particularly the rise of social media, gaming and the internet – have paradoxically both exacerbated isolation and provided new forms of social interaction for young adults who confine themselves at home. This phenomenon underlines the complex interplay between putative individual psychopathology, neurodiversity and broader societal shifts across the globe.
Prior to the No Surprises Act (NSA), numerous states passed laws protecting patients from surprise medical bills from out-of-network (OON) hospital-based physicians supporting elective treatment in in-network hospitals. Even in non-emergency situations, patients have little ability to choose physicians such as anaesthesiologists, pathologists or radiologists. Using a comprehensive, multi-payer claims database, we estimated the effect of these laws on hospital-based physician reimbursement, charges, network participation and potential surprise billing episodes. Overall, the state laws were associated with a reduction in anaesthesiology prices and charges, but an increase in pathology and radiology prices. The price effects for each state exhibit substantial heterogeneity. California and New Jersey experienced increases in network participation by anaesthesiologists and pathologists and reductions in potential surprise billing episodes, but, overall, we find little evidence of changes in network participation across all of the states implementing surprise billing laws. Our results suggest that the effects of the NSA may vary across states.
Chia seeds have gained attention for their potential anti-inflammatory properties, which may be attributed to their high content of omega-3 fatty acids, dietary fibre, and antioxidants. This study aims to provide an overview of the current understanding regarding the effects of chia seeds on inflammatory markers, specifically C-reactive protein (CRP), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α). A comprehensive literature search was conducted on PubMed, Scopus, Web of Science, Cochrane, and Google Scholar up to June 2024. Randomized controlled trials (RCTs) assessing the effect of chia seed on CRP or/and IL-6 or/and TNF-α. Data were extracted and analysed using a random-effects model, and reported as weighted mean differences (WMD) with 95% confidence intervals (CI). Subgroup and sensitivity analyses were also performed. Four RCTs involving 210 participants were included in the meta-analysis. The results showed that chia consumption significantly decreased CRP (WMD: –0.64 mg/dl; 95% CI: –1.24, –0.04; P = 0.03). But it had no significant effect on IL-6 (WMD: 0.29 pg/dl; 95% CI: –0.40, 0.98; P = 0.41), and TNF-α (WMD: 0.05%; 95% CI: –0.21 to 0.30; P = 0.72). Chia consumption can significantly decrease CRP, but no significant effect was observed on IL-6 and TNF-α. To prove our findings, more studies with a larger sample size are needed.
High prevalence of long COVID symptoms has emerged as a significant public health concern. This study investigated the associations between three doses of COVID-19 vaccines and the presence of any and ≥3 types of long COVID symptoms among people with a history of SARS-CoV-2 infection in Hong Kong, China. This is a secondary analysis of a cross-sectional online survey among Hong Kong adult residents conducted between June and August 2022. This analysis was based on a sub-sample of 1,542 participants with confirmed SARS-CoV-2 infection during the fifth wave of COVID-19 outbreak in Hong Kong (December 2021 to April 2022). Among the participants, 40.9% and 16.1% self-reported having any and ≥3 types of long COVID symptoms, respectively. After adjusting for significant variables related to sociodemographic characteristics, health conditions and lifestyles, and SARS-CoV-2 infection, receiving at least three doses of COVID-19 vaccines was associated with lower odds of reporting any long COVID symptoms comparing to receiving two doses (adjusted odds ratio [AOR]: 0.69, 95% CI: 0.54, 0.87, P = .002). Three doses of inactivated and mRNA vaccines had similar protective effects against long COVID symptoms. It is important to strengthen the coverage of COVID-19 vaccination booster doses, even in the post-pandemic era.
Systematic review and meta-analysis were conducted to provide comprehensive information on the prevalence of amphistome infections in domestic ruminants in sub-Saharan Africa. A systematic search of peer-reviewed articles published between 2002 and 2023 was conducted. Prevalence estimates and meta-analysis were based on 76 peer-reviewed articles which met the inclusion criteria. Of the 55,122 domestic ruminants screened, 12,858 were infected, and the overall pooled prevalence was 22% (95% confidence interval [CI], 10-37). The highest prevalence was recorded in southern Africa 25% (95% CI, 0-62), and central Africa 16% (95% CI, 0-61) the lowest. Cattle were the most frequently sampled hosts (76.56%, n = 42,202) and sheep (8.78%, n = 4838) the lowest, and cattle recorded the highest pooled prevalence of 28% (95% CI, 12-47), and goats the lowest at 5% (95% CI, 0-14). Prevalence rate was the high in males 32% (95% CI, 21-44), adult ruminants 37% (95% CI, 15-62) and animals with poor body condition 47% (95% CI, 34-60), and during the wet season 36% (95% CI, 0-94). The highest pooled prevalence was recorded at postmortem 23% (95% CI, 8-43) compared to coprology 20% (95% CI, 6-39) studies. The meta-regression model demonstrated that the body condition score, host, and period, and the interactions of different factors significantly influenced the prevalence. The lowest prevalence rate was noted for the period between 2013 and 2023. This is the first systematic review and meta-analysis in sub-Saharan Africa that provides a comprehensive review of the prevalence of amphistome infections in domestic ruminants in the past 20 years.
Social impact has been widely discussed by the engineering community, but studies show that there is currently little systematic consideration of the social impact of products in both academia and in industry beyond social impacts on health and safety. While Failure Mode and Effect Analysis (FMEA) is useful for evaluating health and safety risks, new developments are needed to create an FMEA-style evaluation that can be applied to a wide range of social impacts for engineered products. The authors describe necessary modifications to traditional FMEA that transform it into a tool for social impact analysis. The modification of FMEA involves the introduction of positive and negative impacts, the inclusion of discrete and continuous impacts, the consideration of various stakeholder types, and the inclusion of uncertainty in place of detectability. This modified FMEA is referred to in this paper as Social Impact Effects Analysis (SIEA). The paper describes how SIEA is performed and articulates the potential benefits of SIEA.
The advent of generative artificial intelligence (AI) models holds potential for aiding teachers in the generation of pedagogical materials. However, numerous knowledge gaps concerning the behavior of these models obfuscate the generation of research-informed guidance for their effective usage. Here, we assess trends in prompt specificity, variability, and weaknesses in foreign language teacher lesson plans generated by zero-shot prompting in ChatGPT. Iterating a series of prompts that increased in complexity, we found that output lesson plans were generally high quality, though additional context and specificity to a prompt did not guarantee a concomitant increase in quality. Additionally, we observed extreme cases of variability in outputs generated by the same prompt. In many cases, this variability reflected a conflict between outdated (e.g. reciting scripted dialogues) and more current research-based pedagogical practices (e.g. a focus on communication). These results suggest that the training of generative AI models on classic texts concerning pedagogical practices may bias generated content toward teaching practices that have been long refuted by research. Collectively, our results offer immediate translational implications for practicing and training foreign language teachers on the use of AI tools. More broadly, these findings highlight trends in generative AI output that have implications for the development of pedagogical materials across a diversity of content areas.
Liquid plug formation in thin channels due to the Plateau–Rayleigh instability of a liquid film is observed in a variety of fields. In this paper, complementarity between theoretical solutions and direct numerical simulations (DNS) based on a front-tracking algorithm is explored to evaluate the importance of inertia for the case of a cylindrical capillary. A linear stability analysis is first performed and DNS results are then used to investigate the spatial distributions of inertial, convective and viscous terms of the Navier–Stokes equation. The existence of both viscous and inertial regimes is evidenced with a threshold given by the film thickness. The presence of the core fluid slows down the instability. In the viscous regime, predictions of the lubrication theory are verified. An example of liquid water as the outer fluid film and water vapour as the inner core fluid is simulated with application to the fuel cells.
Many population biology, ecology, and evolution experiments rely on the accuracy of the classification of individuals and the estimation of size population. The visual classification of vinegar flies, Drosophila melanogaster (Diptera: Drosophilidae), morphs is a laborious task usually performed by bench workers. Because of the size of the flies and the degree of precision needed to distinguish the morphological features on which the classification is based, the work is performed using a dissecting microscope. Here, we describe a method to automate the counting and identification of two types of vinegar flies, white and wild individuals. Our method is based on the image-recognition artificial intelligence (AI) tool, FlydAI (FlyDetector AI), which proved to correctly classify the flies when high-quality images were used, with a success rate of up to 100% in samples containing up to 200 individuals. This is a significant improvement with respect to preexisting approaches in terms of accuracy and specificity of the morphs detected. Although this tool is exclusively trained to routine lab tasks involving wild and white D. melanogaster, the AI can be easily trained to recognise different vinegar fly mutants and other types of insects of similar size, and its potential in other areas still needs to be explored.
Increasingly, policymaking takes place while extraordinary events threaten fundamental societal values. During turbulent times, policy entrepreneurs emerge as pivotal figures. They are energetic actors who pursue dynamic change in public policy and, whereas we know much about how they promote innovation and change in normal policymaking, we know less about how they behave in crises, and even less about how different crises influence policy entrepreneurial action. This Element focuses on interaction between policy entrepreneurs and crises. It analyzes policy entrepreneurial action in six case studies – three fast-burning and three creeping crises – to ascertain policy entrepreneurs' strategies and effectiveness during extraordinary events. It proposes crisis policy entrepreneurial strategies, a framework to understand outcomes based on policy entrepreneurial action and type of crisis and suggests avenues for further research on policy entrepreneurs and crises, including implications for crisis managers. This title is also available as Open Access on Cambridge Core.
Recovery-oriented approaches are gaining increased attention in the mental health sector, including from the World Health Organization and the United Nations, for their potential to support people in recovering and building meaningful lives through strengths-based, person-centered principles. Kyrie Therapeutic Farm (KTF) is a new initiative in Ireland that seeks to develop recovery-oriented model of adult mental health care. The aim of this study was to explore the barriers and facilitators of recovery-oriented models of practice in a small number of therapeutic farm settings across the world in order to inform service design at KTF whilst also addressing a gap in research on this topic.
Methods:
Three semi-structured focus-group interviews were conducted online via MS Teams with ten staff members in different roles and years of experience from three existing therapeutic community farms. reflexive thematic analysis was employed for data analysis.
Results:
Four themes emerged that illustrate how therapeutic farm communities operate in general and specifically in relation to recovery: 1. common humanity, 2. freedom and responsibility, 3. interdependence and community living, and 4. learning organisations.
Conclusion:
This study demonstrates the viability of recovery-oriented practices in community therapeutic farms, including KTF, thereby contributing to the broader trend toward more person-centered mental health services. The values inherent in the recovery-oriented approach – such as community, empowerment, and close, equitable, non-hierarchical relationships – act as facilitators. However, embedding these values in practice can generate tensions for staff which warrant attention. Implications for the integration into service design of KTF and further research are offered.
Exopsychology is a sub-discipline of psychology concerned with how humans contemplateextraterrestrials as well as forming hypothesis about how these beings may think, feel and behave. While researching the former is undoubtedly a subject for empirical science, aspects of the latter remain uncertain. Given the contemporary scientific insight, it may still be possible to identify a set of cornerstones and eventually create a space of possible configurations of the extraterrestrial mind. Here, we identify three basic compatibility requirements: first, any form of life must navigate internal and external (environmental) demands and thus actively ensure the compatibility of its current state with the same demands. Second, any advanced cognitive development and the emergence of remotely detectable technosignatures require not only the relevant capabilities for manipulation but also compatibility with a permissive environment. Lastly, requirements also concern the compatibility of extraterrestrial thinking and behaviour with our search method. In its most basic understanding, search for extraterrestrial intelligence (SETI) searches for something done by somebody. However, the meaning of this simple formula and the psychological theory behind it is underdeveloped. Hence, psychological aid is needed to assist SETI in its effort to reveal whether galactic information indicates the presence of a mere object or activity of an identified subject with whom humans may establish contact. The fact that people believe in and search for extraterrestrials emphasizes that psychology should pay attention to this domain of phenomena. Hence, different imaginations of the extraterrestrial, ranging from benign to cruel, from superior to equally developed, are briefly discussed regarding their emergence and function as coping and motivating mechanisms for the uncertain search.
Investigate the prevalence of adverse childhood experience (ACE) and intimate partner violence (IPV) using a large representative Chinese sample, explore the association mechanism between ACE and adult exposure to IPV and to examine gender differences.
Methods
A total of 21,154 participants were included in this study. The ACE scale was used to assess participants’ exposure to ACE before the age of 18. Participants were evaluated for IPV experienced after the age of 18 using the IPV Scale. Logistic regression model was used to analyse the association between ACE and the risk of IPV exposure in adulthood. Principal component analysis was used to extract the main patterns of ACEs in the Chinese population. Network analyses were employed to identify the most critical types of ACE and IPV, analyse the association mechanisms between ACEs and IPVs, explore gender differences in this association and compare gender differences in the severity of IPVs experienced in adulthood.
Results
Participants with at least one ACE event faced a 215.5% higher risk of IPV compared to those without ACE experiences. In population-wide and gender-specific networks, The ACE and IPV nodes with the highest expected influence are ‘ACE1 (Verbal abuse + physical abuse pattern)’ and ‘IPV5 (Partner compares me to other people and blatantly accuses me, making me feel embarrassed and unsure of myself)’. Positive correlations were found between ‘ACE1 (Verbal abuse + physical abuse pattern)’–‘IPV3 (Partner does not care about me when I am in bad shape [not feeling well or in a bad mood])’, ‘ACE4 (Violent treatment of mother or stepmother + criminal acts in the family pattern)’–‘IPV1 (Partner has ever directly assaulted or hurt me with the help of an instrument)’ and ‘ACE2 (Exposure to sexual assault pattern)’–‘IPV2 (Partner would have physical or sexual contact with me against my will)’, which were the three edges with the highest edge weight values in the ACE pattern and IPV edges. ‘ACE1 (Verbal abuse + physical abuse pattern)’–‘IPV3 (Partner does not care about me when I am in bad shape [not feeling well or in a bad mood])’, ‘ACE2 (Exposure to sexual assault pattern)’–‘IPV2 (Partner would have physical or sexual contact with me against my will)’, ‘ACE4 (Violent treatment of mother or stepmother + criminal acts in the family pattern)’–‘IPV1 (Partner has ever directly assaulted or hurt me with the help of an instrument)’ in the male network and ‘ACE1 (Verbal abuse + physical abuse pattern)’–‘IPV3 (Partner does not care about me when I am in bad shape [not feeling well or in a bad mood])’, ‘ACE4 (Violent treatment of mother or stepmother + criminal acts in the family pattern)’–‘IPV1 (Partner has ever directly assaulted or hurt me with the help of an instrument)’, ‘ACE3 (Substance abuse + mental illness + violent treatment of mother or stepmother pattern)’–‘IPV1 (Partner has ever directly assaulted or hurt me with the help of an instrument)’ in the female network are the three edges with the highest edge weights among the ACE and IPV edges in their networks, respectively, all displaying positive correlations. The strength of ‘IPV3 (Partner does not care about me when I am in bad shape [not feeling well or in a bad mood])’ was higher in the male network than in the female (male = 0.821, female = 0.755, p = 0.002). The edge weight values of ‘ACE3 (Substance abuse + mental illness + violent treatment of mother or stepmother pattern)’–‘IPV1 (Partner has ever directly assaulted or hurt me with the help of an instrument)’ (P = 0.043) and ‘ACE4 (Violent treatment of mother or stepmother + criminal acts in the family pattern)’–‘IPV1 (Partner has ever directly assaulted or hurt me with the help of an instrument)’ (P = 0.032) are greater for females than males.
Conclusions
The most common type of ACE in the Chinese population is verbal violence combined with physical violence, while the predominant type of IPV is verbal violence. Males experience higher levels of emotional neglect from their partners compared to females. The association between witnessing physical violence in childhood and experiencing physical violence from a partner in adulthood is stronger in females than in males. The homotypic continuum between ACE and IPV is a crucial mechanism in understanding intergenerational domestic violence. Enhance economic and educational levels, promote correct parenting concepts, reduce child abuse, establish accurate perceptions of intimate relationships, eliminate shame about violence and further advance gender equality. These efforts are vital for reducing IPV prevalence and breaking the cycle of violence in victims’ lives.
Migrant labor exploitation is widespread in developed countries, which host growing populations of undocumented migrants. While denouncing by migrants is essential to prosecute exploitative employers, an undocumented community actively hiding from the state is unlikely to whistleblow. I consider an intervention providing migrant farmworkers in Italy information and incentives to report on their racketeers. I leverage the staggered rollout of the intervention to study its effects in a difference-in-differences framework. The intervention empowered migrants to whistleblow, increased the prosecution of criminal organizations responsible for racketeering migrants, and raised awareness among natives, who became more favorable toward immigration and parties supporting it. These findings highlight the conditions under which undocumented migrants can take political action for their socioeconomic advancement. Unlike other integration policies which have been shown to backlash, highlighting migrants’ vulnerability to exploitation might foster solidarity and more liberal immigration attitudes among natives.
In this paper, we establish a definitive result which almost completely closes the problem of bounded elementary generation for Chevalley groups of rank $\ge 2$ over arbitrary Dedekind rings R of arithmetic type, with uniform bounds. Namely, we show that for every reduced irreducible root system $\Phi $ of rank $\ge 2$, there exists a universal bound $L=L(\Phi )$ such that the simply connected Chevalley groups $G(\Phi ,R)$ have elementary width $\le L$ for all Dedekind rings of arithmetic type R.
The prevalence of mental health disorders has significantly increased in recent years, posing substantial challenges to healthcare systems worldwide, particularly primary care (PC) settings. This study examines trends in mental health diagnoses in PC settings in Catalonia from 2010 to 2019 and identifies associated sociodemographic, clinical characteristics, psychopharmacological treatments, and resource utilization patterns.
Methods
Data from 947,698 individuals without prior severe mental illness, derived from the Data Analytics Program for Health Research and Innovation (PADRIS), were analyzed for this study. Sociodemographic data, diagnoses, and resource utilization were extracted from electronic health records. Descriptive statistics, chi-square tests, Mann–Whitney tests, and a multivariate binary logistic regression were employed to analyze the data.
Results
Over the study period, 172,112 individuals (18.2%) received at least one mental health diagnosis in PC, with unspecified anxiety disorder (40.5%), insomnia (15.7%) and unspecified depressive disorder (10.2%) being the most prevalent. The prevalence of these diagnoses increased steadily until 2015 and stabilized thereafter. Significant associations were found between mental health diagnoses, female sex, lower socioeconomic status, higher BMI, and smoking status in a multivariate binary logistic regression.
Conclusions
This study highlights a growing burden of stress-related mental health diagnoses in PC in Catalonia, driven by demographic and socioeconomic factors. These findings may be indicative of broader trends across Europe and globally. Addressing this rising prevalence requires innovative approaches and collaborative strategies that extend beyond traditional healthcare resources. Engaging stakeholders is essential for implementing effective, sustainable solutions that promote mental health in Catalonia and potentially inform similar initiatives worldwide.
A classical problem, due to Gerencsér and Gyárfás from 1967, asks how large a monochromatic connected component can we guarantee in any r-edge colouring of $K_n$? We consider how big a connected component we can guarantee in any r-edge colouring of $K_n$ if we allow ourselves to use up to s colours. This is actually an instance of a more general question of Bollobás from about 20 years ago which asks for a k-connected subgraph in the same setting. We complete the picture in terms of the approximate behaviour of the answer by determining it up to a logarithmic term, provided n is large enough. We obtain more precise results for certain regimes which solve a problem of Liu, Morris and Prince from 2007, as well as disprove a conjecture they pose in a strong form.
We also consider a generalisation in a similar direction of a question first considered by Erdős and Rényi in 1956, who considered given n and m, what is the smallest number of m-cliques which can cover all edges of $K_n$? This problem is essentially equivalent to the question of what is the minimum number of vertices that are certain to be incident to at least one edge of some colour in any r-edge colouring of $K_n$. We consider what happens if we allow ourselves to use up to s colours. We obtain a more complete understanding of the answer to this question for large n, in particular, determining it up to a constant factor for all $1\le s \le r$, as well as obtaining much more precise results for various ranges including the correct asymptotics for essentially the whole range.