The epidemiology of respiratory infections may vary depending on factors such as climate changes, geographical features, and urbanization. Pandemics also change the epidemiological characteristics of not only the relevant infectious agent itself but also other infectious agents. This study aims to assess the impact of the COVID-19 pandemic on the epidemiology of viral respiratory infections in children. We retrospectively reviewed the medical records of children aged ≤18 years with laboratory-confirmed viral respiratory infections other than COVID-19 from January 2018 to March 2023. Data on demographic characteristics, month and year of admission, and microbiological results were collected. During the study period, 1,829 respiratory samples were sent for polymerase chain reaction testing. Rhinovirus was identified in 24% of the patients, mixed infections in 21%, influenza virus in 20%, and respiratory syncytial virus in 12.5%. A 38.6% decrease in viral respiratory infections was observed in 2020, followed by a 188% increase in 2021. The respiratory syncytial virus was significantly more common in the post-pandemic period (13.8%) compared to the pre-pandemic period (8.1%), but no seasonal shift in respiratory syncytial virus infection was observed. There was also a yearly increase in influenza infections in the post-pandemic period compared to the pre-pandemic period. After the COVID-19 pandemic, the frequency of parainfluenza virus infections increased during the summer months, and this finding provides a new contribution to the existing literature.

This is a review of the activities and successes of the 44th residential JACT Latin Summer School, run in July–August 2024. Specifically, it covers our typical teaching arrangement, lectures, trips and events and acknowledges the generosity of our sponsors.

The parallel and synergistic developments of atomic resolution structural information, new spectroscopic methods, their underpinning formalism, and the application of sophisticated theoretical methods have led to a step function change in our understanding of photosynthetic light harvesting, the process by which photosynthetic organisms collect solar energy and supply it to their reaction centers to initiate the chemistry of photosynthesis. The new spectroscopic methods, in particular multidimensional spectroscopies, have enabled a transition from recording rates of processes to focusing on mechanism. We discuss two ultrafast spectroscopies – two-dimensional electronic spectroscopy and two-dimensional electronic-vibrational spectroscopy – and illustrate their development through the lens of photosynthetic light harvesting. Both spectroscopies provide enhanced spectral resolution and, in different ways, reveal pathways of energy flow and coherent oscillations which relate to the quantum mechanical mixing of, for example, electronic excitations (excitons) and nuclear motions. The new types of information present in these spectra provoked the application of sophisticated quantum dynamical theories to describe the temporal evolution of the spectra and provide new questions for experimental investigation. While multidimensional spectroscopies have applications in many other areas of science, we feel that the investigation of photosynthetic light harvesting has had the largest influence on the development of spectroscopic and theoretical methods for the study of quantum dynamics in biology, hence the focus of this review. We conclude with key questions for the next decade of this review.

A 2300 year old bark shield found in Enderby, Leicestershire, in 2015 is the only known example of its type. Made from the bark of a willow tree, it has a woven basket boss, a roundwood handle, and a rim of split roundwood edging and lime bast bindings. Pre-Roman shields made from organic materials rarely survive in Britain and Ireland and those without metal components are exceptionally rare. Contemporaneous wooden shields are known from anaerobic environments in Scandinavia but, unlike Enderby, none of these has a body of tree bark. The complexity of the design of the Enderby shield, the skill with which it was made, and the similarities between this and metal examples suggests it was a tried and tested design, rather than a one-off. With no other example against which to compare it, experiments in reproducing the shield have been used as a tool for interpretation and have proved vital to understanding the original design. As a result of this research, it is proposed that this single artefact represents a more commonly available form of shield in the 1st millennium bc than does any metal enhanced version.

In this work we consider the problem of optimizing a stellarator subject to hard constraints on the design variables and physics properties of the equilibrium. We survey current numerical methods for handling these constraints, and summarize a number of methods from the wider optimization community that have not been used extensively for stellarator optimization thus far. We demonstrate the utility of new methods of constrained optimization by optimizing a quasi-axisymmetric stellarator for favourable physics properties while preventing strong shaping of the plasma boundary, which can be difficult to create with external current sources.

Achieving proficiency in reading Latin is the stated aim of nearly every Latin course the world over. However, very little research has been devoted to how beginner students attempt to process Latin when it is placed in front of them for the first time. This paper aims to fill this gap, based on a study of students still relatively close to the start of their Latin journeys. I found that they tend to read Latin sentences in their original order, breaking them down into individual lexical items, and trying to discern their meaning by looking for similarities with words they already know. They will usually skip over words they do not recognise, returning to them later. This suggests that, as they become more familiar with Latin vocabulary and grammar, and so long as they are not taught to read in a different order, they will continue to read Latin in the order it is written. There is, however, a perception among many of the students that grammar is difficult, and so they tend to overly rely on context and common sense instead. Going forward, I would try to ensure my students become more confident with their grammar, as context can sometimes lead them astray. However, it is clear that, rather than just giving them tables and lists to learn, they need as much exposure to the grammatical forms ‘in the wild’ as possible, to promote ease of recognition.

During the course of my teacher training, I have encountered two distinct classroom contexts for oracy: a term that refers to the ability to express oneself in speech. At my first placement school, very few students were willing to answer questions or present arguments in front of their peers. Conversely, the majority of students at my second placement school are keen to demonstrate their knowledge, yet often speak over one another during discussion tasks. In both schools, dialogue is mainly directed towards the teacher; students rarely offer extended answers during lessons, and oral reasoning and argumentation generally take place as a precursor to written work. I therefore wanted to implement a sequence of lessons where the learning was intentionally carried out and measured through student talk and cooperation. In particular, I wanted to examine how far teaching specific oracy skills and providing informal scaffolded opportunities for presentational and exploratory talk can support the development of historical thinking skills in Year 7 (age 11): in other words, students' ability to consider multiple historical perspectives; to appreciate the difference between modern and ancient values; to critically engage with historical terminology, and to present and justify an argument. Students' responses were generally positive and engagement raised. I conclude with further thoughts about future practice.

The “digital twin” is now a recognized core component of the Industry 4.0 journey, helping organizations to understand their complex processes, resources and data to provide insight, and help optimize their operations. Despite this, there are still multiple definitions and understandings of what a digital twin is; all of which has led to a “mysticism” around the concept. Following the “hype curve” model, it can be seen that digital twins have moved past their initial hype phase with only minimal implementation in industry, this is often due to the perceived high cost of initial development and sensor outfit. However, a second hype peak is predicted through the development of “lean digital twins.” Lean digital twins represent conceptual or physical systems in much lower detail (and hence at much lower cost to build and manage the models), focusing in on the key parameters and operators that most affect the desired optimal outcomes of the physical system. These lean digital twins are requirements managed with the system to ensure added value and tapping into existing architectures such as onboard platform management systems to minimize costs. This article was developed in partnership between BMT and Siemens to demystify the different definitions and components of a lean digital twin and discuss the process of implementing a lean digital twin solution that is tied to the core benefits in question and outlining the tools available to make implementation a reality.

We study covering numbers of subsets of the symmetric group $S_n$ that exhibit closure under conjugation, known as normal sets. We show that for any $\epsilon>0$, there exists $n_0$ such that if $n>n_0$ and A is a normal subset of the symmetric group $S_n$ of density $\ge e^{-n^{2/5 - \epsilon }}$, then $A^2 \supseteq A_n$. This improves upon a seminal result of Larsen and Shalev (Inventiones Math., 2008), with our $2/5$ in the double exponent replacing their $1/4$.

Our proof strategy combines two types of techniques. The first is ‘traditional’ techniques rooted in character bounds and asymptotics for the Witten zeta function, drawing from the foundational works of Liebeck–Shalev, Larsen–Shalev, and more recently, Larsen–Tiep. The second is a sharp hypercontractivity theorem in the symmetric group, which was recently obtained by Keevash and Lifshitz. This synthesis of algebraic and analytic methodologies not only allows us to attain our improved bounds but also provides new insights into the behavior of general independent sets in normal Cayley graphs over symmetric groups.

Despite chronicles from the 16th century describing fertile alluvial plains and densely populated wetlands, archaeology in western Mexico has been little studied. The Directorate of Archaeological Salvage (DSA) of National Institute of Anthropology and History (INAH) has initiated a study of two sites in Costa Canuva, at the southern part of Nayarit state: Becerros and Naranjos. Thirty charcoal and shell samples were radiocarbon (14C) dated to determine occupation history. A Bayesian approach was used to build a chronological modeling from charcoal samples. Charcoal and shell samples found in the same context allowed us to calculate the ΔR values of marine offset for this period. In general, the archaeological sites of this area are divided into three major periods: Formative, Classic, and Postclassic. The 14C dating of Becerros recovered materials provided a chronological framework for the site’s occupation, from cal AD 169–1025, corroborating the ceramic studies in the sense that human settlement activities date from the Formative (300 BC–AD 600) to the Early Postclassic (AD 900–1200). Naranjos started in the Classic period and reached its occupancy peak in the Late Classic. The site’s occupation may have persisted for at least two centuries after the conquest of the Altiplano in 1521. The comparison of charcoal dates and associated shell samples from the Naranjos Unit gave a probability distribution for ΔR, that ranged from 118.5 to 199.5 with a mean value of 159 ± 4, slightly higher than other values obtained at nearby sites.