Surgical resection for pterygopalatine fossa schwannomas can be challenging due to the complex anatomy and potential morbidity. Gamma knife radiosurgery (GKRS) offers a minimally invasive alternative with precise targeting and minimal damage to surrounding structures.

A 21-year-old female patient who had a history of progressive left-sided facial numbness over the past year and was diagnosed with progressive pterygopalatine fossa schwannoma underwent gamma knife radiosurgery. The radiological and clinical outcomes of the patient were evaluated over a period of 15 years, with the patient remaining symptom-free and experiencing no adverse effects from the treatment.

The patient’s positive outcome, with significant tumour reduction and symptom relief, underscores the potential of this non-invasive technique as a primary treatment modality for schwannomas in challenging anatomical locations.

Up to 30% of people infected with SARS-CoV-2 report disabling symptoms 2 years after the infection. Over 100 persistent symptoms have been associated with Post-Acute COVID-19 Symptoms (PACS) and/or long-COVID, showing a significant clinical heterogeneity. To develop effective, patient-targeted treatment, a better understanding of underlying mechanisms is needed. Epigenetics has helped elucidating the pathophysiology of several health conditions and it might help unravelling inter-individual differences in patients with PACS and long-COVID. As accumulating research is exploring epigenetic mechanisms in PACS and long-COVID, we systematically summarized the available literature on the topic.

We interrogated five databases (Medline, Embase, Web of Science, Scopus and medXriv/bioXriv) and followed PRISMA and SWiM guidelines to report our results.

Eight studies were included in our review. Six studies explored DNA methylation in PACS and/or long-COVID, while two studies explored miRNA expression in long-COVID associated with lung complications. Sample sizes were mostly small and study quality was low or fair. The main limitation of the included studies was a poor characterization of the patient population that made a homogeneous synthesis of the literature challenging. However, studies on DNA methylation showed that mechanisms related to the immune and the autonomic nervous system, and cell metabolism might be implicated in the pathophysiology of PACS and long-COVID.

Epigenetic changes might help elucidating PACS and long-COVID underlying mechanisms, aid subgrouping, and point towards tailored treatments. Preliminary evidence is promising but scarce. Biological and epigenetic research on long-COVID will benefit millions of people suffering from long-COVID and has the potential to be transferable and benefit other conditions as well, such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). We urge future research to employ longitudinal designs and provide a better characterization of included patients.

Geriatric depression results in additional difficulties for older people and their residing society. The case-control study intended to assess the association between cognitive social capital and depression in rural older people.

We conducted this study from January to December 2020 among 420 rural tenants aged ≥60 years in Bangladesh. We enrolled 210 older persons with depression as cases and another 210 without depression as controls. We used a semi-structured questionnaire, the Geriatric Depression Scale (GDS-15), and a cluster sampling technique to collect data through face-to-face interviews. We performed quality control checks and followed all ethics guidelines.

Geriatric depression had a significant association with gender (p = 0.006), marital status (p < 0.001), education (p < 0.001), occupation (p = 0.001), family type (p < 0.001), family size (p < 0.001), number of family members (p < 0.001), and monthly family income (p < 0.001) of the rural older adults. Both interpersonal trust (p < 0.001) and reciprocity (p < 0.001) were significantly associated with geriatric depression. The older adults who didn’t believe in interpersonal trust (OR = 6.8, p = 0.002) and who disagreed with reciprocity (OR = 31.1, p < 0.001) were more likely to have depression.

The study findings can contribute to formulating cognitive social capital policy and interventions to promote the psychological well-being of rural older people by alleviating geriatric depression.

Using a large, geographically diverse, hospital-based database in the United States (Premier PINC AI Healthcare Database), we aimed to describe the proportion and characteristics of patients receiving phenotype-desirable antimicrobial therapy (PDAT) among those hospitalized with Enterobacterales bloodstream infections.

Adult patients with an admission between January 1, 2017 and June 30, 2022 with ≥1 blood culture positive for Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, or Proteus mirabilis and receiving an empiric antibiotic therapy on blood culture collection (BCC) Days 0 or 1 were included. Receiving PDAT (defined as receipt of any antimicrobial categorized as “desirable” for the respective phenotype) on BCC Days 0−2 was defined as receiving early PDAT.

Among 35,880 eligible patients, the proportion of patients receiving PDAT increased (from 6.8% to 22.8%) from BCC Day 0−4. Patients who received PDAT (8,193, 22.8%) were more likely to visit large (500 + beds, 36% vs 31%), teaching (45% vs 39%), and urban (85% vs 82%) hospitals in the Northeast (22% vs 13%) compared to patients not receiving PDAT (all P <. 01). Among patients receiving PDAT, 61.4% (n = 5,033) received it early; they had a lower mean comorbidity score (3.2 vs 3.6), were less likely to have severe or extreme severity of illness (71% vs 79%), and were less likely to have a pathogen susceptible to narrow-spectrum β-lactams (31% vs 71%) compared to patients in the delayed PDAT group (all P < .01).

The proportion of patients receiving desirable therapy increased between BCC Day 0 and 4. Receipts of PDAT and early PDAT were associated with hospital, clinical, and pathogen characteristics.

Deafness is a leading cause of disability worldwide. This prospective cohort study investigates the impact of cochlear implants on self-reported quality of life in post-lingually deaf adults.

The self-administered 36-item World Health Organization Disability Assessment Schedule 2.0 and the Speech, Spatial, and Qualities of Hearing Scale questionnaires were prospectively used to investigate the impact of cochlear implants in 98 post-lingually deaf adults aged more than or equal to 50 years.

Quality of life improved post-cochlear implant in the cumulative scores and scores for all domains of the Speech, Spatial, and Qualities of Hearing Scale (p < 0.05). QoL improved post-cochlear implant in the sub-domains related to cognition and participation in society of the World Health Organization Disability Assessment Schedule 2.0 (p < 0.05), but there was no significant difference in the cumulative score. Subgroup analysis showed improvement in the participation in society domain only and only in males and participants aged younger than 75 years (p < 0.05).

Cochlear implant improves quality of life in post-lingually deaf adults.

To compare perioperative and oncological outcomes between stapler and manual closure in patients undergoing total laryngectomy for advanced endolaryngeal squamous cell carcinoma.

Patients with advanced endolaryngeal tumours operated between July 2017 and July 2023 were retrospectively dichotomised into stapler closure and manual closure cohorts and compared.

Seventy-one patients with a median age of 57 years were included in our study. The median surgical duration was 270 minutes for the manual closure cohort and 245 minutes for the stapler closure cohort. The pharyngo-cutaneous salivary fistula rate was 6 per cent less in the stapler closure cohort. The estimated mean survival was not significantly different 54.5 months (95 per cent, confidence interval 46.3–62.71) in the manual closure cohort versus 28.12 months (95 per cent, confidence interval 23.6–32.63) in the stapler closure cohort (p = 0.79).

Stapler closure can be used in endolaryngeal tumours, and it reduces operating time, thus facilitating efficient utilisation of operation time with non-inferior oncological outcomes as compared to traditional manual closure.