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The notions of “emergence” and “becoming” have become widely adopted in relational studies in archaeology, but their definition and application remain nebulous. We advocate a middle-range approach to the incorporation of these related concepts into the study of migration and pronounced cultural shifts. Our study relies on the Bayesian modeling of a significant corpus of radiocarbon dates from Mississippian sites in the Tombigbee Valley of southeastern North America. This investigation has identified the likelihood of two broad migration episodes that we hypothesize are related to cultural rephrasings of landscape and temporality.
To evaluate the impact of a guidance document on treatment decisions and clinical outcomes for infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) and Stenotrophomonas maltophilia.
Design:
This was a single-center, retrospective, quasi-experimental, pre- and post-intervention study. The primary outcome was adherence to antibiotic selection and dosing as recommended by the guidance document. Secondary outcomes included clinical efficacy, readmission within 90 days, all-cause 30-day mortality, 90-day microbiologic recurrence, and antibiotic-associated adverse effects.
Setting:
The study was conducted at a large, academic medical center in the Southeastern United States.
Participants:
The study included adult patients who were admitted to our institution from November 2018 to June 2024 who grew CRAB or S. maltophilia from any culture and were definitively treated.
Intervention:
This study included an institution specific treatment algorithm for the treatment of infections caused by resistant gram-negative organisms published on June 1st, 2022, on our institution’s antimicrobial stewardship website.
Results:
Twenty-two patients with CRAB (14 pre- and 8 post-intervention) and 150 with S. maltophilia (75 pre- and 75 post-intervention) were evaluated. For CRAB, 0 (0%) patients in the pre-intervention group and 5 (62.5%) in the post-intervention group met the primary outcome (P < .001). For S. maltophilia, 21 (28%) patients in the pre-intervention group compared to 38 (50.7%) in the post-intervention group met the primary outcome (P < .004). Secondary outcomes did not differ significantly pre- and post-intervention.
Conclusions:
These findings demonstrate that implementing a local treatment guideline based on IDSA guidance may increase the utilization of evidence-based directed antimicrobial therapy for CRAB and S. maltophilia.
This paper aims to theorise how virtual reality (VR) can contribute to the development of contextual architecture. We start by considering how an architectural context may translate into a virtual domain, introducing preliminary definitions of what a virtual design context (VDC) could entail. We then discuss a proposed taxonomy that guides the creation of such a VDC, anchored in principles drawn from virtual realism in art philosophy and contextualism within architecture. This taxonomy is envisioned as a preliminary framework for developing VR-driven design environments with a focus on context. Next, we conducted expert user-testing with 24 architects using two VDCs developed according to the taxonomy. The goal of this step was to gain insights regarding the cognitive load of designers and their user experience while engaged in different types of VDCs. Results suggest that designing in these virtual environments enhanced contextual learning, supported conceptual and creative insight and helped maintain manageable cognitive load. The paper concludes by underscoring the real-world applicability of this taxonomy, highlighting how VR can breathe new life into contextual design, not by reducing context into a digital replica, but by opening new dimensions through which its richness can be explored, interpreted and reimagined.
In the particular world of contemporary EU law, European society has the meaning of a place. Appreciating this requires considering the relationship between European society and another key concept, that of EU values. This relationship is one of mutual balance but also tension: while the latter are abstract calls for offensive action on the part of EU institutions, the former is identified as a concretely located space that must be preserved and defended. The paper begins with a close textual reading of Article 2 TEU, focusing on the provision’s specific architecture. There, European society appears as a singular reality – that of a concretely situated perimeter of social relations that the EU claims as its own – which pre-exists the EU’s institutionality and enables its foundational commitments to the realisation of a series of values. The second and most important part of the paper then contends that this particular arrangement should be understood as a function of the EU’s evolving external ambitions and self-positioning vis-à-vis the outside world. Thus, contrary to the common tendency to see the EU’s external projections as resulting from its own internal identity and dynamics, I will argue that here it is the internal that follows the external. On this basis, it will be shown that the complementary relationship between European society (as place) and EU values (as action) that I identified in the architecture of Article 2 TEU is reflective of the delicate compromise between the rise of the EU’s neo-imperial ambitions at the regional and global levels (for which values serve as a vehicle) and the construction of an increasingly hard boundary between an inside and an outside to the EU order (which the concept of European society serves to draw, justify and implement).
Due to the high prevalence of depression and anxiety in people with epilepsy, the International League Against Epilepsy Commission on the Neuropsychiatric Aspects of Epilepsy recommends implementing routine screening for depression and anxiety symptoms. Our epilepsy group began administering three screening questionnaires to all clinic patients in 2016: the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), the Beck Anxiety Inventory (BAI) and the Generalized Anxiety Disorder-7 (GAD-7).
Objective:
We aim to review our experience with this screening approach.
Methods:
We reviewed 2253 sets of questionnaires completed from January 2018 to March 2020 and studied the actions taken by epileptologists in response to a positive screening.
Results:
Thirty-six percent of all assessed patients screened positive on at least one questionnaire: 13.6% screened positive for depression symptoms (NDDI-E ≥ 16), 12.3% for anxiety symptoms (BAI ≥ 22) and 30.3% for GAD symptoms (GAD-7 > 7). Among patients with a positive screening, 36% received a care intervention, 59% did not and 5% declined the neurologist’s recommendation. Among patients for whom an intervention was implemented, 58% were referred to a mental health professional (generally a neuropsychiatrist), 29% had their antiseizure medication adjusted to alleviate their symptoms and 13% received another intervention.
Conclusion:
In our clinic, an important proportion of patients screened positive for depression and/or anxiety symptoms. Fewer than half received a management option to alleviate their symptoms. We conclude that while routine screening increases the detection of depression and anxiety among epilepsy patients, it must be accompanied by effective interventions and access to mental-health professionals.
Test fairness is a major concern in psychometric and educational research. A typical approach for ensuring test fairness is through differential item functioning (DIF) analysis. DIF arises when a test item functions differently across subgroups that are typically defined by the respondents’ demographic characteristics. Most of the existing research focuses on the statistical detection of DIF, yet less attention has been given to reducing or eliminating DIF. Simultaneously, the use of computer-based assessments has become increasingly popular. The data obtained from respondents interacting with an item are recorded in computer log files and are referred to as process data. In this article, we propose a novel method within the framework of generalized linear models that leverages process data to reduce and understand DIF. Specifically, we construct a nuisance trait surrogate with the features extracted from process data. With the constructed nuisance trait, we introduce a new scoring rule that incorporates respondents’ behaviors captured through process data on top of the target latent trait. We demonstrate the efficiency of our approach through extensive simulation experiments and an application to 13 Problem Solving in Technology-Rich Environments items from the 2012 Programme for the International Assessment of Adult Competencies assessment.
Drylands are still widely perceived as marginal areas, unsuitable for food production and long-term human settlement. This view, reinforced by mainstream global land use models, stands in sharp contrast with archaeological and ethnographic evidence showing that sustainable agriculture and pastoralism have long existed even in hyperarid regions. In this perspective article, we argue for the importance of applying archaeology to build a long-term narrative of land use management in drylands, highlighting the relevance of nonmechanized, resilient subsistence strategies as forms of biocultural heritage and sustainable alternatives rooted in indigenous priorities put in place over centuries. We contend that archaeology is key to shifting this narrative by documenting long-term socio-ecological adaptation in drylands. To this end, we present a range of archaeological methodologies that have helped trace techno-cultural developments in drylands, challenging persistent assumptions about the limits of human occupation and food production in arid environments.
This is a paper about three problems that public political philosophers are likely to encounter and how some underrecognized forms of public philosophy might help overcome them. After clarifying what I take public political philosophy to be, I present the three problems—the problem of academic overrepresentation, the problem of the critical intellectual, and the problem of novel values. These problems are especially acute for a particular form of public philosophy—namely, writing for a general audience. I describe four alternative models of public political philosophy—the organizing model, the participatory model, the policy model, and the bureaucratic model—and give examples of each. For each model, I describe some of its pros and cons, and in particular how it handles (or does not) the three problems. I conclude with some suggestions about the significance of the discussion for philosophical education.
This study explores how loneliness affects earthquake risk perception and preparedness behaviors among older adults in Japan. Aging is often accompanied by increased vulnerability to natural disasters, and loneliness is hypothesized to compromise effective preparedness. Using the Japanese Older Adult Preparedness Model (JOAPM), which integrates the Protective Action Decision Model (PADM) and cultural context, we examine how loneliness influences both perceived earthquake risk and protective behaviors.
Methods
An online survey conducted in April 2024 gathered responses from adults aged 55 and older across 4 earthquake-prone Japanese prefectures. Measures included demographics, disaster experience, loneliness (UCLA Loneliness Scale), risk perception, and preparedness actions such as household adjustments. Regression and mediation analyses assessed the direct and indirect effects of loneliness on preparedness.
Results
Findings show that loneliness has a significant negative direct effect on disaster preparedness. However, it also slightly increases risk perception, which in turn has a positive relationship with preparedness behaviors, suggesting a modest indirect pathway. Overall, the direct negative effect of loneliness outweighs the indirect benefit.
Conclusion
The results highlight the complex role of psychosocial factors in disaster readiness, suggesting that interventions should address information dissemination, self-efficacy, and the emotional isolation experienced by older adults in high-risk areas.
Language AI has become a popular tool across the humanities and social sciences, but it has yet to gain traction in socio-cultural anthropology. Fieldnotes, the core data for anthropologists, present a unique opportunity and challenge for applying language AI to understand diverse human behavior and experience. Anthropological fieldnotes are communicative products in cultural contexts through immersive, extensive and idiosyncratic fieldwork. To read fieldnotes, anthropologists typically engage in qualitative, reflexive interpretations, attuned to local meaning systems and intersubjective encounters. This paper demonstrates a novel synergy, combining anthropological expertise and various AI technologies to analyze natural observation texts about children’s peer-interactions, especially their moral dramas, in the historical context of rural Taiwan during the Cold War. These fieldnotes were collected by the late anthropologists Arthur Wolf and Margery Wolf in the world’s first anthropological study focused on Han Chinese children. Engagement with AI in this project began as methodological cross-fertilization, transforming raw fieldnotes into a text-as-data pipeline and discovering how ethnographic close-reading, machine-learning techniques (e.g., unsupervised topic modeling), transformer models (e.g., S-BERT) and generative models (e.g., GPT) can complement and augment each other’s value. Capitalizing on the systematic nature of Arthur Wolf’s fieldnotes, as well as the special protagonists of these fieldnotes – playful children, the most voracious learners – this paper compares how children, the anthropologist and AI make sense of pretend-fight moral dramas. Such a human–AI hybrid experiment embodies layered-interdisciplinarity at methodological, epistemological and, to some extent, ontological levels, anchored at children’s social cognition. Situated at the intersection of anthropology, digital humanities, developmental science and data science, this work sheds light on the similarities and differences in how machines and humans learn and make sense of morality, and by doing so, critically reflect on the nature of socio-moral intelligence.
The prevalence of mental ill health is increasing in young people worldwide, with rising referrals to child and adolescent mental health services (CAMHS). The numbers and proportions of the youth population who present to CAMHS, however, including how those figures are changing over time, are unclear. Understanding trends in mental health service contacts for young people over time is crucial mental health surveillance data.
Aims
Our aim was to calculate both the lifetime and annual prevalence of CAMHS contact in Wales for young people up to age 18 years.
Method
Using linked Welsh administrative healthcare records, we calculated the annual prevalence of CAMHS contacts between 2004 and 2023. We also calculated the lifetime prevalence of CAMHS contacts for sequential annual birth cohorts born between 1991 and 2005 and followed to age 18 (between 2009 and 2023).
Results
In 2004, 0.8% (n = 4665) of the total child and adolescent population were in contact with CAMHS. By 2022, this had risen nearly five-fold to 3.9% (n = 19 870) of the total child and adolescent population. Among the 1991 birth cohort who turned 18 in 2009, 5.8% had contact with CAMHS at some stage in childhood or adolescence. For individuals born in 2005 who turned 18 in 2023, this figure had risen to 20.2%.
Conclusions
The number of the young people in contact with CAMHS has increased dramatically over the past 15 years, from 1 in 17 young people who turned 18 in 2009 to 1 in 5 young people who turned 18 in 2023.
Cognitive impairment varies widely in bipolar disorder. Identifying cognitive subgroups and their biological correlates may improve understanding of the disorder. Brain-derived neurotrophic factor (BDNF) and C-reactive protein (CRP) are key candidates due to their roles in neuroplasticity and inflammation.
Aims
The aim was to investigate cognitive subgroups in patients with bipolar disorder and their association with serum levels of BDNF and CRP.
Method
A cross-sectional study was conducted on 149 bipolar disorder patients and 48 healthy controls. Cognitive performance was assessed using a comprehensive battery of neuropsychological tests. Cluster analysis was performed to identify cognitive subgroups, followed by discriminant function analysis to validate the classification. Serum levels of BDNF and CRP were measured and compared across cognitive subgroups.
Results
Cluster analysis identified three cognitive subgroups: intact cognition, selectively impaired cognition (SIC) and globally impaired cognition (GIC). SIC exhibited the highest BDNF levels, while GIC demonstrated the highest CRP levels. CRP levels were negatively associated with performance across all cognitive domains. BDNF showed a negative correlation with verbal fluency, short-term memory and working memory. CRP levels exceeding 4.3 mg/L predicted global cognitive impairment with a sensitivity of 72.41% and specificity of 73.63%.
Conclusion
Cognitive impairments in bipolar disorder patients can be classified into distinct subgroups, which are associated with serum levels of BDNF and CRP. These findings suggest that inflammation and neuroplasticity play key roles in the pathophysiology of cognitive decline in bipolar disorder, providing potential biomarkers for identifying patients at risk for severe cognitive impairments.
Salmonella enterica serovar Dublin is host-specific to cattle, causing severe symptoms and economically impacting milk herds. Despite an eradication programme in Denmark, levels of infection have not decreased and suspicion has fallen on the common starling Sturnus vulgaris as a potential vector between herds. The number of breeding starlings in Denmark declined by 60% between 1976 and 2015, a trend correlated with decreases in the number of cattle grazing outside. Ironically, more starlings are now coming into Danish cattle sheds to feed on maize silage outside the breeding season, so it is increasingly important to understand the role of starlings in dispersing Salmonella between cattle herds. We caught and tested 394 different starlings at seven separate dairy farms infected with Salmonella Dublin by swabbing breast feathers, legs, feet and undertail coverts as well as taking faecal samples at these and four other infected farms. We found no trace of the pathogen, indicating that starlings are highly unlikely to be significant in spreading Salmonella Dublin between Danish cattle herds. We recommend investigating alternative contacts that may occur between herds as the cause of disease spread.
The article analyzes whether regulatory sandboxes are a legally intended and useful instrument to create pathways for law enforcement agencies using cutting-edge AI systems in compliance with fundamental rights. It takes a deeper look at the provisions of the EU AI Act for regulatory sandboxes and testing under real-world conditions in contexts relevant to law enforcement. Using a legislative process in Germany as a case study, the article shows the imminent tension of innovative AI systems between modern investigation tools in the digital age, as well as potential pathways towards disproportionate surveillance of citizens. The author suggests taking the extra mile through regulatory sandboxes instead of crafting legal foundations quickly under the influence of current political pressure: On the long run this can save tax money, avoid dependencies to tech companies and pave a European way of AI systems that respect digital human rights in an appropriate manner.
Management of broadleaf weeds in chile pepper may be improved by including a rotation with sorghum treated with selective, non-residual herbicides. However, herbicides applied to sorghum specifically for managing weeds in subsequent chile pepper crops have not been evaluated. This study evaluated two herbicide treatments applied to sorghum for their effects on broadleaf weed density and hand hoeing time in chile pepper crops the following year, and compared the treatments for their net economic benefits across sorghum and chile pepper growing seasons. Treatments included 1) a sorghum nontreated control; 2) one herbicide application, which was a premix combination of 2,4-D (0.35 kg ai ha−1), bromoxynil (0.35 kg ai ha−1), and fluroxypyr (0.14 kg ai ha−1) applied at the 4-leaf stage of sorghum; 3) two herbicide applications, which included the aforementioned premix combination followed by bromoxynil (0.28 kg ai ha−1) applied at the 6-leaf stage of sorghum; and 4) weed-free sorghum using hand hoeing. Results indicated that broadleaf weeds covered less than 10% of the ground where sorghum had been treated with herbicides. The two-application treatment resulted in 24% fewer broadleaf weeds in chile pepper than in sorghum that had been hoed by hand, and 63% fewer than the one-application treatment. Hand hoeing time for chile pepper was similar among the two-application treatment, one-application treatment, and weed-free sorghum. A partial budget analysis indicated that the one-application treatment provided greater net economic benefit than the two-application treatment (US$6,550 ha−1 vs. US$5,894 ha−1), due to lower input costs and greater overall gross revenue. These findings indicate that a two-application treatment maximizes reductions of broadleaf weeds in chile pepper caused by rotational sorghum; however, the one-application treatment may be a cost-effective approach to reducing broadleaf weeds in chile pepper.
There is a lack of knowledge available on how cats adjust their macronutrient partitioning due to the consumption of single-macronutrient meals. The objective of this study was to evaluate consumption of a single meal of ingredients that contained foods of strictly carbohydrates (CHO), fat (FAT) or protein (PRO), on energy expenditure (EE) and macronutrient metabolism in cats. Ten domestic shorthair adult cats (1·9 years; 4·12 kg) were fed 22–24 g of chicken fat (FAT), 56–62 g of whey protein solution (PRO) or 54–56 g of cornstarch solution (CHO) for a single day in a randomised complete block design. Indirect calorimetry was conducted for 24 h post-feeding. Mean average EE over 24 h was highest in cats fed PRO (44 kcal/kg BW) and FAT (43 kcal/kg BW) compared with that in cats fed CHO (42 kcal/kg BW; P < 0·01). During 0 to 4 h, cats fed FAT had greater EE (49 kcal/kg BW), suggesting that cats respond to oxidising more dietary fat over protein in the early postprandial stage. Mean 24 h respiratory quotient (RQ) was greatest for cats fed CHO (0·76) followed by PRO (0·75) and FAT (0·74; P < 0·05). During 4 to 8 h, the RQ of cats fed PRO was the greatest (0·77), suggesting that cats initially increase gluconeogenesis from amino acids for subsequent glucose oxidation. In comparison to omnivores and herbivores, obligate carnivores have unique responses to single macronutrient intake, where they apparently generate energy from carbohydrate metabolism and rely more on gluconeogenic precursors.
Due to an increased awareness of the prevalence and impact of trauma, “trauma-informed care” (TIC) was developed as an organisational framework aiming to centre the needs of survivors of trauma. TIC proposes that organisations can reduce trauma exposure by embedding specific principles (e.g., safety and trust) at every level of an organisation, improving the organisation for both service users and providers. Recent reviews of TIC implementation efforts have demonstrated its use in diverse settings; however, studies are overwhelmingly situated in high-income, predominantly English-speaking countries. Rather than reflecting a lack of TIC efforts in low- and middle-income countries (LMICs), these findings may be a result of the newness of the term TIC. To create a more inclusive evidence map, the current review captures efforts conducted in LMICs that may or may not use the label of TIC but align with the organisational approaches and key principles of TIC. A search of four databases and review of relevant references yielded 3,091 results, of which 255 met the inclusion criteria. Implementation efforts took place across 39 LMICs. The vast majority included involvement of another country, most commonly the United States. Approximately 90% of efforts were implemented within medical settings, and 69% focused on the TIC principle of cultural, historical and gender issues. The results of the current review have both theoretical and applied implications for TIC research. They query how and by whom TIC is conceptualised and defined, and how TIC aligns with other global research approaches. Results also highlight the need for organisational TIC interventions to conduct comprehensive baseline assessments of current efforts before implementing new efforts to avoid unintentional duplication. As the adoption of TIC frameworks becomes more widespread, it is imperative to increase research efforts aimed at developing a more thorough and inclusive definition of TIC.
The Kura-Araxes culture spread over a large area of South-west Asia, participating in the transformational dynamics of Early Bronze Age societies in the region. Yet, the absence of a robust chronological framework for this cultural horizon hinders its integration into wider regional and interregional models. Drawing on a substantial new radiocarbon dataset, collating novel Bayesian chronological models for eight sites and existing data from the wider region, this article identifies settlement patterns that coincide with broader reconfigurations of the Kura-Araxes cultural landscape, which in turn track socioeconomic, and possibly political, shifts observed in eastern Anatolia and the greater Near East.
Shakespeare’s Cymbeline explores the tension between the desire for freedom and the obligations individuals owe to their social and political communities. Through the course of the play, characters seek freedom from the authority of their fathers, kings, emperors, and gods with devastating consequences. Tragedy is only averted once these characters understand that the freedom and authority they variously desire is only fulfilled in a mutual love or good will that is bolstered by forgiveness. The play’s setting at the birth of Christ is carried through in the Christian argument and outcome of the plot.