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Following the independence of African countries in the 1960s and 1970s, many newly minted politicians and political scientists who studied them directed their attention to the effects of ethnic identities, heterogeneity, rivalries, and alliances on African politics. In the aftermath of colonial violence and social engineering, ethnic competition contributed to violent secessionist movements, and ethnic hatred sometimes fueled genocide. Many African governments expelled minorities and banned ethnic parties, established federal institutions, and at times adopted nationalist rhetoric to punish rivals or mitigate the deleterious outcomes of ethnic conflict. As Christof Hartmann summarizes, “political regulation of ethnicity has been a core dimension of state-building in Africa” (“Managing Ethnicity in African Politics,” in Nic Cheeseman, ed., The Oxford Encyclopedia of African Politics, 2019: 1).
Cognitive impairment is central to psychosis and strongly linked to functional outcomes. The Brief Assessment of Cognition (BAC) app is a tablet-based, automated tool for assessing key cognitive domains but has not been validated in Spanish-speaking populations or across illness stages.
Methods
A total of 402 participants (117 with first-episode psychosis [FEP], 125 with schizophrenia, and 160 controls) completed the BAC app along with clinical and functional assessments. We evaluated internal consistency, group differences, convergent and discriminant validity, and the effects of sex, age, and education. Normative percentiles were derived from controls.
Results
The BAC app showed good internal consistency across groups (α = 0.76–0.87) and effectively differentiated individuals with psychosis from controls (area under the curve [AUC] = 0.862), with performance declining from controls to FEP to schizophrenia. Discrimination between FEP and schizophrenia was limited (AUC = 0.649). BAC App correlated positively with estimated intelligence quotient and functional capacity, and negatively with symptom severity, particularly in FEP. Performance varied by age, sex, and education, supporting the need for stratified normative data.
Conclusions
The BAC app showed strong reliability and validity for cognitive assessment in Spanish-speaking individuals with psychosis. Its brevity, automated scoring, and normative data support its clinical and research applications for cognitive screening, monitoring, and treatment evaluation.
Near-future experiments with Petawatt class lasers are expected to produce a high flux of gamma-ray photons and electron–positron pairs through strong field quantum electrodynamical processes. Simulations of the expected regime of laser–matter interaction are computationally intensive due to the disparity of the spatial and temporal scales, and because quantum and classical descriptions need to be accounted for simultaneously (classical for collective effects and quantum for nearly instantaneous events of hard photon emission and pair creation). We study the stochastic cooling of an electron beam in a strong, constant, uniform magnetic field, both its particle distribution functions and their energy momenta. We start by obtaining approximate closed-form analytical solutions to the relevant observables. Then, we apply the quantum-hybrid variational quantum imaginary time evolution to the Fokker–Planck equation describing this process and compare it against theory and results from particle-in-cell simulations and classical partial differential equation solvers, showing good agreement. This work will be useful as a first step towards quantum simulation of plasma physics scenarios where diffusion processes are important, particularly in strong electromagnetic fields.
The UK Early Access to Medicines Scheme (EAMS), launched in 2014, enables pre-license access to medicines for areas of high unmet medical need. This study aimed to evaluate the outcomes of the scheme by analyzing subsequent marketing authorization (MA), health technology assessment (HTA), and commissioning decisions.
Methods
We conducted a retrospective analysis of all completed EAMS programs from 2014 to April 2025, reviewing MA, HTA, and commissioning outcomes.
Results
Fifty-one EAMS programs were completed, over half in oncology. Median times from Scientific Opinion (SO) to MA, and reimbursement outcomes in England and Scotland were 4.3 (Q1: 2.6 and Q3: 7.3), 14.5 (Q1: 9.4 and Q3: 20.9), and 15.0 months (Q1: 11.4 and Q3: 18.1), respectively. Of 48 products appraised by the National Institute for Health and Care Excellence (NICE) or National Health Service (NHS) England, 50 percent received positive recommendations, 44 percent were optimized, and 6 percent were rejected. Of 45 products appraised by the Scottish Medicines Consortium or NHS Scotland, 73 percent were positive, 18 percent optimized, and 9 percent rejected. EAMS was qualitatively referenced in 48 percent of NICE appraisals and quantitatively in 18 percent.
Conclusions
Compared to non-EAMS products, those entering the scheme achieve faster MA and HTA timelines and higher regulatory success. However, EAMS is referenced quantitatively in less than a fifth of NICE appraisals, and fewer than half of Promising Innovative Medicine designations progress to a full SO. Administrative burdens, data demands, and liability concerns may limit uptake; addressing these barriers could enhance the scheme’s impact.
After the Great East Japan Earthquake of March 11, 2011, the Fukushima Prefectural Government commissioned Fukushima Medical University to conduct the “Fukushima Health Management Survey” to investigate long-term low-dose radiation exposure caused by the accident. The primary purposes of this survey are to monitor the long-term health of Fukushima residents and to promote their health and well-being. The survey consists of a Basic Survey and 4 detailed surveys (Thyroid Ultrasound Examination, Comprehensive Health Check, Mental Health and Lifestyle Survey, and Pregnancy and Birth Survey). Some physical and mental health problems have persisted. Survey participants who evacuated from Fukushima and continue to live outside Fukushima showed higher mental health deterioration than those who evacuated from Fukushima and came back to live in Fukushima. Problems arise from misunderstanding radiation health effects among non-Fukushima residents, and the dignity of “place of living” among Fukushima residents.
Today issues about ‘metaphysical grounding’ have come to the centre of philosophical discussion. In the case of Schaffer’s widely influential work, this comes with a defence of monism, according to which everything is grounded in one comprehensive whole. He cites as predecessors Hegel and Spinoza. Part of Schaffer’s case runs through a claim that issues about grounding are unavoidable in philosophy. It is natural to expect that an unavoidability of grounding should help the case of such a monism. But can we read Hegel’s claims for his comprehensive system as similarly supported by a claim for the interwovenness of grounding with philosophy? No. I argue that, in the unusual philosophy of Hegel’s historical context, our expectations are reversed: Hegel and contemporaries who influence him, like Jacobi, see reasons for thinking that claims for the unavoidability of grounding would support rather critique of the prospects for defence of any unity or organization in terms of which everything would be comprehensively explicable or intelligible. Hegel’s challenge in defending a comprehensive system, then, is to resist such unavoidability claims. Seeing this opens an approach to reading Hegel’s Science of Logic in terms of the unusual reasons that animate it.
In October 2022 at the annual board meeting of the Southeastern Archaeological Conference (SEAC), a new image policy for the journal Southeastern Archaeology was adopted that prohibited publication of photographs of funerary objects/belongings. In the discourse surrounding these new policies, a range of misunderstandings and mischaracterizations regarding consultative, collaborative, and community-based Indigenous archaeology were highlighted. Through a range of examples and personal experiences, this paper explores some of the realities of collaborative archaeological practice in the Indigenous American Southeast and aims to contextualize and mediate some recurring misunderstandings. Of particular importance and focus is the unique concept and definition of “the community” as it relates to collaborative practice across Indigenous North America. Importantly, I emphasize that southeastern archaeology and southeastern archaeologists are doing transformative work that puts us in a position to be leaders in the ongoing structural changes to our discipline.
When leveraged together, variable-centered and person-centered statistical methods have the potential to illuminate the factors predicting mental health recovery. However, because extant studies have largely relied on only one of these methods, we do not yet understand why some youth demonstrate recovery while others experience chronic symptoms. This omission limits our understanding of trajectories of physical aggression (AGG) in particular, which are frequently characterized by desistance. The present study examined the development of AGG across childhood and adolescence via variable-centered and person-centered modeling, with neighborhood and family characteristics considered as predictors. Variable-centered results indicated a mean-level decline in AGG with age but were more useful for illuminating predictors of AGG at baseline than predictors of declining engagement. Person-centered analyses, by contrast, identified low parent-child conflict and high household income as predictors of desistance. Although variable-centered analyses were integral to modeling the average AGG trajectory and identifying predictors of engagement at baseline, person-centered techniques proved more useful for understanding predictors of desistance.
This article analyzes the history of the Chilean personal income tax (PIT) to explain the persistence of a class-based and progressive PIT within a context of a regressive fiscal system. We provide new archival evidence regarding fiscal politics since the nineteenth century to estimate the generalization of the PIT between 1925 and 2014. Combining statistical information and parliamentary records, we follow the PIT’s trajectory in relation to elites’ self-interest, paternalistic understandings of the fiscal pact and citizenship, and the looming presence of natural resources. By keeping the PIT class-based, allegedly to protect workers, fiscal politics defined citizenship through expenditure instead of taxation. Those excluded from income taxation bear the brunt of indirect taxes—which support social spending—albeit without voice over fiscal policies.
While there is an enormous literature on friendship, next to nothing has been written about enemyship. This neglect may be due to the assumption that enemyship is simply inverted friendship. We reject that assumption and argue that although enemyship shares some important structural relations with friendship (such as dispositions to act and the presence of significant interactions), there are crucial differences. Unlike friendship, enemyship does not require reciprocity, mutual acknowledgment, or equality in any degree. If we are right, enemyship is a sui generis category of human relationship, in need of further exploration. To that end, we offer a conceptual analysis and taxonomy of enemies before turning to two normative questions: is there anything intrinsically good about having an enemy? Would a good person ever have enemies, of any kind?
Rating procedure is crucial in many applied fields (e.g., educational, clinical, emergency). In these contexts, a rater (e.g., teacher, doctor) scores a subject (e.g., student, doctor) on a rating scale. Given raters’ variability, several statistical methods have been proposed for assessing and improving the quality of ratings. The analysis and the estimate of the Intraclass Correlation Coefficient (ICC) are major concerns in such cases. As evidenced by the literature, ICC might differ across different subgroups of raters and might be affected by contextual factors and subject heterogeneity. Model estimation in the presence of heterogeneity has been one of the recent challenges in this research line. Consequently, several methods have been proposed to address this issue under a parametric multilevel modelling framework, in which strong distributional assumptions are made. We propose a more flexible model under the Bayesian nonparametric (BNP) framework, in which most of those assumptions are relaxed. By eliciting hierarchical discrete nonparametric priors, the model accommodates clusters among raters and subjects, naturally accounts for heterogeneity, and improves estimates’ accuracy. We propose a general BNP heteroscedastic framework to analyze continuous and coarse rating data and possible latent differences among subjects and raters. The estimated densities are used to make inferences about the rating process and the quality of the ratings. By exploiting a stick-breaking representation of the discrete nonparametric priors, a general class of ICC indices might be derived for these models. Our method allows us to independently identify latent similarities between subjects and raters and can be applied in precise education to improve personalized teaching programs or interventions. Theoretical results about the ICC are provided together with computational strategies. Simulations and a real-world application are presented, and possible future directions are discussed.
Early signs suggest that Trump may revise the Biden administration's incentive-driven semiconductor policy and instead rely more heavily on tariffs to restore US semiconductor manufacturing. To what extent can semiconductor tariffs serve as a form of policy whiplash to compel foreign companies to relocate their operations? This article argues that while tariffs can influence investment decisions, Trump overstates their effects on fab locations and supply chain diversification. Semiconductor manufacturers weigh a complex set of factors encompassing partners in the supply chain ecosystem, potential regulatory scrutiny, technological trends, and more. Tariffs in and of themselves may not be a determinative factor behind TSMC's recently announced plan to expand its US investment.
To describe the use of non-beta-lactam agents (NBL) to treat ampicillin-susceptible Enterococcus bacteremia (ASEB), and to identify factors associated with their use.
Methods:
A single-center retrospective study at a rural tertiary referral center was conducted to identify ASEB episodes between January 1, 2016, and 31 December, 2021. Patient, microbiological, infection, clinical management characteristics, and outcomes were compared between those who received NBL versus BL agents for definitive therapy. Multivariable logistic regression analysis was used to determine factors associated with NBL use.
Results:
158 episodes of ASEB in 153 patients were included. 43 episodes (27%) were treated with NBL for definitive therapy. Factors associated with NBL therapy were younger age, history of penicillin allergy, history of cancer, end-stage renal disease (ESRD), polymicrobial bacteremia, lack of metastatic foci, and lack of endocarditis. Combination therapy was used in 23% of those treated with BL therapy versus zero patients receiving NBL therapy. All-cause 30-day and 90-day mortality and 30-day relapse rate were not statistically different. In the regression model, NBL therapy was more likely in those with: younger age (AOR 0.95, p < .01), any penicillin allergy (AOR 5.87, p < .01), history of cancer (AOR 5.25, p < .01), ESRD (AOR 12.48, p < .001), and polymicrobial bacteremia (AOR 4.20, p < .01).
Conclusion:
NBL was used as definitive treatment in 27% of ASEB with good clinical outcomes. This real-life experience suggests NBL can be successfully used to treat ASEB based on clinical discretion.
Core premenstrual disorders (PMDs), including premenstrual syndrome (PMS) and premenstrual dysphoric disorder, can cause significant impairment. Despite evidence linking stress and premenstrual symptoms, a systematic synthesis is lacking.
Aims
To systematically review the literature and meta-analyse evidence on the relationship between premenstrual symptoms and stress.
Method
Four databases (Web of Science, PubMed, PsycINFO, Scopus) and Google Scholar were searched for studies indexed before 27 August 2024 (no language/year restrictions) assessing the relationship between self-reported stress and premenstrual symptoms in regularly menstruating individuals (PROSPERO: CRD42021244503). Three multilevel meta-analyses estimated (a) the correlation between stress and premenstrual symptom severity, (b) stress differences between individuals with and without core PMD across the menstrual cycle and (c) the impact of traumatic experiences on the occurrence of premenstrual symptoms. Study quality and publication bias were assessed.
Results
We synthesised 188 effect sizes from 66 studies (N = 38 344), indicating (a) a positive correlation (r = 0.29, 95% CI 0.23–0.36); (b) higher stress levels in participants with core PMD (d = 0.79, 95% CI 0.32–1.26), particularly during the luteal phase (dlut = 1.01, 95% CI 0.46–1.57); and (c) over twofold higher odds (odds ratio 2.45, 95% CI 1.87–3.23) of PMS in individuals with a history of trauma. Heterogeneity was high (I2 = 84.64–91.38%); one meta-analysis (c) showed evidence of publication bias.
Conclusions
The results indicate an association between stress and premenstrual symptoms, an effect of cycle phase and trauma as a risk factor for PMS. Future research should explore underlying biopsychosocial mechanisms.
This article examines the use of fuck and fucking in Danish, with a focus on their interactional functions for assessing. Data consist of 76 cases found in informal Danish conversations, analyzed within the framework of Interactional Linguistics. Fuck functions as a reactive interjection that prefaces various types of clauses. However, fuck followed by a copula clause develops an assessment out of a telling. Followed by hvor ‘how’ and an adjective, fuck performs agreeing assessment. Hvad fuck ‘what the fuck’ may occur in questions. Fucking is commonly used in copula clause assessments but also within noun phrases when no response is elicited. The study concludes that the use of fuck and fucking in Danish differs from their use in English, but also from the Danish swearword fanden ‘the devil, damn’. The conclusions indicate that interactional functions and constructions are an important factor for understanding the pragmatics of borrowing and swearing.
The two economic superpowers operate increasingly outside WTO norms. China's reliance on non-market practices challenges the competitive equality among WTO members, while the US, under a second Trump administration, has unilaterally raised tariffs in defiance of multilateral rules. This essay examines how the rest of the world is de-risking from the two rogue superpowers while shoring up trade multilateralism. It identifies three interlinked strategies: (1) recalibration – reducing trade dependency through targeted trade remedies against China and narrow bilateral agreements with the US; (2) shielding – collective and unilateral responses to economic coercion of both superpowers; and (3) containment – preventing illegality from spreading to the rest of the world. Together, these modes of governance not only mitigate systemic spillovers from rule-breaking but also help rebalance global trade by addressing structural imbalances in Chinese overproduction and US overconsumption. In doing so, the rest of the world may lay the groundwork for a renewed and more resilient multilateral trading system.
The crystal structure of quizartinib hydrate has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional theory techniques. Quizartinib hydrate crystallizes in space group P-1 (#2) with a = 13.9133(9), b = 17.877(3), c = 19.8459(30) Å, α = 115.080(5), β = 93.768(5), γ = 100.831(5)°, V = 4,332.1(6) Å3, and Z = 6 at 298 K. In the complex crystal structure, the molecules are generally oriented parallel to the (110) plane. Two of the independent molecules are linked into dimers by N–H···O or N–H···N hydrogen bonds. Each molecule exhibits a unique pattern of C–H···O, C–H···N, or C–H···S hydrogen bonds. The powder pattern has been submitted to ICDD for inclusion in the Powder Diffraction File™ (PDF®).
Predictive regressions of market returns on option-implied moments measured before pre-scheduled FOMC meetings show that tail risks play an important role in understanding the market risk premium around FOMC announcement days. Skewness and kurtosis, which capture investors’ expectations of the tails of the return distribution, robustly predict post-FOMC returns both in-sample and out-of-sample. The predictability lasts up to 1 week and is stronger for expansionary monetary policy shocks. The signs of the corresponding risk premiums are consistent with economic intuition, illustrating the role of periods with high risk premiums to confirm theoretical predictions.
This article examines the divergent historical views espoused by Russian and Ukrainian societies and their representatives on topics such as the 1932-1933 famine, Stalinism, and the post-World War II Soviet Union. We draw on an original online survey, conducted simultaneously in January 2021 in Ukraine and Russia, to provide an in-depth analysis of views on history in Ukraine and Russia before the 2022 invasion. In Russia, we illustrate how little contestation there is of official narratives. This may signal the existence of an integrated mnemonic community after a decade of state-curated historical narratives, but it might also imply that Russian society is disengaged from history. In pre-2022 Ukraine, meanwhile, we identify persistent fragmentation in the ways in which society perceives history, largely centered along the country’s linguistic divide. However, a central finding is that Russian-speakers in Ukraine differ in their historical views from Russian citizens on key dimensions such as the memory of Stalin and the Holodomor. These results speak to the evolving and politicized nature of societal memory and provide an important baseline for interpreting potential mnemonic shifts that accompanied the full-scale war launched against Ukraine by Russia in February 2022.
This work presents detailed 3D modelling and simulation of the mechanical effects induced by lightning strikes in protected carbon fibre-reinforced polymer laminates. Firstly, physically based models that represent the mechanical overpressure that results from a lightning strike are revisited. In particular, this paper compares the implementation of an analytical strong shock wave approximation with the solutions obtained from computational fluid dynamics (CFD), considering different equations of state, to represent the supersonic expansion of the hot plasma channel when simulating the mechanical damage induced by lightning strikes. The assessment of the pressure profiles, the numerical predictions of the displacement and velocity fields and the analysis of the predicted damage maps show that, for two lightning protection layers, the effects of the supersonic plasma expansion loads obtained from the strong shock wave approximation compare reasonably well with those obtained from CFD, independently of the equation of state solved numerically. Subsequently, the predictions of the 3D modelling strategy of the mechanical response of composite laminates subjected to lightning strike employing the strong shock wave approximation are compared with mechanical deformation measurements obtained from lab-scale lightning test results. Accurate deflection and out-of-plane velocity fields are predicted, validating the 3D modelling strategy. Moreover, the predicted damage maps correlate well with the (bulk) damage identified by C-scan (considering only the damaged area below the second ply).