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This introduction explains the socio-political context that led to the protest depicted on the cover of the book. This is an instance of an internal, ideological conflict which led to joint collective action of the two communities, one of the few historical instances of such an event in Cyprus that was the result of a process of valorisation of free movement across the divide that started with the opening of the checkpoints in 2003. It is argued that in order to understand conflict and its transformation in conflict and post-conflict settings, it is important to evaluate internal heterogeneity and the transformation from one position to another in the representational field of an ethnic conflict. An integrative framework of a social developmental psychology is then presented, which is sensitive to historical change and change at various time scales (microgenesis, ontogenesis and sociogenesis) and at different levels of analysis. The introduction ends with a preview of the book, its two parts and different chapters.
People living with severe mental illness (SMI) experience a shorter life expectancy and poorer physical health than those without SMI. Cardiometabolic illness accounts for a significant proportion of this health inequality. Pharmacological management could reduce the noted inequalities.
Aims
This umbrella review aimed to synthesise evidence from systematic reviews for pharmacological interventions to manage cardiometabolic outcomes in adults with SMI.
Method
Databases (Embase, MEDLINE, Cochrane Database of Systematic Reviews) were searched from inception to 11 June 2024 for systematic reviews of pharmacological interventions for all cardiometabolic outcomes in adults. Titles, abstracts and full texts were independently screened by two reviewers. Corrected cover area was calculated, and quality was assessed using AMSTAR 2. Results were analysed and a narrative synthesis conducted.
Results
Thirty-three systematic reviews were included following screening of 1723 titles. Metformin, the most commonly studied intervention (n = 18), was effective in preventing and treating weight gain, dyslipidaemia (total cholesterol and triglycerides) and dysglycaemia.
Topiramate and glucagon-like peptide-1 agonists demonstrated efficacy in treating weight gain, but the effect across other parameters was less consistent. Licensed treatments, such as statins for dyslipidaemia, were reviewed in low numbers (n = 2). Nicotine replacement, bupropion and varenicline were effective for smoking cessation, an outcome that can significantly lower cardiometabolic risk.
The corrected cover area was 6.3%, indicating moderate overlap. Most reviews (n = 16, 48%) were rated critically low quality using AMSTAR 2, and the remainder rated either low (n = 7, 21%), moderate (n = 2, 7%) or high quality (n = 7, 24%).
Conclusions
Pharmacological interventions can improve cardiometabolic outcomes in adults with SMI when non-pharmacological interventions are either insufficient alone, impractical or unacceptable. However, licensed treatments have been reviewed in relatively low numbers. Improving cardiometabolic outcomes is a key area in psychiatry, and the results of this review will be important in shaping future guidance.
This paper discusses the teaching of Ancient History in Brazil through the experience of Projeto Vocabulário Político da Antiguidade (Political Vocabulary of Antiquity Project). This project has been developed at the Federal University of Paraíba in João Pessoa, Brazil, since 2016, with a team consisting of professors and students from undergraduate History and Classics programs. The project’s main goal is to create didactical materials that facilitate the teaching of politics and Antiquity to students aged 11 to 17, based on the translation of Greek and Latin texts. This paper will present two educational games developed by this project to teach the theory of forms of government in an engaging and enjoyable way. The positive results of the project highlight the importance of modernizing the teaching of forms of government regbased on the works of authors such as Herodotus, Aristotle, Polybius and Cicero. Furthermore, it demonstrates that the study of Antiquity can effectively contribute to the political awareness of young citizens.
The ctrdata package has been created to boost the use of data available in public registers of clinical trials. It enables user-friendly, reproducible workflows to identify trials of interest, download protocol- and results-related data, and conduct sophisticated analyses, across multiple registers and trials. ctrdata works in the widely used R environment, and its databases can be used with other tools. The package is open source with a permissive licence, to facilitate collaboration.
This report provides an overview of ctrdata, including its implementation, cases of interest to researchers in public health, medicines, and regulatory science, as well as potential limitations and further developments. At this time, ctrdata works with the European Union (EU) Clinical Trials Information System (CTIS), the EU Clinical Trials Register (EUCTR), the US Clinicaltrials.Gov (CTGOV), and the ISRCTN—the UK’s Clinical Study Registry. The registers are complementary in scope and scientific value, yet differences in data models, variable definitions, search parametrisations, and retrieval options hamper efficient scientific workflows, calling for a scientific-technical, programmatic solution and driving the development of ctrdata.
By employing ctrdata to comprehensively use and easily leverage trial register data, researchers can effectively address a variety of questions, gain useful insights into evolving policies and practices of drug development, and inform further clinical research. Patients and their organisations, developers, policymakers, and other interested parties can build on ctrdata to create solutions for their use cases.
Statistical regularities can be acquired from usage. To examine language speakers’ statistical metacognition about multiword expressions (MWEs), we collected ratings for frequency, dispersion, and directional association strength of English binomials from L1, advanced and intermediate L2 speakers. Mixed-effects modeling showed all speakers had limited speaker-to-corpus consistency but significant sensitivity to statistical regularities of language, supporting usage-based (Gries & Ellis, 2015) and statistical learning theories (Christiansen, 2019). Their statistical metacognition was also shaped by word-level cues, consistent with dual-route model (Carrol & Conklin, 2014). Despite similarities, frequency metacognition showed the strongest speaker-to-corpus consistency, while dispersion metacognition was the hardest to develop. Advanced L2 speakers showed the greatest speaker-to-corpus consistency and sensitivity, while lower-proficiency speakers relied more on word-level cues in metacognitive judgments, supporting the shallow-structure hypothesis (Clahsen & Felser, 2006). Overall, L1 and L2 speakers develop diverse statistical metacognition, with L2 speakers not necessarily inferior, suggesting that statistical metacognition is not solely shaped by usage-based experience.
Galen system is based on three pillars: the affected body part, the type of qualities imbalanced, and the degree of imbalance. Therefore, he only distinguishes between mental illness and impaired consciousness when there is a difference between these two entities in any of these three pillars. Thus, he distinguishes phrenitis from melancholia but not from mania. The emphasis on the system, on the other hand, enables him a very tight notion of disease, where symptoms, mechanisms, affected organ and treatment are closely linked.
Timely dissemination of clinical trial results is essential to advance knowledge, guide practice, and improve outcomes, yet many trials remain unpublished, limiting impact. We examine what drives publication and timelines across three major clinical domains.
Methods:
We analyzed study design and factors associated with dissemination of interventional trials, focusing on cardiovascular disease (CVD), cancer, and COVID-19. A total of 10,785 trials (CVD: 5929; cancer: 4210; COVID-19: 646) were linked to PubMed publications using National Clinical Trial identifiers. Study design, operational, and transparency-related features were assessed as predictors of time to publication, defined as the interval from study completion to first publication, using Cox proportional hazards model.
Results:
COVID-19 trials had the highest publication rate (49.6%), followed by CVD (42.3%) and cancer (32.9%), likely reflecting pandemic-related prioritization. Faster publication was associated with larger enrollment, more sites, result posting, randomization, DMC presence, and higher blinding levels (all p < 0.05). Slower publication was linked to supportive care or diagnostic trials (CVD), basic science (cancer), and later COVID-19 trial completion. In subgroups, U.S. facility presence (CVD) and phase 3 design (cancer) predicted faster publication, while healthy volunteer inclusion (CVD) predicted slower publication. Among DMC trials, more secondary outcomes were linked to faster publication across all disease areas.
Conclusions:
Key study design and operational factors consistently predict whether and when trials are published. Strengthening methodological rigor, result reporting, and multi-site collaboration may accelerate timely dissemination into peer-reviewed literature.
Pulsatile fluid flows through straight pipes undergo a sudden transition to turbulence that is extremely difficult to predict. The difficulty stems here from the linear Floquet stability of the laminar flow up to large Reynolds numbers, well above experimental observations of turbulent flow. This makes the instability problem fully nonlinear and thus dependent on the shape and amplitude of the flow perturbation, in addition to the Reynolds and Womersley numbers and the pulsation amplitude. This problem can be tackled by optimising over the space of all admissible perturbations to the laminar flow. In this paper, we present an adjoint optimisation code, based on a GPU implementation of the pseudo-spectral Navier–Stokes solver nspipe, which incorporates an automatic, optimal checkpointing strategy. We leverage this code to show that the flow is susceptible to two distinct instability routes: one in the deceleration phase, where the flow is prone to oblique instabilities, and another during the acceleration phase with similar mechanisms as in steady pipe flow. Instability is energetically more likely in the deceleration phase. Specifically, localised oblique perturbations can optimally exploit nonlinear effects to gain over nine orders of magnitude in energy at a peak Reynolds number of ${\textit{Re}}_{\textit{max}}\approx 4000$. These oblique perturbations saturate into regular flow patterns that decay in the acceleration phase or break down to turbulence depending on the flow parameters. In the acceleration phase, optimal perturbations are substantially less amplified, but generally trigger turbulence if their amplitude is sufficiently large.
This article sheds light on the understudied significance of Islam, Communism, and global politics in defining what constituted an acceptable “religion” (shūkyō 宗教) in wartime Japan. An analysis of the Japanese Imperial Diet’s debates on the place of Islam in the Religious Organizations Law of 1939, which defined state-sanctioned religious organizations, reveals that Muslim attention from around the world, international politics, the global spread of Communism, and the relatively short history of Islam in Japan, affected politicians’ decision not to mention Islam as a religious organization in the law. While previous literature on the Religious Organizations Law has not adequately addressed the significance of international and non-Euro-American transnational influences, this article argues that lawmakers viewed the power of transnational Muslim and Communist networks as crucial when defining both officially acceptable “religion” and the Shrine (jinja 神社), or Shrine Shinto, as the national core to be protected under this law. The debates surrounding Islam offer fertile ground for examining the significance of global affairs in determining acceptable forms of “religion” in Japan, as well as the broader implications of what Japanese state officials called “religion” and “thought” (shisō 思想) in wartime Japanese and world politics.