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The heating effect of electromagnetic waves in ion cyclotron range of frequencies (ICRFs) in magnetic confinement fusion device is different in different plasma conditions. In order to evaluate the ICRF heating effect in different plasma conditions, we conducted a series of experiments and corresponding TRANSP simulations on the EAST tokamak. Both simulation and experimental results show that the effect of ICRF heating is poor at low core electron density. The decrease in electron density changes the left-handed electric field near the resonant layer, resulting in a significant decrease in the power absorbed by the hydrogen fundamental resonance. However, quite a few experiments must be performed in plasma conditions with low electron density. It is necessary to study how to make ICRF heating best in low electron density plasma. Through a series of simulation scans of the parallel refractive index (n//) of the ICRF antenna, it is concluded that the change of the ICRF antenna n// will lead to the change of the left-handed electric field, which will change the fundamental absorption of ICRF power by the hydrogen minority ions. Fully considering the coupling of ion cyclotron wave at the tokamak boundary and the absorption in the plasma core, optimizing the ICRF antenna structure and selecting appropriate parameters such as parallel refractive index, minority ion concentration, resonance layer position, plasma current and core electron temperature can ensure better heating effect in the ICRF heating experiments in the future EAST upgrade. These results have important implications for the enhancement of the auxiliary heating effect of EAST and other tokamaks.
The Connecting People and Community for Living Well initiative recognizes that communities, specifically multisector community teams, are a critical part of the provision of programs and supports for those affected by dementia. Effective collaboration and building and supporting the collective well-being of these multisector community teams is key to their success and sustainability. This research sought to understand what supports the well-being of community teams. Focus groups were conducted with multisector community teams who support those impacted by dementia from across four rural communities. The research team used thematic analysis to identify patterns emerging within and across focus groups. The findings highlighted three areas of importance: the need for a resource to support teams to measure, monitor, and describe the impact of their actions; ongoing support from a system-level team; and the development of local and/or provincial policy and infrastructure that supports sustaining collaborative community-based work.
Chapter 19 looks at two landmark decisions that were issued after the submission of the full manuscript of this book for publication: the Advisory Opinion of the International Tribunal for the Law of the Sea on climate change and marine protection, and the judgment of the European Court of Human Rights in Verein KlimaSeniorinnen Schweiz and Others v Switzerland. The authors situate these decisions within the broader context of climate litigation, examining their implications for future cases and drawing connections to the themes explored in other chapters. They demonstrate how these decisions both reflect and advance emerging best practice in climate jurisprudence, potentially inspiring further innovation based on science and rigorous legal reasoning.
Implementing changes to digital health systems in real-life contexts poses many challenges. Design as a field has the potential to tackle some of these. This article illustrates how design knowledge, through published literature, is currently referenced in relation to the implementation of digital health. To map design literature’s contribution to this field, we conducted a scoping review on digital health implementation publications and their use of references from nine prominent design journals. The search in Scopus and Web of Science yielded 382 digital health implementation publications, of which 70 were included for analysis. From those, we extracted data on publication characteristics and how they cited the design literature. The 70 publications cited 58 design articles, whose characteristics were also extracted. The results show that design is mainly cited to provide information about specific design methods and approaches, guidelines for using them and evidence of their benefits. Examples of referenced methods and approaches were co-design, prototyping, human-centered design, service design, understanding user needs and design thinking. The results thus show that design knowledge primarily contributed to digital health implementation with insights into methods and approaches. In addition, our method showcases a new way for understanding how design literature influences other fields.
This paper presents a Hammir tandem mirror confinement performance analysis based on Realta Fusion’s first-of-a-kind model for axisymmetric magnetic mirror fusion performance. This model uses an integrated end plug simulation model including, heating, equilibrium and transport combined with a new formulation of the plasma operation contours (POPCONs) technique for the tandem mirror central cell. Using this model in concert with machine learning optimization techniques, it is shown that an end plug utilizing high temperature superconducting magnets and modern neutral beams enables a classical tandem mirror pilot plant producing a fusion gain Q > 5. The approach here represents an important advance in tandem mirror design. The high-fidelity end plug model enables calculations of heating and transport in the highly non-Maxwellian end plug to be made more accurately. The detailed end plug modelling performed in this work has highlighted the importance of classical radial transport and neutral beam absorption efficiency on end plug viability. The central cell POPCON technique allows consideration of a wide range of parameters in the relatively simple near-Maxwellian central cell, facilitating the selection of more optimal central cell plasmas. These advances make it possible to find more conservative classical tandem mirror fusion pilot plant operating points with lower temperatures, neutral beam energies and end plug performance requirements than designs in the literature. Despite being more conservative, it is shown that these operating points have sufficient confinement performance to serve as the basis of a viable fusion pilot plant provided that they can be stabilized against magnetohydrodynamic and trapped particle modes.
This study examined the capacity of ChatGPT-4 to assess L2 writing in an accurate, specific, and relevant way. Based on 35 argumentative essays written by upper-intermediate L2 writers in higher education, we evaluated ChatGPT-4’s assessment capacity across four L2 writing dimensions: (1) Task Response, (2) Coherence and Cohesion, (3) Lexical Resource, and (4) Grammatical Range and Accuracy. The main findings were (a) ChatGPT-4 was exceptionally accurate in identifying the issues across the four dimensions; (b) ChatGPT-4 demonstrated more variability in feedback specificity, with more specific feedback in Grammatical Range and Accuracy and Lexical Resource, but more general feedback in Task Response and Coherence and Cohesion; and (c) ChatGPT-4’s feedback was highly relevant to the criteria in the Task Response and Coherence and Cohesion dimensions, but it occasionally misclassified errors in the Grammatical Range and Accuracy and Lexical Resource dimensions. Our findings contribute to a better understanding of ChatGPT-4 as an assessment tool, informing future research and practical applications in L2 writing assessment.
The Scientific Advisory Committee on Nutrition (SACN) provides independent advice on nutrition and related health matters to UK government organisations. In keeping with its commitment to openness and transparency, SACN follows a set ‘Framework’ to ensure a prescribed and consistent approach is taken in all its evidence evaluations. Following an update of the SACN Framework in 2020, which addressed some straightforward issues, the SACN Framework subgroup was established in 2021 to consider more complex matters that were not addressed in the 2020 update. The SACN Framework subgroup considered four main topics for update: (1) the different types of evidence evaluations produced by SACN, (2) interpretation of statistical data, (3) tools for assessment of study quality and (4) tools to assess the certainty of a body of evidence for exposure–outcome relationships. The Framework subgroup agreed clear definitions and processes for the different types of evidence evaluations produced by SACN and agreed that interpretation of P values should be informed by consideration of study size, power and methodological quality. The subgroup recommended use of the AMSTAR 2 tool for quality assessment of evidence from systematic reviews and use of the Grading of recommendations, assessment, development and evaluation approach to assess the certainty of evidence. The updated Framework was published in January 2023. This was followed by publication of a further update in October 2024. As a ‘living’ document, the Framework will be subject to regular review by the Framework subgroup and continue to evolve in line with best practice.
Chapter 3 on Attribution Science delves deeper into the science that establishes causal links between climate change, specific sources of emissions, and its impacts. The authors illustrate how these scientific developments are enhancing our ability to pinpoint the causes of climate impacts, an evolution crucial to a range of procedural and substantive issues that may arise in climate litigation. The authors also delve into specific regional impacts and showcase how attribution science has illuminated the ways in which different parts of the world are experiencing and responding to the unique challenges posed by a changing climate. This includes case studies in Africa, the Americas, Europe, the South Pacific, and Asia. The authors conclude by addressing the limitations and challenges in the field of attribution science before explaining how it is nevertheless poised to play an ever-more critical role in our collective response to climate change.
As an antiquarian at the beginning of the age of professional scholarship, Francis Douce (1737–1834) has enjoyed a mixed reputation, exemplified by Meg Twycross’s account of his influence on beliefs regarding the origins of the Towneley Plays. Widely-read and embedded in a network of like-minded enthusiasts, Douce does not appear to have recorded his insights for publication, but he nevertheless participated in what might be considered scholarly exchange. This article will pay attention to the annotations that Douce made in the margins of – and on sheets tipped into – French-language books published before 1600. It will look at what sort of features attracted Douce’s attention (primarily bibliographical, but also some relating to the content of the books he was reading). It will consider where Douce was getting his information about the works he collected and will note instances where Douce revisited and revised his opinions, evaluating the extent to which he was up-to-date with contemporary advances. Where Douce expresses his own opinion, this article will examine whether this opinion has been supported by later scholars. In short, what do the annotations tell us about the state of scholarship in the first decades of the nineteenth century?
Chapter 6 on Separation of Powers offers a comprehensive exploration of how the balance of power between the judiciary and other branches of government plays out in climate litigation. The authors critically analyse key cases where these doctrines have been invoked, shedding light on how these doctrines shape the courts’ approach to climate cases. They underscore the significant variation in how this issue is dealt with across jurisdictions, acknowledging the diversity of constitutional and legal frameworks globally. Despite this diversity, the authors distil an emerging best practice where courts are increasingly recognising their crucial role in safeguarding fundamental rights and constitutional values in the context of climate change. This recognition is not a one-directional or universal trend but a nuanced evolution detectable across various jurisdictions and legal systems.
Radical right behavior and support for radical right parties have increased across many countries in recent decades. A growing body of research has argued that, similar to the spread of other extremist behaviors, this is due to an erosion of political norms. This suggests that re-stigmatizing radical right parties might be an effective way of countering their growth. We use a survey experiment in Spain that compares the effectiveness of three theory-driven interventions aimed at increasing political stigma against a radical right party. Contrary to expectations, we fail to validate the efficacy of vignette-based attempts at stigmatization, instead identifying some backlash effects. Methodologically, our findings underscore the importance of validating treatments, as we show that simple attempts at re-stigmatization can produce null or opposing effects to their intended purpose. Theoretically, our results support the idea that normalization is a “one-way street,” in that re-stigmatizing parties is difficult after a party has become normalized.
Daptomycin is preferred in outpatient parenteral antimicrobial therapy (OPAT) due to daily dosing. Elevations in creatine phosphokinase (CPK) of 3%–10% and musculoskeletal adverse events have been described with daptomycin, but data regarding risk factors and frequency of monitoring in the OPAT setting is limited. We evaluated the incidence and risk factors for CPK elevation and musculoskeletal adverse effects in patients receiving daptomycin OPAT.
Methods:
This was a single-center, retrospective cohort study of adults on OPAT with daptomycin and at least two CPK values. The primary outcome was the incidence of CPK values greater than 500 U/L.
Results:
We included 127 patients. Most patients were male (55.1%), and the median age was 56 years (IQR 46–63). The most common indication was bone/joint infections (73.2%, n = 93). The median daptomycin dose was 7.4 mg/kg/day (IQR 6.1–8.1) and duration of therapy was 37 days (IQR 21–44). Fifteen patients (11.8%) experienced a CPK greater than 500 U/L within a median 13 days (IQR 9–16). Five patients (3.9%) developed rhabdomyolysis. Independent predictors of CPK>500 U/L included male sex (OR, 4.2 [95% CI, 1.05–16.61]; P = .0424) and cerebrovascular disease (OR, 11 [95% CI, 1.21–99.86]; P = .0332).
Conclusions:
The incidence of CPK elevation was similar previously reported rates. This expands the literature to patients with daptomycin doses>6 mg/kg and prolonged durations of therapy. The incidence of CPK elevation and time to onset of 9–16 days supports the current recommendations for weekly lab monitoring.
This reply responds to criticism of our original symposium, ‘Global IR and the Essentialism Trap.’ We respond to four particular charges and end with a call for Global IR to move beyond its current emphasis on creating a more diverse, equal, and inclusive discipline to identifying specific research programs that demonstrate the necessity of moving beyond the West. We nominate global order and disorder.
Plant-based meat and dairy analogues contain less protein than their animal-based counterparts and rely on various plant protein sources, which frequently display incomplete amino acid (AA) profiles that do not reflect dietary requirements due to low quantities of one or more essential AA (EAA). There is little insight in the AA profiles of most of these plant-based analogues. We assessed the AA composition of forty plant-based meat and dairy analogues that were commercially available in The Netherlands in March 2023 and compared their EAA profile to dietary requirements and to the EAA profile of their meat and dairy counterparts. Total protein contents were lower in most analogues when compared with their animal-based counterparts (meat analogues, n 16 (80 %); lunch meats and cheese analogues, n 10 (100 %); milk and yoghurt analogues, n 9 (90 %)) and accompanied by lower EAA contents. In reference to dietary requirements, the sum of the total EAA contents was adequate in all but one of the analogues. Nevertheless, all analogues displayed deficiencies in one or more specific EAA. Methionine contents were most frequently low (n 39; 98 %), followed by lysine contents (n 11; 28 %). Essential AA compositions varied between analogues irrespective of the protein source(s) used. In conclusion, plant-based meat and dairy analogues exhibit incomplete EAA profiles, which may compromise adequate protein nutrition in plant-centred diets.
We define the generalized equilibrium distribution, that is the equilibrium distribution of a random variable with support in $\mathbb{R}$. This concept allows us to prove a new probabilistic generalization of Taylor’s theorem. Then, the generalized equilibrium distribution of two ordered random variables is considered and a probabilistic analog of the mean value theorem is proved. Results regarding distortion-based models and mean-median-mode relations are illustrated as well. Conditions for the unimodality of such distributions are obtained. We show that various stochastic orders and aging classes are preserved through the proposed equilibrium transformations. Further applications are provided in actuarial science, aiming to employ the new unimodal equilibrium distributions for some risk measures, such as Value-at-Risk and Conditional Tail Expectation.