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This review summarises findings from studies in companion animals with chronic diseases receiving omega-3 supplementation. Investigated conditions included dermatopathies (dogs n = 7), osteoarthritis (dogs n = 7, cats n = 2), cardiovascular diseases (dogs n = 7), dyslipidaemias (dogs n = 1), gastroenteropathies (dogs n = 2), chronic kidney disease (dogs n = 2, cats n = 3), cognitive impairment (dogs n = 4, cats n = 1), and behavioural disorders (dogs n = 3). When possible, dosages were standardised to mg/kg using available data on food intake and EPA/DHA concentrations. The minimum and maximum ranges of EPA and DHA, along with their ratios, were as follows: for dermatology 0·99–43 mg/kg EPA and 0·66–30 mg/kg DHA (ratio 1·4–3·4); for osteoarthritis 48–100 mg/kg EPA and 20–32 mg/kg DHA (ratio 1·5–3·4); cardiology 27–54·2 mg/kg EPA and 18–40·6 mg/kg DHA (ratio 1·3–1·5); dyslipidaemia 58·8 mg/kg EPA and 45·4 mg/kg DHA (ratio 1·3); cognition (1/5 studies) 225 mg/kg EPA and 90 mg/kg DHA (ratio 2·5); behaviour (1/3) 31 mg/kg EPA and 45 mg/kg DHA (ratio 0·7). Nephrology and oncology studies lacked sufficient data for calculation. Gastrointestinal diseases do not appear to benefit from omega-3 supplementation, likely due to inflammation-related malabsorption, although few adverse effects were reported in dogs. Other enteropathy studies were low-quality (case reports/series). The lowest omega-6/omega-3 ratio with anti-inflammatory effect was 1:3·75, and the highest was 5·5:1. In conclusion, the reviewed EPA and DHA doses appear effective for atopic dermatitis, osteoarthritis, cardiac disease, hyperlipidaemia, and cognitive and behavioural disorders. Further research is needed to clarify efficacy in gastrointestinal and oncological conditions.
Aspectual verbs with infinitival complements are often considered ambiguous when it comes to the question of whether they should be classified as raising or control verbs. In present-day German, argument structure properties seem to favor a raising analysis, but arguments for a control analysis cannot be dismissed. Word order properties do not provide conclusive evidence either and seem to support the ambiguity of aspectual verbs in present-day German. However, new diachronic evidence on word order properties of infinitival complements in uncontested raising and control constructions shows that well-established word order differences between raising and control constructions are a fairly recent development in the history of infinitival constructions (De Cesare 2021): Until about the mid eighteenth century, infinitival complements of both raising and control verbs tend to precede the finite verb in final position, with the preference of control verbs for extraposition developing only later. In present-day German, the extraposition of infinitival complements is considered a strong criterion for the sentential nature of the postposed infinitive and thus of the biclausal structure of the infinitival pattern, at least since the influential work of Bech (1983). In the present article, we look into the word order properties of ingressive aspectualizers over time and evaluate them against the emergence of a systematic distinction of raising and control verbs in the recent history of German, aiming at a deeper understanding of the syntactic behavior of aspectual verbs in present-day German.
This study investigated the temporal and spatial variability of temperature, salinity, pH and suspended particulate matter (SPM) in surface water from Admiralty Bay, Antarctic Peninsula. The study aimed to understand how water parameters were affected during high meltwater runoff in the summer of 2019/2020, to verify the influence of rapid temperature changes from the spring and summer of 2022/2023 and to identify the sources of SPM. In January 2020, the water temperature and salinity in the region were influenced by rapid shifts in environmental conditions, while pH and SPM remained similar to previous years. The same pattern was observed in the summer of 2022/2023, with only water temperature and salinity varying towards the end of the summer. The SPM concentrations were mainly influenced by wind speed. Spatially, there was no sectorization between different inlets, with specific sites influenced by meltwater and higher SPM values. The study suggests that strong winds are the primary factor influencing SPM resuspension in Admiralty Bay, with atmospheric deposition and meltwater also contributing. This dynamic variability in the water column highlights the need to closely monitor the water’s physicochemical parameters and the influence of atmospheric conditions. This study contributes to our understanding of the SPM sources on the Antarctic coast.
The Brazilian Worker’s Food Program (WFP) is a public policy initiative that focuses on nutritional assistance for low-income formal workers (less than five minimum wages). Currently, it serves more than 25 million formal workers (around 54%). This systematic review aimed to assess the nutritional quality of meals offered and/or consumed by beneficiaries of the WFP. Observational studies conducted with workers from companies registered in the programme were eligible, with no restrictions on the period of publication. The nutritional quality was assessed according to the guidelines of the programme (Normative Ordinance No. 66/2006). Twenty cross-sectional studies and one cohort study met the inclusion criteria. Most of the participants were male, from manufacturing industries, and their average age was 35.0 years. The results of the analysis showed that fibre, sodium, calories, and proteins were the nutrients that most exceeded the recommended amounts, whereas carbohydrate was the nutrient that had the least amount. The results showed that the nutritional quality of the food offered to or consumed by workers did not fully meet the required guidelines and, in some companies, did not promote an adequate and healthy diet. The WFP has great potential and needs to be reformulated to make it a programme that contributes to strengthening the realisation of the human right to adequate food.
The development of new papaya cultivars with high genetic potential for production, combined with quality traits that meet the demands of emerging markets, facilitates the expansion of the genetic base, reduces production costs, and broadens papaya cultivation. This study continues the largest Brazilian papaya breeding program, a partnership of over 25 years between UENF and Caliman Agrícola S.A. The objective was to evaluate the ability of inbred lines to generate hybrids with market potential in Brazil and for export. A total of 62 hybrids were obtained through topcross strategy. The lines were evaluated based on their specific combining ability (SCA), and the hybrids were analyzed through estimates of functional and varietal heterosis (VH) using three widely cultivated commercial varieties in Brazil: ‘UENF/CALIMAN 01’, ‘Tainung 01’, and ‘UC10’. Promising lines were identified for both hybrid creation and use as commercial varieties, exhibiting desirable traits for domestic and international markets, such as high fruit firmness and elevated soluble solids content (the lines UCLA08-053 and UCLA08-087 with the ‘Intermediate’ pattern and the lines UCLA08-066, UCLA08-122, and UCLA08-080 with the ‘Formosa’ pattern). Several hybrids, including H23, H26, H51, and H89 from the ‘Intermediate’ type and H4, H9, H19, and H68 from the ‘Formosa’ type, outperformed their parental lines and commercial varieties. These genotypes demonstrated superior SCA and VH compared to commercial controls, highlighting their strong genetic potential for the production market, increasing the shelf life of the fruits during storage and transportation, and allowing them to travel long distances without compromising fruit quality.
Fish is high in nutrients that provide a range of health benefits, but people in Great Britain only consume around half the amount that is recommended. This study analysed the demand for fish for consumption at home across different household groups in Great Britain.
Design:
Using a Rotterdam demand model, price and income elasticities were estimated for eleven fish groups across seven household groups. To investigate changes in fish demand, we decomposed growth in fish demand into income, relative price and change in taste and seasonality.
Setting:
The data used for our analysis were drawn from the Kantar Worldpanel dataset for Great Britain for the period from 2013 to 2021.
Participants:
12 492 households in Great Britain.
Results:
Families with children consistently allocated a lower share of their grocery spending on fish and preferred to purchase ready-to-use and convenient fish products, compared with households without children. Purchases of chilled fresh/smoked oily fish, canned oily fish and frozen processed fish led spending across demographic groups, whilst purchases of canned oily fish showed minimal growth. The demand for most fish products across household groups was price inelastic, indicating that the percentage change in the quantity of fish demanded increased or fell by less than the percentage change in price.
Conclusions:
Income and taste were identified as significant determinants of demand changes across all household groups, while price only played a prominent role in demand changes for certain fish groups. Thus, increasing fish consumption, especially in lower-income groups, who do not usually consume much fish, may require a different intervention than simply making fish more affordable.
This paper reports an expansion of the English as a second language (L2) component of the Multilingual Eye Movement Corpus (MECO L2), an international database of eye movements during text reading. While the previous Wave 1 of the MECO project (Kuperman et al., 2023) contained English as a L2 reading data from readers with 12 different first language (L1) backgrounds, the newly collected dataset adds eye-tracking data on English text reading from 13 distinct L1 backgrounds (N = 660) as well as participants’ scores on component skills of English proficiency and information about their demographics and language background and use. The paper reports reliability estimates, descriptive statistics, and correlational analyses as means to validate the expansion dataset. Consistent with prior literature and the MECO Wave 1, trends in the MECO Wave 2 data include a weak correlation between reading comprehension and oculomotor measures of reading fluency and a greater L1-L2 contrast in reading fluency than reading comprehension. Jointly with Wave 1, the MECO project includes English reading data from more than 1,200 readers representing a diversity of native writing systems (logographic, abjad, abugida, and alphabetic) and 19 distinct L1 backgrounds. We provide multiple pointers to new venues of how L2 reading researchers can mine this rich publicly available dataset.
The objective of the trial was to evaluate the effects of arginine supplementation in the feed of gestating sows on the variability of piglet birth weight. The weight of the piglets was evaluated using descriptive analysis, correlation analysis and analysis of variance with a 2 × 3 factorial arrangement. This arrangement included no supplementation or supplementation with 1.0 % L-arginine, combined in three periods. Period 1: from days 25 to 53 of gestation, providing 23 g/day from days 25 to 28 and 18 g/day from days 29 to 53 of gestation; period 2: from days 30 to 60 of gestation and from day 80 of gestation to farrowing, providing 18 g/day in the first period and 45 g/day in the second period and period 3: from day 85 of gestation to delivery, with 24 g/day was provided from day 85 until farrowing and 28 g/day from days 85 to 107, increasing to 56 g/day from day 108 until farrowing. Supplementation with 1.0 % of L-arginine reduced the percentage of total piglets born and piglets born alive with less than 800 g by 2.26 and 2.05 percentage points, respectively; and increased the percentage of total piglets born and piglets born alive between 1601 and 1800g by 5.89 and 6.08 percentage points, respectively. Supplementing with 1.0 % of L-arginine improves litter uniformity, with an average reduction of 4.06 percentage points in the piglet population of less than 1180 g and an increase in the piglet population of 1180 to 1890 g by 4.70 percentage points.
Agricultural monoculture negatively impacts soil quality, particularly in fragile soils that yield limited crop production and are highly susceptible to degradation. Increasing plant diversity in production systems can be an alternative for maintaining soil ecosystem services and increasing crop yields. This study investigated the influence of increased plant diversity on soil health and its impact on soybean and cotton yield in an Ultisol in the Brazilian savanna in Mato Grosso State, Brazil. Tested five rates of plant diversity after soybean harvest: (1) very low (VL), (2) low, (3) average, (4) long-term average and (5) high (integrated crop–livestock systems (ICLS)) were tested. Plant diversity improves the health of sandy loam soil, increases C and N fractions in particulate organic matter (POM-C and POM-N) and leads to differences in C utilization by the soil microbial community. High ICLS diversity raises total organic carbon content, being POM-C and POM-N, the labile fractions, more efficient to show changes in sandy loam soil, in the short term, over a period of three years. High diversity promoted yield gains of up to 251 % for cotton and 82 % for soybean in relation to VL plant diversity. Changes in soil microbial composition are able to partially explain crop yield in diversified production systems (R2 ranging from 0.51 to 0.80). Diversifying production components is a sustainable way to maintain biological functions and agricultural quality of loam sandy soil in the Brazilian Cerrado in Mato Grosso.
Antidepressants’ effects are established in randomised controlled trials (RCTs), but not in the real world.
Aims
To investigate real-world comparative effects of antidepressants for depression and compare them with RCTs.
Method
We performed a cohort study based on the QResearch database. We included people with a newly recorded diagnosis of depression, exposed to licensed antidepressants in the UK. We assessed all-cause dropouts (acceptability), dropouts for adverse events (tolerability), occurrence of at least one adverse event (safety), and response and remission on the Patient Health Questionnaire (PHQ)-9 (effectiveness) at 2 and 12 months. Logistic regressions were used to compute adjusted-odds ratio (aOR) with 99% CIs, assessing the associations between exposure to each antidepressant against fluoxetine (comparator) and outcomes of interest. We compared estimates from the real world with RCTs using ratio-of-odds ratio (ROR) with 95% CI.
Results
A total of 673 177 depressed people were studied: females 57.1%, mean age 42.8 (s.d. 17.7) years, mean baseline PHQ-9 17.1 (s.d. 5.0) (moderately severe depression). At 2 months, antidepressant acceptability was 61.4%, tolerability 94.4%, safety 54.5%, PHQ-9 decreased to 12.3 (s.d. 6.5). At 12 months, acceptability was 12.3%, tolerability 87.5%, safety 28.8%, PHQ-9 12.9 (s.d. 6.8). In the short and long term, tricyclics, mirtazapine and trazodone were worse than fluoxetine for most outcomes; citalopram had better acceptability than fluoxetine (aOR 0.95; 99% CI 0.92, 0.97), sertraline had lower tolerability (aOR 1.12; 99% CI 1.06, 1.18), and both citalopram and sertraline had lower safety (aOR 1.17 and 1.25, respectively). In the long term, citalopram had better acceptability (aOR 0.78; 99% CI 0.76, 0.81) and effectiveness (aOR 1.12 for both response and remission), but worse tolerability (aOR 1.09; 99% CI 1.06, 1.13) and safety (aOR 1.12; 99% CI 1.08, 1.16). Observational and randomised data were similar for citalopram and sertraline, while there was some difference for drugs less prescribed in the real world.
Conclusions
Antidepressants showed low acceptability, moderate-to-high tolerability and safety, and small-to-moderate effectiveness in the real world. Real-world and RCT estimates showed similar findings only when the analyses were carried out using large datasets; otherwise, the results diverged.
The semiarid northeast coast of Brazil harbours just less than 44,300 ha of mangroves, 4% of Brazilian total. Notwithstanding this relatively small area, these forests have high ecological and economic importance, sustaining traditional fisheries and protecting biodiversity, including many threatened species. They present unique biogeochemical characteristics resulting in distinct ecosystem functioning compared to mangroves located in humid areas. Semiarid mangroves present lower aboveground biomass compared to humid region mangroves but show similar belowground biomass. Whereas mangrove soils in humid areas are strongly influenced by sulphate reduction, iron geochemistry is a primary driver of soil characteristics in semiarid mangrove soils, suggesting different responses to climate change drivers between them. Although legally protected, they have incurred continuous degradation due to regional drivers, mostly aquaculture and river damming, which differs from those in humid coast mangroves. Semiarid mangroves are also particularly sensitive to drivers associated with global climate change (high temperatures, reduced rainfall and sea level rise). These conditions occur at a global scale; however, the impacts are worsened by the natural conditions of semiarid coastlines, which already provide biologically stressful conditions for mangroves. This article compares the impacts of such drivers in semiarid mangroves with those of humid mangroves, focusing on their biogeochemical response and eventual rehabilitation.
This Research Communication describes the frequency of occurrence of P. fluorescens, P. putida and P. aeruginosa in raw goat milk stored at 4 and 9°C, to evaluate the spoilage potential and capacity of these species and the presence of the aprX gene, responsible for the synthesis of metalloprotease aprX. Samples of raw goat milk stored at 4 and 9°C for 72 h were plated on Pseudomonas CFC agar base (25°C for 48 h). The presence of P. fluorescens, P. putida, P. aeruginosa and aprX gene were confirmed by polymerase chain reaction. The isolates were evaluated for their proteolytic and lipolytic spoilage capacity and potential using milk agar (10%) and tributyrin agar base (1%), respectively (21°C for 72 h). A total of 184 strains of Pseudomonas spp. were obtained. At both temperatures, P. fluorescens was the most frequent, mostly proteolytic, and the only one to express high proteolytic and lipolytic potentials. Regardless of the temperature, all isolated strains of P. putida were lipoproteolytic, with a predominance of protease synthesis. Strains of P. aeruginosa (4,3%) were isolated occasionally (4.3% of total isolates) but only at 4°C, and 75% of these were lipoproteolytic. The storage temperature of raw goat milk influenced the frequency of P. aeruginosa, but not its spoilage potential. The presence of the aprX gene was verified in most strains isolated from all species at the two temperatures evaluated, although some of these strains did not express proteolytic capacity. Most isolates of Pseudomonas spp. showed lipoproteolytic capacity, which emphasizes the importance of ensuring low initial populations of this genus in raw chilled goat milk when it is used to produce dairy products.
The symbiotic relationship between the syllid polychaete, Haplosyllides floridana Augener, 1922, and the barrel-shaped sponge Xestospongia muta (Schmidt, 1870), originally documented solely in the Caribbean, is presumed to be species-specific. Recently, the host sponge has been found as a single species distributed across approximately 8000 km (from 26°N to 22°S). Herein we addressed new spatial and bathymetric population records of H. floridana to question the persistence of the association with X. muta, and whether, in the case of an association, the polychaete remains as a single species throughout this extensive distribution. Our findings change the restricted distribution of H. floridana, revealing a remarkable association with X. muta from Tropical north-western to south-western Atlantic including records in the Fernando de Noronha Archipelago and the Almirante Saldanha Seamount, at 270 m deep. The populations analysed in this study are morphologically consistent. The study underscores the need for further investigations into the connectivity of Xestospongia species, the presence of Haplosyllides in other ocean basins, and the shared evolutionary history between Xestospongia and Haplosyllides. The observed life cycle completion of H. floridana within the host sponge suggests a potential co-evolutionary relationship, offering insights into the intricate dynamics of symbiotic associations in marine ecosystems.
‘Sound, Image and Motion’ (SIM) is a unique interdisciplinary programme in Brazilian higher education, blending visual arts, audiovisual and sound creation. We start with a brief historical overview of avant-garde traditions in Bahia and delve into the university’s principles and guiding plan in order to situate SIM among art courses and its available resources. We explore its flexible curriculum in detail, considering the limitations posed by a new university with scarce resources, and describe the curricular structure to analyse experiences with teaching and constructing an interdisciplinary sound creation qualification within this programme.
The use of side-rails from the headboard to the foot of both sides of the bed (from now on “the rails”) is the most used tool to prevent falls in our hospital setting. However, its consideration as physical restraint in the different international consensus is not clear. In the GERBAR study (NCT04861025), we intend to evaluate the perception of the rails as a measure of physical restraint, both by hospitalized users and by the health personnel who care for them. The trial is being performed at the Consorci Sanitari Alt Penedes-Garraf, CSAPG (Barcelona, Spain). In this report we show partial results of the data obtained from the health personnel belonging to Nursing Department.
Methods:
An online poll has been carried out through the intranet and corporate emails in the last two months of 2022. All the people who works as health personnel at the CSAPG (1652 people) have been invited to this poll.
Results:
We obtained a total of 246 responses, of which 27 responses have been removed for not being completed correctly. 152 responses were made by health personnel attached to the Nursing Department: 72 auxiliary nursing personnel (15.38% of the total CSAPG professionals in this professional group) and 80 nurses (14.47%). Proportion of job seniority greater than two years was 74.34% (69.44% auxiliary personnel, 78.75% nurses). 91.67% have been women with a median age of 40.87 years. 46.40% of this sample does not considered the rails as physical restraints (50% auxiliary personnel and 41.25% nurses). When analyzing by job seniority, 48.72% of the professionals with <2 years of seniority does not consider the rails as a physical restraint (44.25% in those with >=2 years). Professional group and job seniority were not significantly associated with perception of the rails as a physical restraint (chi-square 1.17, p 0.2793 for professional group and chi-square 0.23, p 0.6288 for job seniority).
Conclusion:
An important proportion of health professional belonging to Nursing Department does not consider the rails as a physical restraint. This perception was not related to the professional group or job seniority.
Highly weathered soils of the humid tropics generally provide a poor mineral reserve of potassium (K), but evidence has been found which indicates that even in such soils non-exchangeable forms of K can be made plant available and this warrants further investigation. The objective of this study was, therefore, to determine the extent to which K can be released from poorly available reserves over a long period of time. The focus was on an Oxisol in southern Brazil cultivated for 32 years with a rotation of soybeans (Glycine max L.), maize (Zea mays L.), wheat (Triticum aestivum L.), and oats (Avena strigosa L.) with and without K fertilization. Mineral sources of K were identified by X-ray diffraction and by sequential chemical extraction from the clay fraction. The amounts of K-bearing mineral species and the amounts of total and plant-available K were quantified, then the effects of the long-term K-fertilization regime on these values were evaluated. The clay fraction was dominated by hematite, gibbsite, and phyllosilicates such as kaolinite. These minerals were unaffected by the K deprivation in the cropping systems, but in the clay fraction the absence of K fertilization for 32 years reduced the structural order of the 2:1 phyllosilicates associated with K reserves. This effect was most prominent in the root zone of the soil. Deprivation of K for more than three decades decreased the crystallinity of 2:1 phyllosilicates, which could be better evaluated from XRD patterns after the removal of kaolinite and Fe (oxyhydr)oxides. The K-free cultivation reduced the amounts of total soil K by increasing the depletion of K from pools that typically are poorly accessible to plants.