The dissemination of Escherichia coli producing extended-spectrum beta-lactamase (ESBL-Ec) is evident in the community. A population-based spatial analysis is necessary to investigate community risk factors for ESBL-Ec occurrence. The study population was defined as individuals with ESBL-Ec isolated in Queensland, Australia, from 2010 to 2019. Choropleth maps, global Moran's index and Getis-Ord Gi* were used to describe ESBL-Ec distribution and identify hot spots. Multivariable Poisson regression models with or without spatially structured random effects were performed. A total of 12 786 individuals with ESBL-Ec isolate were identified. The crude incidence rate increased annually from 9.1 per 100 000 residents in 2010 to 49.8 per 100 000 residents in 2019. The geographical distribution of ESBL-Ec changed from random to clustered after 2014, suggesting presence of community-specific factors that can enhance occurrence. Hot spots were more frequently identified in Outback and Far North Queensland, future public health measures to reduce transmission should prioritise these communities. Communities with higher socioeconomic status (RR = 0.66, 95% CI 0.55–0.79, per 100 units increase) and higher proportion of residents employed in the agricultural industry (RR = 0.79, 95% CI 0.67–0.95, per 10% increase) had lower ESBL-Ec incidence. Risk factors for occurrence appear differential between remote and city settings and this should be further investigated.

There is limited information on the volume of antibiotic prescribing that is influenza-associated, resulting from influenza infections and their complications (such as streptococcal pharyngitis). We estimated that for the Kaiser Permanente Northern California population during 2010–2018, 3.4% (2.8%–4%) of all macrolide prescriptions (fills), 2.7% (2.3%–3.2%) of all aminopenicillin prescriptions, 3.1% (2.4%–3.9%) of all 3rd generation cephalosporins prescriptions, 2.2% (1.8%–2.6%) of all protected aminopenicillin prescriptions and 1.3% (1%–1.6%) of all quinolone prescriptions were influenza-associated. The corresponding proportions were higher for select age groups, e.g. 4.3% of macrolide prescribing in ages over 50 years, 5.1% (3.3%–6.8%) of aminopenicillin prescribing in ages 5–17 years and 3.3% (1.9%–4.6%) in ages <5 years was influenza-associated. The relative contribution of influenza to antibiotic prescribing for respiratory diagnoses without a bacterial indication in ages over 5 years was higher than the corresponding relative contribution to prescribing for all diagnoses. Our results suggest a modest benefit of increasing influenza vaccination coverage for reducing prescribing for the five studied antibiotic classes, particularly for macrolides in ages over 50 years and aminopenicillins in ages <18 years, and the potential benefit of other measures to reduce unnecessary antibiotic prescribing for respiratory diagnoses with no bacterial indication, both of which may contribute to the mitigation of antimicrobial resistance.

This study compared clinico-epidemiological characteristics between Japanese and non-Japanese coronavirus disease 2019 (COVID-19) patients under the pandemic in Japan. We retrospectively analysed nationwide data of hospitalised COVID-19 patients before 31 March 2021. Epidemic curves were constructed to identify the case distribution over time. A total of 28 093 patients were Japanese and 1335 patients were non-Japanese. The major racial and ethnic minorities were East Asians (n = 521), South Asians (n = 260) and Latin Americans (n = 270). Non-Japanese patients were younger and more likely to travel to COVID-19 endemic countries (7.7%), had meals with other people (17.8%), stayed in crowded places (17.9%) and worked mainly in restaurants (6.6%) and service facilities in nightlife businesses (5.2%). In the matched cohorts, we found no clear disparities in time to admission and clinical prognoses. The epidemic curve for non-Japanese patients showed a small peak in the first wave and no definite waves for the second or third waves. Racial and ethnic minorities were at less risk of severe disease but were at a greater risk of COVID-19 exposure; however, the healthcare system in Japan may provide them with equal opportunities to access inpatient care with Japanese. Further research on their social determinants of health in Japan is required.

Nigeria commenced its national foundational digital identity project in 2007 and had enrolled 60 million people by July 2021. The project, led by the National Identity Management Commission (NIMC), seeks to unify the country’s public and private functional identity databases, and aims to improve government services and national security. Although the enrolment process had encountered initial challenges such as the absence of enrolment centers in some communities across the country, enrolment for the biometric ID had proceeded without any significant public objection to its objectives. Following the EndSARS protests of October 2020, where youths protesting police violence and perceived poor governance were shot at by government security forces and protesters placed under surveillance, the government announced an updated national identity policy mandating citizens link their National Identity Number (NIN) with their SIM card information. For the first time, significant pockets of resistance arose against the national ID project by sections of the public who perceived the EndSARS violence as signaling a change in government behavior, and the updated ID policy as a mechanism for empowering government surveillance and authoritarianism. The resistance to the ID project marked a shift in public perception which threatens its future. This paper argues that mistrust in government data collection projects grows when data collection is perceived to be increasing government power to the detriment of human rights and freedom. It also puts forward a proposal on how to restore trust within the low-trust environment in Nigeria including the passage of a data protection law and amendments to the NIMC Act and Policies/Regulations, establishing Federated identity providers which give choices to end-users, and delinking the NIN from functional identity databases.

Consumption of unpasteurised milk in the United States has presented a public health challenge for decades because of the increased risk of pathogen transmission causing illness outbreaks. We analysed Foodborne Disease Outbreak Surveillance System data to characterise unpasteurised milk outbreaks. Using Poisson and negative binomial regression, we compared the number of outbreaks and outbreak-associated illnesses between jurisdictions grouped by legal status of unpasteurised milk sale based on a May 2019 survey of state laws. During 2013–2018, 75 outbreaks with 675 illnesses occurred that were linked to unpasteurised milk; of these, 325 illnesses (48%) were among people aged 0–19 years. Of 74 single-state outbreaks, 58 (78%) occurred in states where the sale of unpasteurised milk was expressly allowed. Compared with jurisdictions where retail sales were prohibited (n = 24), those where sales were expressly allowed (n = 27) were estimated to have 3.2 (95% CI 1.4–7.6) times greater number of outbreaks; of these, jurisdictions where sale was allowed in retail stores (n = 14) had 3.6 (95% CI 1.3–9.6) times greater number of outbreaks compared with those where sale was allowed on-farm only (n = 13). This study supports findings of previously published reports indicating that state laws resulting in increased availability of unpasteurised milk are associated with more outbreak-associated illnesses and outbreaks.

Border artificial intelligence (AI)—biometrics-based AI systems used in border control contexts—proliferates as common tools in border securitization projects. Such systems classify some migrants as posing risks like identity fraud, other forms of criminality, or terrorism. From a human rights perspective, using such risk framings for algorithmically facilitated evaluations of migrants’ biometrics systematically calls into question whether these kinds of systems can be built to be trustworthy for migrants. This article provides a thought experiment; we use a bottom-up responsible design lens—the guidance-ethics approach—to evaluate if responsible, trustworthy Border AI might constitute an oxymoron. The proposed European AI Act only limits the use of Border AI systems by classifying such systems as high risk. In parallel with these AI regulatory developments, large-scale civic movements have emerged throughout Europe to ban the use of facial recognition technologies in public spaces to defend EU citizens’ privacy. The fact that such systems remain acceptable for states’ usage to evaluate migrants, we argue, insufficiently protects migrants’ lives. In part, we argue that this is due to regulations and ethical frameworks being top-down and technology driven by focusing more on the safety of AI systems than on the safety of migrants. We conclude that bordering technologies developed from a responsible design angle would entail the development of entirely different technologies. These would refrain from harmful sorting based on biometric identifications but would start from the premise that migration is not a societal problem.

We study generalizations of the forest fire model introduced in [4] and [10] by allowing the rates at which the trees grow to depend on their location, introducing long-range burning, as well as a continuous-space generalization of the model. We establish that in all the models in consideration the expected time required to reach a site at distance x from the origin is of order $(\!\log x)^{(\!\log2)^{-1}+\delta}$ for any $\delta>0$.

We prove that for a discrete determinantal process the BK inequality occurs for increasing events generated by simple points. We also give some elementary but nonetheless appealing relationships between a discrete determinantal process and the well-known CS decomposition.

Limited prospective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) data in children regarding the impact of Omicron variant in seropositivity have been reported. We investigated SARS-CoV-2 seropositivity in children between 1 September 2021 and 30 April 2022, representing Delta and Omicron predominance periods. Serum samples from children admitted to the major tertiary Greek paediatric hospital for any cause, except for COVID-19, were randomly collected and tested for SARS-CoV-2 natural infection antibodies against nucleocapsid antigen (Elecsys® Anti-SARS-CoV-2 reagent). A total of 506/1312 (38.6%) seropositive children (0–16 years) were detected (males: 261/506(51.6%); median age (IQR): 95.2 months(24–144)). Seropositivity rates (%) increased from Delta to Omicron period from 29.7% to 48.5% (P-value<0.0001). Seropositivity increased for all age groups, except for the age group of 0–1 year (P-value:0.914). The highest seropositivity rate was detected in April 2022 (52.6%) and reached 73.9% specifically for the age group 12–16 years. No significant differences were detected in seropositivity with respect to gender, origin, or hospitalisation status. Median (IQR) antibody titres were higher in the Omicron vs. Delta period in all age groups, especially in 12–16 years [32.2 COI (7–77.1) vs. 11.4 COI(2.8–50.2), P-value:0.009). During Omicron variant period increased SARS-CoV-2 seropositivity was detected in paediatric population, especially in adolescents, implicating either increased transmissibility or reinfection rates.

The Guillain-Barré syndrome (GBS) has been previously associated with Zika virus infection. We analysed the data from all the patients with GBS diagnosis that were admitted to a referral hospital, in Tapachula City during the period from January 2013 to August 2016, comparing the incidence of GBS according to the temporality of the Zika outbreak in Southern Mexico. Additionally, we described the clinical and epidemiological characteristics of the GBS patients admitted before or after the Zika outbreak. We observed a sharp increase in the number of patients hospitalised due to GBS from the time the first confirmed Zika cases appeared in Mexico. Clinically we observed GBS cases before zika outbreak had more frequently history of respiratory/gastrointestinal symptoms and GBS during zika outbreak had significantly more frequently recent history of rash/conjunctivitis. Although we cannot affirm that the increased cases of GBS have a specific aetiologic association with Zika, our results suggest that this observed outbreak of in Tapachula, might have been associated to the emerging Zika epidemic, locally and suggests that rare complications associated with acute infections (such as GBS) might be useful in the surveillance systems for emerging infections.

Digital image correlation (DIC) techniques were used to evaluate strain distributions along tensile gage lengths immediately after yielding of a medium manganese steel (7 wt% Mn) in samples cold rolled in the range of 1–6 pct. With an increase in cold work, DIC confirmed that the yielding behavior transitioned from nucleation and propagation of a single localized deformation zone (Lüders band) to uniform deformation, that is, no evidence of strain localization. At intermediate amounts of cold work, a unique yielding behavior was evident where the initially-low positive strain hardening rate increased with tensile strain until conventional strain hardening (i.e., decrease in strain hardening rate with strain). The intermediate yielding behavior was associated with the development of multiple non‑propagating regions of strain localization, an observation not previously evident without the use of DIC.

This paper investigates how socio-spatial aspects of creativity, operationalized as the causal relations between the built environment and perceived creativity in university campuses’ public spaces, are currently applied in practice. Moreover, it discusses practitioners’ perceptions regarding research-generated evidence on socio-spatial aspects of creativity according to three effectiveness aspects: credibility, relevance, and applicability. The “research-generated evidence” is herein derived from data-driven knowledge generated by multi-disciplinary methodologies (e.g., self-reported perceptions, participatory tools, geospatial analysis, observations). Through a thematic analysis of interviews with practitioners involved in the (re)development of campuses public spaces of inner-city campuses and science parks in Amsterdam, Utrecht, and Groningen. We concluded that socio-spatial aspects of creativity concepts were addressed only at the decision-making level for Utrecht Science Park. Correspondingly, while presented evidence was considered by most practitioners as relevant for practice, perceptions of credibility and applicability vary according to institutional goals, practitioners’ habits in practice, and their involvement in projects’ roles and phases. The newfound interrelationships between the three effectiveness aspects highlighted (a) the institutional fragmentation issues in campuses and public spaces projects, (b) the research-practice gap related to such projects, which occur beyond the university campuses’ context, and (c) insights on the relationship between evidence generated through research-based data-driven knowledge and urban planning practice, policy, and governance related to knowledge environments. We concluded that if research-generated evidence on socio-spatial aspects of creativity is to be integrated into the evidence-based practice of campuses’ public spaces, an alignment between researchers, multiple actors involved, policy framing, and goal achievements are fundamental.

Let $V$ be a finite-dimensional vector space over $\mathbb{F}_p$. We say that a multilinear form $\alpha \colon V^k \to \mathbb{F}_p$ in $k$ variables is $d$-approximately symmetric if the partition rank of difference $\alpha (x_1, \ldots, x_k) - \alpha (x_{\pi (1)}, \ldots, x_{\pi (k)})$ is at most $d$ for every permutation $\pi \in \textrm{Sym}_k$. In a work concerning the inverse theorem for the Gowers uniformity $\|\!\cdot\! \|_{\mathsf{U}^4}$ norm in the case of low characteristic, Tidor conjectured that any $d$-approximately symmetric multilinear form $\alpha \colon V^k \to \mathbb{F}_p$ differs from a symmetric multilinear form by a multilinear form of partition rank at most $O_{p,k,d}(1)$ and proved this conjecture in the case of trilinear forms. In this paper, somewhat surprisingly, we show that this conjecture is false. In fact, we show that approximately symmetric forms can be quite far from the symmetric ones, by constructing a multilinear form $\alpha \colon \mathbb{F}_2^n \times \mathbb{F}_2^n \times \mathbb{F}_2^n \times \mathbb{F}_2^n \to \mathbb{F}_2$ which is 3-approximately symmetric, while the difference between $\alpha$ and any symmetric multilinear form is of partition rank at least $\Omega (\sqrt [3]{n})$.

Let $A \subseteq \{0,1\}^n$ be a set of size $2^{n-1}$, and let $\phi \,:\, \{0,1\}^{n-1} \to A$ be a bijection. We define the average stretch of $\phi$ as

\begin{equation*} {\sf avgStretch}(\phi ) = {\mathbb E}[{{\sf dist}}(\phi (x),\phi (x'))], \end{equation*}

$x,x' \in \{0,1\}^{n-1}$

In this paper, we continue the line of research studying mappings on the discrete hypercube with small average stretch. We prove the following results.

• For any set $A \subseteq \{0,1\}^n$ of density $1/2$ there exists a bijection $\phi _A \,:\, \{0,1\}^{n-1} \to A$ such that ${\sf avgStretch}(\phi _A) = O\left(\sqrt{n}\right)$.

• For $n = 3^k$ let ${A_{\textsf{rec-maj}}} = \{x \in \{0,1\}^n \,:\,{\textsf{rec-maj}}(x) = 1\}$, where ${\textsf{rec-maj}} \,:\, \{0,1\}^n \to \{0,1\}$ is the function recursive majority of 3’s. There exists a bijection $\phi _{{\textsf{rec-maj}}} \,:\, \{0,1\}^{n-1} \to{A_{\textsf{rec-maj}}}$ such that ${\sf avgStretch}(\phi _{{\textsf{rec-maj}}}) = O(1)$.

• Let ${A_{{\sf tribes}}} = \{x \in \{0,1\}^n \,:\,{\sf tribes}(x) = 1\}$. There exists a bijection $\phi _{{\sf tribes}} \,:\, \{0,1\}^{n-1} \to{A_{{\sf tribes}}}$ such that ${\sf avgStretch}(\phi _{{\sf tribes}}) = O(\!\log (n))$.

These results answer the questions raised by Benjamini, Cohen, and Shinkar (Isr. J. Math 2016).

We revisit the problem of estimating the spot volatility of an Itô semimartingale using a kernel estimator. A central limit theorem (CLT) with an optimal convergence rate is established for a general two-sided kernel. A new pre-averaging/kernel estimator for spot volatility is also introduced to handle the microstructure noise of ultra high-frequency observations. A CLT for the estimation error of the new estimator is obtained, and the optimal selection of the bandwidth and kernel function is subsequently studied. It is shown that the pre-averaging/kernel estimator’s asymptotic variance is minimal for two-sided exponential kernels, hence justifying the need of working with kernels of unbounded support. Feasible implementation of the proposed estimators with optimal bandwidth is developed as well. Monte Carlo experiments confirm the superior performance of the new method.

Regularized quantile regression (QR) is a useful technique for analyzing heterogeneous data under potentially heavy-tailed error contamination in high dimensions. This paper provides a new analysis of the estimation/prediction error bounds of the global solution of $L_1$-regularized QR (QR-LASSO) and the local solutions of nonconvex regularized QR (QR-NCP) when the number of covariates is greater than the sample size. Our results build upon and significantly generalize the earlier work in the literature. For certain heavy-tailed error distributions and a general class of design matrices, the least-squares-based LASSO cannot achieve the near-oracle rate derived under the normality assumption no matter the choice of the tuning parameter. In contrast, we establish that QR-LASSO achieves the near-oracle estimation error rate for a broad class of models under conditions weaker than those in the literature. For QR-NCP, we establish the novel results that all local optima within a feasible region have desirable estimation accuracy. Our analysis applies to not just the hard sparsity setting commonly used in the literature, but also to the soft sparsity setting which permits many small coefficients. Our approach relies on a unified characterization of the global/local solutions of regularized QR via subgradients using a generalized Karush–Kuhn–Tucker condition. The theory of the paper establishes a key property of the subdifferential of the quantile loss function in high dimensions, which is of independent interest for analyzing other high-dimensional nonsmooth problems.