To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
In 2019 we published the extensive review paper ‘Petawatt and exawatt class lasers worldwide’ in High Power Laser Science and Engineering. We are delighted that the review has achieved over 1000 citations on Google Scholar and over 750 on Web of Science. We take this opportunity to reflect on the current state of the field.
The objective of this study was to develop, implement, and refine a food environment survey to capture people’s perceptions of their food environments in low-and middle-income countries: the Food Environment Perceptions Survey (FEPS).
Design:
Identifying aspects of food environment to include: drawing from existing survey instruments; a Delphi survey with food environment experts working globally; workshops with local experts in India and Cambodia; cognitive testing of the survey items; and piloting the tools in diverse field settings in India and Cambodia.
Setting:
Rural, peri-urban, and urban communities in India and Cambodia.
Participants:
Global food environment experts for Delphi survey; food environment experts in India and Cambodia for workshops; convenience sample of participants in India (n=44) and Cambodia (n=60) for FEPS piloting.
Results:
The FEPS underwent many iterations prior to piloting. The initial versions of the survey were long, leading us to remove questions and reconfigure the survey to streamline it. The workshop participants rated the revised survey versions relatively favorably. The final survey consists of 109 questions covering six sections: accessibility and availability (48 questions); affordability (5 questions), convenience (17 questions); quality and safety (3 questions); information, promotion, and labeling (16 questions); and an optional sustainability section (20 questions). Based on pilot data, we found significant differences in how participants interacted with different food environment types across rural, peri-urban, and urban transects.
Conclusions:
The finalized FEPS is a newly developed survey instrument that can be incorporated by other researchers to characterize diverse perceptions of food environments in LMICs.
We study the dynamic interaction of two viscous gravity currents in a confined porous layer using laboratory experiments in a vertically placed bead-packed Hele-Shaw cell. By varying the injection rate, along with the density and viscosity of the injecting and ambient fluids, these experiments cover three exact and eight approximate regimes of gravity current interaction, as identified based on the one-dimensional sharp-interface model. By superimposing the theoretically predicted profile shapes and time-dependent frontal locations, a verification is obtained in the different asymptotic regimes of viscous current interaction. Overall, fairly good agreement has been observed between the time-dependent numerical solutions and laboratory measurements on the profile shapes, particularly in the bulk region, where the aspect ratio of the interface shape is fairly large. Such an observation indicates the applicability of the sharp-interface model of viscous current interaction, including the very interesting dynamics of overriding and coflowing. However, the self-similar solutions in some of the exact regimes fail to make reasonable predictions in these experiments, presumably due to the influence of unfinished time transition. We have also observed some degree of disagreement in the frontal regions, which is likely due to the influence of fluid mixing, two-dimensional flow, local heterogeneity and the development of hydrodynamic instabilities for the viscously unstable experiments. The theoretical predictions of the model problem, along with the laboratory experimental observations, offer useful insights into the potential application of, e.g. the technology of co-flooding CO$_2$ and water in oil fields for the co-profits of geological CO$_2$ sequestration and enhanced oil recovery.
This article derives analytical expressions fully describing laminar flow through concentric pipe-within-pipe set-ups, focusing on scenarios where one tube is pressure driven, and the other serves as a lubricant. Both fluid zones are axially unbounded, therefore excluding recirculation, and are connected along longitudinal infinite slits situated on the inner pipe wall, representing fluid–fluid interfaces. Crucially, the viscous interaction along these interfaces is captured by means of a local slip length, for which explicit formulae are provided, allowing a straightforward evaluation. With that, these models provide a full description of the velocity field for slippery concentric pipes, taking into account the viscosity ratio of both fluids and the overall geometry, therefore extending beyond the common assumption of perfect slip applied to superhydrophobic surfaces. Thereby, they enable a precise analysis of the flow, offering important tools to decipher the intricate dynamics of the two coupled fluids within such set-ups. As a result, the insights acquired contribute to the design and optimisation of superhydrophobic and liquid-infused surfaces, with implications for numerous engineering applications such as microfluidic contactors or drag reduction. The analytical models are in excellent agreement with numerical simulations, thus confirming the selected approach. Therefore, our study further illustrates an effective methodology to derive additional analytical models through the presented mathematical techniques, which can serve as a useful template for modelling such surfaces.
This comment examines the rapidly evolving ecosystem of historical research data in the United Kingdom, where cultural heritage collections are increasingly digitised, commercialised and fragmented. Historians face growing challenges in discovering, accessing and reusing data as resources move behind paywalls, and repositories remain scattered, without a national infrastructure to ensure long-term preservation or discoverability. Drawing on examples from major digital initiatives, we analyse the life cycle of historical research data and highlight the complex interplay of commercial, institutional and scholarly interests that shape access. We distinguish three types of data that emerge from historians’ typical engagements with digitised collections: derived, enhanced and aggregated data. We argue that historians must actively participate in the practices relating to the creation, maintenance and reuse of such data. This will involve new forms of citation, favouring open datasets, improving digital skills and building communities around shared resources. The comment concludes with proposals to improve discoverability, sustainability and reuse, urging the discipline to establish common standards and infrastructures to secure an equitable data commons for future research.
Distributed ledgers, including blockchain and other decentralized databases, are designed to store information online where all trusted network members can update the data with transparency. The dynamics of a ledger’s development can be mathematically represented by a directed acyclic graph (DAG). In this paper, we study a DAG model that considers batch arrivals and random delay of attachment. We analyze the asymptotic behavior of this model by letting the arrival rate go to infinity and the inter-arrival time go to zero. We establish that the number of leaves in the DAG, as well as various random variables characterizing the vertices in the DAG, can be approximated by its fluid limit, represented as the solution to a set of delayed partial differential equations. Furthermore, we establish the stable state of this fluid limit and validate our findings through simulations.
Self-regulation is central to adolescent emotional and cognitive development and deficits in self-regulation may associate with depression and anxiety. This scoping review maps the use of the Emotional Go/No-Go (EGNG), Delay Discounting Task (DDT), and Balloon Analogue Risk Task and Youth version (BART) in studies of adolescent depression and anxiety, examines consistency of task implementation, and identifies methodological and geographic gaps.
Methods:
A PRISMA-ScR–compliant search was conducted in MEDLINE (PubMed), Scopus, and PsycINFO from database inception to 15 December 2025 (initial search: 1 December 2023; updated: 15 December 2025). Data were charted using a standardized form. Eligible studies included adolescents, employed EGNG, DDT, or BART, and assessed depressive or anxiety symptoms.
Results:
Thirty reports were included (EGNG n = 21; DDT n = 3; BART n = 6). Twenty-six studies (87%) were conducted in high-income countries and 24 (80%) were English language. Twenty-two studies were cross-sectional (EGNG n = 18/21; DDT n = 2/3; BART n = 2/6); five employed longitudinal designs, and two employed experimental manipulations. Fourteen studies (47%) reported significant task performance associations with depression or anxiety (EGNG n = 8/21; DDT n = 2/3; BART n = 4/6); remaining studies reported no significant associations. The directionality of associations differed across study populations and methodologies.
Conclusion:
The current literature is concentrated in English-speaking higher-income contexts and has yielded few and inconsistent associations with adolescent depression and anxiety. Future research should harmonize protocols, expand evidence from low- and middle-income settings, and increase longitudinal and intervention-based studies to assess sensitivity to change and clinical utility.
This article offers a response of hope to the metacrisis. Because of modernity’s philosophical premises, particularly Enlightenment concepts that separated humanity from nature, modern approaches to environmental challenges embrace a dualistic schism between culture and nature, fragmenting understanding through the compartmentalisation of knowledge. In our current situation, many feel bleak and too helpless to act. In response, we offer the experiences of Māori youth from a specific iwi (tribe) of Aotearoa New Zealand, Rongomaiwāhine. These young people speak of their holistic conceptualisation of humanity, the natural and the spiritual. Their values focus on taking responsibility for care in all realms, often through actions significant in community or land-sky-seascape settings. Their lives and ideas suggest the value of a framework grounded in Indigenous Māori philosophy from which others may learn. Thus, far from seeking new technological solutions we offer rememberings of how the ecology of relationships was and, for the rangatahi, remains. In this, the past, present and future are woven together in an understanding of the natural world of which humanity is merely a small part. The result is a hopeful framing of life in which relations of care protect ecological continuity.
Medical practitioners are among the people with a refugee or asylum seeker background to whom Australia has granted sanctuary. Yet, as the media has reported, refugee doctors (as we refer to them for convenience in this article) are often employed in low-skilled roles, rather than continuing their medical careers in Australia. Provided it is established that they are safe and competent to practise medicine, it would benefit refugee doctors, but also the community if they obtain legal entitlement to do so; Australia is presently facing major shortages of medical practitioners in certain geographical locations and fields of practice. The researchers in this study conducted semi-structured interviews with ten refugee doctors to explore their experiences in navigating the pathways for international medical graduates (‘IMGs’) to attain registration to practise medicine from the Medical Board of Australia. The study identified that refugee doctors encounter substantial challenges in this regard. A comparative analysis of the findings of this study with those of previous research reveals that, while IMGs frequently face barriers, certain obstacles appear to be unique to refugee doctors’ experiences. This article recommends specific reforms to address them.
Impaired autophagy has been implicated in the pathophysiology of neurodegenerative disorders, such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD). Consistent and replicated evidence indicate that Glucagon-like Peptide-1 Receptor Agonists (GLP-1RAs) exert treatment and preventative effects across disparate neurologic and mental disorders, potentially through mechanisms involving autophagy. This systematic review examined the effects of GLP-1RAs on autophagy in cell and animal models of AD and PD, as a proof of concept, to determine if these agents can be repurposed for the prevention and treatment of neurodegenerative and other mental disorders.
Methods:
A systematic search on PubMed, Web of Science, and OVID (Medline, Embase, and APA PsycInfo databases) was conducted from inception to June 17, 2025. Screening was performed independently by two reviewers (MCS and IH) using predefined inclusion and exclusion criteria. Subsequently, a quality assessment was conducted.
Results:
The search yielded 142 studies, of which 14 were included. Across studies, GLP-1RAs (e.g., liraglutide, semaglutide, and exendin-4) autophagy-specific markers, including beclin-1, LC3-II/LC3-I, ATG7, ATG3, and LAMP1, while normalizing p62 levels.
Discussion:
In addition to promoting neurogenesis, neuroplasticity, and reducing inflammation, GLP-1RAs appear to modulate molecular and cellular systems contributing to autophagy, potentially mediating their broad therapeutic effects. Collectively, these studies present promising findings of GLP-1RAs for neurodegenerative and mental disorders; however, further studies are required to establish their translatability to human populations.
The northeastern Arabian Peninsula has an extreme arid climate. To establish past variations in precipitation intensity during the late Quaternary, the oxygen isotope ratios (δ18O) of meteoric calcite cements of the late Quaternary aeolianites of the Ghayathi Formation in Abu Dhabi and Dubai have been analysed. The Ghayathi Formation is a carbonate-rich aeolianite, stabilised by calcite cement precipitated from rising groundwater during humid intervals. The calcite cements are well developed inside and outside a thin micrite rim of now hollow grains, formed by leaching of unstable carbonate grains. The δ18O values of cement analysed in thin sections by secondary ion mass spectrometry vary from −9.1‰ (VPDB) in coastal to +12.7‰ (VPDB) inland areas. This exceptionally wide range of the otherwise petrographically uniform aeolianite is due to the contrasts in humidity and evaporation rate between the coastal and inland areas. The δ18O values as low as −9.1‰ suggest intense precipitation in the late Quaternary, possibly due to the northward expansion of the intertropical convergence zone and intensified Indian summer monsoon. The exceptionally high values must be due to intense evaporation at low humidity in low-salinity, playa-type environments during intermittent arid intervals.
The Great Depression in 1929 had a transformative impact on Turkey. The institutions established to minimize the effects of the crisis propagated a set of statist measures. The National Economy and Savings Association and Public Press Directorate utilized photography and painting in the beginning of the 1930s to propagate those measures. In their efforts, these institutions constructed a new conception of landscape with a moral agenda: citizens and artists should travel in Anatolia to learn about the country, love it, and create art accordingly. Key to this conception was the productivity of the land. The most comprehensive cultural program during World War II, Homeland Tours, mimicked this new conception of a landscape. This article analyzes the conception of productive landscapes up until the end of World War II by drawing attention to the overlooked photography collection in the State Archives, which comprises paintings made during the Homeland Tours. One of the many tools that the statist economic institutions devised was agricultural statistics. The comparison between the paintings and actual land use statistics demonstrates that the artists collectively followed the statist economic agenda.
From 2023–2024, the Maryland Statewide Prevention & Reduction Collaborative (SPARC) led an intervention targeting broad-spectrum antibiotic use for sepsis, aiming to identify the factors that influence the success of collaborative quality improvement (QI) programs.
Design:
Evaluation of a state collaborative run QI intervention.
Participants:
Acute-care facilities in Maryland.
Methods:
Participating sites developed and implemented sepsis-focused interventions with SPARC support, including tailored guidance and bimonthly office hours. Following the implementation of site-level interventions, sites participated in a mixed-methods assessment guided by the RE-AIM framework including brief qualitative interviews and a 6-month follow-up.
Results:
Eight hospitals implemented multi-component, multi-disciplinary sepsis-focused interventions. Facilities involved staff from up to six departments in the implementation of interventions. All sites noted the effectiveness of SPARC in supporting sites’ intervention activities, as well as the effectiveness of the site’s interventions in creating change. Sites identified barriers impacting the implementation of their interventions including lack of resources, administrative red-tape, and challenges changing culture. Facilitators included leadership support, having a structured intervention plan, and opportunities for peer-to-peer learning. Most sites were positive about SPARC’s role identifying interventions and support, utilized information from SPARC as part of their interventions, and found it useful to hear how other institutions implement antibiotic stewardship. Six months post-assessment, all sites were continuing intervention activities.
Conclusions:
This evaluation highlights how statewide QI collaboratives can be effective in promoting hospital-based antibiotic stewardship. Sites identified several facilitators and challenges that contributed to intervention implementation and highlighted the contributions of the SPARC team.
Multilevel modeling accounts for outcome dependence across lower-level units due to unobserved group effects, while spatial modeling accounts for outcome dependence across units in the same level of analysis due to diffusion. Outcome dependence can occur simultaneously due to both spatial diffusion in the lower-level units and spatial diffusion in the unobserved group effects. For example, counties are nested within states and diffusion processes might take place at both levels of analysis. Building on recent research from the spatial econometrics and multilevel modeling literature, we propose a class of spatial hierarchical models with binary outcomes. One method accounts for spatially independent, unobserved group effects and the other method accounts for spatially dependent unobserved group effects. We propose a Bayesian approach to estimate such effects while also accounting for lower-level diffusion in the outcome, and provide software to estimate these models. Our Monte Carlo results demonstrate that failing to correctly account for diffusion and/or the nested structure of data can lead to bias in both parameter estimates and substantive effects. We apply these models to analyze the causes of civil rights protests in the United States in the 1960s.