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The consensus view in the growth literature is that R&D scale effects are absent in mature industrialized economies but may be present in emerging economies undergoing transition. Scale effects imply a proportional relationship between a stationary $I(0)$ regressand (growth rates of real per capita GDP and/or TFP) and a non-stationary $I(1)$ regressor (the scale of R&D), which gives rise to the problem of unbalanced regression and spurious parameter estimates. This issue has not been adequately addressed in the existing literature. Furthermore, emerging economies have received relatively little attention in this context. We address these issues by (i) accurately measuring R&D scale and (ii) adopting an appropriate econometric specification and estimator. We find significant scale effects in a panel of emerging countries, but not in developed countries. We propose an endogenous growth model that captures these properties—presence of scale effects during growth transitions, but not at the long-run equilibrium—thereby reconciling our results. Our model predicts that the long-run growth rates of per capita real GDP and TFP are driven by the growth rates of technological innovation and aggregate employment—although, in the case of emerging economies, only technological innovation significantly contributes to TFP growth.
Over centuries and across continents, authoritarian governments have demonstrated a large appetite for international cooperation to target political opponents across borders. In 1851, the “first modern police organization”—the Police Union of German States, whose members included Austria and Prussia—was established “with the express purpose of policing the political opposition of established autocratic regimes.”1 During the 1970s and early 1980s, military regimes in South America participated in a secret scheme known as Operation Condor to coordinate their efforts to suppress subversion.2 A recent analysis of twenty-nine “hard authoritarian” regional organizations found that twenty-five were engaged in police cooperation.3 The Shanghai Cooperation Organization (SCO) is an example. Its member states have agreed to jointly fight the “three evils” of terrorism, separatism, and extremism.4 Following a 2009 demonstration that led to riots in Urumqi, Xinjiang, some organizers fled abroad; at China’s behest, SCO members Kyrgyzstan and Kazakhstan detained and then extradited them back to China.5
This study investigates how stress and metathesis interact in Sevillian Spanish, focusing on how their interaction sheds light on representation. Metathesis affects /s/–voiceless stop sequences, moving a debuccalised coda /s/ to the release of the following stop ( → [patha]). This process plausibly changes syllable structure: the syllable where /s/ originated is closed at one representational level, but open on the surface ([pah.ta] → [pa.tha]). The change in syllable structure could affect weight-sensitive stress, depending on the level speakers refer to in assigning stress. In a stress judgement task, Sevillian listeners treated syllables from which an /s/ had metathesised out similarly to heavy penults and differently from light penults. I outline a range of analyses to account for their behaviour, and suggest that a comprehensive analysis could include gestural representations and separate stress from metathesis, so that phonetic variability in the realisation of metathesis is permitted but does not affect stress.
To evaluate the implementation and effectiveness of a novel home infusion central line-associated bloodstream infection (CLABSI) and home infusion-onset bloodstream infection (HiOB) dashboard and prevention toolkit.
Design:
Mixed methods study.
Setting and Participants:
Five home infusion agencies participating in the first CLABSI prevention collaborative.
Methods:
Agencies uploaded CLABSI and HiOB data to a comparative dashboard. The dashboard started in December 2022 and accepted retrospective data from June 2021. A CLABSI prevention toolkit was made available in June 2024. Using an interrupted time series, we present CLABSI and HiOB rates before and after dashboard and toolkit implementation. We surveyed and interviewed participants about the tools and toolkit, using directed content analysis to analyze the interviews.
Results:
After dashboard implementation, there was a decrease in CLABSI (−0.23/10,000 home-CVC days, 95% CI −0.28 to −0.18) and HiOB (−0.25/10,000 home-CVC days, 95% CI: −0.31 to −0.18) over time. With toolkit implementation, there was a further decrease in CLABSI (−0.17/10,000 home-CVC days, 95% CI: −0.30 to −0.044) and HiOB (−0.23/10,000 home-CVC days, 95% CI: −0.37 to −0.089) over time. Themes were associated with use of the tools (accessible, adaptable, patient-centered tools; user-friendly education to enhance understanding; barriers identified; tool mismatches; and strategies for tool delivery) and toolkit implementation (structural barriers, user-centered design, collaborative engagement and communication, toolkit used to enhance workforce competency, and concerns related to consistency).
Conclusions:
Implementation of a dashboard and a CLABSI prevention toolkit were each associated with both CLABSI and HiOB reduction in a collaborative of home infusion agencies.
Recruitment and retention of populations with limited prior participation in clinical trials remains a challenge. Thus, an increased understanding of the complex factors that impede or facilitate recruitment and retention is needed. Adapting the Systems Engineering Initiative for Patient Safety (SEIPS), we developed the Systems Engineering Initiative for Participant-Centric Research (SEIPR) framework that researchers can use to develop, implement, and evaluate interventions to increase trial participation.
Methods:
We performed a non-systematic literature review using the digital databases PubMed and Google Scholar to determine factors facilitating and impeding involvement of populations with limited prior participation in clinical trials. From this literature, we developed the SEIPR framework by applying it to the context of recruitment and retention.
Results:
We organized key obstacles and evidence-based solutions into five framework components: Person, Tasks and Tools, Technology, Physical Environment, and Organizational Conditions. Common obstacles included lack of awareness of active trials by participants and healthcare providers, patient’s distance from trial centers, lack of access to traditional advertising technology, and mistrust towards investigators, among others. Solutions included promotional strategies appropriate to the regional or social context, decentralizing trials, providing communication technology to participants, partnering with trusted members from the participant’s community and primary care team, using local connections and community centers, financial incentives, and transportation solutions.
Discussion:
The SEIPR framework presents a promising tool for investigators interested in increasing participant breadth in clinical trials. Future research is needed to explore real-world applications and assess its effectiveness in recruiting and retaining broad populations.
The hydrogen isotope composition of the mantle provides insight into the advection, melting and metasomatism of the mantle, and the Earth’s water cycle. Because of sampling challenges, most estimates for the hydrogen composition of the mantle have been derived from basaltic glasses rather than from direct samples of the mantle. We present the first direct measurement of D/H ratios in nominally anhydrous orthopyroxene and olivine inclusions hosted within diamonds. The diamond hosts were recovered from placer deposits in Guyana, South America. The diamond-hosted inclusions preserve a population with δD of –31 ± 59‰ (normalised to Vienna Standard Mean Ocean Water). This value is D-enriched relative to that expected for a homogeneous upper mantle and is similar to values measured for arc basalts. We introduce three explanations for the observed D-enrichment in the anhydrous silicate inclusions. The hydrogen isotopic composition of the mantle might simply be heterogeneous in space and/or time. The measured D-enrichment could instead preserve local heterogeneity produced by fluids genetically related to the crystallisation of the diamond hosts. Local and mantle-wide processes might also have operated in concert, and overprint each other. Diamond-hosted silicate inclusions preserve an underexplored record of Earth’s water cycle.
Researchers frequently deliver treatments through messages, as in many audit and get-out-the-vote (GOTV) experiments. These message-based experiments often hinge on intermediary variables—actions subjects must take to actually receive the treatment or control embedded in a message. Whether subjects open the message is a crucial intermediary step, which can serve as a condition for estimating downstream treatment effects or as an outcome of interest in its own right. Yet opens are often measured with error, most notably when some openers are misclassified as non-openers in email-based studies. We characterize the resulting bias, derive interpretable bounds on effects for well-defined subgroups, and provide sensitivity analyses for mismeasurement, thereby offering practical guidance for message-based experiments conducted through email and other communication technologies.
Theileria annulata causes tropical theileriosis in cattle, yet the molecular basis of host–parasite crosstalk across intracellular stages remains incompletely defined. We combined RNA sequencing and untargeted metabolomics to profile paired uninfected and infected bovine leukocytes (schizont stage) and erythrocytes (piroplasm stage), together with purified schizonts and piroplasms. Integrated analyses revealed pronounced, cell type-specific reprogramming. Infected leukocytes showed activation of immune signalling, amino acid metabolism and energy-producing pathways, consistent with leukocyte transformation, whereas infected erythrocytes preferentially engaged glutathione metabolism and redox homeostasis. Parasite stage comparisons uncovered extensive transcriptional and metabolic rewiring, including stage-biased expression of mitochondrial components, antioxidant systems and putative stage-regulated transcription factors. These coherent host–parasite adaptations likely facilitate parasite survival and persistence within distinct cellular niches. This work delineates a stage-resolved multi-omics landscape of T. annulata infection spanning host and parasite compartments and identifies signalling and metabolic pathways that merit functional validation as candidates for improved diagnostics and targeted interventions against bovine tropical theileriosis.
Palaeoparasitological studies provide valuable insights into the presence of parasites in human groups and their relationship with diverse lifestyles, health conditions, and cultural practices of past populations. Twenty-two human coprolite samples were analysed to evaluate human–parasite interactions and understand the ways of life and their relationship with the environment during the Late Archaic and Formative Periods at the Aragón-1 site (3300 BCE to 530 CE), Atacama Desert (northern Chile). Samples were prepared using the spontaneous sedimentation technique and analysed by optical microscopy. 48 023 eggs were found and identified exclusively as Dibothriocephalus/Adenocephalus sp., suggesting parasite infection through the consumption of undercooked fish during both the Late Archaic and Early Formative Periods. Our analysis reveals a close ecological interaction between this parasitic genus and the humans who inhabited the Aragón-1 site. The presence of this parasite decreases significantly toward the later Period, a phenomenon that could be explained by cultural and/or environmental factors. Culinary practices, care and prevention, and El Niño and La Niña phenomena may have influenced the human–parasite dynamics. This study contributes to a deeper understanding of the biocultural practices of the Aragón-1 individuals, highlighting their dietary habits based on marine resources and the mobility between inland and coastal areas required for the procurement of these products.
We develop a diagrammatic approach to the representation theory of the quantum symmetric pairs corresponding to orthosymplectic Lie superalgebras inside general linear Lie superalgebras. Our approach is based on the disoriented skein category, which we define as a module category over the framed HOMFLYPT skein category. The disoriented skein category admits full incarnation functors to the categories of modules over the iquantum enveloping algebras corresponding to the quantum symmetric pairs, and it can be viewed as an interpolating category for these categories of modules. We define an equivalence of module categories between the disoriented skein category and the iquantum Brauer category (also known as the q-Brauer category), after endowing the latter with the structure of a module category over the framed HOMFLYPT skein category. The disoriented skein category has some advantages over the iquantum Brauer category, possessing duality structure and allowing the incarnation functors to be strict morphisms of module categories. Finally, we construct explicit bases for the morphism spaces of the disoriented skein and iquantum Brauer categories.
Whatever may have been thought in the past, including within the United Nations (UN), there is now no reason to doubt the status of the International Criminal Police Organization (INTERPOL) as an international organization.1 That is important for many reasons, including its status under international and national law, which is fundamental for its dealings with states and other international organizations, not least the UN, and for immunities and other international privileges.
Iraya Volcano, situated at the northern tip of Batan Island in the Batanes group, marks the northernmost extent of the Philippine archipelago. Aside from the presence of accessible tephra deposits, the numerous archaeological sites on the island provide key insight into tephrochronology and volcanic hazard assessment. This paper presents stratigraphy and 21 radiocarbon ages of Holocene tephra layers distributed on the island. The eruption ages of the Holocene tephra are approximately 12.4 cal ka BP for Rolling Hills at the bottom, 4.5–4.9 cal ka BP for San Antonio, 2.1–2.5 cal ka BP for Mahatao, 1.6 cal ka BP for Basco, and 1.2–1.6 cal ka BP for Boulder Beach, with most of the tephra concentrated in the latter half of the Holocene. Artifacts excavated from Reydante Cabizon Property Site, San Antonio, Basco can be thought to date to around 4 to 2 cal ka BP, which is consistent with tephrochronology.
The archaeology of glaciers and ice patches has developed as a distinct new field in response to climate change and the melting of mountain ice. Thousands of artefacts and biological materials, dating back up to 10 000 years are being released from melting ice patches and retreating glaciers, offering unique insight into past human activities in cold environments. This paper examines the historical development of glacial archaeology, the preservation or loss of archaeological material from snow and ice, and the methodological challenges in locating and recovering such finds. Key finds and sites from North America, the Alps and Norway are presented. The emerging history demonstrates that high mountain areas were used more intensively in the past than previously assumed, including during winter. The paper argues that closer collaboration between glacial archaeology, glaciology and palaeoclimate research would be highly beneficial, particularly through joint investigations of the ice at glacial archaeological sites.