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Increasing survival probabilities among children and young adults with acute lymphoblastic leukemia (ALL) have led to a growing population at risk for long-term neurocognitive sequelae. This study investigated cognitive functioning among individuals treated for ALL under the Nordic Society of Paediatric Haematology and Oncology ALL2008 protocol in Eastern Denmark, including performance across multiple domains and associations with age at diagnosis, sex, time since end of treatment, hematopoietic stem cell transplantation (HSCT), and neurotoxic events during treatment.
Method:
Eighty-three survivors of ALL diagnosed before age 25 underwent neurocognitive testing at a median of 7.24 years post-treatment (interquartile range: 4.20–8.78). Performance was measured as age-standardized Z scores derived from normative data. Impairment was defined as Z ≤ −1.3 and severe impairment as Z ≤ −2.0. Multiple linear regression was used to investigate associations between cognitive outcomes and clinical risk factors.
Results:
Average performance was generally comparable to norms, but at least 38.6% of participants showed severe impairment in one or more domains, and at least 12% in two or more. Younger age at diagnosis was associated with poorer processing speed, executive functions, and non-verbal reasoning, while HSCT was associated with poorer processing speed and non-verbal reasoning.
Conclusions:
Although average performance of the participants was generally comparable to norms, a notable proportion exhibited multi-domain, severe cognitive impairment. Associations with age at diagnosis and HSCT indicate potential for risk-stratified cognitive monitoring and targeted interventions.
An archaeological survey of Kitsissut, a remote island cluster in the High Arctic of Kalaallit Nunaat (Greenland), has revealed a human presence almost 4500 years ago, during the formation of a vital marine environment—Pikialasorsuaq polynya. Kitsissut is accessible only by a difficult open-water journey, and repeated occupation thus permits inferences on the sophistication of watercraft technology and navigational skill. Here, the authors argue that this demonstrable reach of Early Paleo-Inuit communities across marine and terrestrial ecosystems enhances our understanding of their lifeways and environmental legacy, raising critical new questions about Indigenous agency in shaping emerging Arctic ecosystems.
The linear stability of nanofluid boundary-layer flow over a flat plate is investigated using a two-phase formulation that incorporates the Brinkman (1952 J. Chem. Phys., vol. 20, pp. 571–581) model for viscosity along with Brownian motion (BM) and thermophoresis (TP), building upon the earlier work of Buongiorno (2006 J. Heat Transfer, vol. 128, pp. 240–250). Solutions to the steady boundary-layer equations reveal a thin nanoparticle concentration layer near the plate surface, with a characteristic thickness of $O({\textit{Re}}^{-1/2}{\textit{Sc}}^{-1/3})$, for a Reynolds number ${\textit{Re}}$ and Schmidt number ${\textit{Sc}}$. When BM and TP are neglected, the governing equations reduce to the standard Blasius formulation for a single-phase fluid, and the nanoparticle concentration layer disappears, resulting in a uniform concentration across the boundary layer. Neutral stability curves and critical conditions for the onset of the Tollmien–Schlichting (TS) wave are computed for a range of nanoparticle materials and volume concentrations. Results indicate that while the effects of BM and TP are negligible, the impact of nanoparticle density is significant. Denser nanoparticles, such as silver and copper, destabilise the TS wave, whereas lighter nanoparticles, like aluminium and silicon, establish a small stabilising effect. Additionally, the viscosity model plays a crucial role, with alternative formulations leading to different stability behaviour. Finally, a high Reynolds number asymptotic analysis is undertaken for the lower branch of the neutral stability curve.
The Serbian Twin Advanced Registry (STAR), established in 2014, is a multigenerational resource for studying genetic, environmental, and epigenetic influences on behavior and development. STAR currently includes more than 9000 participants, extending the classical twin design to parents and siblings and enabling fine-grained modeling of genetic inheritance, cultural transmission, and shared environments. Methodological innovations include experimental procedures, virtual reality paradigms, and longitudinal, multi-informant assessments from childhood to adulthood, combined with molecular data collection. Published findings highlight heritable structures in executive functions, personality, and psychopathology, alongside environmentally shaped differences in behaviors such as aggression. Epigenetic studies have demonstrated associations between COMT promoter methylation and impulsivity-related traits, while ongoing genomewide analyses aim to identify environmentally mediated methylation variability. By integrating advanced methodologies with open science practices, STAR provides a sustainable platform for behavioral genetics in Serbia and contributes to international research on adaptation and psychopathology across the lifespan.
Academic medical center in Los Angeles, California.
Patients:
Patients whose bronchoalveolar lavage (BAL) cultures grew M. mucogenicum from 2020–2024.
Methods:
We performed an institutional outbreak investigation of M. mucogenicum, reviewed electronic medical records of a subset of affected patients (2023–2024), and assessed the operational impact.
Results:
The incidence of M. mucogenicum in BAL cultures at Hospital A increased from 6.1% (29/473) in 2020 to 18.6% (29/156) in the first quarter of 2024. Epidemiologic investigation revealed non-sterile ice baths used to cool uncapped sterile syringes during bronchoscopy procedures as the contamination source. Next generation sequencing linked clinical isolates to M. mucogenicum recovered from a perioperative ice machine. Nearly all (157/160) clinical isolates grew from nocardia media rather than acid-fast bacilli media. Among 154 patients, including 51 (33.1%) who were highly immunocompromised, no true infections were identified. Thirty-nine (25.3%) patients were referred to infectious diseases for consultation, seven (4.5%) underwent additional workup, and only one received targeted treatment. The pseudo-outbreak incurred 458 hours of microbiology technologist and infection preventionist time and cost the laboratory $88,426.
Conclusions:
A four-year pseudo-outbreak of M. mucogenicum traced to contaminated ice baths used during bronchoscopy resulted in unnecessary infectious disease referrals and substantial operational and financial burden to the institution. Avoidance of non-sterile ice use in procedures prevents costly and burdensome pseudo-outbreaks of environmental mycobacteria in healthcare settings.
We present a mathematical model for tsunami and induced magnetic anomalies originating from a time-dependent seabed deformation in an otherwise quiescent ocean over a conductive seafloor. The deformation is assumed to be a slender fault, whose lateral extension is much larger than the longitudinal scale. Using a perturbative method with multiple time scales and Green’s function approach, we examine the slow evolution of the wave field and induced magnetic anomaly over transoceanic distances from the fault. The model is validated against deep-ocean observations from the 2011 Tōhoku-oki tsunami. Our study reveals that lateral propagation in two horizontal dimensions decreases the period of both the surface wave and induced magnetic signal compared with one-horizontal-dimension scenarios. Over time, initially longitudinal wave propagation alters as wave fronts bend and stretch, affecting the magnetic signal accordingly. Interestingly, the magnetic anomaly gradually separates from the leading tsunami wave and travels ahead of the tsunami by a distance proportional to the fault’s longitudinal scale. We show that increased lateral propagation reduces the detectability of magnetic anomalies. Finally, we derive an asymptotic formula valid for the long leading wave that travels ahead of the dispersive group over transoceanic distances. This formula holds promise for the rapid assessment of tsunami risk. These findings advance fundamental understanding and may inform the development of future tsunami early warning systems relying on magnetic field detection.
A nuclear detonation resulting in radiation exposure to a large population can cause acute radiation syndrome (ARS). Bone marrow colony stimulating factors (CSF), also known as cytokines, are FDA approved to treat hematopoietic-acute radiation syndrome (H-ARS). This review characterizes the use of CSFs (filgrastim, pegfilgrastim, romiplostim, and sargramostim) and stem cell therapies for H-ARS.
Methods
Using identified keywords, the literature search was conducted on biomedical databases from January 1996-July 2022 and returned 7452 articles. However, after review based on PICO and exclusion criteria, a total of 39 animal studies were included in this systematic review.
Results
Data synthesis using vote counting demonstrated that 34 of 39 studies reported benefit with CSFs or stem cell therapies based on an increase in percent survival or physiological improvement in the experimental group when compared to the control (87% [95% CI 71.77%-95.18%], P = <0.001).
Conclusions
While studies looking at efficacy of CSFs given after 24 hours were limited, 2 studies included in this review showed that delayed administration of CSFs up to 120 hours may be beneficial compared to no treatment. Lack of standardization in experimental study design (e.g. radiation doses, animal species, interventions) between studies prevented direct comparisons using meta-analytic statistical approach.
We study transverse profiles and time fluctuations of turbulence dissipation rate, turbulence kinetic energy and integral length scales by means of high-speed stereoscopic particle image velocimetry in the turbulent wake of a 6 : 1 prolate spheroid that has its principal axis aligned with the incoming non-turbulent flow. This turbulent wake of a slender body differs from turbulent bluff body wakes in terms of transverse non-homogeneity of turbulence dissipation rate and because it is not axisymmetric even though it nominally is. Even so, both transverse profiles and time fluctuations of turbulence dissipation rate coefficients (inverse ratio between the rate with which the large scales lose energy and the rate with which the small scales dissipate energy) and of the Taylor length-based Reynolds number (ratio between the turbulent kinetic energy mostly in the large scales and the turbulent kinetic energy at the smallest scales) obey self-regulating non-equilibrium, as previously found in various other turbulent flows. However, the power law relating the transverse variations and the time fluctuations of these two ratios differs from previously reported self-regulating non-equilibrium power law scalings in other turbulent flows.
Social reproduction scholars have made headway in integrating the analysis of capitalism, class, gender, and care. We offer two contributions to this literature. First, we provide a novel framework with insights into companies as sites of decommodification, shaping childcare cost distribution and affecting childbearing rates. Second, we extend social reproduction research geographically to the oft-overlooked region of Eastern Europe. Eastern Europe is home to 15 of the world’s 20 fastest-declining populations, with low fertility as a prime cause. We argue that privatization catalyzes commodification, raising work intensity and financial-temporal uncertainty and eroding collective resources for social reproduction, thereby impacting childbearing. We explore this mechanism quantitatively by employing four distinct definitions of privatization across two datasets: one covering 52 Hungarian towns (1989–2006) and another spanning 29 postsocialist countries (1989–2012). We shed light on the details of the mechanism through a qualitative analysis of 82 life-history interviews in four Hungarian towns, surveying the lived experience of privatization.
The chatbot psychosis phenomenon is no longer just a hypothesis. We call for interdisciplinary frameworks to systematically investigate individual characteristics and artificial intelligence related factors which (on their own or in combination) cause or contribute to this phenomenon, underlying mechanisms and the psychoeducation, ethics, policy and practices needed to reduce harm.
In 2024, the Women and Equalities Select Committee in the UK Parliament published a report entitled Misogyny in Music. It included the recommendations that ‘music colleges, conservatoires and other educational settings need to do more to address the gendering of instruments, roles and genres and improve the visibility of and support for female role models’. While there is a dearth of policy levers available to implement this recommendation, this article critically analyses three existing policy/regulatory frameworks that could be used for its implementation in England. The article also highlights a significant limitation of the report – its exclusion of trans and non-binary musicians.
Between 2012 and 2014, a crew from the Pacbitun Regional Archaeological Project (PRAP) excavated a small mound located on the western periphery of the Pacbitun site, a medium-sized ancient Maya center located in west-central Belize. That mound consisted of a thick deposit of granite sand and debitage, revealing a record of the production of several thousand granite tools dating to the Late Classic period. Since those excavations, a total of 22 similar mounds have been recorded, with 11 tested. All tested mounds reveal a similar material record representing periodically used working platforms where granite tools were shaped and finished during the Late Classic period. The recorded granite debris mounds are distributed over an area of 1 km2 some 500 m from Pacbitun’s core, an area that we suggest represents a community of attached, part-time specialists making granite tools on a seasonal basis. Given the scale of granite tool production, we suspect this community made tools not just for local consumption, but also for consumption outside of Pacbitun as part of a strategy to navigate the dynamic political Late Classic landscape of the Belize River Valley.
This article investigates the history of displaying nuclear energy from the 1980s to the present by tracing the cultural biography of a scale model of the Ignalina Nuclear Power Plant, which operated in Lithuania between 1983 and 2009. By reconstructing the model’s trajectory, from its initial role as a promotional exhibit in Soviet-era industry showcasing to its contemporary status as an artifact of nuclear cultural heritage, the study highlights a shift in the politics and practices of exhibiting the atom, as well as evolving theoretical frameworks and cultural discourses surrounding nuclear energy. The author argues that the model’s movement through industrial, technological, artistic, and heritage domains, along with its diverse functions, has rendered it a techno-political actor that, alongside human and institutional agents, plays a significant role in shaping the dynamics of nuclear culture.
The coupling between Rayleigh–Taylor (R–T) and Saffman–Taylor (S–T) instabilities, when a gas displaces a high-viscosity liquid, remains challenging to elucidate due to the unclear roles of density and viscosity contrasts. Counterintuitively, our radial Hele-Shaw cell experiments revealed that viscosity contrast – typically considered a damping factor – serves as the primary driver of instability. We observed that the glycerin–air interface, despite its higher viscosity, exhibits significantly greater instability than the water–air interface. This anomalous behaviour arises from the S–T mechanism, which accelerates the onset of nonlinearity and induces an early transition to fingering. We applied a unified model to decouple the competing influences of surface tension oscillation and viscous damping on R–T instability and the S–T destabilisation. Moreover, we proposed criteria for either mostly enhancing or completely freezing the instability. These findings offer valuable insights into manipulating hydrodynamic instabilities in contracting/expanding geometries through surface tension and viscosity.