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Discussions of the Gallo-Roman dodecahedron often note the significance of the dodecahedron in Platonic and Pythagorean philosophy, but they tend not to relate the archaeology to the textual evidence in any detail. We attempt to do that in this paper. We argue that, whilst it remains the case that there is no contemporaneous description of the Gallo-Roman dodecahedron, there are several texts – including an overlooked passage in Iamblichus’ On the Pythagorean Life – that point to its possible inspiration. We relate these texts to the location of dodecahedra in Gaul and Britain and to the interest of the Druids in Pythagoras, which was frequently remarked upon by Roman commentators.
An imposed constant magnetic field parallel to the interface in the Rayleigh–Taylor framework strongly modifies the dynamics of the flow. The growth rate of the turbulent mixing layer is almost doubled compared with the purely hydrodynamic case, mainly due to a strong reduction of small-scale mixing. Indeed, magnetic tension inhibits the small-scale perturbations from developing, which in turn creates a strong anisotropy with structures elongated in the field direction. Two theoretical predictions for the asymptotic state of the magnetic Rayleigh–Taylor instability (MRTI) are put forward. First, considering the large-scale dynamics, an upper bound for the mixing layer growth rate is obtained. Second, the phenomenology is embedded in a buoyancy–drag equation from which an analytical relation between the growth rate, mixing, anisotropy and induced magnetic fields is derived. Both predictions are successfully assessed with high resolution direct numerical simulations of the Boussinesq–Navier–Stokes equations under the magnetohydrodynamics approximation. These predictions characterize the quasi-self-similar state of the MRTI driven by strong magnetic fields.
This article examines Paul’s view of the law with attention to the figure of the pedagogue. It suggests that the law stands in a redemptive-historical role to the coming of Christ. It accomplishes this through a comparison between Seneca’s Moral Epistles and Paul. Seneca’s discussion is a helpful heuristic to elucidate Paul’s teaching on Jewish law. Paul highly values the Jewish law and explains that it leads humans to Christ as a pedagogue, although the law itself does not have the power to make righteous. Scholars offer arguments in support of positive or negative attitudes toward the pedagogue, but the pedagogue’s basic role was to bring a child to the age of maturity and rationality. Paul’s thesis is to argue that the Jewish law functions, historically and ethically, to lead one to Christ. This interpretation suggests that the law plays a positive redemptive-historical role in Galatians 3:19–4:11.
Intrinsic capacity, introduced by the World Health Organization, represents a shift in focus from treating disease to maintaining physical and mental capacities individuals as they age. It encompasses five interrelated domains: vitality, sensory, cognition, psychology, and locomotion. Vitality refers to the body’s physiological reserve and is shaped by processes such as energy metabolism, immune function, and neuromuscular integrity. By definition, vitality is closely linked to nutritional status, which plays a central role in maintaining resilience and health in older adults. However, integrating nutritional status into the vitality domain presents several challenges due to inconsistent definitions and varied measurement approaches. This review examines these challenges and explores possibilities for integrating nutritional status in the vitality domain. The absence of standardised nutrition-related indicators limits comparability across studies and constrains the practical application of intrinsic capacity in both research and clinical contexts. To strengthen the role of intrinsic capacity in nutritional monitoring, it is essential to reach consensus on which nutritional indicators to include and how to score them consistently. Addressing these methodological challenges will support the use of intrinsic capacity in identifying early signs of nutritional decline and guiding timely interventions to promote healthy ageing.
This study aimed to investigate the effects of caffeic acid (CA) on the inflammatory response induced by hydrogen peroxide (H2O2) in porcine small intestinal epithelial cells (IPEC-J2 cells) and to elucidate the potential molecular mechanisms involved. Firstly, we treated IPEC-J2 cells with different concentrations of H2O2 to establish the inflammation model caused by oxidative stress. Subsequently, we treated IPECJ2 cells with CA and/or H2O2 to investigate the effect of CA on the inflammatory response of IPEC-J2 cells induced by H2O2. In addition, IPEC-J2 cells were treated with a nuclear factor kappa-B (NF-κB) inhibitor and a NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inhibitor, so as to investigate the molecular mechanism by which caffeic acid alleviates H2O2-induced damage in porcine intestinal epithelial cells. The changes in cell morphology, intestinal epithelial cell damage, and the expression of genes related to the NF-κB/NLRP3 signaling axis were examined. The results showed that CA attenuated H2O2 induced intestinal epithelial cell injury, and the mechanism may be related to the inhibition of NF-κB-mediated NLRP3 inflammasome activation. These findings were expected to provide a theoretical basis for more reasonable and effective application of CA, and provide new ideas for nutritional regulation measures to alleviate intestinal inflammation in piglets.
This paper is interested in the spread of an autocratic ideology and the emergence of a societal belief. It is often assumed that the greater the capacities of an autocratic regime to inculcate an ideological belief into the minds and hearts of subordinate citizens, the more an autocratic ideology is shared in a given society. The extent of an ideological belief is explained by a direct and immediate function of its indoctrination capacities. The paper does not question this top–down, macro–micro approach, but argues that the spread of an ideology also depends on stabilizing micro–micro interactions and micro–macro linkages. In this light, the paper makes use of James Coleman’s famous explanatory model and theorizes the different partial mechanisms. It pays particular emphasis on the micro–macro mechanism. Borrowing insights from epidemiology, it argues that three classes of parameters should be taken into closer consideration: timing, contact structure, and the contagiousness of an ideology. In empirical terms, the paper illustrates its theoretical reasoning with the dissemination of the North Korean Juche ideology from the 1950s to the early 1970s, which represents an extreme case of a rapidly ideologizing autocracy. The paper relies on secondary sources as well as archival material retrieved from the former embassy of the German Democratic Republic in Pyongyang.
Substantial experimental research has explored mental contamination – feelings of internal pollution proposed to result from misinterpreting perceived violations. The Mental Contamination Report (MCR) was developed to measure in-the-moment experiences of mental contamination, and has been used in seminal experiments in this domain. However, the MCR has yet to be psychometrically evaluated. The aim of the current study was to evaluate the psychometric properties of the MCR, and if warranted, propose a revised version with improved research utility.
Method:
Data for this study were collected as part of a larger experiment examining the impact of moral self-violation on mental contamination. A sample of 150 undergraduate students completed the MCR, Vancouver Obsessional-Compulsive Inventory-Mental Contamination Subscale, and the Vancouver Obsessional-Compulsive Inventory.
Results:
The original Emotions Subscale of the MCR demonstrated excellent internal consistency (${\rm{\alpha }}$=0.92) but contained emotions non-specific to mental contamination. We conducted an exploratory factor analysis (EFA) of the emotion items to identify which items load more heavily onto a mental contamination-specific factor. The EFA revealed a two-factor solution, with five items items loading strongly on the mental contamination-specific factor. For the 5-item mental contamination-specific Emotions Subscale, we found excellent internal consistency (${\rm{\alpha }}$=0.90), strong known groups validity, F2,147=63.17, p<.001, ηp2=.46, good convergent validity and mixed results for divergent validity. For the Behavioural Urges Subscale, we found overall mixed psychometric properties.
Conclusions:
Based on the results of the psychometric analysis, a revised version of the MCR is proposed.
Recipients of hematopoietic cell transplantation (HCT) are at increased risk for Clostridioides difficile infection (CDI) and its recurrence, which are associated with significant morbidity. We aimed to characterize risk factors for primary and recurrent CDI in a large cohort of HCT recipients.
Methods:
We conducted a retrospective cohort study of 2725 adults who underwent HCT from 2010–2023 to evaluate the epidemiology, timing, and risk factors for CDI. We compared patients who developed CDI with those who did not, adjusting for patient demographics, comorbidities, transplant factors, medications, and laboratory values. Among patients who developed CDI, we investigated risk factors for recurrent CDI.
Results:
The cumulative 1-year incidence of CDI was 17.8% among allogeneic HCT recipients (181/1016) and 4.1% among autologous recipients (71/1709). Overall CDI incidence increased by 1.4% annually during the study period (95%CI: 1.24–1.53%). Independent risk factors for primary CDI included penicillin antibiotics (aOR 1.51; 95%CI: 1.13–2.02), prior chemotherapy (aOR 8.36; 95%CI: 2.95–23.69 for 1–3 regimens), and umbilical cord blood stem cells (aOR 1.95; 95%CI: 1.07–3.57). Autologous HCT was associated with decreased risk. Among 252 patients with primary CDI, 22 (8.7%) developed recurrence. Macrolide use before index CDI (aOR 7.25; 95%CI: 1.80–29.2) and allogeneic HCT (aOR 31.04; 95%CI: 1.37–731.58) were associated with recurrence.
Conclusion:
CDI is a common, early complication of HCT particularly among allogeneic recipients. Penicillin exposure, prior chemotherapy, and cord blood stem cell source are key risk factors, while macrolide use is associated with recurrence. Our findings highlight potential targets for risk-stratified prevention strategies.
To investigate the stall mechanisms of a multi-stage axial compressor under different rotational speeds and identify the initial stall stages, this study focuses on a high-load nine-stage axial compressor, validated through experimental data. The results reveal that at 100% corrected rotational speed, flow instability is primarily triggered by corner separation in the front four stators (S1–S4). At 80% corrected rotational speed, the instability stems from the interaction between the first rotor (R1) tip leakage vortex and the main flow, coupled with the front four stators’ corner separation. Precise identification of initial stall locations in multi-stage axial compressors is imperative. The study first employs qualitative flow-field analysis to identify initial stall locations by comparing meridional mass flux variation contour maps and axial velocity iso-surfaces. The results show that the stall inception occurs at the S2 root under 100% corrected rotational speed, while at 80% corrected rotational speed, stall initiates simultaneously at both the S2 root and the R1 tip. Furthermore, an innovative three-dimensional flow blockage quantification method was established to systematically evaluate blockage severity within multi-stage blade passages. This approach utilises relative blockage variation metrics to quantitatively identify regions of rapid flow deterioration, achieving remarkable consistency with qualitative flow-field analysis. The qualitative and quantitative analysis results have been mutually corroborated. The proposed blockage quantification approach enables precise evaluation across stages without complex flow fields comparisons, allowing rapid identification of stall-initiating locations and supporting subsequent stability enhancement optimization.
This article examines how “human affect” (renqing) – the interplay of affect, moral obligation and social legitimacy – operates as both a mechanism of governance and a site of contestation in police mediation in contemporary China. Drawing on six months of ethnographic fieldwork in two police stations in Zhejiang province, I conceptualize renqing as an affective grammar: a system of emotional expression and recognition that structures interaction across interpersonal and institutional settings. The party-state’s revival of the Fengqiao model has transformed renqing from a micro-political norm into an institutionalized instrument of affective governance. Mediation formalizes affect through contracts, scripted performances and service quotas, stratifying emotional legitimacy along lines of class, gender and migration. The article theorizes affective autonomy as participants’ resistance through silence, withdrawal or alternative alignments. It complicates portrayals of policing as purely coercive, highlighting the emotional labour and limits of grassroots governance.
This paper addresses the attitude control challenge of hypersonic morphing vehicles (HMVs) with uncertainties and actuator saturation. The primary contribution of this work lies in achieving a predefined settling time while ensuring robust control performance under morphing effects, actuator saturation and disturbances. Firstly, a control-oriented model is established based on the dynamics of HMVs. Subsequently, a nonsingular multivariable sliding mode manifold, utilising a switching function, is designed to attain predefined-time convergence and prevent singularity issues. A disturbance observer with an adaptive law is developed to precisely and swiftly estimate uncertainties and error states, while a predefined-time anti-saturation compensator is implemented to alleviate actuator saturation. Furthermore, closed-loop stability is guaranteed through rigorous Lyapunov synthesis. Extensive numerical simulations confirm the algorithm’s superiority in terms of control effectiveness.
Fluidic levitation of different types of objects is achieved using laboratory experiments and described using simple mathematical models. Air bubbles, liquid tetrabromoethane droplets and solid spherical polytetrafluoroethylene beads were levitated in flowing water inside vertically oriented cylindrical tubes having diameters of 5, 8 and 10 mm. The centre of mass of all levitated objects was observed to undergo horizontal oscillations once a stable levitation point had been established. A simple model that considers the balance of gravitational, buoyancy and drag forces (as well as wall effects) was used to successfully predict the flow rates that are required to obtain stable levitation of objects with a range of different sizes. Horizontal motion was shown to be driven by vortex shedding of the objects in the tubes, and the dependence of the frequency of oscillation on their size was predicted.