To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The essay deals with the rape component of the Muslim Turkish massacres of Christian Armenians, Greeks and Assyrians during the years between 1894 and 1924 and the pertinent archival sources. During the three bouts of massacre, amounting to staggered genocides, in 1894–1896, 1915–1916 and 1920–1924, in which the Muslim Turks, under Ottoman imperial governments and, subsequently, under Ataturk’s Nationalist/republican rule, murdered some two million Christians, tens of thousands of Christian women were raped and/or forcibly abducted to Muslim households and Islamized. While almost all Turkish official records of these events have been destroyed or slicked away, archives in the West - US, German, French and British state archives and archives of missionary societies then operating in Asia Minor - are open to researchers and abound with materials that describe and analyze the massacres and the rapes and abductions that accompanied them. The essay lays out what happened and why, and how researchers have traced what happened.
Patients with familial adenomatous polyposis (FAP) have increased risk of hepatoblastoma (HB). We report monozygotic twins with HB in a FAP family. To explore genetic alterations in the HBs of the twins, we carried out whole exome sequencing (WES), RNA-seq, and immunohistochemical analyses of the tumors. Additional multiregional digital PCR was performed to profile clonality of each tumor. To determine a pathogenic germline variant in APC, Sanger sequencing was applied for the twins, the father, and the siblings of the father. A pathogenic variant of the APC gene was identified in the father as well as the twins. The WES of the HBs in the twins identified somatic mutations, including an NRAS mutation in the tumor of the first infant (C1), and an ACVR2A mutation in the tumor of the second infant (C2). No somatic mutations were identified in the genes associated with the Wnt signaling pathway. However, accumulation of β-catenin was found in the C1 and C2 tumors by immunohistochemical staining, suggesting activation of the Wnt signaling pathway. Digital PCR analysis revealed that the NRAS mutation was found in multiregional specimens of C1 and those of C2. The ACVR2A mutation was found in multiregional specimens of C2, whereas the mutation was also identified in those of C1. The existence of a shared somatic mutation may suggest that microchimerism took place in the development of HBs through the utero-placental circulatory system. Importantly, the initiation of tumorigenesis is thought to occur during the fetal period after organ development of the liver.
David Phillips (2011) and Thomas Hurka (2014a, 2014b) argue that Sidgwick’s critique of deontology contains three serious flaws. First, it has no force against moderate deontologies composed of prima facie duties rather than unconditional duties. Second, Sidgwick’s preferred principles fail to meet the very criteria by which he rejects deontological principles. Third, Sidgwick’s employment of his key maxim of Rational Benevolence equivocates between all-things-considered and other-things-equal formulations. I defend Sidgwick against all three criticisms. (1) While some of Sidgwick’s arguments apply only to absolute deontology, others apply to moderate versions as well. (2) Although Sidgwick’s preferred principles do not fare perfectly against his criteria, they still fare better than the deontological principles. (3) The suggestion that Sidgwick relies on an all-things-considered formulation of Rational Benevolence is based on a misunderstanding of the structure of his argument. The upshot is that Sidgwick’s overarching line of argument is stronger than recent critics suggest.
A retrospective analysis of paediatric infective endocarditis characterised causative pathogens, antimicrobial susceptibility patterns, and treatment outcomes to guide clinical decision-making.
Methods:
The data of patients who received infective endocarditis between 2016 and 2023 were retrospectively collected from the medical records database. The clinical characteristics, treatment plans, and pharmaceutical monitoring characteristics were analysed and summarised.
Results:
A total of 12 paediatric infective endocarditis cases were identified. Bacterial isolates included 27 Gram-positive and 1 Gram-negative strains. The most common pathogen was Staphylococcus aureus (n = 13), all methicillin-resistant Staphylococcus aureus (MRSA), followed by Abiotrophia defectiva (n = 6), Streptococcus mitis (n = 5), Streptococcus sanguinis (n = 2), Bacillus cereus (n = 1), and Klebsiella oxytoca (n = 1). Antimicrobial therapy primarily involved linezolid, vancomycin, and cephalosporin/enzyme inhibitor combinations. Cardiac glycosides were used in 10 cases, and all patients received phosphocreatine to support myocardial energy metabolism. Therapeutic drug monitoring for vancomycin was performed in 25% of cases, while no therapeutic drug monitoring was conducted for meropenem or linezolid.
Conclusion:
All the causative organisms were predominantly Gram-positive cocci, with MRSA accounting for the largest proportion; different streptococci varied considerably in terms of drug resistance. The antimicrobial drugs used were predominantly linezolid and glycopeptides. The rate of blood concentration monitoring was low.
Meritocracy is a central ideal in American workforce management, yet systemic biases and structural barriers often undermine its implementation. Executive orders (EO) 14173, Ending Illegal Discrimination and Restoring Merit-Based Opportunity, and 14281, Restoring Equality of Opportunity and Meritocracy, aim to reinforce meritocratic principles by eliminating diversity, equity, and inclusion (DEI) initiatives and disparate impact protections. However, these orders operate under the flawed assumption that a meritocracy will naturally emerge without intervention, disregarding evidence that superfluous factors outside merit impact organizational decisions. This policy brief argues that evidence-based DEI practices and disparate impact protections are not antithetical to meritocracy but are, in fact, necessary for its achievement. We discuss the implications of these EOs, focusing on how they may harm employee and organizational functioning and undermine the very principles they seek to uphold. Finally, we propose actions I-O psychologists can take, including issuing unified definitions of key terms, setting standards of practice for improving merit-based decision making, publicizing the broad utility of DEI initiatives and disparate impact protections, and advancing related research. These recommendations offer a path to uphold fairness and excellence in workforce management.
Since ancient times, thistles have been used as clotting agents in the production of traditional cheeses, particularly in the Mediterranean area. In recent years, their use in cheesemaking has increased to satisfy the growing requests from vegetarian consumers. In this research paper, four different cheeses, typical of the Mediterranean area, were evaluated from a nutritional point of view: Caciofiore (from Italy) and Torta del Casar (from Spain), both typically produced using vegetable rennet, and Queso de Murcia al vino (from Spain) and Feta (from Greece), traditionally produced using animal rennet. All the cheeses were manufactured according to their traditional cheesemaking procedures and used as controls. Experimental cheeses were produced using aqueous extracts obtained from flowers of either spontaneous or cultivated thistles indigenous to the Mediterranean area (respectively Onopordum tauricum for Caciofiore, and Cynara humilis for Torta del Casar, Queso de Murcia al vino, and Feta). All cheeses were characterized for fat-soluble and mineral compounds to assess their nutritional adequacy according to the recommended daily intake of each evaluated nutrient. All the cheeses were found to be a good source of vitamin A, calcium and phosphorus, with an optimal Ca/P molar ratio, except for Feta. By consuming the recommended serving (50 g) of the studied cheeses, the salt and cholesterol intake is, on average, 16.4% and 15.9%, respectively of recommended intake. The use of aqueous thistle extracts in cheesemaking appears to have no effect on the nutritional quality of the studied cheeses.
Patient death by suicide is a distressing occupational event associated with far-reaching impacts on professional practice and wellbeing. Psychiatrists are commonly tasked with suicide risk assessment and management and ultimately experience greater incidences of patient suicide in comparison with other medical specialists. Therefore, it is important to understand psychiatrists’ experiences of patient suicide and the required supports in an Irish context. This study investigated how patient suicide affects the personal and professional lives of consultant and non-consultant psychiatrists, and what resources/systems psychiatrists find helpful in mitigating the impact of a patient suicide.
Methods:
Survey data collected from 232 consultants and non-consultant clinicians was analysed using frequency analyses and Independent Samples t-tests,. Most participants were female (61.6%) and the largest age group represented was 50–59 years (28.4% of the sample).
Results:
Key personal and professional impacts in the aftermath of a patient’s suicide include pre-occupation with suicide, decreased self-confidence, sadness, burnout, desire for career change/break and fear of negative events following the suicide. A significant difference was observed across gender with respect to sense of responsibility (F = 3.69, dfs = 2,200, p = .026) with females displaying more feelings of responsibility (M = 3.9, SD = 3.1) than males (M = 2.8, SD = 2.7). Support from colleagues and line managers was largely identified as helpful in the aftermath of patient death by suicide.
Conclusions:
Ultimately, there is a need for greater access to guidelines/policy and occupational support for psychiatrists to assist their responses. This study provides much-needed insight into the landscape of experiences and needs of psychiatrists in Ireland who experienced a patient death by suicide.
This note critically examines the tendency of some international human rights treaty bodies to uncritically conflate sex tourism with human trafficking. Through analysis of concluding observations from the Committee on the Rights of the Child (CRC), the Committee on the Elimination of Discrimination Against Women (CEDAW), and the Committee on Economic, Social and Cultural Rights (CESCR), the note reveals a troubling pattern of equating these phenomena without adequate conceptual differentiation. While acknowledging that sex tourism can involve trafficking when the constitutive elements of the Palermo Protocol’s definition are satisfied – namely the act, means, and purpose requirements – this note argues that the wholesale characterization of sex tourism as trafficking is both conceptually inaccurate and potentially harmful. This conflation risks eliding the agency of individuals who make difficult but deliberate choices to participate in sex tourism, particularly women from the Global South.
Cilia exist ubiquitously in nature, and they are very effective in generating flow in a low Reynolds number environment. Inspired by nature, various artificial cilia have been invented for microfluidic applications, and a nature-mimicking tilted conical motion was often used for flow generation due to its simplicity and effectiveness. However, the current theoretical model for predicting the net flow rate generated by the tilted conical motion fails when the cilia are in close confinement, i.e. when the tips of the cilia are close to the ceiling of their channel or chamber, which is, in reality, the most practical way to enhance flow rate generation. Moreover, numerical simulations are very expensive for optimisation of such designs. In this study, we derive a new theoretical model, taking into account the tilting and opening angles of the cone, the height of the chamber and the length of the cilia. The results differ significantly from when the ceiling is not considered, and counter-intuitively in some cases the flow can even reverse. These unexpected results have important implications for artificial cilium design and applications. We validate the model with both numerical simulations and experiments using magnetic artificial cilia, and show that the flow optimisation based on tilted conical cilium motion can now be performed accurately in a realistic and practical manner. This study not only offers a simple tool for optimising designs of artificial cilium-based systems for microfluidic applications, but it also provides fresh insights for understanding natural cilium-driven flows.
Post-stroke neurocognitive disorders are highly prevalent, yet screening tools that are fit for culturally diverse populations are scarce. This study evaluates the impact of cultural differences on the Oxford Cognitive Screen (OCS), a stroke-specific screening tool.
Methods:
To evaluate cultural differences, we compared two populations with varying degrees of cultural diversity and Western, Educated, Industrialized, Rich and Democratic (WEIRD) characteristics. We adapted the Dutch OCS for Suriname through a multi-stage process. Using Bayesian hierarchical regression analysis, we compared 264 Surinamese participants, assessed with the adapted Dutch OCS, with 247 Belgian participants, assessed with the Dutch OCS, while controlling for age and education. We further investigated whether the associations of age and education with performance were comparable between the two populations.
Results:
Our findings revealed minimal differences in OCS performance between the Belgian and Surinamese populations. Both populations showed similar age-related decline and education-related improvement across all subtests, except for Picture naming, where the age-related decline was more pronounced in the Belgian population.
Conclusion:
These findings suggest that with minimal adaptation, the OCS is a viable tool for screening post-stroke neurocognitive disorders in culturally diverse populations.