While prior studies have consistently linked immigration attitudes with public support for the welfare state, it is not yet clear how individuals process immigrant-related information in their home contexts and combine that with their existing immigration attitudes to update their attitudes toward the welfare state. In this paper, we consider how context (i.e., immigrant welfare participation rates in individuals’ home states) works in tandem with immigration attitudes to shape Americans’ support for the welfare state. We merge state contextual data on the welfare consumption rates of immigrants with micro-level public opinion data from the Cumulative American National Election Survey (CANES) for the years from 2004 to 2016. Our results suggest that individuals’ immigration attitudes and the degree of immigrant welfare participation in their home contexts combine to influence Americans’ welfare spending attitudes. More specifically, among individuals with unfavorable immigration attitudes, higher levels of immigrant welfare participation in their state contexts lead to significantly lower levels of welfare support. Likewise, in states with high-immigrant welfare participation rates, negative immigration attitudes have a stronger negative effect on welfare support. These findings suggest that Americans’ support for the welfare state is not only determined by their existing immigration attitudes but also the reality of immigrant welfare usage in their home contexts.

We aimed to develop a new ice cream made from goat milk inoculated with the probiotic bacteria Limosilactobacillus fermentum CABA16. The physicochemical characteristics, meltdown behaviour and sensory properties of ice cream produced with and without the probiotic bacteria were analysed. The ice cream with added L. fermentum was further evaluated for probiotic viability during frozen storage and simulated gastrointestinal conditions. Results showed that the addition of L. fermentum CABA16 decreased the pH to 6.25 (P < 0.05), but had no effect on physicochemical properties such as overrun and melting behaviour of ice cream samples. The viable probiotic count was 6.71 log CFU/g with a survival rate of 90%, which was registered after 120 days of frozen storage. Considering the probiotic cell viability during gastrointestinal conditions, exposure to bile and pancreatin for 6 hours resulted in a decline of 3.6 log CFU/g cycles in ice cream samples previously stored at −18 °C for 120 days. Overall, the goat milk ice cream inoculated with L. fermentum received good sensory scores, and satisfactory probiotic viability (6.7–7 log CFU/g) was maintained throughout the 120 days of frozen storage.

El estudio científico de la literatura lírica náhuatl contenida en manuscritos novohispanos como Cantares mexicanos y Romances de los señores de la Nueva España se ha enfocado en su traducción, estética, temática e interpretación. Esto ha permitido una mayor comprensión de la forma y estilística literaria mexica, así como de su manera de percibir el mundo en relación con su visión política y religiosa. Este estudio propone una aproximación etnohistórico-gastronómica a los elementos comestibles enunciados en los cantares para la interpretación de su contenido ideológico, poniendo atención en aspectos como su transformación culinaria, consumo compartido, simbolismo y significado. Se establece un inventario de sustantivos comestibles y se identifica la presencia de procedimientos culinarios, usos terapéuticos y significados mítico-religiosos que complementan la interpretación del discurso en los cantares. Para ello, se revisaron exhaustivamente los manuscritos, se introdujeron nuevas traducciones y se cotejaron las coincidencias con crónicas y herbarios-recetarios contemporáneos. La aportación consiste en la novedosa aplicación de un enfoque que pone en evidencia la presencia de elementos comestibles en la literatura lírica náhuatl y abre nuevas vías para la lectura e interpretación, más allá de lo literario y formal, de otros documentos literarios novohispanos tempranos.

Salmonella enterica is a Gram-negative bacterium responsible approximately for 155,000 deaths annually. S. enterica is one of the most important foodborne pathogens, affecting mainly people in developed countries. The human immune system produces antibacterial peptides and proteins like lactoferrin (LF). This work addresses the hypothesis that bovine lactoferrin (bLF) and its derivative peptides bLactoferricin17-30, bD-Lactoferricin17-30, bLactoferrampin265-284, bD-Lactoferrampin265-284 and bLF-chimera have antimicrobial activity on planktonic cells and pre-formed biofilms of S. enterica. Planktonic Salmonella enterica ATCC 14028 were treated with bLF and bLF-peptides for two hours, and bacterial viability was determined by counting colony-forming units/ml. In addition, S. enterica biofilms were pre-formed or established on an abiotic surface, and viability or disruption was assessed in the presence of bLF and bLF-peptides by counting colony-forming units/ml or using the live/dead viability kit. We observed that bLF and bLF-peptides were bactericidal against planktonic S. enterica, killing more than 80% of cultures after two hours of treatment. The bactericidal effect was concentration and time-dependent. In addition, bLF, bLFampin165-284, and bLF-chimera showed an anti-biofilm effect against Salmonella biofilms pre-formed during 8 and 12 hours on the abiotic surface, disorganizing more than 50% of the biofilms after 4 or 6 hours of treatment. We conclude that bLF and its peptides show antimicrobial activity against planktonic cells and pre-formed biofilms of S. enterica on abiotic surfaces and could potentially be a therapeutic solution to combat Salmonella infections.

There is increasing demand for milk and dairy products and an associated increase in milk production in Asia and Africa, making them important emerging dairy markets for the future. To the best of our knowledge, there has been little effort to comprehensively review literature on dairy production in these regions despite the changing situation, growth and challenges that require sustainable solutions. Thus, the objective of this review was to present an overview and evaluation of the dairy industry in selected countries in Eastern Africa and Asia using recent literature. The countries were selected based on the potential of dairy production in the respective regions. It focused on two types of countries: those in East Africa, which are at different stages of intensification regarding the global production issue, and those in Asia, which have large dairy industries. Based on this, Ethiopia, Kenya and Tanzania were selected from eastern Africa, while India, Pakistan and China were selected from Asia. The review revealed that dairy production in Eastern Africa predominantly relies on small-scale production systems. Factors such as inadequate feed, disease prevalence, poor access to breeding and formal/organized market pose significant challenges to this region's dairy industry. However, recent efforts have focused on improving productivity through technology adoption, livestock breeding programmes and market development initiatives. In contrast, Asia showcases a diverse range of dairy production systems. Countries like India are known for their large-scale dairy operations involving both indigenous and exotic dairy breeds. Additionally, cooperative models and public-private partnerships have contributed to the growth of the dairy sector in Asian countries. Nevertheless, challenges such as land/feed availability, environmental concern, and market competitiveness remain areas for improvement. While Eastern Africa aims to enhance small-scale farming systems through partly upgrading scale of production, innovation and market access, Asia seeks to bridge the gaps in productivity and sustainability.

This study proposes a novel time-varying, endogenous fiscal reaction function, and investigates whether and how the US government responded to the rising debt to assess the sustainability of its debt over 1916 to 2022. The reaction function is estimated via a state space model using Bayesian methods by treating its coefficient as an unobservable stochastic process. Although there is evidence that the government considered long-term projections of the interest rate in its fiscal decisions, the response to debt was largely driven by unobservable non-economic factors and by large and persistent shocks. We find that the government was more proactive about constraining debt increases during the 20th century than previously thought (such as in Bohn, 1998), but it has become less aggressive ever since. The debt-GDP ratio was sustainable for almost the entire sample period, but its steady state value has been rising consistently in recent years. The government’s response to debt contributed 6.0 percentage points to the surplus-GDP ratio in the postwar 20th century, but only 3.6 percentage points afterward.

The blood-milk barrier (BMB) forms at parturition when the gland switches form a non-lactating state to one of copious milk production and becomes leaky again when milk removal ceases and mammary involution is initiated. In this review the importance of the BMB in milk production and, in particular, its hormonal regulation is explored. Tight junctions (TJ) between adjacent mammary epithelial cells form a barrier to the two-directional paracellular movement of small molecules between the blood and milk and are responsible for establishing and maintaining the BMB. They form part of the cell's junctional complex and consist of transmembrane proteins that are linked to the mammary cell's cytoskeleton. This means that when, during lactation, TJ become “leaky” the resulting perturbation of the cytoskeleton interferes with the cell's secretory function. As such, TJ are involved in regulating and maintaining milk production. Mammary TJ are under hormonal control, with progesterone, glucocorticoids, prolactin, parathyroid hormone-related peptide (PTHrP) and serotonin (5-HT) being the key hormones. Progesterone prevents closure of TJ and the immediate prepartum drop in its concentration is a prerequisite for TJ closure. A simultaneous increase in the levels of glucocorticoids and prolactin is necessary for full TJ closure and initiation and maintenance of lactation. Both PTHrP and 5-HT are important hormones in maintaining extracellular calcium concentrations, a requirement for maintaining TJ integrity. Whereas PTHrP reduces TJ permeability, necessary for establishing and maintaining milk production, 5-HT has an opening effect on TJ. The latter may help speed up mammary involution and facilitate the movement of immune factors into the gland, preventing intramammary infections. In summary, mammary TJ make up the BMB and play a role in establishing and maintaining milk production and are under hormonal control, with progesterone, glucocorticoids, PTHrP and 5-HT being key regulatory hormones and prolactin likely playing a supporting role.

This article examines the theology of Katherine Parr, sixth and surviving wife of Henry VIII, through a close reading of her mature work, The Lamentation of a Sinner. In particular, I treat Parr’s theological use of the epistle to the Romans to inform and structure her doctrine of the work of Christ within The Lamentation. I argue that Parr follows the structure of Romans in her opening lament over sin, her central discussion of the cross of Christ, and her application of this theology to the Christian lives of the people of England’s church. I also posit Parr’s use of several overlapping motifs for Christ’s work within The Lamentation’s treatment of the atonement and its relationship to the Protestant understanding of justification by faith.

The aim of this Research Communication was to develop new flow cytometric tools for the fine identification and characterization of milk somatic cells in water buffalo (Bubalus bubalis). Four multicolour panels of antibodies were designed to identify different subsets of live leukocytes and epithelial cells in bulk milk samples. Panel 1, including the CD18/CD172a/CD14/CD16 markers and Live/Dead vitality dye, allowed us to identify total lymphocytes, polymorphonuclear neutrophils (PMN) and monocyte/macrophage subsets. Panel 2 (CD18/CD4/CD8/δ chain/CD335 and Live/Dead dye) allowed us to identify T helper (CD4+), T cytotoxic (CD8+), γδ lymphocytes and NK cells. Panel 3 (CD18/CD79a/CD21 and Live/Dead dye) allowed us to identify total and CD21+ B lymphocytes. Finally, with Panel 4 (CD18/MHC-I/pan Cytokeratin and Live/Dead dye) the epithelial cells were distinguished from leukocytes. In conclusion, we propose a fine characterization of live milk somatic cell (live differential cell count (LDCC)) in buffalo species. In the future the determination of LDCC could used to identify new markers for detecting early inflammatory states of the mammary gland or for monitoring the technological properties of milks of different somatic cell composition.

On January 20, 2025, President Donald Trump issued a presidential memorandum that mandated all federal employees return to in-person work full time. Implementation guidance from the Office of Personnel Management (OPM) required rapid policy revisions. The order marks a sharp departure from prior federal telework policies, including longstanding efforts to expand flexible work as a tool for recruitment, retention, productivity, and inclusion. Contrary to claims that in-person work boosts efficiency, research shows remote work generally has no adverse impact on productivity and supports performance in both public and private sectors. The return-to-office mandate is likely to lead to turnover, particularly among highly skilled workers, creating risks of brain drain and diminished capacity to compete with the private sector for talent. It also threatens diversity, equity, and inclusion (DEI) efforts by disproportionately burdening women, caregivers, individuals with disabilities, workers of color, and LGBTQ+ employees. These changes, alongside parallel executive actions undermining DEI programs, reflect a broader return to traditional, centralized models of work built on outdated “ideal worker” norms. These changes have the potential to negatively reshape federal employment for years to come.

On what basis may the International Criminal Court (“ICC”) exercise its jurisdiction over States that have withdrawn from the Rome Statute? Is it enough that the alleged crimes occurred before the State withdrew from the treaty? When acting proprio motu, does the Prosecutor have to seek authorization from a Pre-Trial Chamber before they are allowed to proceed with the criminal investigation post-State withdrawal? This issue has received only cursory attention from the ICC and the academic community but the lack of clarity around the Court’s post-withdrawal jurisdiction is a serious concern, and not only for States that have withdrawn their membership (such as the Philippines). It is important because, as things stand, and given what the Court has said so far, States parties cannot be sure of the parameters of the Court’s temporal jurisdiction, nor of the legal effects of a State’s withdrawal.

Although unconditional cash transfers (UCTs) were an important government intervention during the COVID-19 crisis worldwide, research covering UCTs’ impact on compliance with public health recommendations, at an individual level, remains limited to low-income countries. This study assesses the association between UCTs’ reception and compliance with public health recommendations in the United States. Longitudinal data from the Understanding Coronavirus in America panel are applied to difference-in-differences models to estimate how Economic Impact Payments’ reception, associated with the CARES Act 2020, impacted a variety of pandemic health behaviours. UCTs’ reception was associated with increased uptake of explicitly costly health behaviours, such as facemasks, but not with increased compliance amongst behaviours more generally. Moreover, results document stronger effects amongst poorer households. These findings have theoretical implications for how government transfers impact individual behaviour during periods of crisis and for the direction of future research.