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Infertility affects 15% of all couples worldwide and 50% of cases of infertility are solely due to male factors. A decrease in motility in the semen is considered one of the main factors that is directly related to infertility. The use of supplementation to improve the overall sperm quality has become increasingly popular worldwide. The purpose of this study was to evaluate whether sperm motility was affected by the combination of serotonin (5-HT), selenium (Se), zinc (Zn), and vitamins D, and E supplementation. Semen samples were incubated for 75 min at 37°C in medium containing varying concentrations of 5-HT, Se, Zn, vitamin D, and E. 5-HT (200 μM), Se (2 μg/ml), Zn (10 μg/ml), vitamin D (100 nM), and vitamin E (2 mmol) have also been shown to increase progressive sperm motility. Three different mixtures of supplements were also tested for their combined effects on sperm motility and reactive oxygen species (ROS) production. While the total motility in the control group was 71.96%, this was found to increase to 82.85% in the first mixture. In contrast the average ROS level was 8.97% in the control group and decreased to 4.23% in the first mixture. Inclusion of a supplement cocktail (5-HT, Se, Zn, vitamins D and E) in sperm processing and culture medium could create an overall improvement in sperm motility while decreasing ROS levels during the incubation period. These molecules may enhance the success of assisted reproduction techniques when present in sperm preparation medium.
Experiments were performed to document the complex flow field around and over a $70^{\circ }$ swept fin mounted on a $7^{\circ }$ half-angle right-circular cone in a Mach 6 free-stream. Of particular interest is the turbulent transition of the boundary layer over the swept fin, which is expected to be dominated by a cross-flow instability. Stationary features in the surface temperature distribution over the fin are documented using infrared thermal imaging. These were processed further to determine average spatial Stanton number distributions over the fin. Wavelet analysis of the Stanton number distributions revealed stationary patterns with wavelengths near the fin leading edge that were consistent with linear theory predictions of stationary cross-flow modes. Further from the leading edge, the wavelength of the stationary patterns was observed to increase prior to turbulence onset. Based on these observations, specially designed arrays of discrete roughness elements (DREs) were investigated as a means of delaying turbulence transition with the objective of reducing surface heat flux on the swept fin. The DRE designs followed our previous approach used for cross-flow transition control (Corke et al., J. Fluid Mech., vol. 856, issue 10, 2018, pp. 822–849; Arndt et al., J. Fluid Mech., vol. 887, 2020, A30). These focused on either the shorter wavelengths near the leading edge, or the longer wavelengths that developed near turbulence onset. With regard to delaying transition and reducing the surface heat flux, the DREs that focused on the larger wavelengths of stationary modes were most effective. The fin included an array of pressure sensors that were used to document travelling disturbances that could include those associated with travelling cross-flow modes. Phase analysis of the pressure fluctuation time series was used to determine the wavelength, wave angle and phase speed that were consistent with the travelling cross-flow modes. Cross-bicoherence analysis between the stationary and travelling disturbances indicates a nonlinear phase locking that can account for the development of the longer-wavelength stationary features in the surface heat flux, presumed to be due to stationary cross-flow modes, prior to turbulence onset.
Developing policies to reduce carbon emissions in agriculture is crucial for achieving the ‘dual carbon’ goal. Therefore, scientifically analysing the temporal and spatial distribution characteristics of agricultural carbon sinks and their driving factors holds paramount importance for the coordinated and integrated development of regional agriculture and the realization of sustainable development. Based on the perspective of carbon cycle in agricultural production, the measurement system of agricultural net carbon sink was established from the perspective of carbon sink/carbon source, this study conducted an analysis of the temporal and spatial variation characteristics as well as driving mechanisms of agricultural net carbon sinks. The findings are as follows: (1) The agricultural net carbon sink exhibited an increasing trend from 2009 to 2020, with favourable intensity and level. (2) Agricultural land use and livestock and poultry production constituted the primary sources of agricultural carbon emissions. Notably, agricultural carbon emissions demonstrated a decreasing trend during the study period. (3) The net agricultural carbon sink displayed local spatial aggregation, indicating significant regional differences. (4) Factors such as rural economic level, urbanization level and agricultural employment significantly promoted the net carbon sink. In contrast, the rural industrial structure, technical level and crop seeding had inhibitory effects. Therefore, it is imperative to promote the reduction of agricultural carbon emissions in the Beijing-Tianjin-Hebei region. This entails accelerating the construction of new agriculture and rural areas, facilitating industrial upgrading, promoting the development of low-carbon-sink regions into high-carbon-sink regions and actively fostering the coordinated and integrated development of regional agriculture.
The spread and application of enterprise information systems (EISs) has provided scholars and managers with a new perspective to enhance the work–family enrichment. Based on the work–family enrichment theory, this research aims to examine the ability of female employees to enhance their work–family enrichment by applying the resources accumulated through the use of EISs by combining the technology acceptance model with the DeLone & McLean Information Systems Success Model. The findings based on a survey of 823 full-time female employees in China indicated that the information systems quality factors (including information quality, system quality, and service quality) were positively associated with female employees’ work–family enrichment. In addition, the chained mediating effect of perceived ease of use and perceived usefulness was examined. The results can help female employees to perform positively in both work and family spheres and provide positive support for the promotion of the social fertility policies.
This paper argues, in response to scholarly criticism, that Thomas Aquinas’s account of the virtue of humility in the Summa Theologiae does not undermine the importance of humility in the Christian moral life. While the Summa’s classification of humility as a ‘potential part’ of temperance, which results from Thomas’s reliance on classical sources, has been blamed for this work’s perceived belittling of humility, an understanding of the Summa’s overall scope and Aquinas’s system of organizing virtues therein helps demonstrate that this categorization does not imply a lesser significance of humility either than other virtues in the Summa or than humility as treated in his Bible commentaries. Furthermore, even if the Summa’s structure creates limited space for an extensive discourse on humility, the establishment of humility’s reciprocity with magnanimity and absolute contradiction of pride leave no doubts as to the magnitude of this virtue. Thus, the ‘humble’ portrayal of humility in the Summa not only adequately but aptly expresses this uniquely Christian virtue, capturing the way it disposes human beings to ‘creaturely’ reverence before the Creator, and invites a more holistic understanding of Aquinas’s virtue ranking in the Secunda Secundae.
This article explores the experiences of keyworkers within a third-sector employability programme targeted at people furthest from work. Using semi-structured qualitative interviews, the study investigated keyworker perspectives on effective elements of programme design, and what made the critical difference for those who did move into employment. Echoing previous research, findings confirmed the value of a holistic and personalised approach founded upon a consistent and long-term relationship of trust and support, through which programme participants developed the confidence and self-belief that was critical to progression towards employment. However, critical attention to the keyworker perspective offers novel insights, bringing to light challenges in defining role parameters and maintaining personal-professional boundaries in the interests of keyworkers and programme participants. We contribute to the body of research on employability practitioner perspectives, revealing that the strengths of person-centred support may simultaneously present tensions and wellbeing risks, where role parameters are very broadly defined.
Despite increased interest in corporate social irresponsibility (CSI) among business scholars, the current research is still fragmented, its findings lacking a nuanced understanding. We conduct a systematic literature review of 173 journal articles on CSI published in the field of business and synthesize insights regarding the antecedents, consequences, and mechanisms of CSI. We begin by providing a clear definition, distinct types, and the measurement methods of CSI. Then, we provide a comprehensive research framework that demonstrates the three key components of CSI research: antecedent, consequence, and moderating. Building on this, we identify additional specific research methods for each component and apply them to assess and analyze the existing research findings and research gaps concerning CSI. We suggest that scholars pay more attention to (a) the impact of stakeholders on CSI behavior, (b) the different impacts of CSI on firm performance, (c) the relationship among CSI, corporate social responsibility, and firm performance, (d) CSI in the context of emerging economies, and (e) measuring CSI.
This paper proposes a fixed-time anti-saturation (FT-AS) control scheme with a simple control loop for the 6-Degree-of-Freedom tracking (6-DOF) control problem of spacecraft with parameter uncertainties, external disturbances and input saturation. Considering the external disturbance and parameter uncertainties, the dynamical model of the tracking error is established. The traditional methods of handling input saturation usually add anti-saturation subsystems in the control system to suppress the impact of input overshoot. However, this paper directly inputs the input overshoot into the tracking error model, thus constructing a modified lumped disturbance term that includes the influence of input overshoot. Then, a novel fixed-time disturbance observer (FT-DO) is designed to estimate and compensate for this modified lumped disturbance. Therefore, there is no need to add the anti-saturation structures in the control loop, significantly reducing the complexity of the system. Finally, an observer-based fixed-time non-singular terminal sliding mode (FT-NTSM) controller is designed to guarantee the fixed-time stability of the whole system. In this way, the convergence time of the proposed scheme does not depend on the system’s initial conditions. Simulation results illustrate that the proposed method keeps the control input within the limit while achieving high-precision tracking control of attitude and position.
A conceptual revision occurred at the heart of anarchist theory between the end of the nineteenth and the mid-twentieth centuries. As anarchist thinkers grappled with a state transformed beyond recognition by technological change, they reassessed their critique of state power and the rhetorical methods used to expose its inherent violence. Where nineteenth-century anarchists favored organic metaphors to emphasize the monstrosity of the state, twentieth-century anarchists tended to adopt a set of mechanical metaphors. This change focused attention on the idea of technocracy, and informed a more comprehensive assessment of the state's activities. This article analyses this innovation in anarchist political thought, before tracing it through to Herbert Read's critical appraisal of C. P. Snow's influential lecture “The Two Cultures and the Scientific Revolution,” and Snow's response to Read. Their debate, in which Read challenged Snow's argument that the pursuit of technological and political modernization was essential to maintain the nation's international role and address the social and economic challenges of the mid-century, was a contest for Britain's future. Drawing on his anarchism, Read saw such ideas as an existential threat, with the unthinking promotion of a technological “revolution” imperiling “the tender shoots of all that is human.” Contextualizing Read in his anarchist intellectual milieu, this article recovers a neglected voice in British intellectual and cultural history, the complexities of an overlooked political tradition, and a radical vision of Britain's future that questioned the dominant assumptions of the age.
The History of Economics Society (HES) has traveled a long way throughout its fifty conferences, from the first one organized by Warren Samuels and Vincent Tarascio on May 30 and 31, 1973, in Chicago, to the fiftieth annual meetings that took place on June 23 to 25, 2023, in Vancouver, Canada. This journey can be analyzed in different ways, and here we focus on the presidential addresses delivered as a guide to our analysis. From the conference programs we identified a total of forty-four presidential addresses: the first to appear on the conference program was Vincent Tarascio’s speech on Vilfredo Pareto, on the second day of the Boston conference in 1975. Since 1975, presidential addresses have become a regular feature of the conference, with rare exceptions such as the 1977 Irvine, CA, conference or in the recent years when Marcel Boumans’s presidential address was postponed from 2020 to 2022 due to the COVID-19 pandemic. Of the forty-four presidential addresses in the history of HES, we analyzed the forty-one that were published in scholarly journals (see Table 1). However, we could not find whether two presidential addresses—specifically Joseph Spengler, HES conference 1976, Chicago; and Carl Uhr, HES conference 1978, Toronto—have been published. Moreover, Robert Leonard has not published the address he delivered at the 2015 HES conference but two related papers.
The US National Action Plan for Combating Antibiotic-Resistant Bacteria established a goal to decrease unnecessary outpatient antibiotic use by 50%. However, data to inform this goal have been limited to medical settings and have not included dental prescribing. Thus, we sought to identify the proportion of antibiotics prescribed inappropriately by dentists to inform outpatient stewardship efforts.
Methods:
Cross-sectional analysis of 2019 Veterans’ Affairs (VA) national electronic health record data. Antibiotics prescribed by dentists were evaluated for appropriateness based on 2 definitions: one derived from current guidelines (consensus-based recommendations) and the other based on relevant clinical literature (nonconsensus). A clustered binomial logistic regression model determined factors associated with discordant prescribing.
Results:
In total, 92,224 antibiotic prescriptions (63% amoxicillin; mean supply, 8.0 days) were associated with 88,539 dental visits. Prophylaxis for complications in medically compromised patients was associated with the most (30.9%) antibiotic prescriptions, followed by prevention of postsurgical complications (20.1%) and infective endocarditis (18.0%). At the visit level, 15,476 (17.5%) met the consensus-based definition for appropriate antibiotic usage and 56,946 (64.3%) met the nonconsensus definition.
Conclusions:
More than half of antibiotics prescribed by dentists do not have guidelines supporting their use. Regardless of definition applied, antibiotics prescribed by dentists were commonly unnecessary. Improving prescribing by dentists is critical to reach the national goal to decrease unnecessary antibiotic use.
A quaternary ammonium and alcohol-based disinfectant with reported continuous activity demonstrated reduced microbial buildup on surfaces over time compared to routine disinfectants without continuous activity in in vitro and hospital studies. We compared these disinfectants in ambulatory settings and found no difference in bioburden on high-touch surfaces over time.
The novel coronavirus (COVID-19) disease outbreak started in China and went on to affect the entire world. Healthcare providers were among the communities that faced severe challenges during the pandemic, and this was especially true of Pre-Hospital Emergency Medical Services (PHEMS) providers.
Objectives:
This study aims to investigate the effect of the COVID-19 pandemic on service requests submitted to PHEMS providers via calls made to emergency hotlines.
Methods:
Data were obtained on calls made to 112 (the emergency hotline) during March – August 2020 (i.e., during the pandemic) and the same period the previous year (i.e., the pre-pandemic period). These 2 data sets were analyzed and compared using the SPSS 26 software package (IBM Corp., Armonk, New York, USA).
Results:
The results of the analysis indicated that the total number of emergency calls received during the pandemic period (11 745) increased compared to the pre-pandemic period (10 747), whereas there was a decrease in the proportion of trauma-related emergency calls during the pandemic period (5.3%) compared to the pre-pandemic period (6.8%). Furthermore, there was a higher proportion of extended service times among ambulances serving in PHEMS during the pandemic period (ambulance movements longer than 90 seconds: 15.6%) compared to the pre-pandemic period (ambulance movements longer than 90 seconds: 8.6%). Non-emergency ambulance usage rate was 44.90% in the pre-pandemic period and 38.90% in the pandemic period.
Conclusions:
As the study’s results show that there was an increase in the number of calls to PHEMS during the pandemic period, especially given that a significant portion of these calls consisted of non-emergency calls, it is recommended that measures be taken to reduce the excessive load on PHEMS during a pandemic.