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Neuropsychological criteria for mild cognitive impairment (MCI) more accurately predict progression to Alzheimer’s disease (AD) and are more strongly associated with AD biomarkers and neuroimaging profiles than ADNI criteria. However, research to date has been conducted in relatively healthy samples with few comorbidities. Given that history of traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are risk factors for AD and common in Veterans, we compared neuropsychological, typical (Petersen/Winblad), and ADNI criteria for MCI in Vietnam-era Veterans with histories of TBI or PTSD.
Method:
267 Veterans (mean age = 69.8) from the DOD-ADNI study were evaluated for MCI using neuropsychological, typical, and ADNI criteria. Linear regressions adjusting for age and education assessed associations between MCI status and AD biomarker levels (cerebrospinal fluid [CSF] p-tau181, t-tau, and Aβ42) by diagnostic criteria. Logistic regressions adjusting for age and education assessed the effects of TBI severity and PTSD symptom severity simultaneously on MCI classification by each criteria.
Results:
Agreement between criteria was poor. Neuropsychological criteria identified more Veterans with MCI than typical or ADNI criteria, and were associated with higher CSF p-tau181 and t-tau. Typical and ADNI criteria were not associated with CSF biomarkers. PTSD symptom severity predicted MCI diagnosis by neuropsychological and ADNI criteria. History of moderate/severe TBI predicted MCI by typical and ADNI criteria.
Conclusions:
MCI diagnosis using sensitive neuropsychological criteria is more strongly associated with AD biomarkers than conventional diagnostic methods. MCI diagnostics in Veterans would benefit from incorporation of comprehensive neuropsychological methods and consideration of the impact of PTSD.
Acanthocephalans constitute a small taxonomic group related to rotifers and specialized in a parasitic lifestyle. Anurans act as paratenic and definitive hosts and infections always occur trophically. Our objective is to describe and summarize the richness of acanthocephalans in Neotropical anurans. We conducted a literature review in the main research databases, compiling data published until August 2021. We identified 66 articles with records of acanthocephalan-anuran association, 53.03% were carried out in Brazil. We detected 108 species of anurans from 11 families parasitized by acanthocephalans. With the exception of Bufonidae, Hylidae and Leptodactylidae, which are relatively well-studied families, interaction with acanthocephalans remains largely unexplored for most anuran species. We found six families of acanthocephalans: Centrorhynchidae, Echinorhynchidae, Oligacanthorhynchidae, Cavisomidae, Neoechinorhynchidae and Plagiorhynchidae. Centrorhynchidae and Echinorhynchidae presented the largest number of taxa associated with anurans. The largest number of records corresponded to acanthocephalans in the larval stage (cystacanths), for which anurans act as paratenic hosts. We observed a lack of specific taxonomic resolution in the identifications of most reports, because a large part of the records in the larval stage make morphological identification difficult. Brazil, Mexico, Paraguay, Argentina, Ecuador and Peru are the countries with the most records, while Costa Rica, Venezuela, Colombia, Chile and Uruguay exhibited the lowest publication numbers, resulting in gaps in the distribution of acanthocephalans. We expanded the known number of anuran species parasitized by acanthocephalans, compared to the last published review. Overall, we aim to contribute to the understanding of diversity within this intriguing but understudied group.
The late nineteenth-century harbour districts, or so-called ‘sailortowns’, are generally depicted as deterritorialized ‘enclaves’ of heightened globalized transience. However, these neighbourhoods were just as much shaped by semi-durable local labouring communities. This article studies lodging houses as facilitators of global and local entanglements in harbour districts from a socio-cultural perspective, with Antwerp in the late nineteenth century as a case-study. Analysing the spatiality, materiality, sociability and people of the lodging phenomenon, it reveals that next to the highly transient seafarers, sailortown accommodated a diverse yet largely local population of small entrepreneurs and their families right between transience and permanence.
An extended turbulent state can coexist with the stable laminar state in pipe flows. We focus here on short pipes with additional discrete symmetries imposed. In this case, the boundary between the coexisting basins of attraction, often called the edge of chaos, is the stable manifold of an edge state, which is a lower-branch travelling wave solution. We show that a low-dimensional submanifold of the edge of chaos can be constructed from velocity data using the recently developed theory of spectral submanifolds (SSMs). These manifolds are the unique smoothest nonlinear continuations of non-resonant spectral subspaces of the linearized system at stationary states. Using very low-dimensional SSM-based reduced-order models, we predict transitions to turbulence or laminarization for velocity fields near the edge of chaos.
Toxic pharmaceutical pollutants, such as nicotine, represent a significant threat to natural water sources due to their continuous discharge. To address this issue, clay minerals and their composites have demonstrated exceptional adsorptive and remedial capabilities for wastewater purification. This research focused on developing green clay-polymeric adsorbents for the efficient removal of pharmaceutical pollutants from industrial wastewater. The synthesis involves creating halloysite nanotube–polythiophene nanocomposites through a green and cost-effective method using vapour polymerization and a solvent-free, ball-milled technique for the adsorptive removal of nicotine from wastewater. The investigation evaluates the impacts of preparation, modification and environmental conditions on the adsorptive performance of these clay-based nanocomposites compared to pure polythiophene. The polymerization process was evaluated by varying the vapour polymerization holding time for a fixed amount of oxidant (FeCl3) and halloysite nanotube (HNT) to investigate the impacts of monomer vapour exposure time on the polymerization of nanocomposites. Following the characterization of the synthesized adsorbents using various methods, the study investigated the impacts of various parameters (e.g. adsorbent dosage, pH and contact time) on the adsorption capabilities of the materials on a laboratory scale. The results revealed that the incorporation of HNT improved the adsorbing performance of nanocomposites. The pH, absorbent concentration and contact time directly affect nicotine adsorption. Significantly, halloysite–polythiophene 3 with a 2 h polymerization duration demonstrated the maximum adsorption efficacy of 78.94% at pH 10 after a 24 h contact time. The environmentally friendly halloysite-based nanocomposite shows promising potential as an effective adsorbent for pharmaceutical pollutant (nicotine) removal from aquatic environments.
Self- and informant-ratings of functional abilities are used to diagnose mild cognitive impairment (MCI) and are commonly measured in clinical trials. Ratings are assumed to be accurate, yet they are subject to biases. Biases in self-ratings have been found in individuals with dementia who are older and more depressed and in caregivers with higher distress, burden, and education. This study aimed to extend prior findings using an objective approach to identify determinants of bias in ratings.
Method:
Participants were 118 individuals with MCI and their informants. Three discrepancy variables were generated including the discrepancies between (1) self- and informant-rated functional status, (2) informant-rated functional status and objective cognition (in those with MCI), and (3) self-rated functional status and objective cognition. These variables served as dependent variables in forward linear regression models, with demographics, stress, burden, depression, and self-efficacy as predictors.
Results:
Informants with higher stress rated individuals with MCI as having worse functional abilities relative to objective cognition. Individuals with MCI with worse self-efficacy rated their functional abilities as being worse compared to objective cognition. Informant-ratings were worse than self-ratings for informants with higher stress and individuals with MCI with higher self-efficacy.
Conclusion:
This study highlights biases in subjective ratings of functional abilities in MCI. The risk for relative underreporting of functional abilities by individuals with higher stress levels aligns with previous research. Bias in individuals with MCI with higher self-efficacy may be due to anosognosia. Findings have implications for the use of subjective ratings for diagnostic purposes and as outcome measures.
Keeping a tube from being plugged by a fluid is an important process in applications. An interesting re-entrant phenomenon for the capillary state with the occluding state sandwiching the non-occluding state from both the high- and low-Bond-number regions can appear by inserting a rod into a horizontal tube at an eccentric position (Tan et al., J. Fluid Mech, vol. 946, 2022, A7). Containers with rounded corners are very common. We theoretically investigate a situation for a horizontal open tube with rounded corner(s). The results show that a re-entrant non-occlusion at a contact angle can also appear without the insertion of any object. The competition between the rounded corner wetting/non-wetting effect and gravity effect can lead to a re-entrant non-occlusion. The re-entrant non-occlusion is affected by the shape and orientation of the rounded corner(s). For a tube with only one rounded corner, the re-entrant non-occlusion exists when the rounded corner has a not-so-large corner radius and is not in a landscape orientation. For a tube with two (or more) rounded corners, the corner(s) with the strongest corner effect will determine the existence or non-existence of the re-entrant non-occlusion. This paper provides an effective scheme for designing a high-performance capillary with corners that are not easily occluded by a fluid and removing fluid blockage from a capillary in optofluidic/microfluidic applications.
We report new material of the rare early Eocene rodent Lophiparamys debequensis Wood, 1962 from the Willwood Formation of the southern Bighorn Basin, north-central Wyoming. The new material constitutes the first record of L. debequensis from the Bighorn Basin and documents aspects of the anatomy of Lophiparamys that were previously unknown, including a portion of the maxilla and a portion of the tarsus. The maxillary fragment demonstrates that Lophiparamys has a small P3 and a relatively large infraorbital canal. The tarsus of Lophiparamys is similar to that of other early rodents but differs in a few features that suggest an arboreal locomotor repertoire, including an asymmetric astragalar trochlea, long astragalar neck, transverse astragalar sustentacular facet, short calcaneal tuber, elongate calcaneal ectal facet, and circular calcaneal cuboid facet. The presence of arboreally adapted features in the tarsus of Lophiparamys is consistent with a hypothesized relationship between small-bodied Eocene microparamyine rodents and extant Gliridae. Phylogenetic analysis fails to consistently support this relationship or monophyly of Microparamyinae, but both remain plausible. Comparison of L. debequensis with other species of the genus emphasizes the distinctiveness of L. debequensis and suggests the presence of multiple lineages of Lophiparamys.
When is speech on social media toxic enough to warrant content moderation? Platforms impose limits on what can be posted online, but also rely on users’ reports of potentially harmful content. Yet we know little about what users consider inadmissible to public discourse and what measures they wish to see implemented. Building on past work, we conceptualize three variants of toxic speech: incivility, intolerance, and violent threats. We present results from two studies with pre-registered randomized experiments (Study 1, $ N=\mathrm{5,130} $; Study 2, $ N=\mathrm{3,734} $) to examine how these variants causally affect users’ content moderation preferences. We find that while both the severity of toxicity and the target of the attack matter, the demand for content moderation of toxic speech is limited. We discuss implications for the study of toxicity and content moderation as an emerging area of research in political science with critical implications for platforms, policymakers, and democracy more broadly.
Timely intervention is beneficial to the effectiveness of eating disorder (ED) treatment, but limited capacity within ED services means that these disorders are often not treated with sufficient speed. This service evaluation extends previous research into guided self-help (GSH) for adults with bulimic spectrum EDs by assessing the feasibility, acceptability, and preliminary effectiveness of virtually delivered GSH using videoconferencing.
Method:
Patients with bulimia nervosa (BN), binge eating disorder (BED) and other specified feeding and eating disorders (OSFED) waiting for treatment in a large specialist adult ED out-patient service were offered virtually delivered GSH. The programme used an evidence-based cognitive behavioural self-help book. Individuals were supported by non-expert coaches, who delivered the eight-session programme via videoconferencing.
Results:
One hundred and thirty patients were allocated to a GSH coach between 1 September 2020 and 30 September 2022; 106 (82%) started treatment and 78 (60%) completed treatment. Amongst completers, there were large reductions in ED behaviours and attitudinal symptoms, measured by the ED-15. The largest effect sizes for change between pre- and post-treatment were seen for binge eating episode frequency (d = –0.89) and concerns around eating (d = –1.72). Patients from minoritised ethnic groups were over-represented in the non-completer group.
Conclusions:
Virtually delivered GSH is feasible, acceptable and effective in reducing ED symptoms amongst those with bulimic spectrum disorders. Implementing virtually delivered GSH reduced waiting times, offering a potential solution for long waiting times for ED treatment. Further research is needed to compare GSH to other brief therapies and investigate barriers for patients from culturally diverse groups.
The Laboratoire de Mesure du Carbone 14 (LMC14) has operated a radiocarbon dating laboratory for almost twenty years with ARTEMIS, the Accelerator Mass Spectrometer (AMS) based on a NEC 9SDH-2 Pelletron tandem accelerator. A first status report describing the chemical pretreatment methods was published in 2017 (Dumoulin et al. 2017). This article summarizes updates of the routine procedures and presents new protocols. The quality checks in place at the LMC14 and results obtained for the GIRI international inter-comparison are reported. New protocols developed by the laboratory over the last five years are described with the preparation of iron, lead white, cellulose, calcium oxalate, and mortar. This report also provides a summary of practical information for sample preparation and can help the laboratory users who provide samples and publish results to better understand all the work behind a 14C dating.
Drawing on corporate and business association archives, this contribution investigates how Swiss multinational enterprises from the pharmaceutical industry (Ciba, Geigy, Hoffmann-La Roche, Sandoz) navigated governments’ interventions in France to preserve their profitability. Our analysis shows how diplomatic talks were crucial for Swiss firms having to cope with rising inflation and the freezing of drug prices, as well as increased customs controls targeting multinationals’ transfer prices. In particular, promises of future R&D were used as a tool in negotiations, and secrecy about prices and profits formation was key in maintaining pressure on the French government. The article also highlights that from the mid-1980s onwards, pharmaceutical multinationals promoted the creation of the Single Market, since it had the potential to enforce supranational rulings over national discretionary pricing policies.
Let A be a separable (not necessarily unital) simple $C^*$-algebra with strict comparison. We show that if A has tracial approximate oscillation zero, then A has stable rank one and the canonical map $\Gamma $ from the Cuntz semigroup of A to the corresponding lower-semicontinuous affine function space is surjective. The converse also holds. As a by-product, we find that a separable simple $C^*$-algebra which has almost stable rank one must have stable rank one, provided it has strict comparison and the canonical map $\Gamma $ is surjective.
In 2023, prospection of a dried-out lake near Papowo Biskupie in north-central Poland identified substantial deposits of bronze artefacts. Excavation revealed further deposits and dozens of human skeletons that date from 1000–400 BC, suggesting that the site held particular significance as a place for sacrificial offerings in the Lusatian culture.