To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Haemolysis is developing prominence in the setting of supporting increasingly complex children with heart failure with a ventricular assist device. The goal of this study is to better characterise haemolysis and its implications in children supported with pulsatile ventricular assist devices.
Methods:
This is a single-centre retrospective review of 44 children who were supported by Berlin Heart EXCOR between January 2006 and June 2020. Patients were divided into major haemolysers and non-major haemolysers. Major haemolysers were defined as patients with lactate dehydrogenase > 500U/L (2.5x the upper limits of normal) with either total bilirubin > 2mg/dL (with predominantly indirect hyperbilirubinemia) or anaemia out of proportion to the clinical scenario more than three days following implantation of the ventricular assist device(s). Patient demographics, ventricular assist device factors, and outcomes, including end-organ function and mortality, were compared between major haemolysers and non-major haemolysers.
Main results:
Forty-four patients supported by the Berlin EXCOR were included in the analytic cohort of the study: 27 major haemolysers and 17 non-major haemolysers. Major haemolysis was more common in those supported with single-ventricle ventricular assist device (i.e., VAD in the context of functionally univentricular anatomy) compared to those with biventricular hearts, p = 0.01. There were no patients with an isolated left ventricular assist device or isolated right ventricular assist device in our analytic cohort of 44 patients. Of the 19 patients with single-ventricle ventricular assist device, 84% (16/19) were major haemolysers. Of the 25 patients with a biventricular assist device, 44% (11/25) were major haemolysers. Major haemolysers and non-major haemolysers had a body surface area of 0.28 and 0.40, respectively (p = 0.01). Overall, survival to discharge from the hospital was 66% (n = 29/44). Survival to discharge from the hospital was 52% (14/27) in major haemolysers versus 88% (15/17) in non-major haemolysers, p = 0.02. Only 3 of the 27 with major haemolysis had severe haemolysis, that is, lactate dehydrogenase > 2000 and bilirubin above 10. Non-major haemolysers had a better improvement in creatinine clearance during ventricular assist device support, p < 0.0001. (During the same era of this study, 22 patients who were supported with Berlin Heart were excluded from the analytic cohort because they did not have any recorded measurement of lactate dehydrogenase. Seventeen of these 22 patients had no clinical evidence of haemolysis. Survival to discharge from the hospital in this excluded cohort was 86% [19/22].)
Conclusions:
Major haemolysis in patients with pulsatile ventricular assist device is more likely with single-ventricle ventricular assist device support and smaller body surface area.
Recent changes instituted by the US government pose a sinister threat to the integrity of science worldwide. We roundly refute the many contrived assertions that have been unfairly levelled against scientists and their natural philosophy and implore them to champion the apodictic principles of science.
An analysis is presented of the suspensions of small, electrified particles in a gas. Two limits of interest for the electrodynamic particulate suspension technique are considered, corresponding to large and small values of the ratio $t_{coll}/t_s$ of the mean time between particle collisions to the viscous adaptation time required for the particles to reach their terminal velocities. The effect of the particle inertia can be neglected when this ratio is large, and only the distribution of particle charges at each point of the suspension needs to be computed. The way this distribution approaches an equilibrium form, determined elsewhere in the continuum regime when the mean free path of the particles is small compared with the suspension size, is described, as well as the connection between continuum regime and quasi-neutrality of the suspension. In the opposite case when $t_{coll}/t_s$ is small, the inertia of the particles plays an important role, and the joint distribution of particle charges and velocities is required. A Boltzmann equation is proposed for this distribution function, taking advantage of the fact that the charges of the particles have little effect on the redistribution of momentum and energy in the collisions. The equilibrium distribution function in the continuum regime is computed approximately, and hydrodynamic equations for the particle phase analogous to the Euler equations for a monoatomic gas are derived. The simplification of these equations when the particle inertia is negligible at the scale of the suspension is worked out.
Excavations at the Infantas complex in Chillón Valley, Perú, revealed a U-shaped monumental centre with a central mound, clay staircase and columned atrium. Aligned with structures from the Rímac and Lurín valleys, these complexes anchored ritual-political power, serving as hubs for ideological integration and territorial organisation in early Andean societies.
This study examines how human activities influenced soil development at two contrasting Arctic sites: Maiva, a 19th-century farmstead, and Snuvrejohka, a seasonal Sámi reindeer herding settlement in the Lake Torneträsk region, northern Sweden. Using geochemical and geophysical soil analyses, we explore the spatial distribution and vertical development of anthropogenic signals in the soil. At Maiva, prolonged agricultural use and earthworm bioturbation have led to extensive soil mixing and altered soil horizons, resulting in elevated phosphate, lead, and organic matter concentrations in Ap and Ah horizons. In contrast, Snuvrejohka displays more stratified profiles with localized chemical enrichment around hearths, primarily within E horizons. These results highlight how different land-use practices leave distinct geochemical fingerprints in Arctic soils and emphasize the need for sampling strategies adapted to site-specific soil formation processes. Our findings demonstrate that even short-term or seasonal human activities can leave distinct and detectable signatures in Arctic soils. Through an integrated approach combining soil science, geoarchaeological methods, and historical data, this study provides new insights into the reconstruction of past land-use practices and highlights the vulnerability of archaeological soil records in Arctic environments facing rapid climate-driven change.
Explorations of ideology retain special significance in contemporary studies of judicial politics. While some existing methodologies draw on voting patterns and coalition alignments to map a jurist’s latent features, many are otherwise reliant on supplemental proxies – often directly from adjacent actors or via assessments from various prognosticators. We propose an alternative that not only leverages observable judicial behavior, but does so through jurists’ articulations on the law. In particular, we adapt a hierarchical factor model to demonstrate how latent ideological preferences emerge through the written text of opinions. Relying on opinion content from Justices of the Supreme Court, we observe a discernible correlation between linguistic choices and latent expressions of ideology irrespective of known preferences or voting patterns. Testing our method against Martin-Quinn, we find our approach strongly correlates with this validated and commonly used measure of judicial ideology. We conclude by discussing the intuitive power of text as a feature of ideology, as well as how this process can extend to judicial actors and institutions beyond the Supreme Court.
This stidy aimed to identify factors influencing prognosis in severe full-frequency sudden sensorineural hearing loss and develop an early prognostic tool.
Methods
A total of 194 patients with severe full-frequency sudden sensorineural hearing loss were analyzed. Univariate analysis screened variables, followed by multivariate logistic regression to construct a nomogram prediction model. Model performance was evaluated using a receiver operating characteristics curve.
Results
Significant differences (p < 0.05) were found between ineffective and effective treatment groups in gender, age, contralateral ear hearing, duration of hearing loss, dizziness/vertigo, hypertension, platelet count and fibrinogen levels (Fib1, Fib2, Fib3). The nomogram model, incorporating these factors, showed good calibration. The receiver operating characteristics curve analysis revealed an area under the curve of 0.880 (95 per cent confidence interval: 0.829–0.931), with sensitivity of 80.7 per cent and specificity of 87.5 per cent.
Conclusion
The nomogram model, integrating 11 factors, effectively predicts prognosis in severe full-frequency sudden sensorineural hearing loss.
Aristotle’s views about the female body are commonly held to be an insurmountable obstacle to aligning his philosophy with feminism. Sarah Borden Sharkey, however, has attempted a robust Aristotelian feminism that alters only the minimum. She argues that to succeed it must give positive and detailed reasons for sexual equality, a task that she leaves open. Building on Sharkey’s work, this essay argues that Thomas Aquinas’ view of the will allows such a position, by combining it with Aristotle’s notion of thumos as the main dividing factor between the sexes. The result is an Aristotelian–Thomistic view that keeps female biological difference, while allowing equality in attaining virtue and prudence.
The analyzed data provide evidence for sound changes that involve cumulative effects in the phonologization of phonetic duration. The data come from Kashubian, an understudied, endangered language spoken in northwestern Poland, and illustrate two historical processes: preservation and loss of ultra-short vowels (jers) and compensatory lengthening. The unified analysis of the two processes hinges on a reinterpretation of phonetic vowel duration as phonological length. Phonetic duration is contextual: Vowels in head syllables, in open syllables, and before voiced consonants tend to be longer than vowels in non-head syllables, in closed syllables, and before voiceless consonants. The effects are cumulative in the sense that all three conditions must co-occur on a single vowel. The discussed changes provide support for phonological models that (i) allow phonological constraints to access fine-grained phonetic information and (ii) are capable of deriving cumulative effects. The data contribute to the typology of cumulative processes by providing novel evidence of alternations that are simultaneously conditioned by the prosodic and segmental context.
The COVID-19 pandemic, which has killed millions of people worldwide, continues to be marked by waves of reinfections. We aimed to assess the incidence and clinical characteristics of reinfection in COVID- 19 cohort.
Material and Methods
A single-center descriptive study was conducted. Data were collected from all patients who tested positive for SARS-CoV-2 via PCR from March 18, 2020, the onset of the first major COVID-19 wave, until the end of 2020. All PCR-positive patients were followed-up, and those who had SARS-CoV-2 PCR positivity again at least 90 days after the initial onset were contacted via telemedicine.
Results
5814 patients diagnosed with COVID-19 with PCR positive in the first wave were included. The incidence of reinfection among the cohort of patients infected with SARS-CoV-2 during the initial wave of COVID-19 was 0.73%. Among healthcare workers, the 1-year reinfection rate was 2.14%, 3.9 times higher than non-healthcare workers. We observed that the clinical course was milder and less complicated in patients who had reinfection. In cases of reinfection among fully vaccinated individuals, statistically significantly fewer symptoms were observed.
Conclusions
We observed that healthcare workers are at approximately four times greater risk of reinfection. Reinfections generally presented with a milder clinical course.
In this study, the objective examined the contribution of pecha kucha technique instead of standard training in providing crisis management skills to nurse managers.
Methods
102 nurse managers participated in the study conducted with a quasi-experimental structure. Nurse managers participating in the study were divided into 3 groups as experimental, standard, and control, and each group included 34 nurse managers. Crisis management training was given to the experimental group with the pecha kucha technique, and to the standard group with the classical presentation technique. A crisis management scale was applied to measure crisis management skills before and after the trainings.
Results
It was observed that crisis management scores increased in both groups after the trainings compared to the control group. When the scores of the experimental and control groups were compared, a significant difference was found (P < 0.05). The crisis management total and sub-dimension mean scores were higher in the experimental group than in the standard education group.
Conclusions
In line with these findings, it can be said that using innovative training techniques such as pecha kucha instead of standard training for managers or other nurses can increase their professional development and the quality of health care services.
Ce numéro spécial est le résultat de la collaboration entre les membres du Groupe de recherche interuniversitaire sur la normativité (GRIN) durant l’année 2023-2024. Principalement situé dans les universités de l’île de Montréal, ce groupe a pour objectif d’explorer le thème de la normativité en philosophie selon trois axes principaux : normativité et société, normativité et affectivité, normativité et connaissance. Une visée commune s’est progressivement révélée au fil de nos rencontres : dévoiler de manière critique les différentes sortes de normativité qui ont été soit oubliées, soit ignorées. Cela nous a donc laissé croire que certaines normes pourraient avoir été perdues de vue, et c’est de là que nous sont venus le titre et le thème de ce numéro spécial : « À la recherche des normes perdues ». La présente introduction donne un aperçu des huit articles qui forment le numéro.
Special Ricci–Hessian equations on Kähler manifolds $(M,g)$, as defined by Maschler [‘Special Kähler–Ricci potentials and Ricci solitons’, Ann. Global Anal. Geom.34 (2008), 367–380], involve functions $\tau $ on M and state that, for some function $\alpha $ of the real variable $\tau\kern-0.8pt $, the sum of $\alpha \nabla d\tau\kern-0.8pt $ and the Ricci tensor equals a functional multiple of the metric g, while $\alpha \nabla d\tau\kern-0.8pt $ itself is assumed to be nonzero almost everywhere. Three well-known obvious ‘standard’ cases are provided by (non-Einstein) gradient Kähler–Ricci solitons, conformally-Einstein Kähler metrics, and special Kähler–Ricci potentials. We show that, outside of these three cases, such an equation can only occur in complex dimension two and, at generic points, it must then represent one of three types, for which, up to normalizations, $\alpha =2\cot \tau\kern-0.8pt $, $\alpha =2\coth \tau\kern-0.8pt $, or $\alpha =2\tanh \tau\kern-0.8pt $. We also use the Cartan–Kähler theorem to prove that these three types are actually realized in a ‘nonstandard’ way.