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Food insecurity affects the health of college-aged individuals, but its impact on the gut microbiome (GM) over time is poorly understood. This study explored the association between food insecurity and the GM in eighty-five college students, identifying microbial taxa, metabolites and pathways linked to food security status and examining GM stability and microbe–metabolite interactions. Longitudinal GM and metabolomic data were collected from first-year students over an academic year, encompassing periods of variable food security status. Participants were categorised into three groups: food insecure (FI, n 13), food secure (FS, n 44) and variable (VAR, n 28) status. GM composition varied significantly between FS classifications (Bray–Curtis dissimilarity, P ≤ 0·005). Stability analysis revealed correlations between stability scores and microbial features, pathways and metabolites. Specific microbes (e.g. Bifidobacterium species, Faecalibacterium prausnitizii D and Lachnospiraceae), pathways (energy and microbial turnover) and metabolites (cadaverine, N-acetylcadaverine, putrescine, testosterone sulfate and creatine) associated with FI status were identified. Multi-omic integration revealed metabolic pathways influenced by differentially abundant microbial species and co-occurring fecal metabolites in FI participants related to the microbial production of polyamines, detoxification and energy metabolism. The transition from FS to FI showed no significant differences at specific taxonomic, functional or metabolite levels. This study uncovers complex interactions between food security, GM composition and metabolism. Significant differences were found in microbial community variability and metabolic pathways associated with food security status, but the transition from food security to insecurity disrupted the GM without clear taxonomic or functional distinctions, emphasising the need for further research into these mechanisms.
Precision medicine (PM) encompasses various emerging, data-intensive healthcare and biomedical research initiatives aimed at tailoring care to individual patient characteristics. While “precision” primarily denotes an epistemological shift in how biomedical research is approached and care delivered, the conviction that PM empowers patients in clinical decision-making is central to its vision as it is taken up across policy contexts. In this paper, I critically assess these promises by drawing on recent engagements in agential epistemic injustice (Lackey 2020; Medina 2022). I suggest that the social, cultural, and epistemological conditions in which the epistemic practice of precision care unfolds are conducive to epistemic injustice. Despite PM’s explicit aims to address longstanding criticisms regarding the disease-centric nature of contemporary biomedical care practices by including person-centered, non-biomedical features in clinical consideration, exploring its underlying logic suggests its epistemic economy is stacked against patients’ epistemic interests. As such, despite its laudable aim of patient empowerment, the exacerbated risk of epistemic injustice might truncate patients’ (epistemic) agency, further disempowering them in clinical decision-making. To conclude, I suggest that the reliance on “empowerment”- and “person-centered care”-rhetoric dominating PM discourse is a case of epistemic appropriation (Davis 2018), further discouraging engagement with social, experiential, and phenomenological dimensions of illness, defanging critics of raising those concerns, and impeding the realization of epistemic justice in healthcare.
Predicting long-term outcome trajectories in psychosis remains a crucial and challenging goal in clinical practice. The identification of reliable neuroimaging markers has often been hindered by the clinical and biological heterogeneity of psychotic disorders and the limitations of traditional case-control methodologies, which often mask individual variability. Recently, normative brain charts derived from extensive magnetic resonance imaging (MRI) data-sets covering the human lifespan have emerged as a promising biologically driven solution, offering a more individualised approach.
Aims
To examine how deviations from normative cortical and subcortical grey matter volume (GMV) at first-episode psychosis (FEP) onset relate to symptom and functional trajectories.
Method
We leveraged the largest available brain normative model (N > 100 000) to explore normative deviations in a sample of over 240 patients with schizophrenia spectrum disorders who underwent MRI scans at the onset of FEP and received clinical follow-up at 1, 3 and 10 years.
Results
Our findings reveal that deviations in regional normative GMV at FEP onset are significantly linked to overall long-term clinical trajectories, modulating the effect of time on both symptom and functional outcome. Specifically, negative deviations in the left superior temporal gyrus and Broca’s area at FEP onset were notably associated with a more severe progression of positive and negative symptoms, as well as with functioning trajectories over time.
Conclusions
These results underscore the potential of brain developmental normative approaches for the early prediction of disorder progression, and provide valuable insights for the development of preventive and personalised therapeutic strategies.
Climbing aroids, despite their abundance in tropical forests, remain underexplored. This study is focused on species richness, abundance, density, and distribution patterns of climbing aroid community in a lowland rainforest in Los Tuxtlas, Veracruz, Mexico. Over two years, two censuses were conducted across 14 plots, recording 12 aroid species from five genera and their potential hosts. Ontogenetic classes were defined and validated, showing a positive correlation between total plant length/apex height and ontogenetic stage, indicating distinct growth phases. Host size (DBH) was significant predictor of the establishment probability across ontogenetic classes. Vertical distribution varied significantly among species, ranging from Philodendron hederaceum (7 m) to Anthurium flexile (0.88 m), with some species predominantly distributed on specific host sizes. Tree falls impacted specific species. Although limitations, including a short study period, restrict broader generalizations, this research establishes a foundational understanding of climbing aroid ecology and underscores the need for standardized methods and long-term monitoring to elucidate their population dynamics and ecological strategies.
The phenomenon of bulge evolution under the action of gravity on shallow water is prevalent both in natural occurrences and engineering industries. However, despite its ubiquity, its physical process remains largely unexplored. The evolution of bulge contains two fundamental physical processes: collapse and propagation. The collapse process can be further divided into two sub-processes: squeezing process and diffusion process. Based on the weakly nonlinear shallow water assumption with the classical perturbation method, the governing equations controlling the surface elevations in the diffusion process and the propagation process have been theoretically derived, where a bulge-induced surface pressure is modeled for the propagation process. Moreover, their scaling laws for the decay of wave height are also established, which have been validated by direct numerical simulation results. The derived scaling laws for wave height attenuation of bulge evolution provide profound insights, which hold the potential to applications in the engineering industry.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention and/or hyperactivity-impulsivity, accompanied by deficits in executive function (EF). However, how the two core symptoms of ADHD are affected by EF deficits remains unclear. 649 children with ADHD were recruited. Data were collected from ADHD rating scales, the Behavior Rating Inventory of EF (BRIEF), and other demographic questionnaires. Regression and path analyses were conducted to explore how deficits in cool and hot EF influence different ADHD core symptoms. Latent class analysis and logistic regression were employed to further examine whether classification of ADHD subtypes is associated with specific EF deficits. EF deficits significantly predicted the severity of ADHD core symptoms, with cool EF being a greater predictor of inattention and hot EF having a more significant effect on hyperactivity/impulsivity. Moreover, person-centered analyses revealed higher EF deficits in subtypes of ADHD with more severe symptoms, and both cool and hot EF deficits could predict the classification of ADHD subtypes. Our findings identify distinct roles for cool and hot EF deficits in the two core symptoms of ADHD, which provide scientific support for the development of ADHD diagnostic tools and personalized intervention from the perspective of specific EF deficits.
Latin American countries have pioneered innovations in social protection, but their welfare institutions suffer from large and persistent gaps and inequalities in access and provision. This article reviews the substantive body of research addressing this anomaly. A focus on social protection offers a window on what is distinctive about social policy in the region. The social protection matrix in Latin America combines three core institutions: occupational insurance funds, personal pensions and social assistance. The article highlights the role of political realignments shaping current institutions. The critical review yields several pointers for a ‘general’ theory of welfare institutions.
The purpose of the South African Competition Act is to resolve the present problems of inequality by emphasizing its multiple goals, which differ from those of other countries. Its objectives broadly contain efficiency, state economic development and consumer welfare. In addition, the ideas of providing opportunities for small businesses and promoting a greater spread of ownership among different groups indicate its goal of favouring or protecting weak trading parties or certain groups of people. To achieve the aim of equity and fairness, South African competition law should be vigorously applied, but the existing substantive provisions may not fulfil the task of moving towards an equal and fair society. A comparative study of competition law may help to discover a proper model and a better solution for the problems of unequal economic power in South Africa.
This paper presents a method to stabilise oscillations occurring in a mixed convective flow in a nearly hemispherical cavity, using actuation based on the receptivity map of the unstable mode. This configuration models the continuous casting of metallic alloys, where hot liquid metal is poured at the top of a hot sump with cold walls pulled in a solid phase at the bottom. The model focuses on the underlying fundamental thermohydrodynamic processes without dealing with the complexity inherent to the real configuration. This flow exhibits three branches of instability. The solution of the adjoint eigenvalue problem for the convective flow equations reveals that the regions of highest receptivity for unstable modes of each branch concentrate near the inflow upper surface. Simulations of the linearised governing equations show that a thermomechanical actuation modelled on the adjoint eigenmode asymptotically suppresses the unstable mode. If the actuation’s amplitude is kept constant in time, which is easier to implement in an industrial environment, the suppression is still effective but only over a finite time, after which it becomes destabilising. Based on this phenomenology, we apply the same actuation during the stabilising phase only in the nonlinear evolution of the unstable mode. It turns out stabilisation persists, even when the unstable mode is left to evolve freely after the actuation period. These results not only demonstrate the effectiveness of receptivity-informed actuation in stabilising convective oscillations but also suggest a simple strategy for their long-term control.
With numerous applications of coilable masts in high-precision space application scenarios, there are also greater demands on the accuracy of their dynamic modelling and analysis. The modelling of hinges is a critical issue in the dynamic modelling of coilable masts, which significantly affects the accuracy of the dynamic response analysis. For coilable masts, the rotational effect is the most important problem in hinge modelling. However, few studies have focused on this topic. To address this problem, the concept of hinge equivalent rotational stiffness is proposed in this paper to describe the rotational effect of the coilable mast hinges. After that, a new coilable mast dynamic model containing the undetermined hinge equivalent rotational stiffness is introduced, and an identification method for the hinge equivalent rotational stiffness based on the hammer test is proposed. Finally, the dynamic modelling method is validated through an actual coilable mast example, and the analysis and test results show that the accuracy of the dynamic model established by the proposed method in this paper is greater than that of the traditional model.
Resource partitioning remains a central ecological issue for understanding the structures of animal communities. As members of the generalist New World Thraupidae bird family, tanagers can help reinforce knowledge of animal communities. Thus, to study bird trophic ecology and relationships, I followed six tanager species (Schistochlamys ruficapillus, Tangara desmaresti, Stilpnia cayana, Stephanophorus diadematus, Thraupis sayaca and Dacnis cayana) from the Ibitipoca State Park, south-eastern Brazil, for 12 months. I expected 1) more similarities among frugivorous behaviours when compared to the similarities in the frugivorous diet, 2) no differences between the predation behaviours on arthropods against the use of substrates to capture them, 3) no specialisation in the bird–fruit seed dispersal network and 4) similarities of frugivorous diet and substrate use equal those expected by chance due to the absence of specialisation in frugivory and limited use of substrates. Several ecological and behavioural factors seemed to determine the ways in which Ibitipoca tanagers consumed fruits to reduce similarities in diets and reveal network specialisation. On the other hand, the analysis of predation behaviour indicated that tanager species used similar tactics to reach arthropods randomly on substrates. In general, frugivory seems to be more relevant in trophic partitioning than foraging on arthropods in Ibitipoca tanagers.
The study objective was to identify the specific challenges experienced by nurses, assess the mental health impacts, and evaluate their role adaptation in response to the ongoing conflict.
Methods
A quantitative, descriptive study was conducted involving 202 nurses from 3 hospitals in the South West Bank. Data were collected through a structured questionnaire addressing socio-demographic information, psychological challenges, and role adaptation during the conflict.
Results
The study surveyed 300 nurses, revealing critical findings regarding their psychological well-being and professional challenges. Approximately 65% of respondents reported experiencing symptoms consistent with PTSD, indicating a significant psychological toll due to their work conditions. In terms of workload, 78% of nurses reported an increased patient influx, leading to higher stress levels and burnout. The analysis indicated that nurses faced severe resource shortages, with 60% reporting inadequate medical supplies and 55% citing insufficient staffing.
Conclusions
The findings underscore the urgent need for enhanced training programs, mental health support, and improved disaster management protocols. Educational background and marital status significantly influence nurses’ resilience and adaptability in conflict zones. Addressing these challenges is essential to improving the well-being of nurses and enhancing the quality of care in conflict-affected areas.
This article examines socialist globalization from the perspective of technical-labor internationalism in Mozambique, focusing on the final stage of the Cold War. First, it analyzes the four main pathways through which international technicians arrived in Mozambique: Latin American exile, socialist intergovernmental cooperation, European postcolonial humanitarianism, and African regionalism. It offers a cosmopolitan perspective on the relations that socialist Mozambique forged with the world. It then provides an inventory of the models of integration of these international technicians into the Mozambican state apparatus, presenting a framework emphasizing organizational rather than ideological aspects. It concludes that, while these paths were singular, they were not mutually exclusive. More importantly, they were instrumental in shaping the political affinities and frictions between international technicians in that cosmopolitan universe.
This study assesses the validity and reliability of empirical strategies derived from the study of European populisms by applying them to the case of Canada. Using a dataset of 5,845 original tweets by Canadian federal party leaders in 2022, we compare the prevalence and intensity of three characteristic populist discourses: “people-centrism,” “anti-elitism” and “exclusion of others.” Our results raise questions about the role of party ideology in shaping populist communication styles, by revealing a convergence among opposition leaders around primarily economic representations of the “people” and political portrayals of the “elite.” We also confirm the hunch that Canada is “exceptional” with respect to the prevalence of “exclusion of others,” demonstrating that this discourse is rare and has not been embraced by mainstream politics. Finally, the study adds to the skepticism about the value of “people-centrism” to operationalizing populism, given the widespread nature of this discourse.
We report the surgical outcomes and functional results in a pediatric population following the use of the laryngotracheal LT-moldR prosthesis to treat complex glottic and subglottic stenosis.
Methods
A retrospective observational study in children following open and endoscopic surgical treatment for LT stenosis.
Results
Among 46 patients, 91% received LT-mold during an open surgery and 9% had it following an endoscopic procedure. 93% patients were successfully decannulated and 80% needed stent placement for longer than 2 months. Mean time to decannulation was 229 days. Currently, 83% patients have normal breathing, 67% patients have normal voice or mild dysphonia and swallowing outcomes have remained similar in the pre- and post-operative period.
Conclusion
The LT-mold provided an adequate airway stenting, enabling decannulation in most patients with advanced grades of laryngotracheal stenosis. Duration of stenting and time to decannulation showed no correlation with the grade of stenosis or patient comorbidities. Functional results were optimal.