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Experts step into global governance most prominently in times of crisis. But if crisis governance at international organizations (IOs) involves the construction of specific temporal horizons, how do these horizons affect the constitution of expert authority? This article argues that expertise produced under such conditions – to meet a demand for ‘timely’ knowledge – differs substantively from other kinds of expertise. Crisis governance thus contributes in notable ways to the pluralization of expertise. The article examines this phenomenon in the case of the relatively recent proliferation of rapid response mechanisms (RRMs). By examining the making and implementation of RRMs at two major IOs – the World Health Organization and the World Food Programme – the article offers a new understanding for how RRMs have become part of institutional repertoires of expertise. Based on this, it contends that RRM-based timeliness claims a shift in expert knowledge production from credentialed individuals to infrastructures and standardized procedures; second, they prioritize large homogenous datasets over consultation and contestation among different experts; and third, they streamline expert selection such that experts are recruited from existing intra-institutional pools rather than third parties. Jointly, these shifts speed up monitoring and reaction capabilities, but also risk eroding important checks on expert overconfidence.
The Incas territorial expansion process was motivated not only by ideological, political, and economic factors but also involved the ritual integration of ancient sanctuaries through capacocha offerings. Notable examples include the Sacred Rock (Roca Sagrada) of the Island of the Sun (Lake Titicaca) and the Oracle of Pachacamac (Lurín Valley). The antiquity of these two sanctuaries, combined with their roles as destinations for imperial-scale pilgrimages during the Inca period, underscore their significance and uniqueness and the role of the capacocha ritual to connecting places into the Inca world. The material correlates associated with numerous capacocha rituals recorded in the Andes demonstrate that this ritual adhered to standardized conventions and criteria. The canonical archaeological remains of capacocha are characterized by human sacrifices and specific offerings, particularly anthropomorphic figurines made of precious metals or Spondylus. The absence of human corpses in certain contexts can be attributed to taphonomic factors but also to ritual adaptations specific to the locations where they were discovered. In this article, we develop this adaptive model for two of the major sites of Inca cosmology: Lake Titicaca and Pachacamac, emphasizing their close connection to Cuzco, the imperial capital and center of the Inca world.
We consider the filtering problem associated with partially observed McKean–Vlasov stochastic differential equations (SDEs). The model consists of data that are observed at regular and discrete times; the objective is to compute the conditional expectation of (functionals) of the solutions of the SDE at the current time. This problem is challenging even in the ordinary SDE case and requires numerical approximations. Based on the ideas in Ben Rached et al. (2024) and dos Reis et al. (2023), we develop a new particle filter (PF) and multilevel particle filter (MLPF) to approximate the aforementioned expectations. We prove under assumptions that, for $\varepsilon>0$, to obtain a mean square error of $\mathcal{O}(\varepsilon^2)$ the PF has a cost per observation time of $\mathcal{O}(\varepsilon^{-5})$, and the MLPF costs $\mathcal{O}(\varepsilon^{-4})$ (best case) or $\mathcal{O}(\varepsilon^{-4}\log(\varepsilon)^2)$ (worst case). Our theoretical results are supported by numerical experiments.
The objective of the current study was to evaluate 30 previously uncharacterised pure plant secondary metabolites (PSM) for effects on in vitro gas production (GP) and methane concentration. Purified compounds (n = 4) were incubated in buffered rumen fluid for 48 h at a rate of 25 mg per g substrate. Gas production was measured using ANKOM RF pressure analysers and gas composition was measured using gas chromatography. Dry matter and fibre digestibility and volatile fatty acid (VFA) concentrations were determined. Data were analysed using a linear mixed model with fixed effect of treatment, random effect of experimental run and blank as a covariate and Dunnett’s test to compare each treatment to a control. Sabenine, apigenin, galangin, isoliquiritigenin, quercetin, rutin, vitexin, abscisic acid and uridine reduced methane concentration, with a tendency for reduction by kaempferol. Sabenine, thymol, apigenin, quercetin, rutin, vitexin, abscisic acid and uridine reduced methane production, with the greatest reduction occurring for rutin (81.8 %), vitexin (81.7 %) and thymol (80.5 %). Eight compounds increased methane production compared to control, with stigmasterol having the greatest increase (173.0 %). Out of the compounds that reduced methane emissions, a reduction in fibre digestibility was observed for all except quercetin and thymol. Minimal effects of PSM on VFA profile were observed, with myrtenal increasing proportion of acetate, alpha-humulene, alpha-longipinene and beta-caryophyllene increasing proportion of propionate and thymol, apigenin, hyperoside and verbenone increasing proportion of butyrate. Results suggest that quercetin and thymol warrant further exploration as potential feed additives to reduce methane emissions.
In this work, we introduce a new class of algebras that we denominate skew-Brauer graph algebras. This class contains and generalizes the Brauer graph algebras. We establish that skew-Brauer graph algebras are symmetric and can be defined based on a Brauer graph with additional information. We show that the class of trivial extensions of skew-gentle algebras coincides with a subclass of skew-Brauer graph algebras, where the associated skew-Brauer graph has a multiplicity function identically equal to one, generalizing a result over gentle algebras. Furthermore, we characterize skew-Brauer algebras of finite representation type. Finally, we provide a geometric interpretation of cut-sets and reflections of algebras using orbifold dissections.
This article presents and discusses a table of audiovisual transformations based on practice-based experience. The transformations were designed to reinforce the link between sound and object by considering what a particular audio process would look like if translated into visual form. The creative work involves installations that focus on objects integrated with projection mapping and electroacoustic sound. Examples of other artists who create object-based works are introduced, followed by a discussion around how electroacoustic music can influence audiovisual approaches. Screen and installation-based audiovisual theory expands on this and links to a two-part table of transformation strategies. The first part of the table describes process-based links that were created to imagine how certain electroacoustic studio techniques would translate to alter visual material. The second part describes broader conceptual links between audio and visual elements. The findings offer an insight into how electroacoustic practice can inform audiovisual composition choices. Whilst the intended use was for sound installations, there is significant scope for others to adopt and adapt the transformation strategies beyond this, including visual artists who wish to work with sound and those seeking to further theorise audiovisual relationships in a variety of settings.
This study conducted an approximate replication of Teravainen-Goff (2023) to validate the Intensity and Perceived Quality of Engagement Scale for university students in the Japanese EFL context. Teravainen-Goff (2023) developed this scale based on an action-oriented definition of engagement and proposed a novel approach to measuring engagement among secondary school language learners in the UK. The study identified an 18-item, five-factor structure from a pool of 36 items through exploratory factor analysis (EFA). In this replication, we examined the validity and reliability of Teravainen-Goff’s scale in a different context, focusing on the replicability of the EFA results. We undertook this replication because engagement is context-dependent and EFA results can vary across samples. We compared the factorial structure with that of the initial study while modifying the target language and participant demographic. Results revealed a 22-item, six-factor structure with good fit. Although the same underlying factors emerged, several notable differences were observed. This approximate replication provided stronger evidence for the psychometric properties of the scale in a new context. Transparent documentation of modifications to the initial study and systematic comparison offered a promising approach to building robust evidence for engagement research and improving the rigour of questionnaire-based research overall.
Caregivers of older individuals with dementia experience substantial and enduring burden, often exacerbated by patient neuropsychiatric symptoms (NPS). Few longitudinal studies have examined how specific NPS contribute to prolonged caregiver burden.
Methods:
We conducted a 6-month prospective cohort study of 100 dyads of caregivers and older adults with Alzheimer’s disease, frontotemporal dementia and Lewy body dementia recruited from specialized neurology and geriatric clinics. Caregiver burden was assessed using the Zarit Burden Interview (ZBI), and NPS were measured with the neuropsychiatric inventory (NPI) and associated distress scale (NPI-D). Correlation analyses examined associations between baseline NPS and both concurrent and prolonged high caregiver burden.
Results:
At baseline, nearly one-third of caregivers reported moderate-to-severe burden (mean ZBI 31.4 ± 15.4), a prevalence that persisted at 6 months. Higher burden was strongly correlated with total NPI and NPI-D scores (p < 0.001). Specific symptoms – including delusions, hallucinations, agitation, anxiety, disinhibition, depression, sleep disorders and irritability – were consistently associated with greater burden. Depression, anxiety, disinhibition and sleep disturbances predicted prolonged high burden over 6 months. Sex-specific patterns emerged: psychotic symptoms and sleep disorders were more strongly associated with burden in female caregivers, whereas depression and irritability were key drivers for male caregivers.
Conclusion:
Caregiver burden in dementia is both prevalent and persistent, with NPS emerging as major correlates and predictors. Recognition of sex-related patterns may enable earlier identification of at-risk caregivers. Interventions addressing both patient NPS and caregiver coping resources could help reduce long-term distress and improve outcomes for both caregivers and patients.
To describe neuropathological findings in autopsies of patients with isolated, partial or all classic features of the septo-optic-pituitary dysplasia (SOD) triad, speculate on SOD etiology and ascertain the causes of death.
Method:
Retrospective review of autopsy reports of patients with one or more features of the SOD triad.
Results:
Twenty-one (14 females) cases were identified. Median age at death was 2.3 years. Two fetuses died soon after birth, and the rest died at postnatal ages of 3 weeks to 50 years. Ten cases had optic nerve hypoplasia (ONH) with either (i) small pituitary gland/hypopituitarism (five cases) or (ii) absent septum pellucidum (SP)/abnormal corpus callosum (CC) (two cases) or (iii) both (three cases). Eleven cases had one or two features of the SOD triad. A wide spectrum of neuropathological findings was evident, with 12 cases resulting from in utero/perinatal vascular lesions in brain regions that led to ONH/chiasm hypoplasia, hypothalamus/pituitary gland anomalies and agenesis or abnormalities in the SP, CC and olfactory bulbs and tracts. Other suspected causes included three genetic (one with holoprosencephaly), two in utero infection and one arachnoid cyst with hydrocephalus. The most common cause of death was a respiratory illness.
Conclusions:
The autopsy findings appear to be the result of destructive or less commonly impaired developmental processes. Our findings suggest that SOD is not a single disease entity but represents a syndrome with ONH and one or more of: hypothalamic-pituitary dysfunction and absent SP or abnormal CC. We consider ONH an essential part of SOD.
Recent excavations at Gre Fılla, located in the northern part of the Upper Tigris region in modern-day Türkiye, have revealed an architecturally diverse settlement that was occupied during much of the Pre-Pottery Neolithic (c. 9300–7500 BC). While early architecture at the site aligns with developments seen more widely in northern Mesopotamia, the typological diversity that fluoresces during the Pre-Pottery Neolithic B (c. 8800–7500 BC) has previously been under-represented in the region. Here, the author examines the evolution of the architecture uncovered at Gre Fılla, arguing that the increasing architectural complexity reflects the developing social complexity of Neolithic communities.
This article argues that the extent and longevity of dry conservancy systems in urban England between the 1870s and 1920s is underappreciated for its impact on health and disease. Using Birmingham as a case-study, it advances knowledge on the systemized development of municipal pail systems and offers a deeper understanding of living with conservancy. It draws out the importance of looking at the fly problem and the transmission relationship, largely ignored until the second decade of the twentieth century. It also explores and challenges existing ideas in the debates surrounding investment in sanitation infrastructure and mortality decline.
The confirmatory factor analysis technique was used to quantify a latent variable for test-day lactation performance (TDLP) in the first parity of Chinese Holstein dairy cows by applying five measurable traits, including test-day milk yield (TDMY), test-day milk fat percentage (TDFP), test-day milk protein percentage (TDPP), test-day somatic cell score (TDSCS) and test-day milk urea nitrogen (TDMUN). The standardised factor loadings of TDMY, TDFP, TDPP, TDSCS, and TDMUN for describing TDLP were 0.46, −0.52, −0.70, −0.14 and −0.19, respectively. Genetic analysis was conducted using a multivariate repeatability model within a Bayesian framework. The posterior means for the heritability and repeatability estimates of TDLP were 0.26 ± 0.02 and 0.34 ± 0.02, respectively. In general, posterior means for heritability and repeatability estimates of the measurable traits were low to medium. The heritability estimates ranged from 0.05 for TDSCS to 0.28 for TDPP, and repeatability estimates ranged from 0.15 for TDMUN to 0.38 for TDMY. The latent variable of TDLP exhibited positive genetic (0.62) and phenotypic (0.40) correlations with TDMY, whereas its genetic and phenotypic correlations with other measurable traits were negative, ranging from −0.96 (TDLP–TDPP) to −0.11 (TDLP–TDSCS). The corresponding phenotypic correlations ranged from −0.85 (TDLP–TDPP) to −0.07 (TDLP–TDSCS). It may be concluded that breeding for higher TDLP might increase TDMY but could reduce milk composition traits. In general, the negative genetic and phenotypic correlations suggest a trade-off between milk quantity (yield) and quality (composition).
We present several combinatorial properties of semiselective ideals on the set of natural numbers. The continuum hypothesis implies that the complement of every selective ideal contains a selective ultrafilter, however for semiselective ideals this is not the case. We prove that under certain hypothesis, for instance, $V=L$, there are semiselective ideals whose complement does not contain a selective ultrafilter, and that it is also consistent that the complement of every semiselective ideal contains a selective ultrafilter; specifically, we show that if $V=L$ then there is a generic extension of V where this occurs. We present other results concerning semiselective ideals, namely, an alternative proof of Ellentuck’s theorem for the local Ramsey property, and we prove some facts about the additivity of the ideal of local Ramsey null sets, and also about the generalized Suslin operation on the algebra of local Ramsey sets.
Vitamin D deficiency is a common nutritional problem in exclusively breastfed infants. Dilated cardiomyopathy is a rare but potentially fatal complication of this condition. We describe a 15-month-old who presented with cardiogenic shock. Laboratory and radiographic findings were consistent with vitamin D deficiency. Metabolic parameters normalised within one week and echocardiography normalised by 19 months after supplementation. Although rare, severe vitamin D deficiency must be on the differential for young children presenting with new-onset dilated cardiomyopathy. Clinicians must maintain a high index of suspicion for vitamin D deficiency in at-risk populations to prevent potentially life-threatening complications.
Fully resolved three-dimensional simulations of planar gravity currents are conducted to investigate the influence of imposed spanwise perturbations on flow evolution and mixing at two Reynolds numbers ($ \textit{Re}=3450$ and 10 000). The initial perturbations consist of sinusoidal waves with a varying number of repeating waves, $k_y$, with simulations spanning $0 \leqslant k_y \leqslant 8$. At low-$ \textit{Re} $, cases with perturbations ($k_y \gt 0$) exhibit a more rapid breakdown of spanwise coherence compared with the unperturbed case ($k_y = 0$), although the resulting structures retain spatial periodicity and remain relatively ordered. This earlier disruption leads to greater front propagation distances beyond the self-similar inertial phase compared with the unperturbed case. Notably, imposed perturbations exhibit minimal influence on the flow transition; all cases follow the slumping velocity reported in the literature, with the transition into the inertial phase occurring at comparable times across different $k_y$ values at both $ \textit{Re} $. The increased propagation speed is accompanied by reduced mixing efficiency due to the premature disruption of coherent Kelvin–Helmholtz (K–H) billows, which play a key role in maintaining multi-scale mixing. At high-$ \textit{Re} $, the influence of initial spanwise perturbations diminishes, as three-dimensional turbulence induces a more chaotic, fine-scale breakdown of spanwise coherence across all $k_y$ cases, overriding the effects of the initial perturbations. Consequently, the dominant stirring mechanism shifts from K–H billows to vortices within the current head. Nevertheless, the unperturbed case maintains comparatively higher mixing efficiency at both low- and high-$ \textit{Re} $. This is attributed to the persistence of recognisable K–H billow structures, which, despite undergoing chaotic breakdown at high-$ \textit{Re} $, still contribute to effective stirring by stretching and folding the density interface. These results highlight the dual role of K–H billows: they promote efficient mixing, yet the enhanced mixing reduces the density difference between the current and the ambient fluid, weakening buoyancy and slowing front propagation despite stronger stirring. These findings are supported by consistent trends in streamwise density distribution and ‘local’ energy exchange analyses.
This text addresses the materiality of radio art, situating it within the theoretical frameworks of contemporary research on new materialism as well as the materiality of media and sound. The analysis employs perspectives from Christoph Cox’s sonic materialism and approaches by such writers as Salomé Voegelin, Gregory Whitehead, Allen S. Weiss and Margaret Hall, who emphasise the ontological autonomy of sound and its impact on space and listeners. A critical close reading of the relevant literature is conducted with regard to its applicability to radio art. The article analyses radio art practices structurally and phenomenologically across composition, reception, materiality and technology, aligning with practice-informed media analysis. The author’s aim is to outline and systematise diverse theoretical approaches and frameworks that capture the materiality of radio being, as well as to reveal the ways in which the radio medium co-creates artistic sound reality. The results of the literature and artistic practice analysis highlight the significance of sound’s materiality and its relational character, indicating that sound does not exist in isolation but in interaction with the environment, technology and listener. Consequently, seven dimensions of radio art materiality are delineated, which integrate existing concepts and provide a comprehensive perspective on radio artistic works.
Discussions of social organisation in early complex societies often rely on traditional narratives of a linear progression to hierarchy, but archaeological evidence is increasingly showcasing a spectrum of social structures. Here, examination of burial practices in 50 tombs from Kedurma, Sudan, helps illustrate social stratification and identity negotiation beyond the binary rendering of elite/non-elite during the Meroitic period (third century BC to fourth century AD). The diversity of architectural forms and grave goods highlights the importance of inter-regional exchange networks and a more fluid social dynamic, contributing to our understanding of early African state formation.
In the twenty-first century, leftist politics has taken a turn toward antiwork philosophy and postwork imaginaries. These politics critique not only the work-centered capitalist society but also challenge the “productivist ethics” of other leftist traditions. A popular variation of this antiwork/postwork politics calls for full automation, the replacement of as much human labor as possible with technological alternatives. Positioning work as a realm of unfreedom, these thinkers argue that human liberation can only be achieved in a world with less work. This article reads Oscar Wilde’s “The Soul of Man Under Socialism” (1891) as a precocious articulation of a postwork imaginary that demands full automation. In response to contemporaries like William Morris, who argued that capitalism had severed humanity from a natural affinity for work, Wilde expresses an antiwork position, arguing that humanity was made for contemplative leisure and creative expression. Thus, automated labor becomes a key element of his utopian vision. Though Wilde formulates a necessary critique of a Victorian radical politics that was decidedly prowork, his postwork utopia is based on a troubling premise: “civilization requires slaves.” In reading twenty-first-century postwork thinkers alongside Wilde, we find the same premise still subtly operative within this politics.