Recent literature describes the controversy relating to brain death/death by neurological criteria (DNC), which some have referred to as “widely accepted, but not universally supported.” This article provides an overview of differences in state laws relating to DNC and describes recent proposals to reform the definition of brain death. In 2023, the American Academy of Neurology (AAN) issued clinical guidelines stating that clinicians may declare a patient DNC despite evidence of neuroendocrine function — a position that directly conflicts with state law requirements for determining death. This article offers a critical analysis of AAN guidelines, an update on proposals to reform the Uniform Determination of Death Act, and explains why policy discussions should include how DNC exams occur in practice. Research suggests there are flaws with current clinical testing methods, which contributes to two separate problems: (1) false positives from insufficient testing, and (2) inadvertent misdiagnosis from unintentional errors. Together, this has produced confusion and reduced public trust in the concept of brain death. This article provides recommendations to clarify and retain the current legal standard for brain death, explains the ethical importance of accurate standards for determining DNC, and offers practical solutions to reduce errors.

This letter presents key findings from a study conducted in Eastern Turkey, which explored the impact of individuals’ fear of COVID-19 on their participation in cancer screenings. Data from 393 participants aged 50-70 years revealed that higher levels of COVID-19 fear significantly decreased the likelihood of engaging in screening behaviors during the pandemic. The study highlights that fear of infection led to health care avoidance, posing a barrier to early cancer detection. These findings underscore the importance of addressing psychological factors such as fear during public health emergencies to ensure continued access to preventive care.

Riboswitches are RNA elements with a defined structure found in noncoding sections of genes that allow the direct control of gene expression by the binding of small molecules functionally related to the gene product. In most cases, this is a metabolite in the same (typically biosynthetic) pathway as an enzyme (or transporter) encoded by the gene that is controlled. The structures of many riboswitches have been determined and this provides a large database of RNA structure and ligand binding. In this review, we extract general principles of RNA structure and the manner or ligand binding from this resource.

How do “novel” spaces of transnational law emerge rather than being captured within existing legal regimes? This article argues that processes driving how the subject matter of a transnational legal space is defined and framed and by whom are notable in mediating such outcomes. The article presents the empirical case study of global neurotechnology governance and examines socio-legal processes whereby individual and organizational actors have constructed and defended neurotechnology as a distinct space of transnational law. Here, I argue that this can be understood as boundary work, which examines discursive and spatial processes of demarcating social entities from one another. The article shows how attention to external and internal boundaries around and within a transnational legal domain can sensitize socio-legal analysis to the more emergent features of these spaces, including more subtle modes of exclusion, cooperation, and coordination. The article concludes by reflecting on how attention to processes of boundary work can enrich inquiry into, and critique of, the earliest stages of transnational legal ordering.

For a spectrally negative Lévy process X, consider $g_t$ and its infinitesimal generator. Moreover, with $t\geq 0$, the last time X is below the level zero before time $\{(g_t,t, X_t), t\geq 0 \}$ the length of a current positive excursion, we derive a general formula that allows us to calculate a functional of the whole path of $U_t\,:\!=\,t-g_t$. We use a perturbation method for Lévy processes to derive an Itô formula for the three-dimensional process $ (U, X)=\{(U_t, X_t),t\geq 0\}$ in terms of the positive and negative excursions of the process X. As a corollary, we find the joint Laplace transform of $(U_{\mathbf{e}_q}, X_{\mathbf{e}_q})$, where $\mathbf{e}_q$ is an independent exponential time, and the q-potential measure of the process (U, X). Furthermore, using the results mentioned above, we find a solution to a general optimal stopping problem depending on (U, X) with an application in corporate bankruptcy. Lastly, we establish a link between the optimal prediction of $g_{\infty}$ and optimal stopping problems in terms of (U, X) as per Baurdoux, E. J. and Pedraza, J. M., $L_p$ optimal prediction of the last zero of a spectrally negative Lévy process, Annals of Applied Probability, 34 (2024), 1350–1402.

As surrogacy grows, many states and countries are enacting or considering relevant regulations, while others oppose it. Ethical, legal and policy questions arise: how to balance the rights of various kinds of parents (e.g., heterosexual and same-sex couples and single individuals) against the rights and well-being of surrogates. Concerns include risks of exploitation, autonomy, benefits of enabling prospective parents to create loving families, and mitigating possible harms through regulations. Though a few instances of abuse have been reported in developing countries, these do not appear to have occurred in developed countries, where robust regulations exist. The limited data available on surrogates in general (i.e., including traditional and non-commercial surrogacy) do not suggest exploitation or trafficking. In 2021, New York State enacted robust regulations allowing commercial surrogacy. Subsequent competing bills have sought to loosen or enhance certain restrictions. These regulations may be a model for commercial surrogacy regulations elsewhere, but certain ethical, legal and policy questions remain (e.g., where to draw the line to prevent trafficking). Additional data and exploration of these challenges are crucial

During the 2020 presidential election, the Trump campaign incorrectly claimed that a lower-than-expected proportion of Republican votes among populations living on and near military bases signaled evidence of voter fraud. These claims rested on assumptions that military bases and their surrounding communities are strongholds for political conservativism––a belief held by scholars, pundits, and politicians alike. While the logic behind these arguments is appealing, it fails to consider the complexities surrounding military service and institutions, political geography, partisan preferences, and voting behavior. We directly test the notion that communities close to military bases will be and vote more Republican. Using three different but related empirical strategies that rely on a large dataset spanning 16 years, we find evidence contradicting the conventional wisdom. No consistent pattern across military installations exists. While some lean Republican, others lean Democratic, and the vast majority exhibit no party pattern at all. Our results carry implications for American civil–military relations and the maintenance of American democracy.

Contemporary scholarship on constitutional amendment and change unfolds against a backdrop of significant, and often troubling, new developments. Amendments today are increasingly unmoored from their traditional purpose – to adapt constitutions to new realities and to reflect emerging consensus – and instead often emerge as part of projects that put core constitutional functions and commitments under stress. As a result, scholarly focus has shifted from questions of the object, modality, or frequency of constitutional amendment to questions of its legitimacy. This article calls for a broadening of our analytic vocabulary to foster a more expansive and critical discourse on the subject. It begins by showing how the growing complexity of constitutional amendment practices challenges traditional theoretical frameworks, such as the ‘unconstitutional constitutional amendment’ doctrine and other standards of internal legitimacy. In response, the article introduces the notion of ‘external legitimacy standards’ and examines their various forms. Particular attention is given to an approach that ties the legitimacy of amendments to the provision of adequate justification. The article concludes by identifying two types of context in which recourse to the notion of external legitimacy standards may prove valuable, either independently or alongside standards of internal legitimacy.

The purpose of this study was to measure meal quality in representative samples of schoolchildren in three cities located in different Brazilian regions using the Meal and Snack Assessment Quality (MESA) scale and examine association with weight status, socio-demographic characteristics and behavioural variables. This cross-sectional study analysed data on 5612 schoolchildren aged 7–12 years who resided in cities in Southern, Southeastern and Northeastern Brazil. Dietary intake was evaluated using the WebCAAFE questionnaire. Body weight and height were measured to calculate the BMI. Weight status was classified based on age- and sex-specific Z-scores. Meal quality was measured using the MESA scale. Associations of meal quality with weight status and socio-demographic and behavioural variables were investigated using multinomial regression analysis. Schoolchildren in Feira de Santana, São Paulo and Florianópolis had a predominance of healthy (41·8 %), mixed (44·4 %) and unhealthy (42·7 %) meal quality, respectively. There was no association with weight status. Schoolchildren living in Feira de Santana, those who reported weekday dietary intakes, and those with lower physical activity and screen activity scores showed higher meal quality. Schoolchildren aged 10–12 years, those who reported dietary intakes relative to weekend days, and those with higher screen activity scores exhibited lower meal quality.

Value transparency is thought to promote trust in scientific expertise. Yet, transparency is a complex concept. I will argue that transparency requirements come with a varying extent of engagement: merely disclosing information, providing information that is publicly accessible, or having additional mechanisms for criticism in place. It is often not clear in which sense transparency requirements are to be understood in the context of trust in expertise. However, each sense can backfire in different ways. Merely talking about transparency in a general sense hides these possible trade-offs. This furthermore shows that requiring transparency may come with a greater regulatory force.

Weighted sieves are used to detect numbers with at most S prime factors with $S \in \mathbb{N}$ as small as possible. When one studies problems with two variables in somewhat symmetric roles (such as Chen primes, that is primes p such that $p+2$ has at most two prime factors), one can utilise the switching principle. Here we discuss how different sieve weights work in such a situation, concentrating in particular on detecting a prime along with a product of at most three primes.

As applications, we improve on the works of Yang and Harman concerning Diophantine approximation with a prime and an almost prime, and prove that, in general, one can find a pair $(p, P_3)$ when both the original and the switched problem have level of distribution at least $0.267$.

Acquisition of reading skill in a second language (L2) requires development and coordinated use of multiple component skills. This acquisition is less effortful the more similar the first language (L1) of the L2 learner is to that L2. While ways to quantify the L1–L2 distance are well defined in the current literature, the theoretical status of this distance in models of L2 reading acquisition is under-specified. This paper tests whether the L1–L2 distance influences English reading fluency and comprehension directly, via the mediation of component skills of reading, or both. We used text reading data and tests of component skills of English reading from the Multilingual Eye-movement Corpus database, representing advanced L2 readers of English from 18 distinct language backgrounds. Mediation analyses show that the L1–L2 distance has both a direct and an indirect effect on English reading fluency and eye movements, yet it has no effect on reading comprehension. These findings are novel in that they specify the mechanism through which the L1–L2 distance affects L2 reading acquisition.

This paper considers whether assisted suicide and euthanasia (AS/E) is an area for medical regulation or whether there is a better alternative regulatory mechanism to govern it. Drawing from empirical evidence across a range of jurisdictions where it is legalized, the paper argues that there are at least four good reasons to consider demedicalizing AS/E: (1) pragmatic ethical issues of infrastructural weakness in AS/E service provision in already overstretched healthcare systems globally; (2) challenges of medicalization; (3) regulatory complexities concerning medical law (including pharmaceutical law) and criminal law; (4) the risk that AS/E becomes more easily susceptible to healthcare economics. The paper suggests several recommendations concerning a possible “demedicalized model.”