Armed conflict devastates children across all regions and ideologies – inflicting profound and lasting harm on their bodies, minds, and developmental trajectories. While all sides may commit atrocities, the experience of children is tragically consistent: they are the least responsible, yet often the most harmed. This article traces the evolving global understanding of war’s impact on children, charting a journey in modern history to present-day realities. It begins with the landmark 1996 UN report by Graça Machel, which exposed the wide-ranging and systematic nature of the effects of war on children – where violence, displacement, and severed attachments force children into premature adulthood. Building on this, the 2009 and 2013 UN efforts codified the “Six Grave Violations” against children in armed conflict, now central to global monitoring and advocacy. Despite these frameworks and legal protections, including the Convention on the Rights of the Child, the 2024 UN Secretary-General’s report shows violations have surged – up 21% in the past year alone. To bring these patterns into focus, the article concludes with a case study of Gaza. Chosen for its immediacy and visibility, Gaza is emblematic of the ongoing failure to shield children from war’s worst impacts. Similar suffering persists in Sudan, Myanmar, and Ukraine. The article calls for an urgent, universal imperative: end hostilities to protect children. A trauma-informed, attachment-sensitive approach – grounded in lessons from Rwanda, Bosnia, and Syria – is essential. Clinicians, humanitarians, and policymakers must place children at the heart of all post-conflict recovery and accountability efforts.

Anorexia of ageing – the age-related reduction in appetite and food intake – is a public health concern for an ageing global population. However, current understanding of the aetiology of the condition is limited. In this review, evidence of gut hormone responses to feeding in older adults is reviewed, and it is proposed that a dysregulation of this process is a mechanism driving low appetite in later life. The evidence is synthesised to critically present this case, spotlighting recent data demonstrating a highly anorexigenic gut hormone profile in older adults exhibiting low appetite, which is not observed in older adults exhibiting a “healthy” appetite. These findings and this theory are interrogated with an appreciation that appetite control is complex and multifactorial, not least in the context of anorexia of ageing; it is posited that changes in gut hormone secretions are a mechanism rather than the mechanism, but propose that this may explain certain presentations of anorexia of ageing. The current knowledge base is contextualised for practical implications and priorities for future research are highlighted.

We extend the framework of abstract algebraic logic to weak logics, namely, logical systems that are not necessarily closed under uniform substitution. We interpret weak logics by algebras expanded with an additional predicate, and we introduce a loose and strict version of algebraizability for weak logics. We study this framework by investigating the connection between the algebraizability of a weak logic and the algebraizability of its schematic fragment, and we then prove a version of Blok and Pigozzi’s Isomorphism Theorem in our setting. We apply this framework to logics in team semantics and show that the classical versions of inquisitive and dependence logic are strictly algebraizable, while their intuitionistic versions are only loosely so.

This study examines paid and unpaid childcare distribution connected to gender relations and inequalities. We ask: what are the gender consequences of childcare distribution in Mexico? To answer this enquiry, we apply Razavi’s diamond model, examining the social dimensions of the family/household, the State, the Market, and not-for-profit (NFP) sectors. We utilise national statistics and representative surveys from the Mexican National Institute of Statistics and Geography (INEGI), complemented with published studies on Latin America and Mexico.

The article is structured as follows. First, we provide a literature review on the model related to welfare and care provision. Second, we summarise important aspects of the Mexican context. Our analysis is structured in subsections following each dimension of the diamond. We discuss our findings through a graphic representation of the model applied to Mexico, and conclude with final remarks.

Our concrete application of the model shows how the distribution of – paid and unpaid – childcare has consequences in (re)producing and strengthening gender inequalities in a myriad of spaces, dynamics, and arrangements. Key findings indicate a reduction in public childcare provision, transferring responsibilities to the household and the NFP dimensions, enhancing gendered expectations. Additionally, there is an increased protagonism of market relations within the domestic sphere and unequal conditions for those with resources.

We contribute to current studies on gender inequalities connected to welfare systems – and the lack thereof – by offering conceptual elements to develop research pathways sensitive to context-specificities, closely aligned with countries and societies within the Global South.

Throughout the twentieth century, senior roles in UK public health were reserved for doctors. Local authority medical officers of health were replaced in 1974 by NHS community physicians and from 1989 by medical directors of public health. Over the last decade of the century, an increasingly vocal group of non-medical public health professionals sought to break the glass ceiling that restricted them from advancing to senior roles; although they received encouragement from some leaders within the Faculty of Public Health Medicine, there was also significant resistance from many members. A number of factors came together around the year 2000, which culminated in a ground-breaking decision by the English Department of Health to allow non-medical appointments as directors of public health and consultants in public health in the NHS, with the then Secretary of State memorably declaring it was time to ‘take public health out of the ghetto’. At the same time, the leadership of the Faculty of Public Health Medicine overcame opposition from some of its members and opened its training, examinations, and membership to non-medical candidates. By the early 2020s, half of the renamed Faculty of Public Health members were from backgrounds other than medicine as well as 90% of directors of public health in England. This paper explores the complex history behind this unprecedented opening of a medical specialty to non-medical membership, the factors that enabled it, and the continuing legacy of tensions and inequalities within an occupation that is both a medical specialty and a multidisciplinary profession.

We described a 14-year-old boy who underwent catheter ablation for atrial tachycardia that had difficulty in creating the whole circuit of 3D map due to widely spread scar after repeated surgery for multivalvular heart disease. The classical atrial entrainment method was very effective in planning the catheter ablation for the invisible circuit of the atrial tachycardia.

Pulmonary valve or main pulmonary artery infective endocarditis is rare in children and is associated with high morbidity and mortality. Fungal infective endocarditis, most commonly caused by Candida species, is particularly aggressive and often requires a combination of antifungal therapy and surgical intervention. We report two infants who developed Candida endocarditis following pulmonary artery banding.

In the first case, a female infant developed persistent candidemia after pulmonary artery banding, with echocardiography revealing a mobile mass at the pulmonary bifurcation and computed tomography angiography demonstrating a mycotic pseudoaneurysm. Blood cultures confirmed Candida albicans. She underwent debanding and main pulmonary artery reconstruction, later requiring pacemaker implantation, and recovered without relapse. In the second case, a female infant presented with fever and candidaemia after pulmonary artery banding. Echocardiography identified a distal main pulmonary artery vegetation, and cultures grew Candida parapsilosis. She received amphotericin B–based induction therapy followed by fluconazole step-down after surgical source control, achieving clinical cure at follow-up.

These cases highlight the diagnostic and therapeutic challenges of Candida endocarditis after right-sided palliation. Early multimodality imaging, species-directed antifungal therapy, and timely surgery are critical to optimise outcomes in this rare but life-threatening complication.

Elk Ridge was the largest pueblo in the northern Mimbres River Valley during the Classic Mimbres period. Data from the pueblo and surrounding sites indicate that it was the economic and ritual center of a larger community. Here, we use multiple lines of evidence—including survey data, ceramics, architecture, and faunal remains—to reconstruct the extent and structure of the Elk Ridge community. We see social interaction as the basis for community development, with (1) community members interacting to negotiate access to land, resources, and labor; and (2) communal rituals serving to reinforce cooperation and cohesion. The Elk Ridge community produced ceramics and raised turkeys that were traded to other Classic Mimbres communities, and these exchange networks created social ties between communities. Data from Elk Ridge also document interaction with non-Mimbres communities to the north, revealing a network of cultural interaction across the region. This study illustrates how landscape, location, kin relations, exchange networks, and ritual activities translate into a social community, similar to those we see throughout the US Southwest and elsewhere in the Neolithic world.

This single center retrospective observational study of serial plasma metagenomic next-generation sequencing testing shows that >95% of serial testing was without meaningful clinical impact. Only 5/173 cases were adjudicated as having significant clinical impact.

We report two adult patients who had rare systemic artery lesions with a history of Kawasaki disease, with a review of the literature. A 39-year-old male with Kawasaki disease at the age of 2 months underwent coronary artery bypass grafting to the right coronary artery and left anterior descending artery because of coronary artery stenoses. In the screening by thoracic-abdominal CT before the operation, calcification of the distal abdominal aorta was detected, and an abdominal aortic aneurysm with stenosis was diagnosed. He had been asymptomatic, and there were no differences in his extremities’ blood pressure. Although a slight dilatation of the distal abdominal aorta had existed in his aortogram at 2 years 9 months old, the abnormal finding had been unnoticed. A 26-year-old female with coronary artery bypass grafting at the age of 23 months had hypertension. A stenosis of the orifice at the right renal artery was detected by two-dimensional echocardiography and a magnetic resonance angiogram. Her hypertension in adulthood was suspected to result from her renal artery stenosis, which acute Kawasaki vasculitis underlies. Although coronary artery lesions in both patients were diagnosed in their childhood, systemic artery lesions were not realised until adulthood. Because abdominal aortic aneurysms and renal artery stenosis are extremely rare, they were not recognised as systemic artery lesions caused by Kawasaki disease. Their lesions can occur in patients with severe acute vasculitis at a significantly younger age, less than 6 months. Systemic artery lesions in such adult patients must be carefully evaluated.