To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Individuals differ in a range of processes related to reading comprehension, including working memory capacity, decoding skills, inference making and main idea identification. In this exploratory study, we examined evoked potential N400 amplitude during reading comprehension tasks and focused on identifying the main idea in the text, modulated by working memory capacity. Participants included monolinguals or bilinguals who were either typical readers (n = 33) or had been diagnosed with dyslexia (n = 19). Analyses revealed significant group differences for main idea conditions. Participants with dyslexia showed greater N400 amplitude than typical readers, particularly in the right hemisphere, when the main idea was in the last position in the paragraph. There were no significant differences in performance between bilinguals and monolinguals, which does not support the idea of a cognitive advantage for bilingualism. It was noteworthy that, if they had dyslexia, they were similarly negatively impacted by their reading disability. Findings highlight the processing advantages typical readers have relative to dyslexia.
Digital tools offer promising solutions to improve eligibility screening, recruitment, and retention in research, particularly in human genetic studies where representative sampling is critical. SMS text messaging has been found effective in population-based survey research, but evidence of its impact on genetic study recruitment – and how it varies by demographics – is limited.
Objective:
We examined the effect of tailored SMS messages on enrollment in a population-based genomic screening study. We assessed differences in message open and consent rates across four message types and explored how these outcomes varied by demographic factors.
Methods:
Participants were randomized to receive one of four SMS messages emphasizing different social values: generic, individual impact, community impact, or research discoveries. We calculated descriptive statistics for open and consent rates and used generalized linear logistic regression and Pearson’s Chi-Square Test to assess demographic differences.
Results:
Among 15,977 messages sent, 2.4% were opened (n = 382), and 35.3% of those who opened consented (n = 135). Females were more likely than males to open (3.1% vs. 1.6%) and consent (1.1% vs. 0.5%). Individuals aged 30–39 had the highest open rate (3.4%), and those 40–49 had the highest consent rate (1.6%). Message type was not significantly associated with open or consent rates.
Conclusion:
Sociodemographic factors were more predictive of engagement than message content. Tailoring messages by demographic group may improve recruitment in genomic studies. Future research should explore the drivers of participant engagement in digital recruitment strategies.
The overturning of the landmark Supreme Court case Roe v. Wade (1973) in the United States during the summer of 2022 with Dobbs v. Jackson Women’s Health Organization eliminated the nearly 50-year constitutional right to abortion, leading to the introduction of numerous new restrictions. This article examines how the language used in federally proposed anti-abortion legislation has evolved in the aftermath of the Roe decision. By exploring the gender and power dynamics that shape the contemporary abortion debate, alongside feminist legal theory, this study analyzes the language and effects of five bills that have been introduced since the ruling. After analyzing the proposed bills, there was a noticeable shift in anti-abortion strategies by Republican elected officials. Rather than directly criminalizing pregnant individuals, these bills target abortion providers, state funding, and the dissemination of information. This indirect approach sets to restrict abortion access by making it practically unattainable for many regardless of its legality.
We define two types of the α-Farey maps Fα and $F_{\alpha, \flat}$ for $0 \lt \alpha \lt \tfrac{1}{2}$, which were previously defined only for $\tfrac{1}{2} \le \alpha \le 1$ by Natsui (2004). Then, for each $0 \lt \alpha \lt \tfrac{1}{2}$, we construct the natural extension maps on the plane and show that the natural extension of $F_{\alpha, \flat}$ is metrically isomorphic to the natural extension of the original Farey map. As an application, we show that the set of normal numbers associated with α-continued fractions does not vary by the choice of α, $0 \lt \alpha \lt 1$. This extends the result by Kraaikamp and Nakada (2000).
Transient growth mechanisms operating on streaky shear flows are believed important for sustaining near-wall turbulence. Of the three individual mechanisms present – Orr, lift-up and ‘push over’ – Lozano-Duran et al. 2021 (J. Fluid Mech.914, A8) have recently observed that both Orr and push over need to be present to sustain turbulent fluctuations given streaky (streamwise-independent) base fields whereas lift-up does not. We show here, using Kelvin’s model of unbounded constant shear augmented by spanwise-periodic streaks, that this is because the push-over mechanism can act in concert with a Orr mechanism based upon the streaks to produce much-enhanced transient growth. The model clarifies the transient growth mechanism originally found by Schoppa & Hussain (2002 J. Fluid Mech.453, 57–108) and finds that this is one half of a linear instability mechanism centred at the spanwise inflexion points observed originally by Swearingen & Blackwelder (1987 J. Fluid Mech.182, 255–290). The instability and even transient growth acting on its own are found to have the correct nonlinear feedback to generate streamwise rolls which can then re-energise the assumed streaks through lift-up indicating a sustaining cycle. Our results therefore support the view that, while lift-up is believed central for the roll-to-streak regenerative process, it is Orr and push-over mechanisms that are both key for the streak-to-roll regenerative process in near-wall turbulence.
Bipolar disorder (BD) is assumed to follow a progressive course, conceptualized through staging models. It is unclear whether white matter (WM) microstructure abnormalities, central to BD pathophysiology, parallel this development throughout disease progression. This study explored the link between WM and disease progression in BD, using a comprehensive approach based on clinical staging models.
Methods
This cross-sectional diffusion tensor-imaging study included 153 BD patients and 153 healthy controls (HCs) matched for age, sex, and study site. Using tract-based spatial statistics (TBSS), we examined associations between WM integrity and three criteria: (1) number of manic episodes, (2) remission quality between episodes, and (3) inter-episode global functioning.
Results
Analyses revealed significant fractional anisotropy (FA) differences between early and late stages of BD based on the number of manic episodes (ptfce-FWE = 0.003), but not on remission quality (ptfce-FWE = 0.075). However, compared to HC, BD patients with persistent symptoms between episodes showed more widespread FA differences (ptfce-FWE < 0.001) than those with stable remission (ptfce-FWE = 0.031). Regression analyses indicated a positive association between global functioning and FA in euthymic BD patients (ptfce-FWE < 0.001).
Conclusions
Results indicated more severe WM disruptions in patients at advanced stages compared to earlier stages of the disease. While these findings may imply changes occurring with disease progression, the cross-sectional design cannot rule out that they instead reflect stable clinical subtypes of varying severity. The results highlight the clinical relevance of WM alterations and the need for longitudinal studies to better understand the neurobiology and complexity of BD.
In this study, we present data from two experiments investigating the effect of prosodic focus marking on German L1 and L2 speakers’ interpretation of pronouns. Experiment 1 tested L2 speakers’ interpretation of personal and demonstrative subject pronouns. Experiment 2 examined L1 and L2 speakers’ interpretation of unaccented and accented personal subject and object pronouns. The results of experiment 1 reveal that L2 speakers are sensitive to the different functions of the two subject pronouns. However, grammatical role and focus marking influenced referential choice to similar degrees for both pronouns, suggesting that L2 speakers’ weighting of these linguistic factors differs from that of L1 speakers. Experiment 2 showed L1 and L2 speakers to prefer the subject referent for both subject and object pronouns. Referent preference reversal is only observed with the accented subject pronoun in L1 speakers. Ultimately, this study emphasizes the varying levels of sensitivity to grammatical role and information structure observed not only for the different pronoun types but also among different speaker groups.
By 2050, 1.31 billion people will be living with type 2 diabetes (T2DM). Those with social disadvantage experience greater diabetes prevalence, morbidity and mortality. Gestational diabetes (GDM) is an established factor for T2DM, with 3–4 times greater risks among women who are Black, Hispanic and South and South East Asians. Lifestyle interventions that include diet and physical activity reduce T2DM in at-risk populations, including women with prior GDM, regardless of ethnicity. However, migrant women from non-Western backgrounds are less likely to engage with the programme despite its efficacy. This review paper aims to describe the social disparities in GDM globally, with a focus on equity issues and interventions in Australia. It outlines a five-part approach to solutions that move us towards equity in reach and uptake for women from non-Western migrant backgrounds in Australia. Culturally inclusive solutions start with evaluating reach in underserved groups through equity audits or stratified analyses and identifying groups where reach is low. Community partnerships can then be formed with key actors across health and social sectors identified through stakeholder mapping. Effective reach strategies, including implementation and evaluation plans, will be co-developed through these partnerships, addressing risk factors, enablers and barriers to a healthy lifestyle. Solutions that integrate medical and social services, such as social prescribing, could facilitate healthy lifestyle choices through restructuring the social environment of the individual. These steps lead to interventions that promote social cohesion and resilience, enabling individuals to attain health and well-being in the face of external challenges.
This study aimed to develop a shared understanding about the drivers of nutrition security in Puerto Rico (PR) from the collective perspective of multi-sector stakeholders in the agri-food, environmental and the health/disease systems.
Design:
A participatory community-based system dynamics approach (group model building) engaged stakeholders during one 4-h workshop March 2023 (followed by two 2.5-h member checking sessions).
Setting:
San Juan, PR.
Participants:
Stakeholders (n 22) in PR representing the agri-food, environmental and health/disease systems from multiple sectors (commercial food retail and technology, food production, public servants, academia and civil society) participated in the workshop.
Results:
Stakeholders collectively framed nutrition security as an outcome of six interconnected subsystems exacerbated by climate change: (1) governance and public policy; (2) demographic change and rural disinvestment; (3) climate change and adaptive capacity; (4) local food production economy; (5) food culture; and (6) nutrition security and health. Stakeholders identified leverage points mostly focused on strengthening information flow within and across subsystems and expanding cross-sectoral collaboration (systems structures and elements). We identified three paradigms that have the potential to transform the system structure and function: ecological conscience, traditional and healthy food culture, and social cohesion.
Conclusions:
These findings deepened the collective understanding of systemic interdependencies that drive nutrition security as stakeholders identified locally feasible leverage points.
Led by national policy, standardisation has enhanced hospital discharge communication to primary care over recent decades. However, discharge summary content standards and their corresponding templates can be over-relied on by authors, risking the exclusion of important contextual and explanatory information for patients with more complex care.
This information can be critical for GPs to deliver high quality, safe, and efficient post-discharge care, especially for this patient cohort which can be at higher risk of avoidable harm from suboptimal communication. Discharge summary authors can lack sufficient understanding of the recipient primary care perspective to mitigate this issue and communicate effectively through standardised letter templates. Strengthening this interprofessional understanding is an essential next step to improve discharge communication.
In response to this challenge, we propose the basis of a new framework of interprofessional discharge communication that accounts for the different paradigms of specialism and generalism and supports summary authors to tailor their content to the patient’s post-discharge care.
We call for the co-development of this framework through a programme of applied research, alongside the exploration of primary–secondary care interface learning communities as a vehicle for interprofessional education. These initiatives can serve to augment the current strengths of standardised discharge summaries and mitigate their limitations, maximising the quality, safety, and efficiency of post-discharge care. Progress in this field can benefit wider cross-interface communications and practice and assist the NHS integration agenda.
The breakup of viscous liquid threads is governed by a complex interplay of inertial, viscous and capillary stresses. Theoretical predictions near the point of breakup suggest the emergence of a finite-time singularity, leading to universal power laws describing the breakup, characterised by a universal prefactor. Recent stability analyses indicate that, due to the presence of complex eigenvalues, achieving similarity may only be possible through time-damped oscillations, making it unclear when and how self-similar regimes are reached for both visco-inertial and viscous regimes. In this paper, we combine experiments with unprecedented spatio-temporal resolution and highly resolved numerical simulations to investigate the evolution of the liquid free surface during the pinching of a viscous capillary bridge. We experimentally show for the first time that, for viscous fluids the approach to the self-similar solution is composed of a large overshoot of the instantaneous shrinking speed before the system converges to the nonlinear pinch-off similarity solution. In the visco-inertial case, the convergence to the stable solution is oscillatory, whereas in the viscous case, the approach to singularity is monotonic. While our experimental and numerical results are in good agreement in the viscous regime, systematic differences emerge in the visco-inertial regime, potentially because of effects such as polymer polydispersity, which are not incorporated into our numerical model.
In maximum likelihood factor analysis, we need to solve a complicated system of algebraic equations, known as the normal equation, to get maximum likelihood estimates (MLEs). Since this equation is difficult to solve analytically, its solutions are typically computed with continuous optimization methods, such as the Newton–Raphson method. With this procedure, however, the MLEs are dependent on initial values since the log-likelihood function is highly non-concave. Particularly, the estimates of unique variances can result in zero or negative, referred to as improper solutions; in this case, the MLE can be severely unstable. To delve into the issue of the instability, we algebraically compute all candidates for the MLE. We provide an algorithm based on algebraic computations that is carefully designed for maximum likelihood factor analysis. To be specific, Gröbner bases are employed, powerful tools to get simplified sub-problems for given systems of algebraic equations. Our algebraic algorithm provides the MLE independent of the initial values. While computationally demanding, our algebraic approach is applicable to small-scale problems and provides valuable insights into the characterization of improper solutions. For larger-scale problems, we provide numerical methods as practical alternatives to the algebraic approach. We perform numerical experiments to investigate the characteristics of the MLE with our two approaches.
It is well understood that safeguarding confidentiality is paramount to ensuring the success of research and the protection of participations. However, professional responsibilities and ethics of care can, at times, manifest in a requirement, or even a desire, to breach promises of confidentiality. We unpack this tension by drawing on research on the concepts of legal privilege, the right to report and the duty to report, the impacts of disclosures, as well as a study conducted with socio-legal and criminological researchers and criminalized or socially sanctioned communities who have participated in qualitative a research project. Our findings illustrate that while researchers with a clinical designation (e.g., nurses and social workers), enjoy clarity on professional duties, for researchers without such professional policies (e.g., criminologists) there is little guidance on when and how disclosures could and should take place. That said, when faced with the potential of actual and imminent threats of harm to an identifiable person, most researchers align with Supreme Court of Canada guidance, and would consider reporting, but with much deliberation regarding what constitutes harm, to whom one should report, and the consequences of disclosures. In the interests of contributing to this conversation, we conclude this paper with a decision-making framework that puts the Wigmore test into conversation with the Supreme Court of Canada’s 1999 Smith v Jones decision.
Do oral arguments influence state supreme courts, and if so, how? Focusing on a “thinking-fast” framework, this study analyzes 2014–2021 New York Court of Appeals oral arguments to test whether non-traditional factors such as expressed emotion can shape decisions. Empirical analysis drawn from textual data shows that oral arguments can explain decision-making, and that justices’ emotion during arguments likely plays a role. The findings challenge normatively rational models of judicial behavior by underscoring affective, real-time influences and highlight oral arguments as a consequential stage in subnational adjudication. This is the first evidence of their meaningful role in state supreme courts.
We analyse direct numerical simulations of homogeneous, forced, stably stratified turbulence to study how the pressure–strain and pressure scrambling terms are modified as stability is increased from near neutral to strongly stratified conditions. We decompose the pressure into nonlinear and buoyancy components, and find that the buoyancy part of the pressure–strain correlation changes sign to promote large-scale anisotropy at strong stability, unlike the nonlinear component, which always promotes large-scale isotropy. The buoyancy component of the pressure scrambling term is positive semidefinite and increases monotonically with stability. As its magnitude becomes greater than the nonlinear component (which is negative), the overall scrambling term generates buoyancy flux at very strong stability. We apply quadrant analysis (in the pressure-gradient space) to these correlations to study how contributions from the four quadrants change with stability. Furthermore, we derive exact relationships for the volume-averaged buoyancy components of these correlations which reveal (i) the buoyancy component of the pressure–strain correlation involves a weighted sum of the vertical buoyancy flux cospectrum, so counter-gradient buoyancy fluxes contribute to enhanced anisotropy by transferring vertical kinetic energy into horizontal kinetic energy; (ii) the buoyancy component of the pressure scrambling term involves a weighted sum of the potential energy spectrum; (iii) the weighting factor accentuates contributions from layered motions, which are a prominent feature of strongly stratified flows. These expressions apply generally to all homogeneous stratified flows independent of forcing and across all stability conditions, explaining why these effects have been observed for both forced and sheared stably stratified turbulence simulations.
To better meet the growing demand and complexity of clinical need, there is a broad international trend towards greater integration of various elements of health- and social care. However, there has been a lack of research aimed at understanding how healthcare providers have experienced these changes, including facilitators and inhibitors of integration.
Aims
This study set out to generate new understandings of this from three UK staffing ‘levels’: ‘micro’ frontline workers, a ‘meso’ level of those leading a healthcare organisation and a ‘macro’ level of commissioners.
Method
Using Rogers’ Diffusion of Innovation framework, qualitative analysis of individual interviews from provider staff perceptions was undertaken at these three levels (total N = 33) in London.
Results
English legislation and policy captured the need for change, but fail to describe problems or concerns of staff. There is little guidance that might facilitate learning. Staff identity, effective leadership and culture were considered critical in implementing effective integration, yet are often forgotten or ignored, compounded by an overall lack of organisational communication and learning. Cultural gains from integration with social care have largely been overlooked, but show promising opportunities in enhancing care delivery and experience.
Conclusions
Findings are mixed insofar as staff generally support the drivers for greater integration, but their concerns, and means for measuring change, have largely been ignored, limiting learning and optimisation of implementation. There is a need to emphasise the importance of culture and leadership in integrated care, and the benefits from closer working with social care.
Earthworms are postdispersal seed predators that can influence weed communities in temperate agroecosystems. Recent studies have found that seed feeding by earthworms tends to be driven by the active selection of certain seed species rather than random encounter. Numerous seed traits are expected to affect seed selection by earthworms, including seed size, shape, coat hardness, and nutritional content. The impact of these traits on seed selection by earthworms tends to vary depending on seed species identity and earthworm species identity, rendering the outcome of earthworm–seed interactions hard to predict. We carried out laboratory experiments to investigate the impact of seed physical and chemical traits on seed choice by the common earthworms (Lumbricus terrestris). Seeds of six weed species typical of the Northern Great Plains agroecosystem, wild mustard (Sinapis arvensis L.), field pennycress (Thlaspi arvense L.), shepherd’s purse [Capsella bursa-pastoris (L.) Medik.], catchweed bedstraw (Galium aparine L.), green foxtail [Setaria viridis (L.) P. Beauv.], and redroot pigweed (Amaranthus retroflexus L.), were offered to L. terrestris in multiple-choice feeding arenas. The results showed that seeds of S. arvensis and C. bursa-pastoris, both of which have high lipid content, were the most consumed. Seed ingestion was negatively influenced by irregular seed shapes and long seed length, but these physical traits did not override the strong preference for lipid-rich seeds. These findings suggest that seed selection by L. terrestris earthworms was strongly influenced by the lipid content of the seed when seed morphology (i.e., size and shape) varied within certain limits. Therefore, seed nutrients are likely to play an important role in weed seed choice by L. terrestris earthworms when seed physical traits do not impose major constraints on ingestion.
Program equivalence checking is the task of confirming that two programs have the same behavior on corresponding inputs. We develop a calculus based on symbolic execution and coinduction to check the equivalence of programs in a non-strict functional language. Additionally, we show that our calculus can be used to derive counterexamples for pairs of inequivalent programs, including counterexamples that arise from non-termination. We describe a fully automated approach for finding both equivalence proofs and counterexamples. Our implementation, nebula, proves equivalences of programs written in Haskell. We demonstrate nebula’s practical effectiveness at both proving equivalence and producing counterexamples automatically by applying nebula to existing benchmark properties.