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We present a novel approach to synthesizing recursive functional programs from input–output examples. Synthesizing a recursive function is challenging because recursive subexpressions should be constructed while the target function has not been fully defined yet. We address this challenge by using a new technique we call block-based pruning. A block refers to a recursion- and conditional-free expression (i.e., straight-line code) that yields an output from a particular input. We first synthesize as many blocks as possible for each input–output example, and then we explore the space of recursive programs, pruning candidates that are inconsistent with the blocks. Our method is based on an efficient version space learning, thereby effectively dealing with a possibly enormous number of blocks. In addition, we present a method that uses sampled input–output behaviors of library functions to enable a goal-directed search for a recursive program using the library. We have implemented our approach in a system called Trio and evaluated it on synthesis tasks from prior work and on new tasks. Our experiments show that Trio significantly outperforms prior work.
Network analysis is a promising approach for elucidating the dynamics of the transition from psychopathology to well-being. Recently, symptom connectivity strength has been proposed as a measure of plasticity – the capacity to change disease severity. Yet, empirical findings remain inconsistent. We propose that this inconsistency can be resolved by recognizing that the interpretation of connectivity strength varies along the recovery process from depression, whether at baseline or during clinical change.
Methods
We analyzed 2,710 depressed patients from the STAR*D dataset, grouped by the magnitude of change in depressive score. Symptom network connectivity was estimated from QIDS-C items at three time points: (i) baseline, (ii) change – defined as when clinical change in depression score occurs, (iii) post-change - corresponding to when the maximum clinical change is achieved.
Results
At baseline, connectivity strength predicts the maximum clinical change, inversely correlating with its magnitude (ρ = −0.95, p = 0.001). At the change time point, connectivity strength parallels clinical change (ρ = 0.92, p = 0.002). A direct and significant association between connectivity strength and depression severity emerges only at the change (ρ = 0.98, p = 0.0003) and post-change (ρ = 0.95, p = 0.001) time points.
Conclusions
The interpretation of connectivity strength for predicting depression trajectories varies by timepoint: at baseline, it measures plasticity -- the capacity for change -- whereas during clinical change, it indicates the magnitude of change in symptom severity. This framework supports the reliability of this prognostic marker for designing personalized therapeutic interventions in psychiatry.
Many countries have permitted community pharmacists to administer vaccines to increase the immunization rate. The policy of Thailand has recently expanded and permitted pharmacists to play a role in immunization.
Aim:
The objective of this study was to survey the opinion and readiness of community pharmacists as immunizers.
Methods:
This study was a prospective, mixed-methods questionnaire and semi-structured interview. The study included community pharmacists in Hatyai, Songkhla, Thailand. A Likert scale questionnaire to evaluate readiness, opinions, and barriers to providing vaccines was distributed online. The volunteer pharmacists were interviewed about their opinions, distress, and benefits of vaccination services.
Findings:
An online survey was completed by 146 pharmacists, and 12 community pharmacists agreed to be interviewed. More than 65% of respondents agreed that vaccination services in community pharmacies are easily accessible to patients. Approximately 46% of pharmacist respondents were willing to be immunizers, and 45% of respondents showed readiness with the availability of pharmacy space for handling vaccinations, their storage, and disposing of sharp objects. Almost all of the respondents showed readiness with knowledge of adverse events following immunization (AEFI) and management. However, most of the concerns were vaccine administration skills, the conflict with other professionals, and the cost of setup and management. The pharmacists required training in vaccine administration skills before providing the service.
Conclusions:
The community pharmacies were willing and ready to provide vaccination services for the National List of Essential Vaccines. Vaccine administration skills were the main barriers to vaccination. The training should be done in faculty classes or workshops.
The semiotic construction of corporate persons in law is key to the contemporary organization of global capitalism. The economic capacities enjoyed by corporations stem significantly from how the semiotics of corporate personhood work within domestic and international legal orders fundamentally designed for human persons. Signs (especially in documents—laws, incorporation papers, tax filings, etc.) construct corporations as legal persons—entities modeled on human persons yet differently bound to human embodiment. Corporations multiply themselves through the creation of legally independent corporate persons (“subsidiaries”), while unifying themselves through their control over these persons. Unlike human offspring, corporations’ corporate offspring are easily created, may take up residence in almost any jurisdiction, and always obey their parents. The paper will discuss the implications of these features of corporations with respect to tort liability, international trade, property, taxation, and private militaries.
While research shows that public preferences across policy domains tend to move in parallel, the mechanisms behind this dynamic remain unclear. We examine four explanations: (1) alignment in preferred policy levels; (2) parallel policy movement combined with domain-specific thermostatic feedback; (3) feedback to global policy across domains; and (4) responsiveness to presidential partisanship. These mechanisms matter for how we interpret public opinion change and policy responsiveness. We develop and test a theoretical model using data on four social spending domains in the USA. Our findings suggest that spending mood reflects both parallelism in preferred policy levels and responsiveness to overall social spending and presidential party affiliation.
In the UK, parents receiving working-age social security benefits have been the target of intensifying labour market activation policies, particularly following the introduction of Universal Credit (UC). Concurrently, state support for parents has reduced, and help with childcare is complex and limited. Under UC, parents, and increasingly mothers, are meeting more often with street-level agents, Work Coaches, who are responsible for ‘activating’ parents into work. Work Coaches operate at the interface between the state and citizens, but we know little about street-level implementation of UC. Through analysing interviews with ten Work Coaches and sixty-seven parents, this article draws on a gendered street-level approach to explore how policy limits choices for Work Coaches (by restricting spaces for personalisation) and parents (by rules determining how to manage work and care responsibilities). Within this rigid context, moral assumptions of low-income parents emerge, with increased expectations placed on mothers and outdated assumptions about fathers.
In the treatment of obsessive-compulsive disorder (OCD) with antidepressant medication, the earliest reliable indication of treatment failure remains uncertain. We investigated if non-improvement following 4 weeks of treatment predicts nonresponse at the end of the trial.
Methods
We conducted a random-effects bivariate diagnostic accuracy study using individual patient data from industry-sponsored short-term trials of adults with OCD receiving selective serotonin reuptake inhibitors or clomipramine, submitted for marketing approval. The primary outcome was accuracy of non-improvement (<25% reduction on the Yale–Brown Obsessive Compulsive Scale [YBOCS] after 4 weeks) in predicting nonresponse (<35% YBOCS reduction at trial endpoint [10–13 weeks]). Secondary outcomes were accuracy of non-improvement after 6 weeks, nonresponse after 8 weeks, and inclusion of Clinical Global Impression Scale – Improvement in definitions of improvement and response. We performed meta-regressions for sex, age, severity, trial duration, dosing regimen, and compound.
Results
In 11 studies totaling 1,753 patients, non-improvement at week 4 predicted subsequent nonresponse (positive predictive value, PPV) in 86% of cases (95% confidence interval [CI] = 83–88%). Sensitivity was 78%, specificity was 70%, and the negative predictive value was 60%. Secondary outcomes showed similar PPV after 6 weeks and a PPV of 93% for nonresponse after 8 weeks. Predictive accuracy was significantly higher in men relative to women (β = −0.64, 95% CI = −1.12 to −0.16, p = 0.0089).
Conclusions
Patients with OCD who do not improve after 4 weeks of antidepressants will likely not respond to short-term treatment. Thus, a change in strategy should be considered after 4 weeks without treatment benefits.
Physical activity (PA) promotion in primary healthcare is an effective way of addressing population-based physical inactivity. Advancements in technology could help overcome barriers to promoting PA. This scoping review aims to provide an overview of technology (digital health) for PA promotion in primary healthcare, including effectiveness and acceptability, from research published between January 2020 and December 2023.
Methods:
A scoping review was conducted across five databases (Cochrane library, Embase, MEDLINE, PubMed and WebofScience). Search terms focused on three components: PA counselling, technology and primary healthcare. Articles from 01/01/2020 to 05/12/2023 were included. Paediatric populations and populations with diseases requiring specialist care were excluded.
Results:
Of 2717 studies identified during database searches, twenty-nine were included in the review. Mobile-phone applications were the preferred method of implementation (n = 12, 52%), with most interventions aiding in assessment of PA levels (n = 16, 70%) and/or assisting in addressing it (via education, monitoring or support) (n = 22, 96%). Findings revealed mixed evidence on the effectiveness of digital health interventions in increasing PA but reported widespread acceptability of digital health interventions. Qualitative studies revealed three main themes desired by stakeholders: (1) ease of use, (2) complements pre-existing primary healthcare provision and (3) patient-centred.
Conclusion:
Future research should focus on developing standardised approaches for assessing digital health interventions, exploring the impact on prescribing behaviours and addressing the desired features highlighted by stakeholders. Integration of technology in healthcare, including PA promotion, holds promise for enhancing access and facilitating widespread implementation.
We introduce a set of axioms for locally topologically ordered quantum spin systems in terms of nets of local ground state projections, and we show they are satisfied by Kitaev’s Toric Code and Levin-Wen type models. For a locally topologically ordered spin system on $\mathbb {Z}^{k}$, we define a local net of boundary algebras on $\mathbb {Z}^{k-1}$, which provides a mathematically precise algebraic description of the holographic dual of the bulk topological order. We construct a canonical quantum channel so that states on the boundary quasi-local algebra parameterize bulk-boundary states without reference to a boundary Hamiltonian. As a corollary, we obtain a new proof of a recent result of Ogata [Oga24] that the bulk cone von Neumann algebra in the Toric Code is of type $\mathrm {II}$, and we show that Levin-Wen models can have cone algebras of type $\mathrm {III}$. Finally, we argue that the braided tensor category of DHR bimodules for the net of boundary algebras characterizes the bulk topological order in (2+1)D, and can also be used to characterize the topological order of boundary states.
This article re-examines archaic and classical treatment of beer drinking to argue, contra Nelson, that beer in archaic and classical Greek texts is not primarily feminine nor does it necessarily feminize its drinkers. Rather, a review of sympotic lyric, historiography, ethnography and Athenian drama demonstrates that beer is primarily an ethnic marker with no inherent gendered connotations. At the same time, in contexts where definitions of Greek masculinity are being constructed, beer can gain gendered connotations which enhance the ethnic otherness of the beverage and contribute to the definition of the Greek man. Any gendered implications of beer, furthermore, come not from the beverage itself but from the method of consumption, of sucking through a tube of sorts rather than sipping from a cup. This article thus argues that beer in the Archaic and Classical periods marks non-Greek status first and foremost and only secondarily effeminizes drinkers through associations with oral sex in contexts where ideas of masculinity are in play.
The benefits of pulmonary rehabilitation (PR) on exercise capacity, health-related quality of life (HRQoL), and prevention of readmission post exacerbation in chronic respiratory diseases (CRD) are well established. However, accessibility to PR programmes is limited by PR programmes mostly being available through hospital clinics only. Utilizing existing workforce and infrastructure in private physiotherapy and exercise physiology practices may be a solution to increase access.
Methods:
A mixed-methods assessor-blinded randomized controlled feasibility trial will be conducted in two parts. First, the efficacy of a training programme for private practice (PP) physiotherapists and accredited exercise physiologists who have not previously provided PR will be evaluated. Participant knowledge, skills, and confidence to provide PR will be measured before and after the training and at three months follow-up. Secondly, patient participants with CRD will be randomly allocated to receive twice weekly PP PR for 8 weeks or usual care from their general practitioner (GP). Exercise capacity, HRQoL, and health status will be measured before and after PR. A purposive sample of clinician and patient participants will partake in semi-structured interviews at the study conclusion. Interviews will continue until data saturation is achieved.
Discussion:
This study will provide data on the feasibility of providing PR by physiotherapists and exercise physiologists in the PP setting. Provision of PR in the PP setting has the potential to increase access to this highly evidence-based intervention to improve outcomes for people with CRD.
Martin, Mossinghoff, and Trudgian [19] recently introduced a family of arithmetic functions called “fake $\mu $’s,” which are multiplicative functions for which there is a $\{-1,0,1\}$-valued sequence $(\varepsilon _j)_{j=1}^{\infty }$ such that $f(p^j) = \varepsilon _j$ for all primes p. They investigated comparative number-theoretic results for fake $\mu $’s and, in particular, proved oscillation results at scale $\sqrt {x}$ for the summatory functions of fake $\mu $’s with $\varepsilon _1=-1$ and $\varepsilon _2=1$. In this article, we establish new oscillation results for the summatory functions of all nontrivial fake $\mu $’s at scales $x^{1/2\ell }$ where $\ell $ is a positive integer (the “critical index”) depending on f; for $\ell =1$ this recovers the oscillation results in [19]. Our work also recovers results on the indicator functions of powerfree and powerfull numbers; we generalize techniques applied to each of these examples to extend to all fake $\mu $’s.
We prove the existence of small-amplitude periodic travelling waves in dimer Fermi–Pasta–Ulam–Tsingou (FPUT) lattices without assumptions of physical symmetry. Such lattices are infinite, one-dimensional chains of coupled particles in which the particle masses and/or the potentials of the coupling springs can alternate. Previously, periodic travelling waves were constructed in a variety of limiting regimes for the symmetric mass and spring dimers, in which only one kind of material data alternates. The new results discussed here remove the symmetry assumptions by exploiting the gradient structure and translation invariance of the travelling wave problem. Together, these features eliminate certain solvability conditions that symmetry would otherwise manage and facilitate a bifurcation argument involving a two-dimensional kernel and cokernel.
Plants respond to stresses like drought and heat through complex gene regulatory networks (GRNs). To improve resilience, understanding these is crucial, but large-scale GRNs (>100 genes) are difficult to model using ordinary differential equations (ODEs) due to the high number of parameters that have to be estimated. Here we solve this problem by introducing BADDADAN, which uses machine learning to identify gene modules—groups of co-expressed and/or co-regulated genes—and constructs an ODE model that predicts gene module dynamics under stress. By integrating time-series gene expression data with prior co-expression data it finds modules that are both coherent and interpretable. We demonstrate BADDADAN on heat and drought datasets of A. thaliana, modelling over 1,000 genes, recovering known mechanistic insights, and proposing new hypotheses. By combining machine learning with mechanistic modelling, BADDADAN deepens our understanding of stress-related GRNs in plants and potentially other organisms.
The Underworld is a ‘shared space’ for poets and their poems, but one that exists on different timelines to Upperworld spaces, such that it is built on cyclicality rather than linearity. In this article, I explore the cycles within and between the homoerotic Underworld poetry of Tibullus, Domitius Marsus, Ovid and Statius. Using a combination of traditional philology and queer temporal approaches, I show how characters ‘recycle’ through these texts, so that Tibullus’ Marathus cycles into Statius’ Philetus through metapoetic metempsychosis. I begin with the role of the Underworld in Latin poetry, before turning to Tibullus’ death, as commemorated by Ovid and Marsus. Next, I explore how Tibullus ‘kills’ Marathus, so that Ovid can hint at his being in the Underworld. Finally, I turn to Statius’ poem on Philetus to show how it continues the cycles of earlier poetry, before concluding with a discussion of the consequences of Elysium’s queerness.
Escherichia coli, frequently abbreviated as E. coli, is a common gastrointestinal tract inhabitant in both people and animals. It may also be found in soil, aquatic settings, and plants.
Aim:
The purpose of the study was to identify the frequency and three susceptibilities of E. coli in various clinical samples taken from patients in the Jazan area.
Materials and methods:
Using a multi-center approach, this retrospective cross-sectional study analyzed the results of culture and antimicrobial susceptibility of isolates from urine, wound swabs, and sputum samples. The study covered the period from January 2023 to December 2023 and included all public and private hospitals in the Jazan region.
Results:
The majority of isolates were derived from urine samples in 1161 patients (85.49%), followed by pus in 123 patients (9.06%) and sputum in 74 patients (5.45%). There were high sensitivity rates to Amikacin, Tigecycline, and Imipenem by (97.49%), (90.87%), and (90.35%), respectively, while there were high resistance rates to Norfloxacin, Ampicillin, and Cefotaxime by (93.67%), (79.60%), and (71.65%), respectively.
Conclusion:
There was considerable resistance to commonly used antibiotics among Escherichia coli germs isolated from several clinical specimens. Antibiotics, including imipenem, amikacin, and nitrofurantoin, demonstrated the highest efficacy against E. coli isolates. Nalidixic acid, cefexime, and ceftriaxone showed efficacy against E. coli; nevertheless, several clinical isolates exhibited resistance.
Polymorphism, the occurrence of different morphs of a trait within the population of a single species, plays a crucial role in species diversification, genetic variation, and adaptation. Detecting polymorphism in a single character helps us to understand population dynamics, particularly in species that inhabit diverse environments. However, detecting polymorphisms in fossil taxa is challenging due to the fragmentary and incomplete records. Dimorphism, defined as the occurrence of different morphs of a trait within the population of a single species, represents the simplest and most common form of polymorphism. This study focuses on dimorphism instead of polymorphism, which allows for a more streamlined analysis. We use computational simulation experiments to estimate the minimum sample size required to detect bimodal distribution in univariate morphological variables. We describe the morphological diversity of a measured variable (e.g., body mass or skeletal length) as a probability density distribution with specific parameter sets. Subsequently, we simulate the diversity of the measured variable with varying sample sizes and conduct resampling procedures to ensure the robustness. Four key parameters that characterize the probability distribution are identified as having significant influence on the minimum sample size for dimorphism recognition. According to the simulation experiments, a model is built to estimate the minimum sample size for dimorphism recognition based on these parameters. A dataset from extant avian and reptilian species is used to test the model. Furthermore, we calculate a reference for the minimal sample size required for assessing phenotypic dimorphism in fossil avian taxa by applying parameters derived from extant avian species.
Molecular evidence (28S DNA) has suggested that Triplotaenia undosa from macropodid marsupials is a species complex. Additional data (cox 1) presented in this study confirmed the hypothesis and a morphological examination of all available specimens identified a new species, T. macropodis sp. nov., in the grey kangaroos Macropus fuliginosus and M. giganteus as well as the tammar wallaby, Notamacropus eugenii, and the red kangaroo, Osphranter rufus. The new species differs in the ratio of the number of testes to the number of female genital complexes. Specimens of T. undosa from the swamp wallaby, Wallabia bicolor, the type host, and the common wallaroo, Osphranter robustus, are each genetically distinct, but the fixed material from O. robustus is too fragmentary to permit a detailed morphological description. An amended description and new illustrations of T. undosa from W. bicolor are provided.