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Implementing changes to digital health systems in real-life contexts poses many challenges. Design as a field has the potential to tackle some of these. This article illustrates how design knowledge, through published literature, is currently referenced in relation to the implementation of digital health. To map design literature’s contribution to this field, we conducted a scoping review on digital health implementation publications and their use of references from nine prominent design journals. The search in Scopus and Web of Science yielded 382 digital health implementation publications, of which 70 were included for analysis. From those, we extracted data on publication characteristics and how they cited the design literature. The 70 publications cited 58 design articles, whose characteristics were also extracted. The results show that design is mainly cited to provide information about specific design methods and approaches, guidelines for using them and evidence of their benefits. Examples of referenced methods and approaches were co-design, prototyping, human-centered design, service design, understanding user needs and design thinking. The results thus show that design knowledge primarily contributed to digital health implementation with insights into methods and approaches. In addition, our method showcases a new way for understanding how design literature influences other fields.
This paper presents a Hammir tandem mirror confinement performance analysis based on Realta Fusion’s first-of-a-kind model for axisymmetric magnetic mirror fusion performance. This model uses an integrated end plug simulation model including, heating, equilibrium and transport combined with a new formulation of the plasma operation contours (POPCONs) technique for the tandem mirror central cell. Using this model in concert with machine learning optimization techniques, it is shown that an end plug utilizing high temperature superconducting magnets and modern neutral beams enables a classical tandem mirror pilot plant producing a fusion gain Q > 5. The approach here represents an important advance in tandem mirror design. The high-fidelity end plug model enables calculations of heating and transport in the highly non-Maxwellian end plug to be made more accurately. The detailed end plug modelling performed in this work has highlighted the importance of classical radial transport and neutral beam absorption efficiency on end plug viability. The central cell POPCON technique allows consideration of a wide range of parameters in the relatively simple near-Maxwellian central cell, facilitating the selection of more optimal central cell plasmas. These advances make it possible to find more conservative classical tandem mirror fusion pilot plant operating points with lower temperatures, neutral beam energies and end plug performance requirements than designs in the literature. Despite being more conservative, it is shown that these operating points have sufficient confinement performance to serve as the basis of a viable fusion pilot plant provided that they can be stabilized against magnetohydrodynamic and trapped particle modes.
This study examined the capacity of ChatGPT-4 to assess L2 writing in an accurate, specific, and relevant way. Based on 35 argumentative essays written by upper-intermediate L2 writers in higher education, we evaluated ChatGPT-4’s assessment capacity across four L2 writing dimensions: (1) Task Response, (2) Coherence and Cohesion, (3) Lexical Resource, and (4) Grammatical Range and Accuracy. The main findings were (a) ChatGPT-4 was exceptionally accurate in identifying the issues across the four dimensions; (b) ChatGPT-4 demonstrated more variability in feedback specificity, with more specific feedback in Grammatical Range and Accuracy and Lexical Resource, but more general feedback in Task Response and Coherence and Cohesion; and (c) ChatGPT-4’s feedback was highly relevant to the criteria in the Task Response and Coherence and Cohesion dimensions, but it occasionally misclassified errors in the Grammatical Range and Accuracy and Lexical Resource dimensions. Our findings contribute to a better understanding of ChatGPT-4 as an assessment tool, informing future research and practical applications in L2 writing assessment.
The Scientific Advisory Committee on Nutrition (SACN) provides independent advice on nutrition and related health matters to UK government organisations. In keeping with its commitment to openness and transparency, SACN follows a set ‘Framework’ to ensure a prescribed and consistent approach is taken in all its evidence evaluations. Following an update of the SACN Framework in 2020, which addressed some straightforward issues, the SACN Framework subgroup was established in 2021 to consider more complex matters that were not addressed in the 2020 update. The SACN Framework subgroup considered four main topics for update: (1) the different types of evidence evaluations produced by SACN, (2) interpretation of statistical data, (3) tools for assessment of study quality and (4) tools to assess the certainty of a body of evidence for exposure–outcome relationships. The Framework subgroup agreed clear definitions and processes for the different types of evidence evaluations produced by SACN and agreed that interpretation of P values should be informed by consideration of study size, power and methodological quality. The subgroup recommended use of the AMSTAR 2 tool for quality assessment of evidence from systematic reviews and use of the Grading of recommendations, assessment, development and evaluation approach to assess the certainty of evidence. The updated Framework was published in January 2023. This was followed by publication of a further update in October 2024. As a ‘living’ document, the Framework will be subject to regular review by the Framework subgroup and continue to evolve in line with best practice.
Chapter 3 on Attribution Science delves deeper into the science that establishes causal links between climate change, specific sources of emissions, and its impacts. The authors illustrate how these scientific developments are enhancing our ability to pinpoint the causes of climate impacts, an evolution crucial to a range of procedural and substantive issues that may arise in climate litigation. The authors also delve into specific regional impacts and showcase how attribution science has illuminated the ways in which different parts of the world are experiencing and responding to the unique challenges posed by a changing climate. This includes case studies in Africa, the Americas, Europe, the South Pacific, and Asia. The authors conclude by addressing the limitations and challenges in the field of attribution science before explaining how it is nevertheless poised to play an ever-more critical role in our collective response to climate change.
As an antiquarian at the beginning of the age of professional scholarship, Francis Douce (1737–1834) has enjoyed a mixed reputation, exemplified by Meg Twycross’s account of his influence on beliefs regarding the origins of the Towneley Plays. Widely-read and embedded in a network of like-minded enthusiasts, Douce does not appear to have recorded his insights for publication, but he nevertheless participated in what might be considered scholarly exchange. This article will pay attention to the annotations that Douce made in the margins of – and on sheets tipped into – French-language books published before 1600. It will look at what sort of features attracted Douce’s attention (primarily bibliographical, but also some relating to the content of the books he was reading). It will consider where Douce was getting his information about the works he collected and will note instances where Douce revisited and revised his opinions, evaluating the extent to which he was up-to-date with contemporary advances. Where Douce expresses his own opinion, this article will examine whether this opinion has been supported by later scholars. In short, what do the annotations tell us about the state of scholarship in the first decades of the nineteenth century?
Chapter 6 on Separation of Powers offers a comprehensive exploration of how the balance of power between the judiciary and other branches of government plays out in climate litigation. The authors critically analyse key cases where these doctrines have been invoked, shedding light on how these doctrines shape the courts’ approach to climate cases. They underscore the significant variation in how this issue is dealt with across jurisdictions, acknowledging the diversity of constitutional and legal frameworks globally. Despite this diversity, the authors distil an emerging best practice where courts are increasingly recognising their crucial role in safeguarding fundamental rights and constitutional values in the context of climate change. This recognition is not a one-directional or universal trend but a nuanced evolution detectable across various jurisdictions and legal systems.
Radical right behavior and support for radical right parties have increased across many countries in recent decades. A growing body of research has argued that, similar to the spread of other extremist behaviors, this is due to an erosion of political norms. This suggests that re-stigmatizing radical right parties might be an effective way of countering their growth. We use a survey experiment in Spain that compares the effectiveness of three theory-driven interventions aimed at increasing political stigma against a radical right party. Contrary to expectations, we fail to validate the efficacy of vignette-based attempts at stigmatization, instead identifying some backlash effects. Methodologically, our findings underscore the importance of validating treatments, as we show that simple attempts at re-stigmatization can produce null or opposing effects to their intended purpose. Theoretically, our results support the idea that normalization is a “one-way street,” in that re-stigmatizing parties is difficult after a party has become normalized.
Daptomycin is preferred in outpatient parenteral antimicrobial therapy (OPAT) due to daily dosing. Elevations in creatine phosphokinase (CPK) of 3%–10% and musculoskeletal adverse events have been described with daptomycin, but data regarding risk factors and frequency of monitoring in the OPAT setting is limited. We evaluated the incidence and risk factors for CPK elevation and musculoskeletal adverse effects in patients receiving daptomycin OPAT.
Methods:
This was a single-center, retrospective cohort study of adults on OPAT with daptomycin and at least two CPK values. The primary outcome was the incidence of CPK values greater than 500 U/L.
Results:
We included 127 patients. Most patients were male (55.1%), and the median age was 56 years (IQR 46–63). The most common indication was bone/joint infections (73.2%, n = 93). The median daptomycin dose was 7.4 mg/kg/day (IQR 6.1–8.1) and duration of therapy was 37 days (IQR 21–44). Fifteen patients (11.8%) experienced a CPK greater than 500 U/L within a median 13 days (IQR 9–16). Five patients (3.9%) developed rhabdomyolysis. Independent predictors of CPK>500 U/L included male sex (OR, 4.2 [95% CI, 1.05–16.61]; P = .0424) and cerebrovascular disease (OR, 11 [95% CI, 1.21–99.86]; P = .0332).
Conclusions:
The incidence of CPK elevation was similar previously reported rates. This expands the literature to patients with daptomycin doses>6 mg/kg and prolonged durations of therapy. The incidence of CPK elevation and time to onset of 9–16 days supports the current recommendations for weekly lab monitoring.
This reply responds to criticism of our original symposium, ‘Global IR and the Essentialism Trap.’ We respond to four particular charges and end with a call for Global IR to move beyond its current emphasis on creating a more diverse, equal, and inclusive discipline to identifying specific research programs that demonstrate the necessity of moving beyond the West. We nominate global order and disorder.
Plant-based meat and dairy analogues contain less protein than their animal-based counterparts and rely on various plant protein sources, which frequently display incomplete amino acid (AA) profiles that do not reflect dietary requirements due to low quantities of one or more essential AA (EAA). There is little insight in the AA profiles of most of these plant-based analogues. We assessed the AA composition of forty plant-based meat and dairy analogues that were commercially available in The Netherlands in March 2023 and compared their EAA profile to dietary requirements and to the EAA profile of their meat and dairy counterparts. Total protein contents were lower in most analogues when compared with their animal-based counterparts (meat analogues, n 16 (80 %); lunch meats and cheese analogues, n 10 (100 %); milk and yoghurt analogues, n 9 (90 %)) and accompanied by lower EAA contents. In reference to dietary requirements, the sum of the total EAA contents was adequate in all but one of the analogues. Nevertheless, all analogues displayed deficiencies in one or more specific EAA. Methionine contents were most frequently low (n 39; 98 %), followed by lysine contents (n 11; 28 %). Essential AA compositions varied between analogues irrespective of the protein source(s) used. In conclusion, plant-based meat and dairy analogues exhibit incomplete EAA profiles, which may compromise adequate protein nutrition in plant-centred diets.
We define the generalized equilibrium distribution, that is the equilibrium distribution of a random variable with support in $\mathbb{R}$. This concept allows us to prove a new probabilistic generalization of Taylor’s theorem. Then, the generalized equilibrium distribution of two ordered random variables is considered and a probabilistic analog of the mean value theorem is proved. Results regarding distortion-based models and mean-median-mode relations are illustrated as well. Conditions for the unimodality of such distributions are obtained. We show that various stochastic orders and aging classes are preserved through the proposed equilibrium transformations. Further applications are provided in actuarial science, aiming to employ the new unimodal equilibrium distributions for some risk measures, such as Value-at-Risk and Conditional Tail Expectation.
The Greek model of mental healthcare delivery in rural and remote low-resourced areas is based on Mobile Mental Health Units (MMHUs). MMHUs are low-cost, interdisciplinary, generic community psychiatric services that collaborate closely with the primary healthcare system and local social services. MMHUs may be effective in the treatment of patients with severe and persistent mental illness and cost-effective in the treatment of patients with common mental disorders. The Council of Europe categorised this model as an effective community-based initiative. Major challenges derive from the difficulties MMHUs run by public general hospitals face in recruiting and retaining personnel.
Chapter 9 examines the principle of the duty of care in the context of climate litigation. The authors explore how this principle has been invoked in a growing range of jurisdictions, in different ways, to hold governments and corporations accountable for their respective contributions to climate change. By analysing judicial decisions in prominent cases such as Urgenda and Milieudefensie in the Netherlands, Neubauer in Germany, and Notre Affaire à Tous in France, the authors explore the potential of the duty of care principle to compel more ambitious climate action in pending and future cases. The emerging best practice they identify suggests a growing willingness of courts to recognise a duty of care for governments and corporations towards citizens in relation to climate change.
Seabirds play an important role as top consumers in the food web and can be used as biomonitors for exposure to pollutants. Erythrocyte nuclear abnormalities (ENAs) represent one of the most important ways to detect genomic damage associated with environmental degradation and pollution. This study investigates the number of ENAs in three populations of two species of Leucocarbo shags. Blood samples from the Antarctic shag (Leucocarbo bransfieldensis) breeding on the Antarctic Peninsula and the South Shetland Islands and the South Georgia shag (Leucocarbo georgianus) breeding on the South Orkney Islands were analysed. The results revealed evidence of genomic damage in all individuals, with a mean number of ENAs of 26.54 and 43.51/10 000 red blood cells for Antarctic and South Georgia shags, respectively. Thus, the shags from the Orkney Islands showed a higher number of erythrocyte abnormalities, whereas no significant differences were observed among shag populations across the Antarctic Peninsula and South Shetland Islands. These results suggest that, in the northern part of the region, shags might be more exposed to pollutants. They also provide the first reference values for cytogenetic damage in this species and establish a critical baseline for future biomonitoring efforts.
Los estudios sobre la relación entre música y fuerzas militares suelen estar mediados por enfoques tradicionales que analizan la música marcial o sus usos para los fines de la institución. Sin embargo, existe una producción musical de integrantes activos y retirados de las fuerzas militares que no es marcial, que no necesariamente está institucionalizada y que se aleja de los usos y temáticas que usualmente se asocian a la música militar. El estudio de estas producciones complejiza y enriquece los enfoques tradicionales sobre la relación entre música y fuerzas militares. Este texto presenta los hallazgos de la recopilación y análisis de 463 canciones compuestas y/o interpretadas por militares activos y retirados en Colombia entre 1989 y 2021, junto con entrevistas a algunos de estos artistas. Los hallazgos sugieren que abordar este tipo de música, que pocas veces es reconocida como ‘militar’, permite conocer la perspectiva del soldado como individuo en contextos de guerra y posconflicto; facilita la comprensión de la relación entre música institucional y no institucional y los distintos usos que se le da; y abre líneas de investigación sobre la forma en la que estas producciones entran en diálogo con géneros musicales, identidades regionales y el mercado artístico en el que participan.
If elections are fair and free, citizens should accept their results regardless of the party or candidate they voted for. The evaluation of democracy should not be tainted by ‘winning’ or ‘losing’ an election. However, research on ‘losers’ consent’ has demonstrated that winners evaluate the functioning of democracy more positively than losers. We argue that the effect of losing is even more pronounced for populist voters. For them, winning and losing is indicative of the functioning of the democratic system itself. To demonstrate this, we use cross-sectional data from the Comparative Studies of Electoral Systems as well as panel data from Germany and the Netherlands for longitudinal analysis. We show that the more populist a citizen is, the stronger the effect losing is on the level of satisfaction with democracy.