In the field of International Relations, sovereignty refers to a state’s authority to govern itself without external interference, closely tied to the principle of non-intervention. Recent scholarship has illuminated sovereignty as socially constructed and dynamic, yet non-interference remains central to its conception. Catherine MacKinnon’s feminist critique exposes the patriarchal implications of fetishising non-interference, silencing marginalised voices, and perpetuating gendered power imbalances. This Forum examines whether Indigenous conceptions of sovereignty that prioritise non-interference are shaped by patriarchal ideologies, particularly through the emphasis on relationality – rooted in kinship – and the central role of consent in Indigenous understandings and practices of sovereignty. By examining the intersection of non-interference with systems of oppression, this paper contributes to a nuanced understanding of Indigenous sovereignty, self-determination, and gendered relations. It concludes with a discussion of the relationship between consent, non-interference, and non-domination.

Although much research confirms a gender gap in political science and its subfields internationally, only recently have scholars analyzed country-specific conditions for women within the field. Our study contributes to this national-level examination of gender diversity and inclusion by examining the extent to which a gender gap within the subfield of security studies, identified in the international literature, also is present in Canada. Research on gender representation and gendered experiences mostly centers on the academic workforce in the United States. However, in this article, we share the results of a multi-method investigation into the state of gender diversity in Canadian security studies—a national context in which the university sector has signaled a strong commitment to diversity and the government has actively promoted gender equality in official policy. By analyzing data collected from an online survey of security studies scholars in Canada and a document analysis of Canadian security-related journals and selected security studies syllabi, this contribution provides evidence that women are underrepresented in Canadian security studies and experience the subfield in less positive ways. We discuss the implications of these findings for the security studies subfield and suggest paths for future research and key recommendations.

Synthetic biology aims to create a viable synthetic cell. However, to achieve this goal, it is essential first to gain a profound understanding of the cellular systems used to build that cell, how to reconstitute those systems in the compartments, and how to track their function. Transcription and translation are two vital cellular systems responsible for the production of RNA and, consequently, proteins, without which the cell would not be able to maintain itself or fulfill its functions. This review discusses in detail how the Protein synthesis Using Recombinant Element (PURE) system and cell lysate are used to reconstitute transcription–translation in vitro. Furthermore, it examines how these systems can be encapsulated in GUVs using the existing methods. It also assesses approaches available to image transcription and translation with a diverse arsenal of fluorescence microscopy techniques and a broad collection of probes developed in recent decades. Finally, it highlights solutions for the challenge ahead, namely the decoupling of the two systems in PURE, and discusses the prospects of synthetic biology in the modern world.

When the impact of populism on liberal democracy is examined, the focus often is on populists in power. After all, when in office, populists have the possibility to change legislation, thereby negatively affecting individual freedoms and rights, and to transform the political system, often toward democratic decline and illiberalism (Pappas 2019; Ruth-Lovell and Grahn 2023).1 Far less attention has been devoted to populist parties in opposition, even though this is the position in which populists find themselves most frequently.2 Prominent examples of Western European populist parties with a decades-long position in opposition include the Rassemblement National in France and the Vlaams Belang in Belgium on the right and Die Linke in Germany and the Socialistische Partij in the Netherlands on the left. Outside of Western Europe, populist parties often have less longevity and more frequently assume office. However, many of these parties spend years in opposition before taking on government responsibility and/or have returned to the opposition benches afterwards (e.g., Partido Justicialista in Argentina and Prawo i Sprawiedliwość in Poland).

This article undertakes a Kleinian analysis of the early feedback works of Éliane Radigue. By reading the melancholic nature of these works – their fixation on the ‘lost objects’ of recorded sound, and the self-recursivity of their feedback techniques – as sonically generative rather than merely mournful, I argue that Radigue's feedback works transcend the signifying order of much elegiac music, offering a distinct intervention and epistemology within the history of musique concrète, electronic music and the sonic arts.

Under what conditions do insurgents challenge gender norms in the midst of conflict? And what do they gain by doing so? Using an original data set of 137 armed groups fighting between 1950 and 2019, I argue that armed groups challenge gender customs to reshape local power relations. With 40 percent of rebel groups regulating civilian gender customs during civil war, this strategy is remarkably widespread, comparable to taxation or the provision of basic security in its prevalence. I demonstrate that armed groups exploit pre-existing gender grievances, using strategies like punishing domestic violence (9 percent of groups), banning dowries (15 percent), and enforcing dress codes (11 percent) to empower targeted subsections of the population and undermine local elites. I combine cross-national analysis with qualitative case studies of al-Qaeda in the Islamic Maghreb and Katiba Macina, two Islamist groups in Mali. This allows me to demonstrate how the approach to local elites drives gender governance in two groups with a shared ideology, goals, and societal context.

Single-stranded nucleic acid (ssNA) binding proteins must both stably protect ssNA transiently exposed during replication and other NA transactions, and also rapidly reorganize and dissociate to allow further NA processing. How these seemingly opposing functions can coexist has been recently elucidated by optical tweezers (OT) experiments that isolate and manipulate single long ssNA molecules to measure conformation in real time. The effective length of an ssNA substrate held at fixed tension is altered upon protein binding, enabling quantification of both the structure and kinetics of protein–NA interactions. When proteins exhibit multiple binding states, however, OT measurements may produce difficult to analyze signals including non-monotonic response to free protein concentration and convolution of multiple fundamental rates. In this review we compare single-molecule experiments with three proteins of vastly different structure and origin that exhibit similar ssNA interactions. These results are consistent with a general model in which protein oligomers containing multiple binding interfaces switch conformations to adjust protein:NA stoichiometry. These characteristics allow a finite number of proteins to protect long ssNA regions by maximizing protein–ssNA contacts while also providing a pathway with reduced energetic barriers to reorganization and eventual protein displacement when these ssNA regions are diminished.

How can political science scholars use visualization and mapping tools to refine the development of research on complex theoretical concepts? Literature mapping, a powerful method commonly used in the natural sciences to visualize scientific landscapes, is not yet widely used in political science. This study illustrates the capabilities of this method by analyzing visual maps of academic research on the term “organizing” in the context of political action. We describe our multistep methodological approach for generating the maps and demonstrate how they can be analyzed to produce insights about themes, potential gaps, canonical literature, and levels of dialogue across research areas. We conclude by outlining future research possibilities generated by this study’s literature mapping approach.

Behavioral science researchers have shown strong interest in disaggregating within-person relations from between-person differences (stable traits) using longitudinal data. In this paper, we propose a method of within-person variability score-based causal inference for estimating joint effects of time-varying continuous treatments by controlling for stable traits of persons. After explaining the assumed data-generating process and providing formal definitions of stable trait factors, within-person variability scores, and joint effects of time-varying treatments at the within-person level, we introduce the proposed method, which consists of a two-step analysis. Within-person variability scores for each person, which are disaggregated from stable traits of that person, are first calculated using weights based on a best linear correlation preserving predictor through structural equation modeling (SEM). Causal parameters are then estimated via a potential outcome approach, either marginal structural models (MSMs) or structural nested mean models (SNMMs), using calculated within-person variability scores. Unlike the approach that relies entirely on SEM, the present method does not assume linearity for observed time-varying confounders at the within-person level. We emphasize the use of SNMMs with G-estimation because of its property of being doubly robust to model misspecifications in how observed time-varying confounders are functionally related to treatments/predictors and outcomes at the within-person level. Through simulation, we show that the proposed method can recover causal parameters well and that causal estimates might be severely biased if one does not properly account for stable traits. An empirical application using data regarding sleep habits and mental health status from the Tokyo Teen Cohort study is also provided.

This article examines five Sasanian bullae from the fire temple of Ādur Gušnasp with seal impressions depicting Aphrodite and Eros, and Aphrodite Anadyomene. It is argued that the original seal with Aphrodite and Eros likely dates from the late 1st century BCE to the early 1st century CE, reused between the 5th–7th centuries CE, while the Aphrodite Anadyomene seal is from the 2nd or 3rd century CE. Contextualizing these findings within Graeco-Roman and Iranian cultures, this article explores reinterpretations of Graeco-Roman iconography for both Zoroastrian and non-Zoroastrian audiences, as well as highlights that bullae with concave impressions of cylindrically curved objects on the reverse had once been attached to vessels, not just documents. Additionally, this article also discusses other sealings on the new bullae, some with Middle Persian inscriptions, identifying a mgw (priest) and an astrologer, providing the first attestation of the word axtar (constellation) on a Sasanian seal.

Bioarchaeologists commonly record porous cranial lesions (PCLs). They have varied etiologies but are frequently associated with nutritional anemia without a differential diagnosis. This article provides a literature review, evaluates diet in the US Southwest over time, and identifies issues with associating PCLs with poor diet in this region. Generally, diet was adequate across time and space. Although maize was a dietary staple, other food items such as rabbits and amaranth provided complementary micronutrients. PCLs exhibit varied morphologies, which generally correspond with age: those characterized by fine, scattered porosity are associated with younger ages at death. Variation in PCL morphology indicates different and sometimes unrelated etiologies. Nutritional anemia is an insufficient explanation for PCL frequency in the Southwest, partly because the diet was adequate across time.

This article reviews recent advances in the psychometric and econometric modeling of eye-movements during decision making. Eye movements offer a unique window on unobserved perceptual, cognitive, and evaluative processes of people who are engaged in decision making tasks. They provide new insights into these processes, which are not easily available otherwise, allow for explanations of fundamental search and choice phenomena, and enable predictions of future decisions. We propose a theoretical framework of the search and choice tasks that people commonly engage in and of the underlying cognitive processes involved in those tasks. We discuss how these processes drive specific eye-movement patterns. Our framework emphasizes the central role of task and strategy switching for complex goal attainment. We place the extant literature within that framework, highlight recent advances in modeling eye-movement behaviors during search and choice, discuss limitations, challenges, and open problems. An agenda for further psychometric modeling of eye movements during decision making concludes the review.

Iroquoian groups inhabiting the St. Lawrence Valley in the fifteenth and sixteenth centuries AD practiced agriculture and supplemented their diet with fish and a variety of wild plants and terrestrial animals. Important gaps remain in our knowledge of Iroquoian foodways, including how pottery was integrated to culinary practices and the relative importance of maize in clay-pot cooking. Lipid analyses carried out on 32 potsherds from the Dawson site (Montreal, Canada) demonstrate that pottery from this village site was used to prepare a range of foodstuffs—primarily freshwater fish and maize, but possibly also other animals and plants. The importance of aquatic resources is demonstrated by the presence of a range of molecular compounds identified as biomarkers for aquatic products, whereas the presence of maize could only be detected through isotopic analysis. Bayesian modeling suggests that maize is present in all samples and is the dominant product in at least 40% of the potsherds analyzed. This combination of analytical techniques, applied for the first time to Iroquoian pottery, provides a glimpse into Iroquoian foodways and suggests that sagamité was part of the culinary traditions at the Dawson site.

Several criteria from the optimal design literature are examined for use with item selection in multidimensional adaptive testing. In particular, it is examined what criteria are appropriate for adaptive testing in which all abilities are intentional, some should be considered as a nuisance, or the interest is in the testing of a composite of the abilities. Both the theoretical analyses and the studies of simulated data in this paper suggest that the criteria of A-optimality and D-optimality lead to the most accurate estimates when all abilities are intentional, with the former slightly outperforming the latter. The criterion of E-optimality showed occasional erratic behavior for this case of adaptive testing, and its use is not recommended. If some of the abilities are nuisances, application of the criterion of As-optimality (or Ds-optimality), which focuses on the subset of intentional abilities is recommended. For the measurement of a linear combination of abilities, the criterion of c-optimality yielded the best results. The preferences of each of these criteria for items with specific patterns of parameter values was also assessed. It was found that the criteria differed mainly in their preferences of items with different patterns of values for their discrimination parameters.

This study both reveals and resolves a basic problem elided by the historiography of early kabbalah. The problem is that scholarship has followed obsolete research from the 1940s by putting a single fragmentary text to a task that it is unfit to perform. More than eighty years ago, Gershom Scholem adduced a short fragment copied in sixteenth-century Italy to show that the kabbalists’ signature doctrine of divine androgyny goes all the way back to the earliest medieval authority to whom kabbalistic knowledge is traditionally ascribed, namely, the Provençal sage Rabbi Abraham ben David of Posquières (the Rabad, per his acronym). After reviewing the contents of the fragment and exposing its paratextual relationship to the Rabad’s Baʿale ha-nefesh, this study provides ample grounds for dismissing the fragment’s ascription to the Rabad, and, more generally, for rejecting the attribution of any kabbalistic writing to this foundational figure. The study then proceeds to collate the fragment with an early-fourteenth-century family of texts associated with Shem Ṭov ben Abraham Ibn Gaon—texts expounding the wisdom of Naḥmanides—to establish the late provenance of a fragment, thought heretofore to date to twelfth-century France, espousing a doctrine that scholars believed had shaped the tradition from the beginning. The conclusion, which discusses the ramifications of removing the (Pseudo-)Rabad fragment from the archive of early kabbalah, is followed by an appendix containing a suite of paleographic evidence supporting the arguments advanced in the study.

Is political science research that explores gender and LGBTQIA+ politics still underrepresented in the discipline’s top journals? This article examines publication trends in gender research and LGBTQIA+ research in five top political science journals, between 2017 and 2023 (inclusive). I find that gender research and LGBTQIA+ research together account for 5% to 7% of published research in the selected top journals; however, most of this research is on gender politics rather than LGBTQIA+ politics. Overall, gender research and LGBTQIA+ research largely appears in top journals when it conforms to disciplinary norms about methods and author gender. The majority of published gender and LGBTQIA+ research is quantitative. Men author gender research at rates almost three times their membership in the American Political Science Association’s Women, Gender, and Politics research section and also are overrepresented as authors of LGBTQIA+ research. This study suggests that editorial teams’ signaling influences which manuscripts land at which journals.

The multidimensional forced-choice (MFC) format has been proposed to reduce faking because items within blocks can be matched on desirability. However, the desirability of individual items might not transfer to the item blocks. The aim of this paper is to propose a mixture item response theory model for faking in the MFC format that allows to estimate the fakability of MFC blocks, termed the Faking Mixture model. Given current computing capabilities, within-subject data from both high- and low-stakes contexts are needed to estimate the model. A simulation showed good parameter recovery under various conditions. An empirical validation showed that matching was necessary but not sufficient to create an MFC questionnaire that can reduce faking. The Faking Mixture model can be used to reduce fakability during test construction.