Influenza and other acute respiratory viral infections (ARVIs) are among the most common human diseases. In recent decades, the discovery of cytokines and their significance in the pathogenesis of diseases has led to extensive research on these compounds in various pathologies including ARVIs. The aim of the research was to study the cytokine profile in patients with ARVIs. The cases of 30 patients were investigated. Etiological diagnosis was performed by polymerase chain reaction. Different classes of cytokines in the serum were defined by the enzyme-linked immunosorbent assay (ELISA). The level of cytokines depended on the number of pathogens. The highest levels of pro-inflammatory interleukins and the lowest levels of anti-inflammatory IL-4 were observed in patients with a combination of five or more viruses compared to those with a monoinfection. Analysis of the data showed that in the acute phase, the levels of all studied pro-inflammatory cytokines – IL-2, IL-6, and TNF-α – increased by 8, 39, and 9 times, respectively, compared to those in healthy individuals. In the acute phase of ARVI, the levels of pro-inflammatory cytokines were significantly higher and depended on the severity of the disease. The imbalance of cytokines in the serum has been established in cases of ARVIs, depending on the severity of the disease.

In this paper, we prove a cocycle version of marked length spectrum rigidity. There are two consequences: the first one is marked length pattern rigidity for arithmetic hyperbolic locally symmetric manifolds, and the second one is a strengthened marked length spectrum rigidity for surfaces and closed locally symmetric manifolds.

Scholarship on early modern English Catholic music after the reformations tends to focus on the activities of male musicians and male institutions. Despite increased study of English convent culture by scholars of religious, social, and literary history, there remains little specialist examination of music at post-Reformation English convents in exile, and their role in wider musical networks in early modern Europe is markedly under-acknowledged. This article aims to highlight how complex miscellanies with links to English monastic institutions in exile can offer insight into the convents’ otherwise elusive musical world. Using a hitherto unanalysed miscellany – Douai Ms 785 – this article will show how codicological study of manuscripts, combined with study of concordances and unica, can illuminate the role of English convents in early modern musical networks. In doing so, it will demonstrate the need to understand miscellanies like Douai Ms 785 as witness to interacting, overlapping musical and religious ecosystems in early modern Europe.

In December 2018, an outbreak of Salmonella Enteritidis infections was identified in Canada by whole-genome sequencing (WGS). An investigation was initiated to identify the source of the illnesses, which proved challenging and complex. Microbiological hypothesis generation methods included comparisons of Salmonella isolate sequence data to historical domestic outbreaks and international repositories. Epidemiological hypothesis generation methods included routine case interviews, open-ended centralized re-interviewing, thematic analysis of open-ended interview data, collection of purchase records, a grocery store site visit, analytic comparison to healthy control groups, and case–case analyses. Food safety hypothesis testing methods included food sample collection and analysis, and traceback investigations. Overall, 83 cases were identified across seven provinces, with onset dates from 6 November 2018 to 7 May 2019. Case ages ranged from 1 to 88 years; 60% (50/83) were female; 39% (22/56) were hospitalized; and three deaths were reported. Brand X profiteroles and eclairs imported from Thailand were identified as the source of the outbreak, and eggs from an unregistered facility were hypothesized as the likely cause of contamination. This study aims to describe the outbreak investigation and highlight the multiple hypothesis generation methods that were employed to identify the source.

We develop a new class of spatial voting models for binary preference data that can accommodate both monotonic and non-monotonic response functions, and are more flexible than alternative “unfolding” models previously introduced in the literature. We then use these models to estimate revealed preferences for legislators in the U.S. House of Representatives and justices on the U.S. Supreme Court. The results from these applications indicate that the new models provide superior complexity-adjusted performance to various alternatives and that the additional flexibility leads to preferences’ estimates that more closely match the perceived ideological positions of legislators and justices.

This paper examines the impact that the finally approved Artificial Intelligence Act (AIA) will have on European public authorities when developing, acquiring and using AI systems. It argues that, despite the initial disappointment that the Act may cause when approaching it from an administrative law perspective, and despite the fact that some of the solutions that have been finally chosen are questionable, it represents a remarkable step forward, duly addressing many of the problems raised in the literature in relation to the automation of administrative decisions and the use of AI systems by public authorities.

Does resident diplomacy influence international outcomes? Theoretically, I argue that resident diplomats tend to adopt uniquely cooperative stances toward their hosts. I test this expectation using a natural experiment involving British visa issuance. Starting in 2007, the UK transferred visa decision making from local diplomatic posts to centralized hubs, located either at third country diplomatic posts or domestically. I study this rollout to credibly estimate the causal effects of visa adjudication by local posts. I find that resident diplomats implement a much more lenient visa policy—transferring adjudication to an outside hub reduces issuance by about fifteen percent. There is a robust difference between the behavior of local and third-country posts, showing that this cooperative effect of diplomacy is relationship-specific.

The legally binding unilateral application of norms holds potential for abuse. Nonetheless, self-judgment is alive and kicking. Self-judgment language commonly features in treaties and states frequently invoke their authority to ‘self-judge’ sensitive issues, such as matters related to national security, before international judicial bodies. In many of these cases, the controversy whether a norm has a self-judgment quality or not has been decisive for the outcome of the dispute. Yet, the meaning and consequences of self-judgment remain contested.

This article develops self-judgment as the authoritative application of international legal norms by states. It posits that steps towards the judicialization of self-judgment by judicial bodies have given rise to state efforts to preserve unfettered discretion. Notably, states have responded to attempts by judicial bodies to gain authority over the application of self-judgment by drafting provisions more explicitly. This dynamic continues to make self-judgment a site of judicialization and pushback. The only way to understand the meaning, limitations and development of self-judgment is by studying this process. Doing so conceptually refines self-judgment and allows for more meaningful references to the notion in practice.

An investigation into an outbreak of Salmonella Newport infections in Canada was initiated in July 2020. Cases were identified across several provinces through whole-genome sequencing (WGS). Exposure data were gathered through case interviews. Traceback investigations were conducted using receipts, invoices, import documentation, and menus. A total of 515 cases were identified in seven provinces, related by 0–6 whole-genome multi-locus sequence typing (wgMLST) allele differences. The median age of cases was 40 (range 1–100), 54% were female, 19% were hospitalized, and three deaths were reported. Forty-eight location-specific case sub-clusters were identified in restaurants, grocery stores, and congregate living facilities. Of the 414 cases with exposure information available, 71% (295) had reported eating onions the week prior to becoming ill, and 80% of those cases who reported eating onions, reported red onion specifically. The traceback investigation identified red onions from Grower A in California, USA, as the likely source of the outbreak, and the first of many food recall warnings was issued on 30 July 2020. Salmonella was not detected in any tested food or environmental samples. This paper summarizes the collaborative efforts undertaken to investigate and control the largest Salmonella outbreak in Canada in over 20 years.

The public trust doctrine holds promise as a tool for combatting international climate inaction. A global public trust in the Earth’s atmosphere may be a feasible avenue for generating international cooperation in this issue. The public trust doctrine is a viable and underutilized mechanism of understanding our collaborative obligations with respect to natural resources. This Article looks to the historical origins and current presentations of public trusts to extract features which indicate its effectiveness and appeal for modern climate change applications. Additionally, it presents two circumstances under which a global public trust in the atmosphere could eventually develop.

This article analyses the law-making power of international sports federations, with a specific focus on their authority of shaping global norms on gender. It explores a variety of international sporting rules from feminist and queer perspectives. These include the ban of rainbow armbands at the 2022 FIFA (Men’s) World Cup, rules on the participation of transgender persons in rugby, gendered and racialized uniform regulations in sports, and the Semenya case concerning the sports participation of women with variations in sex characteristics The analysis asserts that despite being non-state actors, international sports federations are de facto international lawmakers that disseminate hegemonic gender norms reflecting cis-hetero-sexism and white body norms. However, analysing the Semenya case and the decision of the Chamber of the European Court of Human Rights in the case shows that the law-making power of international sports federations in shaping gender norms is not absolute but embedded in a transnational network of norms. The article concludes that subjecting international sports federations to a feminist, queer, and anti-racist legal analysis assists in understanding how hegemonic norms on gender circulate transnationally and enhances knowledge on how international law works in practice.

The trend of global cooling across the Cenozoic transformed the North American landscape from closed forest to more open grasslands, resulting in dietary adaptations in herbivores in response to shifting resources. In contrast, the material properties of the predator food source (muscle, skin, and bone) have remained constant over this transition, suggesting a corresponding lack of change in predator dietary adaptations. We investigated the North American mammalian predator fossil record using a tooth-shape metric and body mass, predicting that the former would exhibit stability. Instead, we found that mean molar morphology became more blade-like, with our tooth-shape metric sharply increasing in the late Eocene and remaining high from the Oligocene onward. Subsequent tests in extant carnivorans reveal taxa with more bladelike teeth are prevalent in more open environments. Our results reveal an unexpected functional shift among North American predators in response to large-scale environmental changes across the Cenozoic.

In recent decades, historians have acknowledged the role that women played in shaping and disseminating scientific knowledge during the Enlightenment. Current scholarship also suggests that fashion was a means through which haptic, economic, and practical knowledge was shared among women. This article focuses on one particular fashion accessory – the artificial flower – to explore its contribution to our understanding of women’s knowledge of botany in eighteenth-century France. An analysis of the receipts preserved in the credit records of France’s most famous fashion merchant, Marie-Jeanne (Rose) Bertin (1747–1813), demonstrates high levels of specificity in the flowers that women chose to adorn their outfits. Seventy-five different types of flowers are mentioned using their vernacular names, suggesting that knowledge about a wide variety of flowers was exchanged between fashion merchants and their clients during conversations about clothing. This article therefore casts the fashion merchant’s shop as a site of botanical knowledge generation and exchange.

Germany’s content moderation law—NetzDG— is often the target of criticism in English-language scholarship as antithetical to Western notions of free speech and the First Amendment. The purpose of this Article is to encourage those engaged in the analysis of transatlantic content moderation schemes to consider how Germany’s self-ideation influences policy decisions. By considering what international relations scholars term ontological security, Germany’s aggressive forays into the content moderation space are better understood as an externalization of Germany’s ideation of itself, which rests upon an absolutist domestic moral and constitutional hierarchy based on the primacy of human dignity. Ultimately, this Article implores American scholars and lawmakers to consider the impact of this subconscious ideation when engaging with Germany and the European Union in an increasingly multi-polar cyberspace.

We study the dynamics of dissipative billiard maps within planar convex domains. Such maps have a global attractor. We are interested in the topological and dynamical complexity of the attractor, in terms both of the geometry of the billiard table and of the strength of the dissipation. We focus on the study of an invariant subset of the attractor, the so-called Birkhoff attractor. On the one hand, we show that for a generic convex table with ‘pinched’ curvature, the Birkhoff attractor is a normally contracted manifold when the dissipation is strong. On the other hand, for a mild dissipation, we prove that, generically, the Birkhoff attractor is complicated, both from the topological and the dynamical points of view.