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In this article, I critically examine the ‘Cyber Kill Chain’, a methodological framework for thought and action that shapes both contemporary cybersecurity practice and the discursive construction of security threats. The history and epistemology of the Cyber Kill Chain provide unique insight into the practice of contemporary cybersecurity, insofar as the Kill Chain provides cybersecurity practitioners with predetermined categories and indicators of threat that shape how threats are conceptualised and understood by defenders and suggests actions to secure against them. Locating the origins of the kill chain concept in US military operational logics, its transformation through the anticipatory inquiries of intelligence, and its automation in computational networks, this article argues that the Cyber Kill Chain is emblematic of a vigilant socio-technical logic of security, where human perception, technical sensing, and automation all respond to and co-produce the (in)security through which political security concerns are articulated. This practice makes politics; it excludes, includes, and shapes what is perceived to be dangerous and not, directly impacting the security constructed. Through a critical reading of the Cyber Kill Chain, this article provides insight into cybersecurity practitioners’ epistemic practice and as such contributes to discussions of cybersecurity expertise, threat construction, and the way in which cybersecurity is understood and practised as a global security concern.
Inadequate access to cancer care, high mortality, and out-of-pocket expenditure contribute to health-related suffering in low- and middle-income countries, making palliative care a relevant option. How palliative care development has alleviated suffering is not systematically studied, necessitating this review’s conduct. The objective of this systematic review with a framework synthesis approach is to identify and map the dimensions and indicators of cancer palliative care development and the components of integration between cancer and palliative care in LMICs.
Methods
Uni- and multi-disciplinary databases like Cochrane, MEDLINE (PubMed), EMBASE, CINAHL Complete, and PsycINFO will be systematically searched for eligible studies exploring cancer palliative care development in LMICs and their contribution to alleviating health-related suffering in the cancer context. Our selection process will encompass countries classified by the World Bank as low-income (26 countries), lower-income (54 countries), and upper-middle-income (54 countries).
Results
Review findings will be synthesised and analysed using a best-fit framework synthesis method using 2 frameworks (the WHO model of components and indicators for palliative care development and integration elements between oncology and palliative care), and the findings will be developed as themes and subthemes, and patterns interpreted using these 2 models.
Significance of results
This review will analyse the development of cancer palliative care in LMICs. It will identify gaps in provision, solutions derived at the regional level to address them, and best practices and failed models with reasons underpinning them.
During the late eighteenth and early nineteenth centuries, mutual associations predominated in insuring the large fleet of ships that carried coal from Britain's northeast to London and other ports. The number of associations grew rapidly from the late 1770s, initially on the Tyne, then spreading to other ports on the east coast. They largely saw off the challenge from joint-stock companies created after the liberalisation of the marine insurance market in 1824. Low administrative and legal costs and the ability to mobilise local knowledge to minimise risks allowed the associations to offset the disadvantage of insuring vessels in the same trade facing similar adversities. This article discusses how mutual associations were organised and operated, traces their development on the Tyne and the competition they encountered there from Lloyd's of London and joint-stock insurance companies, and examines the incidence of mutual associations elsewhere in Britain.
Causal inference requires contrasting counterfactual states under specified interventions. Obtaining these contrasts from data depends on explicit assumptions and careful, multi-step workflows. Causal diagrams are crucial for clarifying the identifiability of counterfactual contrasts from data. Here, I explain how to use causal directed acyclic graphs (DAGs) to determine if and how causal effects can be identified from non-experimental observational data, offering practical reporting tips and suggestions to avoid common pitfalls.
Resolving trauma may contribute to mental health and parenting in mother with histories of childhood maltreatment. The concept of trauma-specific reflective functioning (T-RF) was developed to assess the complexity of thought processes regarding trauma. The study aimed to validate the T-RF scale applied to the Trauma Meaning-Making Interview by examining its psychometric properties, associations with measures of trauma-processing strategies, maternal reflective functioning and mental health (depression and post-traumatic stress disorder [PTSD]), as well as evaluating whether T-RF offered a unique contribution to maternal insightfulness. Good construct validity of the T-RF scale was confirmed in a sample of 112 mothers with histories of childhood maltreatment using an independent coding system of trauma-processing. Better mentalization of trauma was prospectively associated with higher parental reflective functioning and mothers with high T-RF were much more likely to be insightful regarding the child’s mental states than non-reflective mothers and mothers with limited T-RF. The association between T-RF and insightfulness was observed even when controlling for maternal reflective functioning, trauma-processing strategies, maternal education and sociodemographic risk. T-RF was associated neither with depression, PTSD nor the characteristics of trauma. Findings suggest that mentalizing trauma would be an important protective factor in the intergenerational trajectories of trauma.
The study of very short-period contact binaries provides an important laboratory in which the most important and problematic astrophysical processes of stellar evolution take place. Short-period contact systems, such as CC Com, are particularly important for binary evolution. Close binary systems, especially those with multiple system members, have significant period variations, angular momentum loss mechanisms predominance, and pre-merger stellar evolution, making them valuable astrophysical laboratories. In this study, observations of CC Com, previously reported as a binary system, and new observations from the TÜBİTAK National Observatory (TUG) and the space-based telescope TESS have revealed that there is a third object with a period of about eight years and a fourth object with a period of about a century orbiting the binary system. From simultaneous analysis of all available light curves and radial velocities, the sensitive orbital and physical parameters of the system components are derived. The orbital parameters of the components are P$_\mathrm{A}=0.2206868 \pm 0.0000002$ days, P$_\mathrm{B}=7.9\pm0.1$ yr, P$_\mathrm{C}=98\pm5$ yr, $e_3$ = 0.06, $e_4$ = 0.44 and the physical parameters as M$_\mathrm{A1}=0.712\pm0.009$ M$_{\odot}$, M$_\mathrm{ A2}=0.372\pm0.005$ M$_{\odot}$, $m_{B;i^{\prime}=90^\circ}=0.074$ M$_{\odot}$, $m_{C;i^{\prime}=90^\circ}=0.18$ M$_{\odot}$, R$_\mathrm{A1}=0.693\pm0.006$ R$_{\odot}$, R$_\mathrm{A2}=0.514\pm0.005$ R$_{\odot}$, L$_\mathrm{A1}$ = 0.103 L$_\odot$, L$_\mathrm{A2}$ = 0.081 L$_\odot$. Finally, the evolutionary status of the multiple system CC Com and its component stars is discussed.
This study investigates the changes in the Spanish lexical and grammatical skills of 26 Spanish–English dual language learners during their first year of preschool. We also explore the impact of age, gender, and maternal cultural orientation on children’s language outcomes over time. The results show that, despite one year of English-only instruction, the children’s Spanish productions became more intelligible, lexically diverse, and grammatical between 3;7 and 4;7. However, Spanish productions were mostly limited to sentence fragments and contained errors in grammatical gender, verb morphology, object clitic pronouns, and prepositions. Girls had an advantage over boys, as attested by the higher lexical diversity, mean length of utterance, and grammaticality of their Spanish productions. Both maternal enculturation and acculturation predicted the grammaticality of children’s utterances, suggesting that mothers with high levels of orientation to both Latinx and American culture may be the most successful at promoting Spanish in the United States.
The COVID-19 pandemic and subsequent policy response to mitigate disease spread had far-reaching impacts on health and social well-being. In response, the Supplemental Nutrition Assistance Program (SNAP) underwent several pandemic-era modifications, including a 15 % monthly benefit increase on January 1, 2021. Research documenting the health effects of these SNAP modifications among low-income households and minoritized groups who were most impacted by the economic fallout during the first years of the pandemic is lacking. We aimed to estimate the health effects of the 15 % SNAP benefit increase in January 2021, among SNAP-eligible US households.
Design:
We estimated the effects of the SNAP increase on food insufficiency, mental health, and financial well-being using a rigorous quasi-experimental difference-in-differences (DID) analysis.
Setting:
August 19, 2020, to March 29, 2021.
Participants:
Participants were drawn from the national US Census Bureau Household Pulse Survey waves 13–27 (n 44 477).
Results:
Compared with SNAP-eligible non-recipients, SNAP-eligible recipients experienced decreased food insufficiency (–1·9 percentage points (pp); 95 % CI –3·7, –0·1) and anxiety symptoms (–0·09; 95 % CI –0·17, –0·01), and less difficulty paying for other household expenses (–3·2 pp; 95 % CI –4·9, –1·5) after the SNAP benefit increase. Results were robust to alternative specifications.
Conclusions:
Expansions of federal nutrition programmes have the potential to improve health and financial well-being. This study provides timely evidence to inform comprehensive safety net nutrition policies during future economic crises and public health preparedness response plans.
How might the ideas and practices of Global South migrants and activists inform normative frameworks and conceptual repertoires that political theorists and activists bring to bear on questions regarding justice and migration? Taking seriously the call for conceptual innovation to move beyond Eurocentrism this article builds on oral histories collected from refugees and migrants from the Tribal Areas of Pakistan to argue that the concept of haqq raises important questions about the reliance on statist justice in contemporary theorizing about migration ethics and provides insights into alternative ethical concerns. Ideas and practices of haqq foreground social relationships as well as the imbrication of responsibility and entitlement for communities and individuals. Crucially, engagement with haqq helps dislodge assumptions regarding state-enforced rights as universal vehicles of justice. Consequently, different ethical questions and imaginaries become available for consideration that resonate much beyond debates about migration.
Access to psychedelic drugs is liberalizing, yet responses are highly unpredictable. It is therefore imperative that we improve our ability to predict the nature of the acute psychedelic experience to improve safety and optimize potential therapeutic outcomes. This study sought to validate the ‘Imperial Psychedelic Predictor Scale’ (IPPS), a short, widely applicable, prospective measure intended to be predictive of salient dimensions of the psychedelic experience.
Methods
Using four independent datasets in which the IPPS was completed prospectively – two online surveys of ‘naturalistic’ use (N = 741, N = 836) and two controlled administration datasets (N = 30, N = 28) – we conducted factor analysis, regression, and correlation analyses to assess the construct, predictive, and convergent validity of the IPPS.
Results
Our approach produced a 9-item scale with good internal consistency (Cronbach's α = 0.8) containing three factors: set, rapport, and intention. The IPPS was significantly predictive of ‘mystical’, ‘challenging’, and ‘emotional breakthrough’ experiences. In a controlled administration dataset (N = 28), multiple regression found set and rapport explaining 40% of variance in mystical experience, and simple regression found set explained 16% of variance in challenging experience. In another (N = 30), rapport was related to emotional breakthrough explaining 9% of variance.
Conclusions
Together, these data suggest that the IPPS is predictive of relevant acute features of the psychedelic experience in a broad range of contexts. We hope that this brief 9-item scale will be widely adopted for improved knowledge of psychedelic preparedness in controlled settings and beyond.
We investigate a class of adjective phrases composed of a deadjectival adverb ending in -ly and an adjective head (e.g. staggeringly incompetent, absolutely terrific, fiscally responsible), a compact construction whereby two adjectives may jointly contribute to evaluative meaning. Using corpus methodologies on more than 1 million examples and relying on semantic analyses of about 1,000 instances, we propose that the construction can be divided into different semantic subtypes, including Degree (deeply disturbing), Focus (utterly ridiculous), Manner (delightfully performed), Reaction (strangely compelling), Topical (historically inaccurate) and Epistemic (intuitively obvious), among others. Using this typology, we investigate the relative distribution of each subtype across several registers of written English. We found a high frequency of the Reaction subtype in book, film and art reviews, and we suggest a discourse-functional explanation for this, linked to the perceived value of originality in expressive writing. This investigation reveals the power of semantically informed, corpus methodologies to shed light on the distribution of specific constructions.
We investigate the relationship between a galaxy cluster’s hydrostatic equilibrium state, the entropy profile, K, of the intracluster gas, and the system’s non-thermal pressure (NTP), within an analytic model of cluster structures. When NTP is neglected from the cluster’s hydrostatic state, we find that the gas’ logarithmic entropy slope, $k\equiv \mathrm{d}\ln K/\mathrm{d}\ln r$, converges at large halocentric radius, r, to a value that is systematically higher than the value $k\simeq1.1$ that is found in observations and simulations. By applying a constraint on these ‘pristine equilibrium’ slopes, $k_\mathrm{eq}$, we are able to predict the required NTP that must be introduced into the hydrostatic state of the cluster. We solve for the fraction, $\mathcal{F}\equiv p_\mathrm{nt}/p$, of NTP, $p_\mathrm{nt}$, to total pressure, p, of the cluster, and we find $\mathcal{F}(r)$ to be an increasing function of halocentric radius, r, that can be parameterised by its value in the cluster’s core, $\mathcal{F}_0$, with this prediction able to be fit to the functional form proposed in numerical simulations. The minimum NTP fraction, as the solution with zero NTP in the core, $\mathcal{F}_0=0$, we find to be in excellent agreement with the mean NTP predicted in non-radiative simulations, beyond halocentric radii of $r\gtrsim0.7r_{500}$, and in tension with observational constraints derived at similar radii. For this minimum NTP profile, we predict $\mathcal{F}\simeq0.20$ at $r_{500}$, and $\mathcal{F}\simeq0.34$ at $2r_{500}$; this amount of NTP leads to a hydrostatic bias of $b\simeq0.12$ in the cluster mass $M_{500}$ when measured within $r_{500}$. Our results suggest that the NTP of galaxy clusters contributes a significant amount to their hydrostatic state near the virial radius and must be accounted for when estimating the cluster’s halo mass using hydrostatic equilibrium approaches.
We investigated whether individuals with Williams Syndrome (WS) produce language with a bias towards statistical properties of word combinations rather than grammatical rules, resulting in an overuse of holistically stored, familiar phrases. We analysed continuous speech samples from English children with WS (n = 12), typically developing (TD) controls matched on chronological age (n = 15) and TD controls matched on language age (n = 14). Alongside word count, utterance length, grammatical complexity, and morphosyntactic errors, we measured familiarity of expressions by computing collocation strength of each word combination. The WS group produced stronger collocations than both control groups. Moreover, the WS group produced fewer complex sentences, shorter utterances, and more frequent function words than chronological-age matched controls. Language in WS may appear more typical than it is because familiar, holistically processed expressions mask grammatical and other difficulties.
Caregiver-child interactions are commonly used to examine children’s language learning environment. However, few studies consider interaction configurations beyond dyadic interactions or explore the conceptual complexity of caregiver talk. Thus, we examined if the complexity of a caregiver’s opportunities to respond (OTR) varied when sampled across three interaction configurations. Our study included twelve preschool-aged children with Down syndrome and both of their biological parents. Our preliminary findings suggest no differences in mothers’ and fathers’ frequency of OTRs across complexity levels during dyadic interactions. However, caregivers produced fewer OTRs across complexity levels during family choice than dyadic interactions.
Vitamin D deficiency (VDD) is common among young women and causes various health problems, including those that occur during pregnancy and childbirth. Thus, we investigated the risk factors for VDD in young Japanese women and developed a simple risk scoring system called Vitamin D Deficiency Predicting Scoring (ViDDPreS).
Design:
A cross-sectional study, using the following factors for multivariate logistic regression analysis to create the ViDDPreS score: residential area, season, cumulative ambient ultraviolet-B irradiation, BMI, vitamin D supplement use, sun exposure habits, frequency of habitual food intake and eating habits. The subjects were randomly divided into development and test sets for analysis. Serum 25-hydroxivitamin D concentration of less than 20 ng/ml was defined as VDD.
Setting:
Four regions (Hokkaido/Tohoku, Kanto, Chubu/Kinki/Shikoku and Kyushu/Okinawa) in Japan.
Participants:
Five hundred and eighty-three healthy women aged 18–40 years.
Results:
In the development set, the VDD group (68·4 %) had higher proportions of the following variables than the non-VDD group: residential area outside the Kanto region; blood samples obtained in winter; low BMI (<18·5 kg/m2); vitamin D supplement non-users; short time regularly spent outside on weekdays; intake of fish, vitamin D-abundant fish, dried fish and redfish less than once a week. VDD risk was classified as low, medium or high according to the ViDDPreS scores including these contributing factors, with a test set C-index of 0·671.
Conclusion:
We identified the risk factors for VDD in young Japanese women and developed a simple risk scoring system that enables us to assess VDD risk and aid in the development of appropriate prevention and treatment strategies for this population.