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The range of digital sources available to historians has expanded at an enormous rate over the last fifty years; this has enabled all kinds of innovative scholarship to flourish. However, this process has also shaped recent historical work in ways that have not been fully discussed or documented. This article considers how we might reconcile the digitisation of archival sources with their materiality, with a particular focus on the probate records of the Prerogative Court of Canterbury (PCC). The article first considers the variety of digital sources available to historians of the United Kingdom, highlighting the particular influence of genealogical companies in shaping what material is available, how it has been digitised and how those sources are accessed. Secondly, we examine the PCC wills’ digitisation, what was gained and what was lost in that process, notably important material aspects of the wills. This article does not seek to champion archival research in opposition to digitally based scholarship; instead, we remind historians of the many ways in which the creation of sources shape their potential use, and call on historians to push for improvements in the United Kingdom’s digital infrastructure to avoid these problems in future.
Commentary of ‘Elemental psychopathology: distilling constituent symptoms and patterns of repetition in the diagnostic criteria of the DSM-5’ Vincent P. Martin 1, Régis Lopez 2,3, Jean-Arthur Micoulaud-Franchi 4,5, Christophe Gauld 4,6,*
Researchers across outdoor and environmental education (OEE) are drawing on relational ontologies to break down dualisms, human-centric thinking and challenge neoliberal education that focusses on outcomes and achievements. Digital technology has been seen as problematic in OEE because of its distracting qualities within notions of authentic outdoor experiences. Re-conceptualising digital technology as something learners are entangled with — rejecting a dualistic position — offers a nuanced way of understanding how digital technology could be harnessed for OEE. This research presents speculative findings from a new materialist inspired project on how teachers considered video-making and the more-than-human in OEE. Working with assemblage theory and attention to affect, we portray ways assemblages of video-making and the more-than-human can shape OEE in new ways. Implications for educators in how they might assemble OEE with technology are suggested.
Global governance institutions have increasingly ‘opened up’ to non-state actors, leading to more formally inclusive governance arrangements. This has prompted inquiry into the extent and the drivers of this inclusivity, patterns of participation, and the consequences for the legitimacy and effectiveness of global governance. However, while the measurement of formal openness has expanded, the quality of inclusion remains underexplored. We therefore introduce a framework centred on the notion of ‘meaningful inclusion’, distinguishing between formal (de jure) structures and the perceived quality of actual (de facto) engagement. Drawing on extensive empirical data, we then examine the Global Partnership for Effective Development Cooperation. This case exemplifies strong formal mechanisms for inclusion that are contrasted sharply by significant shortcomings in effective engagement. Our findings suggest that improvements in formal global governance structures alone cannot ensure meaningful inclusion. Instead, we highlight the centrality of power dynamics and vested interests in shaping inclusivity dynamics in practice.
Psychoeducational interventions are a critical aspect of supporting adults with attention-deficit hyperactivity disorder (ADHD). The Understanding and Managing Adult ADHD Programme (UMAAP) is a six-session, group-based webinar intervention that incorporates psychoeducation with acceptance and commitment therapy. UMAAP relies on self-referrals and is facilitated by a charity, to promote accessibility.
Aims
The present study aimed to evaluate the feasibility of UMAAP and explore preliminary effectiveness.
Method
Adults with formally diagnosed or self-identified ADHD (n = 257) participated in an uncontrolled pre–post design. Feasibility was indicated by attendance, confidence in completing the home practice and satisfaction. Quality of life, psychological flexibility, self-acceptance and knowledge of ADHD were assessed at baseline, 1 week post-intervention and 3 months later, to explore preliminary effectiveness.
Results
Feasibility was demonstrated by the high attendance ratings and satisfaction with the intervention, although there was only moderate confidence in the ability to complete the home practices. Quality of life (mean increase 9.69, 95% CI 7.57–11.80), self-acceptance (mean increase 0.19, 95% CI 0.10–0.28) and knowledge of ADHD (mean increase 1.55, 95% CI 1.23–1.82) were significantly improved post-intervention. The effects were maintained at the 3-month follow-up. Psychological flexibility did not significantly change immediately post-intervention, but increased significantly at the 3-month follow-up (mean increase 0.42, 95% CI 0.26–0.58).
Conclusions
Overall, UMAAP is a feasible intervention for adults with ADHD. Findings highlighted the feasibility of delivering psychological interventions online in group settings, to increase access to support for adults with ADHD.
We need to better understand the risk factors and predictors of medication-related weight gain to improve metabolic health of individuals with schizophrenia. This study explores how trajectories of antipsychotic medication (AP) use impact body weight early in the course of schizophrenia.
Methods
We recruited 92 participants with first-episode psychosis (FEP, n = 92) during their first psychiatric hospitalization. We prospectively collected weight, body mass index (BMI), metabolic markers, and exact daily medication exposure during 6-week hospitalization. We quantified the trajectory of AP medication changes and AP polypharmacy using a novel approach based on meta-analytical ranking of medications and tested it as a predictor of weight gain together with traditional risk factors.
Results
Most people started treatment with risperidone (n = 57), followed by olanzapine (n = 29). Then, 48% of individuals remained on their first prescribed medication, while 33% of people remained on monotherapy. Almost half of the individuals (39/92) experienced escalation of medications, mostly switch to AP polypharmacy (90%). Only baseline BMI was a predictor of BMI change. Individuals in the top tercile of weight gain, compared to those in the bottom tercile, showed lower follow-up symptoms, a trend for longer prehospitalization antipsychotic treatment, and greater exposure to metabolically problematic medications.
Conclusions
Early in the course of illness, during inpatient treatment, baseline BMI is the strongest and earliest predictor of weight gain on APs and is a better predictor than type of medication, polypharmacy, or medication switches. Baseline BMI predicted weight change over a period of weeks, when other traditional predictors demonstrated a much smaller effect.
Newborn calf diarrhea has led to widespread overuse of antibiotics. Therefore, it is crucial to find effective solutions for calf diarrhea. In this study, we aimed to evaluate the impact of the synthetic organic zinc-chelating-peptide glycine-glutamine-Zn (GQ-Zn) on the microbiota and metabolites in the gut of calves with diarrhea. The results showed that GQ-Zn alleviated diarrhea in calves. Additionally, 16S rDNA sequencing and metabolomic analysis revealed that GQ-Zn improved antioxidant capacity, relieved inflammation, altered the gut microbiota by decreasing the number of harmful bacteria Prevotella denticola, Fusobacterium necrophorum and influenced metabolomic profiles via the linoleic acid metabolic pathway in calves. In conclusion, GQ-Zn supplementation alleviated diarrhea through regulating the gut microbiota and metabolites in pre-weaning Holstein calves.
Abolition of slavery in British colonies led to the facilitation of Indian indentured migration by the British government. This form of migration came about when the discourse of economic freedom and individual liberty strongly resonated in British political economy circles, following the work of Adam Smith and John Stuart Mill. We analyze how unfreedom in indentured labor was rationalized when the rhetoric of freedom was essential to the dominant intellectual milieu. We consider why free labor was deemed unfeasible in the plantation colonies. We also consider the constraints that asymmetric information and unequal bargaining posed to freedom within the institution of indenture. We conclude that indenture represented an uneasy compromise between the problems of slavery and the unattainable goal of free labor.
This article analyzes Turkish foreign policy during the Iranian oil crisis of 1951–1953 and argues that Turkey shaped its policy based on Cold War politics. While Turkey cared less for Iran’s nationalization of oil, it was more concerned about the political implications of the crisis. At the beginning of the crisis, Turkey was focused on guaranteeing its own NATO membership. After joining NATO in 1952, the country assumed a more active role in the crisis. As the coalition behind Premier Dr Mohammad Mosaddegh dissolved, Turkey became more concerned about both the internal situation in Iran and the broader Middle Eastern context following the July 21, 1952 events in Iran and the 1952 Egyptian coup. The strongest opposition to Mosaddegh came from Ayatollah Abul Qassim Kashani who was both an important religious figure and the speaker of the Majlis. Turkey was concerned about Kashani’s politics of a “third bloc” and supported Mosaddegh’s pro-American position. Keeping Mosaddegh in power was in line with Turkey’s general Middle Eastern policy which aimed at forming a Western-oriented regional defense organization. This article will analyze the shaping of Turkish foreign policy towards the Iranian oil crisis within the context of this regional rivalry.
Knowledge of local antibiotic resistance data, provided by antibiograms (a cumulative summary of in vitro-antimicrobial-susceptibility-test results), can aid prescribing of appropriate empirical antibiotics. This study aimed to explore the feasibility of antibiogram development for residential aged care facilities (RACFs).
Design:
Retrospective observational study of culture and sensitivity data.
Setting:
Nine RACFs in Queensland, Australia.
Method:
Available antimicrobial susceptibility results were collected retrospectively for all residents of recruited RACFs from January 1, 2020, to December 31, 2022. Data were managed and analyzed with WHONET software®, and antibiograms were developed in accordance with the CLSI-M39 guidelines. Antibiogram data beyond the standard 12-months and pooling of data from geographically similar RACFs were explored as options to improve feasibility and validity of the antibiograms.
Results:
The most prevalent bacteria in the RACFs were Escherichia coli and Staphylococcus aureus. Due to the low number of positive cultures (less than 30) for individual RACFs, an annual antibiogram was not feasible. Extending the time-period to three years improved feasibility of antibiograms for E.coli in seven RACFs and S.aureus in five RACFs. Combining the data from closely located RACFs allowed for sufficient urinary and skin swab isolates to produce annual pooled antibiograms for all three years.
Conclusion:
Use of extended time period antibiograms can provide RACF specific urinary and skin/soft tissue resistance data without the necessity of private pathology provider input. However, pooled syndromic antibiograms can be made available on an annual basis, which may be the preferred option.
Drop collision with a solid particle is a ubiquitous phenomenon in a wide range of applications, including rain, spray coating, cooling or cleaning, particle encapsulation, inkjet printing, and additive manufacturing. Understanding the dynamics of drop collision is essential for optimizing these processes. In this study, we present a comprehensive experimental and analytical investigation of non-axisymmetric as well as axisymmetric drop impact on a solid particle. We use a high-speed video system to visualize the drop profile during the impact, and measure the drop height and spreading diameter for different liquid viscosities, ratios of the target to drop diameters, offsets, and various other impact parameters. We then develop a theoretical model for drop spreading on a solid spherical particle that relies on the formulation of a remote asymptotic solution for the inviscid flows, generated by non-axisymmetric drop impact. Next, the viscous effects in a thin viscous boundary layer are considered, which allows the formulation of an expression for the residual lamella thickness and maximum spreading. The theoretically predicted evolution of the lamella thickness, the residual film thickness, and the maximum spreading angle agree well with the experimental data presented in this work and the literature. Finally, we present a novel approach for in situ measurement of liquid viscosity, drop impact viscometry, at high shear rates via a single drop impact experiment, with potential application in industries where non-Newtonian drops play a major role, such as pesticide spraying, paint droplet spreading, blood drop impact and fuel injectors.
This retrospective cohort study analyzed differences in rates of central line-associated bloodstream infections (CLABSI) in Black and White inpatients across 11 southeastern US hospitals from 2019 to 2021. Results showed higher CLABSI rates in Black patients during the coronavirus disease 2019 (COVID-19) pandemic, even after adjustment for COVID-19 infection and clinical factors.
We showed images of classic Blalock–Taussig–Thomas shunt in a 35-year-old male patient with tetralogy of Fallot who underwent palliative surgery in 1992. It is a rare image echocardiography in our modern life.
The case has been made — many of the approaches humans employ to address environmental collapse are founded on the very (White, Western, colonial, positivist, capitalist, human supremacist) thinking that advanced planetary degradation in the first place. We know how this story ends. If we continue perpetuating narratives of management, mastery and (White) human supremacy through environmental education (EE) and confront environmental issues accordingly, we will only advance Earth’s demise. Only by countering narratives of human exceptionalism and acknowledging the entangled and deeply relational nature of our existence can we begin to envision worlds of care for all. Reconceptualising EE as a polyphonic storying of relations with the more-than-human “keeps the way open” for humans to reassess our role in the world.
To assess the impact of nutritional and multiple-micronutrient supplementation to lactating mothers on the micronutrient status of mother–infant dyad at 6 months of age postnatally.
Design:
This study was a trial that aimed to investigate the impact of maternal nutritional supplementation on infant growth. A secondary objective was to assess the effect on the micronutrient status of mother–infant pairs. The intervention group mothers received snacks with 600 kcal energy, 20 g protein and daily micronutrient tablets.
Setting:
Blood samples were collected from both mothers and infants at 6 months.
Participants:
The participants in this study were mother–infant pairs. The micronutrient status of these pairs was assessed through blood samples, focusing on vitamins A, D, B12, ferritin, Zn and folate.
Results:
Micronutrient analysis of serum samples from 600 mother–infant pairs showed that mothers in the intervention group had higher levels of serum ferritin (mean difference (MD) 14·7 ng/ml), retinol (MD 0·6 μmol/l), folate (MD 3·3 ng/ml) and vitamin D (1·03 ng/ml) at 6 months postpartum. Additionally, the supplementation was associated with a higher mean ± sd of serum ferritin (MD 8·9 ng/ml) and vitamin A (MD 0·2 μmol/l) levels in infants at 6 months.
Conclusions:
The study found that supplementing maternal nutrition with additional dietary and micronutrient intakes during lactation improved maternal micronutrient status and slightly increased ferritin and vitamin A levels in infants at 6 months. The findings highlight the importance of nutritional interventions for improving the micronutrient health of mother–infant pairs, with significant public health implications.
This article provides the first systematic account of relativization in Likpakpaln, an understudied Mabia (Gur) language of Ghana. Broadly speaking, Likpakpaln features two types of relative clauses: restrictive and non-restrictive. Both types of relative clauses are finite and marked by a relative pronoun as well as a clausal definite determiner. The first type is always headed by an indefinite noun. The second is invariably headed by a definite head noun, is additionally marked by a prosodic break, and is usually under focus. The relative pronoun is a composite form comprised of a noun class agreement marker and an invariant relative marker. A number of the features of relative clauses in Likpakpaln align it with other Mabia languages of the region, whereas others distinguish it from these languages. This analysis situates Likpakpaln within its genealogical and areal context while providing new typological perspectives on the Mabia languages as a whole.
To identify (1) who experiences food insecurity of differing severity and (2) who uses food banks in England, Wales and Northern Ireland; (3) whether the same groups experience food insecurity and use food banks; and (4) to explore country- and region-level differences in food insecurity and food bank use.
Design:
This pooled cross-sectional study analysed the characteristics of adults experiencing food insecurity of differing severity using generalised ordinal logistic regression models and the characteristics of adults using food banks using logistic regression models, using data from three waves of the Food and You 2 surveys, 2021–2023.
Setting:
England, Wales and Northern Ireland.
Participants:
18 557 adults.
Results:
20·8 % of respondents experienced food insecurity in the past 12 months, and 3·6 % had used a food bank. Food insecurity was associated with income, working status, respondent age, family type, ethnicity, country, long-term health conditions, food hypersensitivity, urban-rural status and area-level deprivation. Severe food insecurity was concentrated among respondents with long-term health conditions and food hypersensitivities. Food bank use was more prevalent among food insecure respondents and unemployed and low-income respondents. Neither outcome showed clear geographical variation. Certain groups experienced an elevated likelihood of food insecurity but did not report correspondingly greater food bank use.
Conclusions:
Food insecurity is unevenly distributed, and its nutrition and health-related consequences demonstrate that food insecurity will intensify health inequalities. The divergence between the scale of food insecurity and food bank use strengthens calls for adequate policy responses.
This article examines India's journey towards a cross-border insolvency regime and its draft law on cross-border insolvency. The article analyses the areas of convergence and divergence between India's draft law and the UNCITRAL Model Law on Cross-Border Insolvency and identifies the factors behind the divergences. The article concludes that the implementation of a cross-border insolvency regime is crucial for India to ensure coordination in cross-border insolvency proceedings and thereby attract foreign investment. The analysis of the reasons behind the divergences suggests that four areas of divergence are particularly relevant: the structure of existing legal institutions; the reciprocity requirement; restrictions on the rights of access of foreign representatives; and the historical practice of the Indian courts to follow the principle of territorialism. The success of the Indian cross-border insolvency regime will very much depend on the ability of the adjudicating authorities to overcome territorialism and embrace the principle of modified universalism.