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In this article, we adopt assemblage as methodology and as a way to foreground the vitality and relational agency of other species as they encounter humans. Research as assemblage is a process of becoming with others, and we experienced that ontological process during three environmental excursions as we became entangled in multispecies assemblages with children, the Crow, the Sea Eagle and the Bee. The production of the three assemblages and the rhizomic networks that formed materially and discursively across time occurred within an affective milieu characterised by sensory attentiveness and attunement to the affective power of coincidence. Analysing the formation and reformation of the assemblages enabled us to identify the phenomenon of “ontological flickering” where the ontological foundation of experience shifted moment by moment and remained playfully unresolved. We also consider how multispecies encounters relate to wildness, understood in Thoreau’s terms as unsettling encounters with otherness. In concluding, we recognise our incomplete becoming with others as co-authors and acknowledge the Crow the Sea Eagle and the Bee as powerful teachers.
El presente artículo aborda los alcances y limitaciones del reconocimiento obtenido por el Pueblo Tribal Afrodescendiente Chileno en el proceso constituyente iniciado en Chile luego de la revuelta social de 2019 y, particularmente, en las deliberaciones de la Convención Constitucional que sesionó entre 2021 y 2022. Además de analizar la presentación y votación de normas relacionadas con el Pueblo Tribal Afrodescendiente, el principal foco está puesto en los discursos de los/as convencionales constituyentes relacionados con dichas normas. Mediante un análisis crítico del discurso, se identifican tres ejes discursivos que enmarcaron el apoyo o rechazo de iniciativas en torno al reconocimiento afrodescendiente, vinculados al significado de la categoría jurídica de “pueblo tribal”, a la cuestión de la preexistencia y a la extranjerización. El artículo concluye con una discusión de las posturas adoptadas por diferentes sectores de la Convención, identificando algunos imaginarios que comportaron límites para la inclusión del pueblo afrochileno en la propuesta constitucional.
We propose a stock market model with chartists, fundamentalists and market makers. Chartists chase stock price trends, fundamentalists bet on mean reversion, and market makers adjust stock prices to reflect current excess demand. Fundamentalists’ perception of the stock market’s fundamental value is subject to animal spirits. As long as the stock market is relatively stable, fundamentalists neutrally believe in a normal fundamental value. However, fundamentalists optimistically (pessimistically) believe in a high (low) fundamental value when the stock market rises (falls) sharply. Our framework may produce boom-bust stock market dynamics that coevolve with waves of optimism and pessimism for parameter settings that would ensure globally stable stock market dynamics in the absence of animal spirits. Responsible for such a surprising outcome is the destabilizing nature of temporarily attracting virtual fixed points, brought about by animal spirits.
India has one of the highest burdens of childhood undernutrition in the world. The two principal dimensions of childhood undernutrition, namely stunting and underweight can be significantly associated in a particular population, a fact that is rarely explored in the extant literature. In this study, we apply a copula geoadditive modelling framework on nationally representative data of 104,021 children obtained from the National Family Health Survey 5 to assess the spatial distribution and critical drivers of the dual burden of childhood stunting and underweight in India while accounting for this correlation. Prevalence of stunting, underweight and their co-occurrence among under 5 children were 35.37%, 28.63% and 19.45% respectively with significant positive association between the two (Pearsonian Chi square = 19346, P-value = 0). Some of the factors which were significantly associated with stunting and underweight were child gender (Adjusted Odds Ratio (AOR) = 1.13 (1.12) for stunting (underweight)), birthweight (AOR = 1.46 (1.64) for stunting (underweight)), type of delivery (AOR = 1.12 (1.19) for stunting (underweight)), prenatal checkup (AOR = 0.94 (0.96) for stunting (underweight)) and maternal short-stature (AOR = 2.19 (1.85) for stunting (underweight)). There was significant spatial heterogeneity in the dual burden of stunting and underweight with highest prevalence being observed in eastern and western states while northern and southern states having relatively lower prevalence. Overall, the results are indicative of the inadequacy of a “one-size-fits-all” strategy and underscore the necessity of an interventional framework that addresses the nutritional deficiency of the most susceptible regions and population subgroups of the country.
The semantics of gradually typed languages is typically given indirectly via an elaboration into a cast calculus. This contrasts with more conventional formulations of programming language semantics, where the semantics of a language is given directly using, for instance, an operational semantics. This paper presents a new approach to give the semantics of gradually typed languages directly. We use a recently proposed variant of small-step operational semantics called type-directed operational semantics (TDOS). In a TDOS, type annotations become operationally relevant and can affect the result of a program. In the context of a gradually typed language, type annotations are used to trigger type-based conversions on values. We illustrate how to employ a TDOS on gradually typed languages using two calculi. The first calculus, called $\lambda B^{g}$, is inspired by the semantics of the blame calculus, but it has implicit type conversions, enabling it to be used as a gradually typed language. The second calculus, called $\lambda e$, explores an eager semantics for gradually typed languages using a TDOS. For both calculi, type safety is proved. For the $\lambda B^{g}$ calculus, we also present a variant with blame labels and illustrate how the TDOS can also deal with such an important feature of gradually typed languages. We also show that the semantics of $\lambda B^{g}$ with blame labels is sound and complete with respect to the semantics of the blame calculus, and that both calculi come with a gradual guarantee. All the results have been formalized in the Coq theorem prover.
Three-dimensional non-rotating odd viscous liquids give rise to Taylor columns and support axisymmetric inertial-like waves (J. Fluid Mech., vol. 973, 2023, A30). When an odd viscous liquid is subjected to rigid-body rotation however, there arise in addition a plethora of other phenomena that need to be clarified. In this paper, we show that three-dimensional incompressible or two-dimensional compressible odd viscous liquids, rotating rigidly with angular velocity $\varOmega$, give rise to both oscillatory and evanescent inertial-like waves or a combination thereof (which we call of mixed type) that can be non-axisymmetric. By evanescent, we mean that along the radial direction, typically when moving away from a solid boundary, the velocity field decreases exponentially. These waves precess in a prograde or retrograde manner with respect to the rotating frame. The oscillatory and evanescent waves resemble respectively the body and wall-modes observed in (non-odd) rotating Rayleigh–Bénard convection (J. Fluid Mech., vol. 248, 1993, pp. 583–604). We show that the three types of waves (wall, body or mixed) can be classified with respect to pairs of planar wavenumbers $\kappa$ which are complex, real or a combination, respectively. Experimentally, by observing the precession rate of the patterns, it would be possible to determine the largely unknown values of the odd viscosity coefficients. This formulation recovers as special cases recent studies of equatorial or topological waves in two-dimensional odd viscous liquids which provided examples of the bulk–interface correspondence at frequencies $\omega <2\varOmega$. We finally point out that the two- and three-dimensional problems are formally equivalent. Their difference then lies in the way data propagate along characteristic rays in three dimensions, which we demonstrate by classifying the resulting Poincaré–Cartan equations.
The Bad Bridget project centres on Irish-born female criminal suspects in North America from 1838 to 1918. Its title derives from the common occurrence of the forename Bridget in nineteenth- and early-twentieth-century Ireland, and its application as a collective name to Irish women in the US. The ‘Bad Bridget’ title seemed to capture our focus on the individual, as well as the diverse experiences of the girls and women on whom the project is based. While we hesitated about using the title initially, lest ‘bad’ suggest a shaming of behaviour or individuals, or ‘Bridget’ a judgement on Irish heritage, we decided that the benefits of the collective name outweighed potential drawbacks. This article expands on the idea that a name can imply shame. It focuses on our use of real forenames and surnames instead of pseudonyms (or other anonymisation alternatives) to identify individual girls and women in our project outputs to date. The article makes the case for the use of real names in this context, exploring in turn our roles and responsibilities as historians, archival and scholarly expectations, our responsibilities towards our subject matter, and our audiences (including the descendants of the Irish girls and women suspected of criminal behaviour).
To characterise consumption of ultra-processed foods and drinks (UPF) across a range of socio-demographic characteristics of Canadians.
Design:
Cross-sectional study. The national-level 2015 Canadian Community Health Survey–Nutrition provided data on all foods and drinks consumed on the previous day via a 24-hour dietary recall. All food items were classified according to the type of industrial processing using the NOVA system. Multivariable linear regression models examined associations between a range of socio-demographic characteristics and the mean energy contribution (% of total daily energy intake) from total UPF and UPF subgroups.
Setting:
The ten Canadian provinces.
Participants:
Canadians aged 2 or older (n 20 103).
Results:
UPF contributed, on average, nearly half (44·9 %) of total daily energy intake of Canadians. Children aged 6–12 and adolescents aged 13–18 consumed over half of total daily energy from UPF (adjusted means of 51·9 % and 50·7 %, respectively). Recent and long-term immigrants consumed a significantly lower share of energy from UPF (adjusted means of 42·2 % and 45·1 %, respectively) compared with non-immigrants (54·4 %), as did the food secure (42·8 %) v. those in moderately (48·1 %) or severely food-insecure households (50·8 %). More modest differences were observed for intake of total UPF and UPF subgroups by sex, education, income adequacy and region of residence.
Conclusion:
Levels of UPF consumption in 2015 in Canada were pervasive in all socio-demographic groups and highest among children and adolescents, non-immigrants and those living in food-insecure households. These findings can inform public health interventions to reduce UPF consumption and promote healthier diets in various socio-demographic groups.
Inconsistent results regarding the risk of relapse and better subjective outcomes of previous antipsychotic dose reduction trials in patients with remitted psychosis have not been verified using therapeutic drug monitoring (TDM). This study examined plasma drug concentrations of a dose-tapering trial which exhibited the potential of successful maintenance under lower antipsychotic dosages.
Methods
A 2-year open-label randomized prospective trial recruited remitted patients to undergo guided antipsychotic tapering. Blood samples were collected at baseline, annually, and after each dose reduction. Plasma aripiprazole/dehydroaripiprazole concentrations were determined using LC–MS/MS. The relationship between the dose and serum drug levels was examined using Spearman's correlation. Divided at 120 ng/mL, relapse rate, global function, quality of life, and psychopathology were compared between high- and low- drug level groups.
Results
A total of 126 blood samples were collected, after excluding13 samples due of non-adherence. The correlation coefficients between dosage and drug level were 0.853 (aripiprazole) and 0.864 (dehydroaripiprazole), and the dose and concentration plots were parallel along the tapering trajectories, except patients with non-adherence. The concentration-to-dose ratio of aripiprazole in this cohort, 17.79 ± 7.23 ng/mL/mg, was higher than that in Caucasian populations. No significant differences were observed in the clinical outcomes between the high- and low-level groups. Remarkably, 12 of 15 patients maintained remission at plasma aripiprazole concentrations of <120 ng/mL.
Conclusions
The lower-than-expected doses reached in our antipsychotic tapering trial were substantiated to provide adequate prophylactic effects by TDM results in a subset of patients treated with aripiprazole, even considering the differences in pharmacogenomics between ethnicities.
For many years, scholars consistently dated cup marks – shallow depressions found on both portable and immovable stones – of northern Germany and southern Scandinavia to the Bronze Age. Novel findings trace them back to at least as far as the Late Neolithic period (LN, c. 2350 bc). Recently, portable cup marked stones belonging to a late Funnel Beaker context (c. 2800 bc) have been found. There are even indications of cup marks dating back to the 4th millennium bc. At present, a gap exists in the knowledge of cup marks and non-figurative art in general during the Younger Neolithic (YN) Corded Ware Culture (CWC) (c. 2800–2250 bc). This paper establishes the significance of three related types of secondary treatments of battle axe fragments, namely the addition of (hourglass shaped) unfinished shaft holes, deep pecking holes, and shallow cup marks. The argument put forward is that they were present in small numbers in the 4th millennium bc, becoming increasingly common during the proposed ‘gap phase’ in the context of CWC societies. The late 3rd millennium is a period of enormous social change. During this period, of the three types of secondary treatment only cup marks persist, while the potential media on which such cup marks are applied diversifies, with them appearing on objects and items other than battle axe fragments. It is proposed that this development is related to the social changes that characterise the onset of the LN. Finally, it is suggested that the LN and Bronze Age cup mark tradition is based on an earlier tradition initially associated with battle axes.
In recent years, many countries have significantly increased military spending, mainly due to geopolitical instability in several regions and the potential risk of armed conflicts spreading worldwide. In this context, understanding the nutritional needs of soldiers in different climates (warm, cold and high altitude) is important and directly impacts the performance and health of soldiers, especially in extreme environments. The amount of liquids, calories, and macro- and micronutrients contained in military rations must be determined considering the type of exercise, duration and environment. Military rations, in addition to being nutritionally adequate, must be practical, sustainable and easy to consume at any temperature and situation. Given these considerations, this study aimed to review scientific knowledge regarding the convenience, sensory attributes and nutritional components of military rations. Furthermore, this review studied the factors influencing soldiers’ appetite, gut microbiota and nutritional needs during training or combat in extreme environments (warm, cold and high altitude). This exploration further advances our understanding of contemporary nutritional strategies for military personnel, contributing to future research and highlighting areas that must be developed.
While Indigenous knowledges have long recognised forests as sentient and caring societies, western sciences have only acknowledged that trees communicate, learn and care for one another in recent years. These different ways of coming to know and engage with trees as sentient agents are further complicated by the introduction of digital technologies and automated decision-making into forest ecosystems. This article considers this confluence of forest sentience and digital technologies through a pedagogy and ethic of immanent care as a relational framework for analysis and praxis in environmental education. The authors apply this framework to three key examples along Birrarung Marr, an ancient gathering place and urban parklands in the city of Naarm (Melbourne). These include an immersive theatre-making project exploring forest communication networks with young children; the Melbourne Urban Forest data set, which hosts digital profiles for over 70,000 trees; and the Greenline masterplan which aims to revitalise the north bank of the Birrarung over the next five years. Exploring the ethical and pedagogical contours of these examples leads to propositions for rethinking the role of environmental education in navigating the current confluence of animal, vegetal, fungal and digital life.
Preserved ratio impaired spirometry (PRISm) is a new lung function impairment phenotype and has been recognized as a risk factor for various adverse outcomes. We aimed to examine the associations of this new lung function impairment phenotype with depression and anxiety in longitudinal studies.
Methods
We included 369 597 participants from the UK Biobank cohort, and divided them into population 1 without depression or anxiety and population 2 with depression or anxiety at baseline. Cox proportional hazard models were performed to evaluate the associations of lung function impairment phenotype with adverse outcomes of depression and anxiety, as well as their subtypes.
Results
At baseline, 38 879 (10.5%) participants were diagnosed with PRISm. In population 1, the adjusted hazard ratios (HRs) for PRISm (v. normal spirometry) were 1.12 (95% CI 1.07–1.18) for incident depression, and 1.11 (95% CI 1.06–1.15) for incident anxiety, respectively. In population 2, PRISm was a risk factor for mortality in participants with depression (HR: 1.46; 95% CI 1.31–1.62) and anxiety (HR: 1.70; 95% CI 1.44–2.02), compared with normal spirometry. The magnitudes of these associations were similar in the phenotypes of lung function impairment and the subtypes of mental disorders. Trajectory analysis showed that the transition from normal spirometry to PRISm was associated with a higher risk of mortality in participants with depression and anxiety.
Conclusions
PRISm and airflow obstruction have similar risks of depression and anxiety. PRISm recognition may contribute to the prevention of depression and anxiety.
We assessed the effectiveness of heterologous vaccination strategy in immunocompromised individuals regarding COVID-19 outcomes, comparing it to homologous approaches.
Design:
Systematic literature review/meta-analysis.
Methods:
We searched PubMed, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science from January 1, 2020 to September 29, 2023. We included studies that evaluated the heterologous vaccination strategy on immunocompromised individuals through outcomes related to COVID-19 (levels of anti-SARS-CoV-2 spike protein IgG, neutralizing antibodies, symptomatic COVID-19 infection, hospitalization, and death) in comparison to homologous schemes. We also used random-effect models to produce pooled odds ratio estimates. Heterogeneity was investigated with I2 estimation.
Results:
Eighteen studies met the inclusion criteria for this systematic review. Fourteen of them provided quantitative data for inclusion in the meta-analysis on vaccine response, being four of them also included in the vaccine effectiveness meta-analysis. The vaccination strategies (heterologous vs homologous) showed no difference in the odds of developing anti-SARS-CoV-2 spike protein IgG (odds ratio 1.12 [95% Cl: 0.73–1.72]). Heterologous schemes also showed no difference in the production of neutralizing antibodies (odds ratio 1.48 [95% Cl: 0.72–3.05]) nor vaccine effectiveness in comparison to homologous schemes (odds ratio 1.52 [95% CI: 0.66–3.53]).
Conclusions:
Alternative heterologous COVID-19 vaccinations have shown equivalent antibody response rates and vaccine effectiveness to homologous schemes, potentially aiding global disparity of vaccine distribution.
Reward and threat processes work together to support adaptive learning during development. Adolescence is associated with increasing approach behavior (e.g., novelty-seeking, risk-taking) but often also coincides with emerging internalizing symptoms, which are characterized by heightened avoidance behavior. Peaking engagement of the nucleus accumbens (NAcc) during adolescence, often studied in reward paradigms, may also relate to threat mechanisms of adolescent psychopathology.
Methods:
47 typically developing adolescents (9.9–22.9 years) completed an aversive learning task during functional magnetic resonance imaging, wherein visual cues were paired with an aversive sound or no sound. Task blocks involved an escapable aversively reinforced stimulus (CS+r), the same stimulus without reinforcement (CS+nr), or a stimulus that was never reinforced (CS−). Parent-reported internalizing symptoms were measured using Revised Child Anxiety and Depression Scales.
Results:
Functional connectivity between the NAcc and amygdala differentiated the stimuli, such that connectivity increased for the CS+r (p = .023) but not for the CS+nr and CS−. Adolescents with greater internalizing symptoms demonstrated greater positive functional connectivity for the CS− (p = .041).
Conclusions:
Adolescents show heightened NAcc-amygdala functional connectivity during escape from threat. Higher anxiety and depression symptoms are associated with elevated NAcc-amygdala connectivity during safety, which may reflect poor safety versus threat discrimination.
Mood and anxiety disorders are heterogeneous conditions with variable course. Knowledge on latent classes and transitions between these classes over time based on longitudinal disorder status information provides insight into clustering of meaningful groups with different disease prognosis.
Methods
Data of all four waves of the Netherlands Mental Health Survey and Incidence Study-2 were used, a representative population-based study of adults (mean duration between two successive waves = 3 years; N at T0 = 6646; T1 = 5303; T2 = 4618; T3 = 4007; this results in a total number of data points: 20 574). Presence of eight mood and anxiety DSM-IV disorders was assessed with the Composite International Diagnostic Interview. Latent class analysis and latent Markov modelling were used.
Results
The best fitting model identified four classes: a healthy class (prevalence: 94.1%), depressed-worried class (3.6%; moderate-to-high proportions of mood disorders and generalized anxiety disorder (GAD)), fear class (1.8%; moderate-to-high proportions of panic and phobia disorders) and high comorbidity class (0.6%). In longitudinal analyses over a three-year period, the minority of those in the depressed-worried and high comorbidity class persisted in their class over time (36.5% and 38.4%, respectively), whereas the majority in the fear class did (67.3%). Suggestive of recovery is switching to the healthy class, this was 39.7% in the depressed-worried class, 12.5% in the fear class and 7.0% in the high comorbidity class.
Conclusions
People with panic or phobia disorders have a considerably more persistent and chronic disease course than those with depressive disorders including GAD. Consequently, they could especially benefit from longer-term monitoring and disease management.
In 2022, the Welsh Government announced a basic income pilot for care leavers in Wales. This article uses this policy experiment to provide an insight into the relationship between devolution and social citizenship. This article makes two claims. First, the basic income pilot is part of an approach the Welsh Government has taken over the past twenty years to expand the idea of social citizenship to include rights to money. This is justified by a principle of progressive universalism, but this principle also has a wider UK context. Second, the financial constraints imposed by the UK Government frustrates the extent to which the Welsh Government can turn such experiments into reality.
The invitation is to discuss my JHET editorship, which ran from 2013 to 2018, in light of the once and future challenges of the journal. After accepting it, I gathered my recollections, perused back issues of the journal, and finally reviewed my correspondence and reports to the HES Executive Committee.
Very late-onset psychosis (VLOP) is associated with higher rates of dementia but the proportion who develop dementia with Lewy bodies (DLB) is unknown. We aimed to identify individuals with VLOP who develop dementia and DLB and characterize the risk factors for progression.
Methods
Anonymized data were retrieved from electronic records for individuals with VLOP. Patients developing dementia after psychosis were identified, in addition to those with >2 core features of DLB at the time of dementia or DLB identified by a natural language processing application (NLP-DLB). Demographic factors, Health of the National Outcome Scale (HoNOS) and symptoms at index psychosis were explored as predictors of progression to dementia.
Results
In 1425 patients with VLOP over 4.29 years (mean) follow up, 197 (13.8%) received a subsequent diagnosis of dementia. Of these, 24.4% (n = 48) had >2 core features of DLB and 6% (n = 12) had NLP-DLB. In cox proportional hazard models, older age and cognitive impairment at the time of psychosis were associated with increased risk of incident dementia. Visual hallucinations and 2+ core features of DLB at index psychosis were associated with increased risk of dementia with 2+ symptoms of DLB but not all-cause dementia. Two or more core features of DLB at index psychosis were associated with 81% specificity and 67% sensitivity for incident NLP-DLB.
Conclusions
In patients with VLOP who develop dementia, core features of DLB are common. Visual hallucinations or two core features of DLB in VLOP should prompt clinicians to consider DLB and support further investigation.
This study aimed (1) to identify distinct family trajectory profiles of destructive interparental conflict and parent-child emotional warmth reported by one parent, and (2) to examine whether these codevelopmental profiles were associated with the longitudinal development of children and adolescents’ self-reported internalizing and externalizing problems. Six longitudinal data waves from the German Family Panel (pairfam) study (Waves 2–7) from 722 parent-child dyads were used (age of children and adolescents in years: M = 10.03, SD = 1.90, range = 8–15; 48.3% girls; 73.3% of parents were native Germans). Data were analyzed using growth mixture and latent growth curve modeling. Two classes, harmonious and conflictual-warm families, were found based on codevelopmental trajectories of interparental conflict and emotional warmth. These family profiles were linked with the development of externalizing problems in children and adolescents but not their internalizing problems. Family dynamics are entangled in complex ways and constantly changing, which appears relevant to children’s behavior problems.