Russell and Burch’s 1959 original definitions of the 3Rs (replacement, reduction and refinement) are widely used today as standards for the ethical use of non-human animals in research, although they have a number of limitations. Authors and institutions around the world have addressed some of these, coming up in certain cases with more accurate, functional, and up-to-date definitions. However, not only do there still remain limitations needing to be addressed, but some that have been addressed resulted in discrepancies, contradictions, and general confusion as to how best apply the 3Rs in practice. In order to clarify the meaning of the 3Rs and enable more optimal implementation of these principles in animal experimentation, this article provides a theoretical discussion for revised definitions of the original 3Rs via examination of some of their main limitations and inconsistencies. First, we offer up the original definitions as presented in the context of Russell and Burch’s book The Principles of Humane Experimental Technique. Then, we examine the main limitations and present clear specifications and requirements for such revised definitions. After presenting our revised definitions, we conclude with various implications for animal welfare within the context of experimentation.

Philosophers have conjectured that human cognitive limitations might preclude our ever resolving the hard problem of consciousness. Few, however, have offered suggestions as to what it might be about our conceptual apparatus that poses the problem. I do so in this essay, arguing that our central difficulties lie with two conceptual categories that pervade philosophical discussion of the hard problem. They are compositional concepts -- part/whole, constituents/constitution, and the like – and instantiational concepts: properties/objects, universals/particulars, and the like. I look at the uses of these two conceptual categories in four contexts in which the hard problem is considered: multiple realizability, zombies, mental causation, and panpsychism. I show that the two conceptual categories run into the same kinds of obstacles in each case, which suggests that they might be key to the cognitive limitations about which some have speculated

Detection of the 21 cm signal from the Epoch of Reionisation (EoR) ($z \sim 6 - 10$) amidst the dominant foregrounds, which are 3–4 orders of magnitude greater than the weak cosmological signal, is a challenging task for the existing 21 cm experiments. The detection is further challenged by the large Field of View (FoV) of the instrument used for observation, as it becomes necessary to excise foregrounds present within the FoV to make a successful detection. In response to the challenges faced, in our previous work, we developed and installed a new instrument – the Central Redundant Array Mega-tile (CRAM) – and integrated it within the MWA Phase II configuration. It is a larger antenna tile configuration ($8\times 8$ dipoles) with a smaller FoV at every frequency under consideration and has multiple sidelobes of reduced response when compared with the existing Murchison Widefield Array (MWA) tiles. In this paper, we aim to demonstrate through power spectrum simulations that using the larger tile, such as the CRAM, can reduce the impact of bright radio foregrounds near the field edge. For the pedagogical approach aimed with this work, we developed a power spectrum pipeline to estimate the cylindrically averaged power spectrum. The power spectrum is estimated for MWA-MWA baselines and CRAM-MWA baselines using analytical beams, simulated diffuse sky maps and a semi-numerical 21 cm signal. Employing a drift scanning strategy, we estimate 1D and 2D power spectra for a series of two-minute observations spanning 24 hrs using the diffuse sky maps. Our simulations predict a power reduction at the edge of the EoR wedge. The reduction in foreground power is confirmed with the Fisher analysis of the expected signal-to-noise ratio (SNR) improvement, which reports a higher SNR with the power estimations from CRAM baselines when compared with the regular MWA baselines. The reduced power obtained with the CRAM baselines is consistent with the fact that the larger tile configuration has reduced the impact of foregrounds from near the horizon.

Liberal neutrality compels governments to respect individual preferences. Yet health-promotion campaigns, such as modern tobacco control policies, often seek to cultivate a preference for a healthy lifestyle. Liberal theorists have attempted to justify these policies by appealing to the concept of ‘means paternalism’, whereby these policies align with existing preferences. In contrast, this article argues that shaping preferences can be not only permissible but also morally required. Governments can preserve neutrality while influencing preferences by promoting generic goods valued in diverse societies and considering the preference-formation of future generations. This argument provides a stronger rationale for tobacco control policies.

Scholars have debated how the themes discussed by Pomerius in his De vita contemplativa found ample resonance across Gregory the Great's work, and reflect similar concerns. While it is impossible to determine whether the Roman bishop read the treatise authored by the North African rhetor, their parallel authority on the matter was recognised by Carolingian copyists, who often reported their works alongside each other. The discovery of a glossa sourced from Gregory's literary production in Pomerius’ manuscript tradition might both substantiate this claim and shed some light on the networks of medieval scriptoria.

This study investigates the effect of government size, as measured by the tax revenue to gross domestic product (tax-GDP) ratio, on output responses to increases in government purchases. First, we show that in a standard static neoclassical model, the stimulus effect of fiscal expansion on output increases with the tax-GDP ratio. This finding is quantitatively confirmed using a dynamic neoclassical model with standard functional forms and parameter values. To empirically test the theoretical findings, we analyze the responses of macroeconomic variables to an unanticipated increase in government purchases for 12 Organisation for Economic Cooperation and Development (OECD) countries during 1985–2019 using a state-dependent local projection method. The estimation results reveal that while output responses to an unanticipated fiscal expansion are significantly positive when the tax-GDP ratio is high, they are statistically indistinguishable from zero when the ratio is low. Overall, our findings suggest that fiscal expansion can stimulate output more effectively at high tax rates, unlike the well-known predictions of the traditional Keynesian model.

Contrary to the southern Appalachians, where Alleghanian magmatism is widespread and well documented, the expressions of magmatism in the Canadian Appalachians are limited. In this study, a suite of leucocratic dykes from the Cape Spencer area in southern New Brunswick, Canada, were investigated to determine the nature, timing and source of these magmas using zircon and monazite U-Pb geochronology, whole-rock geochemistry and Nd-Hf isotopes. An LA-ICP-MS U-Pb monazite Alleghanian age of 273.7 ± 1.3 Ma obtained for these dykes constitutes a new example of magmatism in the northern segment of the orogen, where significant strike-slip movement and reheating have been the primary markers of the Alleghanian Orogeny. These metaluminous leucocratic dykes are enriched in light rare elements, U and Th; depleted in high-field strength elements (HFSE; Nb, P, Ti); and have slight negative Europium anomalies [(Eu/Eu*)N = 0.72–0.95]. All the dykes samples have negative εNd(t) values (−9.76 to −5.7), negative εHf(t) values (−1.8 to −1.0) and Mesoproterozoic Nd depleted-model ages (TDM = 1371–1618 Ma). The geochemical and isotopic characteristics suggest that the dykes were formed by the partial melting of lower crust that assimilated Meguma metasedimentary rocks and/or Avalonian sedimentary rocks, following terminal subduction of the Rheic Ocean and thermal re-equilibration during the Alleghanian orogeny. The effects of the closure of the Rheic Ocean in the oblique collision between composite Laurentia and Gondwana were, to a certain extent, accommodated along the Minas Fault Zone, where magmatism and regional fluid flow were concentrated.

The episcopal mission of Englishman John Bale to Ireland in 1553 provides historians with a unique window into the interconnected British and Irish histories of the early English Reformation. Scholarship on Bale has long explored his life and theology in all European theatres of the Reformation in which he was involved. Yet, key features of his mission and theology remain underappreciated. Building on recent work that has contextualized Bale’s Irish mission and ecclesiology within the imperial outlook of the Edwardian regime and Reformation, the article examines Bale’s mission against the worlds of English evangelical and continental Protestant political theology he inhabited, and the mingling of Henrician and Edwardian ‘reformist’ energies in Ireland with which it intersected and clashed. It argues that, under conditions of English colonial rule and empire in Ireland, Bale expressed a political theology that, imperial by circumstance and implication, turned his spiritual vocation modelled on Christ into a receptacle for divine and princely sovereignty that set rival conceptions of royal authority, idolatry, and Anglo-Irish constitutional relations against each other. Evangelical political theology thus acquired different hues on either side of the Irish Sea, with important implications for how we understand the early English Reformation across England and Ireland.

The aim of this study is to assess nutritional status and associated factors among infants and young children aged 6–23 months in Yeka sub-city, Ethiopia, 2021. An institution-based cross-sectional study was conducted in selected health centres found in the Yeka sub-city from May 2021 to July 2021. In total, 396 systematically selected infants and young children aged 6–23 months attended the selected health centres were included in the study. Data were collected by using a structured questionnaire and anthropometric measurements. A multinomial logistic regression model was used.

The overall magnitude of undernutrition and overnutrition among infants and young children were 24.7% and 5.5%, respectively. Dietary diversity score (DDS) ((adjusted odd ratio (AOR) = 5.65; 95% CI = 2.301, 10.87; P value = 0.003), minimum meal frequency (MMF) (AOR = 5.435; 95% CI = 2.097, 11.09; P value = 0.0052), and diarrhoea (AOR = 2.52; 95% CI = 1.007, 6.310; P value = 0.002) were statistically significantly associated factors for nutritional status among infants and young children. Malnutrition (undernutrition and overnutrition) is a public health problem among infants and young children in Yeka sub-city, Ethiopia. DDS, MMF, and diarrhoeal disease were associated with higher odds of undernutrition.

While political philosophers often assume that we need to imagine a better future in order to hope for it, philosophers of hope doubt that hope and imagination are constitutively intertwined. In order to solve this puzzle, the article introduces a particular kind of hope in which we imaginatively inhabit a desired future. Combining insights from the philosophy of hope and of imagination, I unpack what imaginative hope is and why it is particularly significant in political contexts. I contend that in cases where we pursue a goal the realization of which requires collective action over a long time-scale (as it is paradigmatically the case in politics), the imagination has the potential to bolster the practical value of hope, i.e., its power to guide and sustain our agency.

Early morning flowering (EMF) is a desirable trait in rice to avoid heat stress as temperatures in early morning hours are low compared to afternoon and flowering is the most sensitive stage to heat exposure. Cultivated rice accessions including both Oryza glaberrima and O. sativa were phenotyped for an EMF trait in 2016–2018 in two locations viz. Cotonou in Benin Republic and Ibadan in Nigeria. The initial screening was done in Cotonou in three phases in 2016 dry season, 2017 wet season and 2017 dry season, respectively. The 2093 accessions used in initial screening were subdivided into three groups based on flowering duration ensuring that each accession was grown under conditions which were best suited to their flowering duration. Further screening was done in Ibadan in 2018 dry season and 2018 wet season. Out of 2093 accessions taken in the initial screening only 1754 accessions germinated out of which only 64 accessions exhibited EMF phenotype consistently across the cultivated years, seasons and locations. Among the 64 accessions exhibiting EMF phenotype, 15 accessions also showed an early peak in spikelet opening time (EPSOT) trait, more than 80% flowering before 09:00 h. We conclude that 15 O. glaberrima accessions identified possessing both the EMF and EPSOT traits are suitable donors for use in breeding for heat escape in rice.