Mitochondrial dysfunction is a common feature of brain disorders. Mitochondria play a central role in oxidative phosphorylation; thus changes in energy metabolism in the brain have been reported in conditions such as Alzheimer’s disease, Parkinson’s disease, and stroke. In addition, mitochondria regulate cellular responses associated with neuronal damage such as the production of reactive oxygen species (ROS), opening of the mitochondrial permeability transition pore (mPTP), and apoptosis. Therefore, interventions that aim to protect mitochondria may be effective against brain disorders. Fucoxanthin is a marine carotenoid that has recently gained recognition for its neuroprotective properties. However, the cellular mechanisms of fucoxanthin in brain disorders, particularly its role in mitochondrial function, have not been thoroughly discussed. This review summarises the current literature on the effects of fucoxanthin on oxidative stress, neuroinflammation, and apoptosis using in vitro and in vivo models of brain disorders. We further present the potential mechanisms by which fucoxanthin protects mitochondria, with the objective of developing dietary interventions for a spectrum of brain disorders. Although the studies reviewed are predominantly preclinical studies, they provide important insights into understanding the cellular and molecular functions of fucoxanthin in the brain. Future studies investigating the mechanisms of action and the molecular targets of fucoxanthin are warranted to develop translational approaches to brain disorders.

We consider the stochastic volatility model obtained by adding a compound Hawkes process to the volatility of the well-known Heston model. A Hawkes process is a self-exciting counting process with many applications in mathematical finance, insurance, epidemiology, seismology, and other fields. We prove a general result on the existence of a family of equivalent (local) martingale measures. We apply this result to a particular example where the sizes of the jumps are exponentially distributed. Finally, a practical application to efficient computation of exposures is discussed.

An important quality to assess in others is their cooperativeness. We hypothesized that people use linguistic markers in their partners’ speech as a proxy of their cooperativeness in other tasks: specifically, we predicted that participants would prefer syntactically similar conversation partners as cooperation partners in a monetary game. We found that, indeed, participants preferably selected syntactically similar conversation partners as cooperation partners, but only when the participants could communicate using their naturally preferred constructions. In contrast, when participants were forced to communicate using dispreferred constructions, they rather cooperated with those partners that matched their natural preference than with those that matched their overt linguistic use. This pattern of results was likely driven by participants valuing representational alignment (i.e., being aligned on both linguistic features and their mental representations) more than incidental behavioral alignment (i.e., superficial convergence on similar linguistic features during interaction). This is because representational alignment is a potential indicator of group membership and may be associated with in-group benefits such as reputation, reciprocity and normative behavior. Those benefits may outweigh the benefits of simple behavioral alignment, which could be a potential indicator of others’ willingness to cooperate. This has important implications for communication in intercultural settings where members of diverse linguistic groups negotiate cooperative actions.

Fuel subsidies have been an enduring policy in Ecuador’s political and economic history. Given their lack of targeting and high opportunity cost, they have been amply criticized. As of 2017, the Ecuadorian government started a budget consolidation plan that so far has involved seven reforms to subsidies policy in less than seven years. In late 2019, in response to social unrest motivated by a temporal elimination of fuel subsidies, the government pledged to study new targeting mechanisms for this policy to mitigate the impact on the most vulnerable sectors. This work seeks to contribute to that effort by evaluating the macroeconomic effects of these subsidies and serving as a guideline for targeting. A computable general equilibrium model is used to assess counterfactual scenarios. The results suggest that by implementing progressiveness and productive linkage criteria, targeting household final consumption and intermediate consumption is a feasible way to reduce the reforms’ negative effects.

This paper uses material efficacy as an analytical position to consider how silver helped to shape large-scale historical trajectories in Iron Age Scotland. Roman silver entered Scotland as imperial matter beginning in the first century ad and later inspired an assemblage of indigenous wearable silver in the fourth–fifth centuries. I investigate the human–silver collaborations involved in the transition from hoarding Roman silver coins to recycling Roman Hacksilber. By tracing the object trajectory of spiral rings, I show how silver's material properties and entanglements played a role in developing Scotland's earliest silver products. Around the fourth century, a diversity of spiral rings was replaced by a specific style of silver spiral finger ring. Silver brought to Iron Age Scotland by the Romans inspired and afforded individuals in northern Britain a new and empowering regional socio-political identity. Material efficacy, as explored in this case study, has relevance beyond Iron Age/Roman studies to any anthropological investigation of underrepresented human agency.

Mukti Mangharam’s Freedom Inc.: Gendered Capitalism in New Indian Literature and Culture, conducts a though investigation into the culture and ideology of neoliberal capitalism being produced in India today. But Mangharam’s approach is not to dismiss but to take seriously the appeal of individualism and entrepreneurism among its target audience: ordinary people looking for a way out of the material crises that neoliberalism has produced. In this response to Freedom Inc., Pranav Jani recognizes the empathetic and democratic impulse in Mangharam’s method and narrative style and finds a parallel in his own work as a scholar and organizer. How can scholars and activists concerned with the voice of the people recognize the fundamental heterogeneity of popular consciousness, neither romanticizing struggle nor foreclosing the possibility of reform, or even revolutionary change?

Access to waste management services is crucial for urban sustainability, impacting public health, environmental well-being, and overall quality of life. This study employs logistic regression analysis on survey data collected from 1,032 household heads residing in Nouakchott, the capital of Mauritania. The survey investigated key household factors that determine access to waste management services. The findings reveal a significant interplay among waste service provision, the presence of cisterns, housing type and size, and access to electricity. Socioeconomic disparity in service access, with poorer housing formats like shacks receiving substandard services. In contrast, areas with robust electrification report better service access, although inconsistencies remain amid power outages. The research highlights the challenges faced by Riyadh municipality, particularly rapid growth and inadequate infrastructure, which hinder waste management efficiency. Overall, the results not only illuminate Nouakchott’s unique challenges in service provision but also propose actionable recommendations for a sustainable urban future. These recommendations aim to inform and guide targeted policies for improving living conditions and environmental sustainability in urban Mauritania.

Geotechnical drilling for a tunnel between Port Moody and Burnaby, BC, Canada, uncovered a buried fjord. Its sedimentary fill has a thickness of at least 130 m and extends more than 37 m below present mean sea level. Recovered sediments record cyclical growth and decay of successive Cordilleran ice sheets. The oldest sediments comprise 58 m of almost stoneless silt conformably overlying ice-proximal sediments and till, which in turn overlie bedrock. These sediments may predate Marine Isotope Stage (MIS) 4. Glacial sediments assigned to MIS 4 overlie this basal succession and, in turn, are overlain by MIS 3 interstadial sediments and sediments from two MIS 2 glacial advances. Indicators of relative sea-level elevations that bracket glacial deposits of MIS 4 and 2 indicate the cyclic existence of moat-like isostatic depressions in the front of expanding ice sheets. Compared with present sea level, these depressions were at least 160 m during the onsets of MIS 4 and MIS 2. Assuming a maximum eustatic drawdown of 120 m during MIS 2, isostatic depression may have exceeded 200 m during retreat of glacial ice from the Evergreen tunnel area. This is consistent with region-specific low mantle viscosity and rapid Cordilleran Ice Sheet buildup and wasting.

This paper explores Muṣṭafá Khāliqdād ʿAbbāsī's 1590s Persian retranslation of the Panchatantra, commissioned by the Mughal emperor Akbar. Examining this text vis-à-vis other translations by Khāliqdād, other court-commissioned Sanskrit-Persian translations from Akbar's time, and the long Kalīla wa Dimna tradition in the Persianate world, this paper argues that retranslations, particularly unsuccessful ones, are where literary traditions and translation norms are most clearly negotiated and contested. Studying retranslations, as shown here, is a useful methodology for revealing tensions between different contemporaneous perspectives on what it takes to fully Persianize a text.

This article offers a new interpretation of καθαρίζων πάντα τὰ βρώματα in Mark 7.19c. After reviewing and offering some nuance to an emerging non-antinomian interpretation of 7.15a/18b, I turn to Mark 7.19c and argue that the phrase καθαρίζων πάντα τὰ βρώματα should be understood as a part of Jesus' speech in 7.18–19. Jesus’ argument, I suggest, is that ritually defiled food cannot defile humans through ingestion because humans purify all foods from ritual impurity through digestion. This reasoning depends on a widespread Jewish view that excrement is impervious to ritual impurity: because all excrement is pure, the stomach acts as a purifying agent that purifies all food from ritual impurity. I proffer that the common translation of Mark 7.19c – ‘Thus he declared all foods clean’ (NRSV) – should therefore be abandoned.

This article defines and explores the concept of ‘resistance’ as a source of musical meaning in performance. Using Pierre Bourdieu's concept of ‘habitus’ as a framework, I examine my musical habitus: the embodied, internalised ways I play my instrument and think about music, which reflect my extensive musical histories and the fields in which these histories have taken place. Resistance arises in practice when this habitus is undermined. When the types of musicking undertaken circumvent my habituated understanding of acceptable performance and performative roles, it manifests as a pull towards more familiar modes of musical engagement. Making specific reference to resistance experienced in the development and performance of Alex Harker's Drift Shadow (2021), for solo oboe and electronics, the article outlines the ways in which my subjective relationship to my instrument and my role as a performer produce particular understandings of a work that can then nuance the way I play the piece.