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In recent years, there has been extensive work on inequalities among partition functions. In particular, Nicolas, and independently DeSalvo–Pak, proved that the partition function $p(n)$ is eventually log-concave. Inspired by this and other results, Chern–Fu–Tang first conjectured the log-concavity of $k$-coloured partitions. Three of the authors and Tripp later proved this conjecture by introducing recursive sequences and a strict inequality for fractional partition functions, giving explicit errors. In this paper, we show that the log-concavity is, in fact, strict for $k\geq 2$. We shed further light on this phenomenon by utilizing Hardy–Littlewood–Pólya’s notion of majorizing. We prove that for partitions $\boldsymbol{a},\boldsymbol{b}$ of $n\in{\mathbb N}$, if $\boldsymbol b$ majorizes $\boldsymbol a$, then $p_k(\boldsymbol{a}) \gt p_k(\boldsymbol{b})$. Numerical calculations indicate that our result is sharp.
This Element critically examines the claim that United States economic sanctions on Venezuela constituted 'collective punishment' of the Venezuelan population, contributing significantly to the country's economic collapse and humanitarian crisis. Through comprehensive analysis of economic, developmental, and welfare indicators from 2013 to 2023, it demonstrates that the bulk of Venezuela's economic devastation - including 52 percent of GDP losses and 98 percent of import declines - largely occurred before financial sanctions were imposed in August 2017. Key welfare indicators such as infant mortality, undernourishment, and life expectancy had deteriorated substantially by 2017 and subsequently stabilized or improved following sanctions implementation, contradicting narratives that attribute Venezuela's collapse primarily to external economic pressure. The Element provides a timeline of Venezuelan economic and political events around sanctions and a critical review of the literature on their economic effects. This title is also available as Open Access on Cambridge Core.
Automated translations can break down language barriers and increase access to information, but they can also be highly inaccurate. This timely book explores the social challenges and ethical considerations of using artificial intelligence (AI) translations in high-stakes professional environments. Based on contributions from over two thousand professionals from critical sectors including healthcare, social work, emergency services and the police, the analysis explores the motivations and consequences of multilingual uses of AI across these sectors. Real-life examples provided throughout the book bring home the delicate balance of risks and benefits of using AI to serve and communicate with multilingual communities. By drawing on concepts such as virtue, trust, empathy and AI literacy, this book makes a case for nuance and flexibility, defends the value of language access, and calls for greater transparency in the development and deployment of AI translation tools. This title is also available as open access on Cambridge Core.
Like many other world religious and spiritual traditions, the Sikh tradition is philosophically rich. However, its contributions have been wholly unrepresented in Western analytic philosophy. The goal of this Element is to present a central aspect of Sikh philosophy, its ethics, by using the tools and methods of analytic philosophy to reconstruct it in a form that is understandable to Western audiences, while still accurately capturing its unique and autochthonous features. On the interpretation of Sikh ethics this Element presents, the Sikh ethical theory understands ethics in terms of truthful living – in particular, living in a way that is true to the fundamental Oneness of all existence. Features of the Sikh ethical theory discussed include its account of vice and virtue, its account of right conduct, and the philosophical relationship between ethical theory and practice. This title is also available as Open Access on Cambridge Core.
In preparing for our Clinical and Translational Science Award (CTSA) UM1 application, we recognized the need to develop a shared understanding of the distinctions between translational science (TS) and translational research (TR). We describe our efforts to develop and evaluate the reliability of a concise instrument that investigators and reviewers could use to distinguish between TS and TR.
Methods:
Groups of faculty and staff individually reviewed published translational studies to determine whether the project involved TS and, separately, TR. One group (n = 10) first reviewed 14 publications with limited guidance; the same group and a second group (n = 9) then reviewed another set of 14 publications guided by a detailed algorithm. We used kappa statistics to measure agreement in the determinations of TS and TR for each publication.
Results:
The overall kappa coefficients in the three sets of TS determinations (two by the first group and one by the second group) were 0.61, 0.33, and 0.18, respectively. The overall kappa coefficients in the three sets of TR determinations were 0.26, 0.11, and 0.40, respectively. The median kappa coefficients for all 42 determinations were 0.39 for TS and 0.22 for TR, both indicating only fair agreement. We found no evidence that the algorithm helped to improve agreement rates.
Conclusion:
Our results show gaps in understanding the distinction between TS and TR among CTSA hub faculty and staff. We discuss some reasons for this gap and propose ways that could improve the recognition of TS and TR.
This study aimed to adapt the Chronic Conditions Physician–Patient Relationship Scale (CC-PPR) into Turkish and to examine its validity and reliability among patients with chronic diseases receiving care from family physicians.
Methods:
A methodological study was conducted with 254 adult patients attending the Family Medicine Centers between May 01-October 01, 2025. The adaptation process followed World Health Organization guidelines. Construct validity was examined using confirmatory factor analysis (CFA), and reliability was assessed through internal consistency (Cronbach’s α, McDonald’s ω) and item–total correlations.
Results:
The CFA supported the original one-factor, 22-item structure with an excellent model fit (χ2[209] = 59.847, p = 1.000; comparative fit index [CFI] = 1.000; Tucker–Lewis index [TLI] = 1.016; root mean square error of approximation [RMSEA] = 0.000; standardized root mean square residual [SRMR] = 0.048). Sampling adequacy was good (Kaiser–Meyer–Olkin [KMO] = 0.970; Bartlett’s χ2[231] = 5934.429, p < 0.001). All standardized factor loadings were high (0.63–0.81, p < 0.001). Internal consistency was excellent (Cronbach’s α = 0.977; McDonald’s ω = 0.976), and corrected item–total correlations ranged from 0.74 to 0.86. Marital status, employment status, and type of health institution were significantly associated with relationship scores (p < 0.05).
Conclusion:
The Turkish version of the CC-PPR is a psychometrically robust, unidimensional, and reliable tool for evaluating the quality of family physician–patient relationships among individuals with chronic conditions. It can be used to assess communication and relational competencies of family physicians, support patient-centred care initiatives in chronic disease management.
We present a detailed characterisation of radio frequency interference (RFI) in the 2.4 GHz band around Murriyang, CSIRO’s Parkes radio telescope. The dominant sources of interference are Wi-Fi and Bluetooth transmissions. We quantify how the intensity and directionality of this RFI vary with time of day and document its evolution over several years. Although most observers currently discard data within this band, our analysis shows that the interference is confined in both time and frequency and can be effectively mitigated. Using 10 seconds of 16-bit voltage data recorded during observations of the Vela Pulsar (PSR J0835—4510), we demonstrate that the majority of the channelised data remain unaffected by RFI. We compare three RFI detection and mitigation algorithms and evaluate their relative performance. All methods perform effectively, and any could be implemented in real time to enable productive use of this observing band. A real time implementation would allow the scientific use of this 128MHz observing band to increase, from almost 70% of the band being completely unusable all of the time, to over 90% of becoming accessible for science. Given its simplicity and efficiency, a basic power-threshold approach offers a relatively straightforward solution.
Data Coordinating Centers (DCCs) play essential roles in multisite clinical and translational research, ensuring consistent protocol implementation, data integrity, and regulatory compliance across geographically and organizationally diverse sites. As study design, regulatory, and technological complexity have evolved, DCC responsibilities have expanded beyond data coordination. This rapid scoping review maps published experiences from academic DCCs to address two questions: (i) What key organizational and operational challenges have been reported? (ii) What solutions and emerging technologies have been adopted in response? We conducted a rapid scoping review in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). We searched the peer-reviewed literature (2010–2025) using PubMed, Scopus, and the Web of Science Core Collection. Fifteen reports describing 16 DCCs were included in this review. DCCs faced recurring challenges related to infrastructure development, multisite coordination, regulatory governance, data heterogeneity, and workforce development. Reported adaptations include homegrown modular infrastructure solutions, standardized workflows, streamlined proactive regulatory processes, and workforce investments. By synthesizing evidence on DCC challenges and adaptations, this review provides practical guidance to help DCCs enhance operational feasibility and uphold scientific integrity in multisite clinical and translational research.
Recent advances in healthcare and rising life expectancy intensify longevity risk, motivating a deeper understanding of how cause-of-death (COD) rates interact. Using male COD data from 1978 to 2018 in the United States, we develop a copula-based hierarchical framework for seven major causes: cancer, diabetes, external causes, influenza, mental disorders, nephritis, and vascular disease. The framework integrates reconciliation, hierarchical dependence, and long-run equilibrium using a Lee–Carter (LC) setting. More specifically, the LC period indices are estimated under reconciliation penalties and are modeled through a sparse vector error correction model, with dependence captured by a hierarchical Archimedean copula. Two applications illustrate the value of our approach. In out-of-sample forecasting, the framework outperforms the standard LC model by improving the accuracy of aggregate mortality rates. In structural analysis, fitted connectedness reveals that diabetes and vascular disease act as net transmitters of mortality shocks, while cancer and external causes are net receivers. These insights help actuaries, demographers, clinicians, and policymakers enhance mortality forecasting to assess whether prioritizing government interventions for high-transmission causes could potentially maximize overall mortality improvements for society.
Cognitive reappraisal deficits are a transdiagnostic risk factor for major depressive disorder (MDD) and social anxiety disorder (SAD) and are observed in patients with these disorders at the neural level. Preliminary research suggests less activation of prefrontal regions during reappraisal (vs. viewing) of negative stimuli associates with overall symptom severity in patients with MDD or SAD, however, this is not reliably observed across studies. Consistent with research showing that reappraisal may only be adaptive when employed to cope with uncontrollable adversity, this study sought to examine whether neighborhood-level adversity (i.e. socioeconomic disadvantage, crime) moderated the relation between internalizing symptom severity and neural correlates of reappraisal.
Methods
This study included patients with a current diagnosis of MDD (n = 51) or SAD (n = 39). Patients completed measures of symptom severity as well as an emotion regulation task while in the scanner to assess neural activation during reappraisal. Patients’ addresses were geocoded to assess neighborhood socioeconomic disadvantage and crime.
Results
Results indicated that greater symptom severity was associated with decreased activation of key prefrontal regions underlying reappraisal, but only for patients living in neighborhoods characterized by high levels of personal (i.e. violent) crime. Unexpectedly, the opposite was found for patients living in low-crime neighborhoods, such that greater symptom severity was associated with increased neural activation during reappraisal (vs. viewing) of negative stimuli.
Conclusions
Findings highlight the critical importance of considering patients’ neighborhood contexts when evaluating associations between symptom severity and neural correlates of reappraisal in patients with internalizing disorders.
We study a nonlinear branching diffusion process in the sense of McKean, i.e. where particles are subjected to a mean-field interaction. We consider first a strong formulation of the problem and we provide an existence and uniqueness result by using contraction arguments. Then we consider the notion of weak solution and its equivalent martingale problem formulation. In this setting, we provide a general weak existence result, as well as a propagation of chaos property, i.e. the McKean–Vlasov branching diffusion is the limit of a large-population branching diffusion process with mean-field interaction.
In this Opinion Paper, we argue that the absence of animal welfare in the United Nations’ sustainable development goals (SDGs) may not be as detrimental as some suggest. We put forward the view that the welfare of animals is an integral part of the concept of sustainability, that development which affects animals cannot be sustainable without due consideration to their welfare, and we give examples in support of this position. Put simply: no mention means animal welfare could be, and potentially should be, anywhere and everywhere in the goals. For livestock species, we submit that the synergies between the SDGs when animal welfare is included greatly outweigh the conflicts usually highlighted. Further, considering animal welfare as both an achievable goal and as a mechanism for sustainable development allows improvement of animal welfare to carry the weight it warrants: an animal with poor welfare is not a sustainable animal. By extension, products from animals with poor welfare cannot be considered sustainable, and animal welfare is necessarily included in a well-functioning ecosystem. Through the paper we argue that the challenge is not to add in animal welfare, but to think sustainability with animal welfare. We conclude by giving directions to where animal welfare can be integrated when developing sustainable actions.
This study examines how grassroots gender NGOs in China navigate online fundraising amid tightening regulations and declining external funding. Drawing on a longitudinal analysis of 463 crowdfunding projects by 124 gender NGOs on Tencent Charity, it shows how these organizations pursue gender equality under pressure from the state and the platform economy. The study identifies two interrelated strategies: (1) strategic conformity through issue reframing to ally with state agendas for algorithmic visibility and (2) strategic stealth in intersectional boundary-spanning, calibrating (in)visibility while leveraging cross-sectoral collaboration to sustain gender advocacy. These practices reflect how gender NGOs continually negotiate visibility, legitimacy, and autonomy. The findings suggest that digital philanthropy, rather than diversifying fundraising, often reproduces hierarchies of attention and access. Conceptualizing strategic stealth in intersectional boundary-spanning as adaptive, issue-expanding practices, this study deepens understanding of NGOs’ constrained agency and highlights platform governance as a key force channeling state priorities in civic fundraising.
This study evaluated the effectiveness of a one-year smoking cessation intervention for people with severe mental illness compared with treatment as usual (TAU) in outpatient mental healthcare.
Methods
The KISMET study is a pragmatic cluster-randomized controlled trial conducted in 21 outpatient mental healthcare teams in the Netherlands. Eleven teams delivered the KISMET intervention comprising cognitive-behavioral and peer support, combined with optional pharmacological reatment. Ten teams participated in the TAU condition. We collected data between October 2022 and July 2024. The primary outcome was self-reported smoking cessation at 12 months, verified through exhaled carbon monoxide levels below 10 parts per million. Secondary outcomes included depression and anxiety (HADS), severity of psychotic symptoms (PANSS-6), quality of life (SF-12), disease self-management (PAM-13), lipid profile, blood pressure, body mass index, glucose level, and physical fitness. Crude and adjusted linear and multivariable logistic regression and mixed model analyses were performed.
Results
Eighty-nine participants were included in the KISMET intervention and 44 in TAU. Smoking cessation rates were significantly higher in the KISMET group at 3 months (OR 12.1, 95% CI 1.4 to 103.7) and at 12 months (OR 4.2, 95% CI 1.0 to 17.2) but not at 6 months (OR 1.9, 95% CI 0.5 to 6.9). No significant differences between groups were found for secondary outcomes. Dropout rates were 58% in the intervention and 32% in the TAU group.
Conclusions
The KISMET intervention shows potential without signs of physical or psychopathological complications. However, results must be interpreted with the high dropout rates in mind.
The nosological status and psychopathology of delusional disorder have been a subject of debate since Kraepelin distinguished it from schizophrenia and affective psychoses. Contemporary diagnostic manuals define delusional disorder primarily by the presence of delusions, offering limited guidance for its differentiation from schizophrenia. Notably, DSM-5 introduced a major, seemingly unexplained change by allowing bizarre delusions in delusional disorder, contrary to ICD-11, prior DSM editions, and classical descriptions. This narrative review revisits the seminal works of six classical authors (Kraepelin, Jaspers, Kretschmer, Sérieux and Capgras, and De Clérambault), who shaped the concept of delusional disorder (paranoia), and their detailed clinical cases of the disorder. All considered delusional disorder to be an independent psychotic disorder, characterized by chronic, systematized, nonbizarre delusions, preservation of personality, and minimal hallucinations, with a largely intact experiential framework outside of the delusional theme. Additional features such as delusional misinterpretations, illusions, and false memories were also emphasized in the classical literature. We examined these authors’ clinical cases of delusional disorder for the presence of delusional features characteristic of schizophrenia (delusional mood, first-rank symptoms, autistic-solipsistic delusions, and double bookkeeping), which index alterations in the structure of experience rather than mere delusional content. Such delusions were rarely found in the classical clinical cases of delusional disorder. Our findings highlight psychopathological distinctions between delusional disorder and schizophrenia, suggesting that schizophrenia involves a qualitative alteration of the experiential framework that is absent in delusional disorder. These findings raise concerns about the validity of the DSM-5 change, allowing bizarre delusions in delusional disorder.
Depression in cancer patients is a common condition that poses significant challenges for prognosis, treatment adherence, and quality of life. Its onset reflects the interplay of diverse biological, psychological, and social factors, which has been the focus of numerous studies.
Methods
We identified both systematic and non-systematic reviews examining cross-sectional or prospective studies reporting associations between DAFs and depression. We extracted data relative to DAFs, as well as the direction and statistical significance of the reported association. Consistency of findings was assessed by estimating the proportion of concordant studies (PCS) for each DAF. Methodological quality and risk of bias were assessed using a standardized tool.
Results
We identified 73 reviews (26 systematic and/or meta-analyses, 47 narrative) encompassing 514 unique primary studies, reporting the associations between depression and 198 distinct DAFs. DAFs were grouped into six domains (sociodemographic, cancer-related, somatic, psychological, biological-genetic, and other). The strongest associations (PCS ≥ 75% and ≥5 studies) were observed for sociodemographic factors (e.g., high social support, being unmarried), inflammatory markers (IL-6, TNF-α, CRP), psychological factors (e.g., history of depression, distress, anxiety), and somatic factors (e.g., fatigue, low functional status, malnutrition). When restricting analyses to prospective studies, consistent associations emerged for cancer-related physical symptoms and time dedicated to patient communication.
Conclusions
Depression in cancer is multifactorial, with physical and psychosocial factors likely iteracting dynamically. Prospective studies are still greatly needed. Further research on risk and protective factors may facilitate risk stratification, early diagnosis and patient management.
As Lucy Grace writes, “Our lives are a bundle of stories.”1 In fact, even the self, that seemingly solid and continuous “I” we carry through the world, is a story, a narrative we construct and reconstruct by piecing together memories and experiences into what feels like, as Guy Saunders writes, “a single unified self.”2 We are thus all storytellers at heart, and the story we are most often telling, retelling, and revising is ourselves. As cognitive scientist Daniel Dennett argues in Consciousness Explained, our selves are “magnificent fictions,” not “independently existing soul-pearls” but “artifacts of the social processes that create us.”3 We do not discover who we are; we narrate ourselves into being.
The present study addresses the question of whether an individual who does not understand a sentence might still be able to repeat it verbatim. To answer this question, we examined paraphrasing and repetition data from two previous studies: Pavlenko et al. (2019), which analyzed L1 and L2 participants’ paraphrasing of seven Miranda warning sentences, and Akbary et al. (2023), which compared L1 and L2 participants’ paraphrasing and elicited imitation (EI) performance on 30 commonly used EI sentences. We formulated our questions into four predictions, two of which directly addressed whether rote repetition without comprehension occurs at all. Our results confirmed both predictions, identifying 36 (5.6%) of the 646 instances of verbatim sentence repetition in the data as potential cases of repetition without comprehension. However, a broader analysis showed that the evidence for a lack of comprehension was relatively weak and ambiguous. We conclude with recommendations for overcoming the limitations of the present study and resolving the ambiguity of our findings.
Participants in NIH-funded multicenter clinical trial received the compound opposite to the randomization intention. We report the problem, subsequent root cause analysis (RCA) and corrective and preventative action (CAPA).
Methods:
The RCA was independently facilitated to identify study-level causes of the problem. Results were reviewed by institutional research administration leaders to identify institution-level causes and formulate corresponding CAPA. Both culminated in consensus.
Results:
The resulting causal chain consisted of two physical causes, two study-level system causes, and two institution-level system causes for which two institution-level CAPAs were formulated by institutional leadership. The CAPAs established institutional procedures for independent verification of critical processes, their specification, and their planned control on high-risk studies.
Conclusions:
Lack of study-level procedural infrastructure jeopardized a multicenter study led by our institution. Lack of institutional infrastructure supporting identification of critical study processes, risks to them, and appropriate controls enabled the problem to occur. Studies conducted in settings lacking institutional or study-level procedural infrastructure are susceptible to similar problems. Adding the needed institutional processes to support identification of critical study processes, risks to them, and appropriate controls required reprioritizing existing resources.