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Using 3,154 tokens from American English, we test whether optionality in verb–particle placement increases speech-planning cost, measured as pre-verbal silence. Tokens were coded for object properties, idiomaticity and verb frequency. We find that pre-verbal silence does not differ between split (pick the book up) and joined (pick up the book) orders. While idiomaticity favours the joined order, it does not raise planning cost. Verb frequency shortens pauses only in fast speech, suggesting predictability acts lexically, not structurally. Choice symmetry does not lengthen pauses. We therefore fail to reject the null hypothesis: the two orders are equally easy to plan. This null result, from tests designed to detect a theoretically predicted effect, aligns with other evidence that syntactic choice imposes no production cost. We conclude that variation in verb–particle constructions (VPCs) is cost-free; distributional differences reflect object properties and idiomaticity, not derivational markedness.
This study examined the association between transitions in BMI growth channel (BMI-GC) and the odds of underweight and overweight in young adulthood. Data were drawn from 2759 participants in the Young Lives study (YL) and 2782 participants in the National Longitudinal Survey of Youth 1997 (NLSY97). Normal weight subsamples, consisting of 1922 participants from YL and 1477 from NLSY97, were selected for sensitivity analyses. Individual BMI-GC trajectories were estimated using linear mixed-effects models and classified into four groups: Stable, Crossing Upwards, Crossing Downwards and Fluctuating. Associations between BMI-GC groups and underweight and overweight at age 22 were assessed using logistic regression models. Compared with the Stable group, participants in the Crossing Downwards group had higher odds of being underweight in YL (OR 2·62; 95 % CI 1·95, 3·54), whereas those in the Crossing Upwards group had higher odds of overweight in YL (OR 3·96 (95 % CI 2·61, 5·99)) and in NLSY97 (OR 2·55 (95 % CI 1·95, 3·33)). In sensitivity analysis (normal weight subsamples), Crossing Downwards remained associated with underweight in YL (OR 1·75; 95 % CI 1·23, 2·48), and Crossing Upwards remained associated with overweight in both cohorts (OR 1·95; 95 % CI 1·14, 3·34 in YL and OR 1·67; 95 % CI 1·00, 2·78 in NLSY97). Crossing BMI-GC was associated with both underweight and overweight outcomes, including among participants with normal weight during childhood and adolescence. These findings highlight the importance of BMI-GC in weight assessments, offering a more nuanced understanding of growth trajectories and emphasising the need to move beyond BMI categories alone to predict long-term nutritional risks.
We present and conduct a novel experiment on a multi-period beauty contest game. Leveraging the multi-period feature, we investigate how participants revise their forecasts in periods when new information—such as shocks or announcements—arrives and how they form their expectations in the absence of new information. We make two key contributions. First, we develop a new method based on forecast revisions to evaluate whether participants behave in a forward-looking manner. The experimental results show that participants do react to anticipated shocks: namely, the announcements of future shocks. Second, we identify a new strategic environment effect during periods without new information; only when the game exhibits strategic complementarity do participants use extrapolation and expect continuously rising prices. This finding suggests that expectation formation is endogenous to the economic environment; and policy design should thus take this endogeneity into account.
Although the shift from traditional to digital food environments has enhanced accessibility and convenience in food purchasing and delivery, emerging evidence suggests that current digital food environments tend to promote energy-dense foods rather than healthier options. Therefore, this commentary aims to highlight the challenges faced by healthcare professionals in shaping a healthier digital food environment and to offer practical recommendations for fostering such an environment in Malaysia. This commentary also emphasises that shaping a healthier digital food environment is not an individual endeavour but a collaborative effort among key stakeholders, including government ministries, platform operators, online food vendors and platform users.
Recent advances in Artificial Intelligence (AI) reveal a mismatch between the EU’s individual-centric data protection shell and automated systems’ ability to affect entire groups of people, sealed within that shell. AI routinely processes data about groups, while the GDPR still allocates rights and remedies to identifiable individuals. This design produces a structural collective redress gap where injunctions may be obtained without individual mandates (GDPR Art. 80(2), RAD Art. 8), but compensation remains tied to identifiability. Here, I show how the GDPR’s model (consent, data subjects’ rights, Art. 80) fits in and why it fails against AI’s capacity to de-anonymise and infer traits about persons whose data were never collected or volunteered. I then examine the AI Act 2024/1689. Although it repeatedly refers to “groups of persons,” trilogue negotiations removed the Parliament’s key collective remedy tools, leaving only ex‑ante risk and transparency duties. The example of online behavioural advertising or affinity profiling illustrates how AI‑designed groups fall outside the scope of meaningful GDPR or AI Act remedies. I argue for a right to group protection and propose four main revisions: a definition of groups, a mechanism for a group complaint and redress, group-level impact assessment requirements and group data protection by design.
Persistent funding shortfalls undermine protected areas (PAs) worldwide, yet few studies analyse these patterns across space and time. We examined funding deficits in 300 Brazilian federal PAs from 2014 to 2023 using spatial Durbin error models. Deficits were measured as the gap between evidence-based minimum management costs and actual spending. We analysed how PA age, size, management group, ecological region, population density and per capita GDP predict deficits, decomposing socioeconomic effects into direct and spillover components. In 2023, 72% of the PAs faced deficits totalling 958 million international dollars, despite a 30% investment increase over the decade. Larger PAs had greater shortfalls; older PAs had smaller ones. Amazon PAs averaged 79.2% deficits versus 27.6% in the Atlantic Forest. No significant difference emerged between management types. Higher population density predicted lower deficits, probably reflecting greater political visibility near urban centres. No direct local GDP effect was detected, but spillovers from neighbouring high-income regions suggest regional prosperity influences PA funding through spatial networks. Funding deteriorated in 2020–2021 amid fiscal contractions and policy shifts, then recovered in 2022–2023. These findings reveal deep structural inequities, particularly in the Amazon, highlighting the need for transparent national PA financing systems.
The drag wake of a towed inclined 6 : 1 prolate spheroid in unstratified and stratified ambients is investigated experimentally using stereoscopic particle image velocimetry. Tow speed, stratification strength and inclination angle are varied independently, resulting in a parameter space spanning Reynolds numbers $\textit{Re} = (1.25{-}20) \times 10^3$, Froude numbers $\textit{Fr}= U/\textit{ND} = 2{-}32$ and $\infty$, and inclination angles $\theta = 0^\circ$ and $20^\circ$. Measurements are repeated at each parameter combination to obtain converged wake statistics for $3 \leqslant x/D \leqslant 40$. Unstratified measurements provide a baseline experimental dataset for inclined spheroids that has not previously been reported. In the absence of stratification, inclination generates persistent wake asymmetries and a net vertical impulse that deflects the wake trajectory. Although inclined configurations exhibit larger initial wake heights than axisymmetric cases, the early wake evolution collapses when scaled by an effective body diameter, indicating that this increase is geometric in origin. Regular vertical velocity protrusions are observed in inclined wakes, with a characteristic spacing that depends on Reynolds number but shows no measurable dependence on Froude number. At sufficiently low Froude number, buoyancy influences the near-body flow, and modifies the wake trajectory and streamwise velocity profiles. For $\textit{Re} = 5000$, wake heights for both axisymmetric and inclined configurations collapse across stratification strengths when scaled by an effective diameter. In this regime, the wake trajectory exhibits oscillations with period $2\pi /N$, in agreement with previously reported stratified wake dynamics.
CAR-T cell gene therapy has advanced from an experimental concept to a standard curative treatment for selected hematologic malignancies. Substantial clinical evidence has established CAR-T therapy as a cornerstone for relapsed/refractory B-cell malignancies and multiple myeloma, demonstrating durable, long-term remissions. In 2025, the U.S. Food and Drug Administration (FDA) eliminated the Risk Evaluation and Mitigation Strategy (REMS) requirement, reflecting improved clinical management of Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS). Yet, the widespread adoption of these therapies has unveiled a new landscape of long-term and next-generation challenges.
Methods
This review critically analyzes CAR-T therapy’s clinical trajectory and the bioengineering strategies redefining its safety, scalability, and translational potential.
Results
A major hurdle is therapeutic resistance driven by antigen escape, notably through alternative splicing and lineage switching. The emergence of long-term safety signals, specifically secondary T-cell malignancies, has necessitated rigorous surveillance, exemplified by the European Medicines Agency’s (EMA) mandate for lifelong patient monitoring. The therapeutic landscape is further complicated by histopathological and immunological barriers limiting the expansion and persistence of engineered cells. These include deficient T-cell trafficking, an immunosuppressive tumor microenvironment (TME), and antigen heterogeneity, which have historically constrained efficacy in solid tumors. To address these hurdles, the field is leveraging CRISPR-enhanced allogeneic platforms, cytokine-secreting armored CARs (TRUCKs), and logic-gated systems showing early clinical promise.
Conclusion
Building on these developments, we hypothesize that CAR-T therapy is undergoing a paradigm shift from single-target cytotoxicity toward a multi-functional, programmable framework capable of overcoming resistance, enhancing safety, and enabling effective penetration of solid tumors.
Early psychological deprivation is associated with increased risk for cardiometabolic disorders, and rapid catch-up growth following improved care environments may further influence this risk. Using data from the Bucharest Early Intervention Project – a randomized longitudinal study of children institutionalized in infancy assigned to high-quality foster care, continued institutional care, or raised by biological families – we examined cardiometabolic outcomes in early adulthood. Participants were 81 women and 58 men (mean age 22.6 years), predominantly Romanian. We assessed associations between care type and cardiometabolic traits including blood pressure, lipid and glucose metabolism, and metabolic syndrome. Results indicated that adults with histories of institutionalization displayed poorer lipid metabolism compared to non-institutionalized controls. Notably, individuals randomized to foster care showed increased BMI and waist circumference in adulthood relative to those who remained in institutional care. Longitudinal latent class analyses revealed four distinct BMI trajectories from infancy to early adulthood. The accelerated BMI trajectory, predominantly comprising foster care participants, was associated with the greatest prevalence of metabolic syndrome. These findings suggest that both lipid dysregulation and persistent increases in BMI represent ongoing concerns for cardiometabolic risk following early psychosocial deprivation. Those exposed to early adverse care may benefit from ongoing cardiometabolic monitoring and lifestyle interventions.
In 1970, Ted Williams – a medical missionary who had been running a small hospital at Kuluva in the West Nile region of Uganda for decades – was approached by the International Agency for Research on Cancer (IARC) to help establish a major study on the possible role of Epstein–Barr Virus in the aetiology of Burkitt’s lymphoma (BL). At the time, there was intense global interest in BL, as the cancer promised to be the first shown to have a viral aetiology. IARC centred its project at Kuluva Hospital and in the West Nile district because of Williams’ unusually detailed and accurate records. Williams was a meticulous record-keeper, who relied on various methods of data collection, from collecting and comparing to selecting and sorting. His paper-based archives and recording practices provide a rare window onto epidemiological knowledge production in East Africa in the decades before computing reshaped medical record-keeping. By tracing the ‘sociomaterial paper trail’ of Williams’s work, this paper examines how persona, place, and paper intersected in the making of medical knowledge, and how the researcher’s persona shapes the kinds of epidemiological data that are ultimately produced.
The interaction between acoustic waves and turbulent grazing flow over an acoustic liner is investigated using lattice-Boltzmann very-large-eddy simulations. A single-degree-of-freedom liner with 11 streamwise-aligned cavities is studied in a grazing flow impedance tube. The conditions replicate reference experiments from the Federal University of Santa Catarina. The influence of grazing flow (with a centreline Mach number of 0.32), acoustic wave amplitude, frequency and propagation direction relative to the mean flow is analysed. Impedance is computed using both direct (i.e. the in situ method) and model-fitting inference (i.e. the mode-matching) methods. The former reveals strong spatial variations; however, averaged values throughout the sample show minimal differences between upstream- and downstream-propagating waves, in contrast to what is obtained with the latter method. Flow analyses reveal that the orifices displace the flow away from the face sheet, with this effect amplified by acoustic waves and dependent on the wave propagation direction. Consequently, the boundary layer displacement thickness ($\delta ^*$) increases along the streamwise direction compared with a smooth wall and exhibits localised humps downstream of each orifice. The growth of $\delta ^*$ alters the flow dynamics within the orifices by weakening the shear layer at downstream positions. This influences the acoustic-induced mass flow rate through the orifices at equal sound pressure level, suggesting that acoustic energy is dissipated differently along the liner. The asymmetry of the flow field experienced by the acoustic wave, depending on its propagation direction, highlights the need to consider a spatially evolving turbulent flow when studying the acoustic–flow interaction and measuring impedance.
To examine whether the number of parents using high levels of structure or coercive control food parenting practices is associated with children’s dietary intake.
Design:
Cross-sectional analysis of father–mother dyads from the Fathers & Families cohort study. Fathers and mothers independently reported their food parenting practices and child’s dietary intake. Multivariate logistic regression models estimated associations between the number of parents (0, 1 or 2) using high structure or coercive control practices and children’s intake of fruit, vegetables, fast food and sugar-sweetened beverages (SSB), adjusting for demographics and recruitment site.
Setting:
United States
Participants:
474 father–mother dyads with a child aged 2–6 years
Results:
Structure, but not coercive control, was positively associated with vegetable intake. Compared with none, having one parent report high structure increased the odds of children consuming vegetables > once/day (adjusted OR (aOR) = 2·09; 95 % CI: (1·06, 4·54)); associations were stronger when both parents reported high structure. Structure was also associated with lower fast food and SSB intake frequency. Compared with none, having one parent report high structure increased the odds of children consuming fast food < once/week (aOR = 1·79; 95 % CI: (1·23, 2·62)) and limiting SSB to < once/week (aOR = 1·52; 95 % CI: (1·03, 2·23)); associations were stronger when both parents reported high structure. Compared with none, high coercive control by one (aOR = 0·69; 95 % CI: (0·49, 0·96)) or both parents (aOR = 0·57; 95 % CI: (0·33, 1·00)) was associated with lower odds of limiting SSB to < once/week.
Conclusions:
Children’s dietary patterns were healthiest when both parents used structure-based food parenting practices. Coercive control from one or both parents was associated with greater SSB intake frequency.
The present study compares several lexical diversity (LD) measures to determine which measure, or measures, best predict receptive lexico-grammatical ability in written L2 Spanish, and whether a composite LD score is better than any single measure. We analyzed 1,225 written responses with eight different LD measures: six popular measures, a composite score based on Principal Component Analysis (PCA) of those six measures, and the traditional TTR to be used as a baseline against which to compare the other measures. Other predictor variables included the age and gender of the writers, the age of first exposure to Spanish, the number of years studying Spanish, and study abroad participation. The results of a series of mixed-effect logistic regression models suggest that the composite LD measure is best, and that among the LD measures studied, two predicted lexico-grammatical ability nearly equally well. We conclude with the recommendation that L2 language researchers use multiple LD measures, including a composite measure based on PCA, rather than any single LD measure.
This article contributes to ongoing attempts to move historical understanding of Christian attitudes to Jews beyond a dichotomy between philo- and antisemitism. Employing the history of emotions, it examines how ‘love’ was understood in the specific religious, social and historical contexts in which it was advocated. Focusing on the Church of Scotland’s 1839 ‘Mission of Enquiry to the Jews’, it shows how the Church advocated a system of shared feeling towards Jews among believers. This ‘love’ engaged a variety of different emotional states linked to contemporary internal tensions within the Church of Scotland, and prophetic hopes for their resolution.
Which social groups do political parties appeal to? This is an important question, yet a lack of comparative data has constrained research. To address this gap, we introduce the Parties’ Social Group Appeals (PSoGA) Database, which includes two novel datasets covering 791 election manifestos from 139 parties across Austria, Denmark, Germany, Ireland, the Netherlands, Spain, Switzerland, and the United Kingdom from 1970 to 2025. This article outlines the methodology for constructing and validating the datasets, demonstrates compatibility with policy-focused resources like MARPOR, and highlights key aspects. This database provides researchers with unprecedented insight into representation dynamics across space and time by documenting the groups that parties speak about and appeal to.
Expanded multiplex PCR gastrointestinal panels (GIPs) are routinely ordered to diagnose infectious diarrhea. However, recommendations for repeat GIP testing are limited, resulting in variable testing practices. We evaluated the diagnostic yield of repeat GIP testing within 14 days.
Methods:
We conducted a retrospective cohort study of adults (age ≥ 18 years) tested with GIPs across 12 hospitals and outpatient centers (2019–2024). We analyzed the first diarrheal episode per patient, excluding cases with invalid/missing results and C. difficile results. Repeat testing was defined as a GIP completed within 14 days of an index GIP, excluding confirmatory testing using the same stool sample. The primary outcome was diagnostic yield (new pathogen detection), and the secondary outcome was pathogen persistence (same pathogen detection).
Results:
Among 16,502 patients, 507 (3.1%) underwent repeat GIP testing within 14 days (median interval: 6.3 days; IQR: 2.7–9.8). Only 4.6% [19/415] index-negative patients and 2.2% [2/92] index-positive patients detected new pathogens on repeat testing, with 51% [47/92] index-positive patients demonstrating persistence of at least one pathogen from their initial test. The number needed to test (NNT) to identify one new pathogen was 24 (95% CI: 16–39) tests overall, and 127 (95% CI: 50–455) tests to identify one new pathogen warranting antimicrobial treatment. Most repeat testing (86% [436/507]) was ordered by a different clinician.
Discussion:
Repeat GIP testing within 14 days rarely provided new diagnostic information, highlighting the limited utility of early repeat testing. Institutional policies discouraging repeat GIPs within 14 days may improve diagnostic stewardship.