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Multilevel regression and poststratification (MRP) is widely used to estimate opinion in small subgroups and to adjust unrepresentative surveys. Yet, even flexible MRP models contain errors generated by non-response and model misspecification. We propose a principled, data-driven method to leverage observable errors on auxiliary quantities with known marginal distributions—for example, election outcomes—to improve estimates of policy attitudes. Our method leverages the correlation between auxiliary variables and outcomes of interest to calibrate MRP estimates to these known marginal distributions. We illustrate our approach using a pre-election poll measuring support for an abortion referendum. We find that the method reduces county-level error by nearly two-thirds relative to traditional MRP. We also show how our calibration approach can be used to generate estimates for smaller nested geographies, such as precincts, even in the absence of poststratification data at this level. Our approach provides a framework for fully incorporating known population data to improve estimates of public opinion in small subgroups, providing scholars another tool to study representation.
This qualitative study explores how wage and payment practices inflict both economic hardship and psychological distress among tea garden workers in Sylhet and Moulvibazar. Using an interpretivist approach, semi-structured interviews were conducted with 12 purposively sampled workers in Sylhet. Transcripts in Bengali and the local Sylheti dialect were evaluated using reflexive thematic analysis. The findings reveal six key themes centered on the psychological impacts of wage insufficiency, unpredictable payment schedules, disproportionate quota penalties, and opaque deductions. Participants identified low base wages as the primary driver of chronic food insecurity and debt cycles. Furthermore, systemic issues like delayed payments, poor-quality rations, and gendered care burdens severely exacerbated their acute stress. Workers expressed their psychological suffering through culturally encoded idioms such as tension, chinta (worry), and khitkhite (irritability). Ultimately, the study highlights that workers' top priorities for mitigating distress include fair and sufficient wages, transparent payment systems, food security, and accessible healthcare. These findings emphasize that improving mental well-being in this vulnerable population requires systemic reforms in payment governance.
Floods repeatedly disrupt lives, livelihoods, and public services across Indonesia, while available warnings do not always lead to timely action. This article shows how rainfall forecasts can become practical early actions before flood impacts escalate. Evidence from four Indonesian regions highlights that rainfall thresholds can support earlier decisions, while stakeholder engagements reveal the procedures, coordination, and community readiness needed to act on warnings. The study demonstrates that linking forecasts with clear responsibilities and prepared local systems can reduce avoidable losses, improve disaster governance, and strengthen resilience to elevating climate-related risks.
Technical summary.
Despite advances in weather forecasting and flood warning systems, the operational translation of early warning into anticipatory action remains limited in Indonesia. This gap constrains the effectiveness of disaster risk reduction, particularly in regions exposed to recurrent hydrometeorological hazards. To address this challenge, historical rainfall, flood occurrence, and impact records from Gresik Regency, Samarinda City, South Barito Regency, and Medan City were analyzed using Log Pearson III return-period estimation and cumulative distribution functions to identify locally relevant trigger thresholds. The results indicate that rainfall exceedance levels around the 90th, 95th, and 99th percentiles provide technically credible benchmarks for preparedness escalation and resource mobilization, with marked variation across hydroclimatic settings. Stakeholder consultations further reveal that forecasting information is increasingly available, but implementation shall be supported by standard operating procedures, systematic communication pathways, functional role clarity, and sufficient local validation mechanisms. An operational framework is proposed, which links forecast thresholds, impact monitoring, verification processes, and predefined actions. The findings provide evidence for embedding forecast-based action within decentralized disaster governance systems in Indonesia and comparable flood-prone settings of other countries.
Social media summary.
Operationalizing warnings into action can strengthen anticipatory disaster governance.
We numerically investigate the steady and unsteady wakes of three-dimensional permeable disks over Reynolds number ($\textit{Re}$) range 100–300 and Darcy number ($Da$) range $10^{-9}$–$10^{-3}$. For disks with low permeability ($Da\le 8\times 10^{-5}$), the dynamical transition route is the same as that of impervious disks, with the critical $\textit{Re}$ for all bifurcations increasing with decreasing permeability. In contrast, for disks with high permeability ($Da\ge 2\times 10^{-4}$), all unsteady bifurcations are suppressed, and the wake remains in a steady regime throughout the $\textit{Re}$ range considered. Interestingly, at moderate $Da$, permeability gives rise to two previously unreported flow regimes. The first is the ‘SVR breathing’ regime, occurring at $Da\approx 10^{-4}$ and $\textit{Re}\approx 200$, and is attributed to the subharmonic lock-in between two distinct unsteady dynamics: the shedding of hairpin vortices and the low-frequency unsteadiness of the near-wake recirculation regions. The second is the ‘intermittency’ regime, which occurs at $Da\approx 1.5\times 10^{-4}$, $\textit{Re}\approx 200$; the wake alternates irregularly between two periodic modes with orthogonal planes of symmetry. Future work might include verifying whether intermittency arises from the energy competition between two modes, as the vortices lack sufficient energy to sustain stable single-mode harmonic oscillations. These findings demonstrate that permeability can fundamentally alter wake dynamics and introduce new wake structures that do not occur on an impervious disk.
Methods for extracting archaeological information from large, digital databases of cultural resource management (development-led archaeology) records are frequently quantitative or aggregative. This approach can struggle to capture the details of how archaeological knowledge is produced socially. Here, the authors draw on archival science to describe ‘project biography’ as a means to understand how archaeological records—and their silences—are produced through decisions weighing the risks of development. This approach is illustrated using examples from South Africa’s digital heritage records database (SAHRIS), while also considering ethical entailments and the need to better understand the social worlds of cultural resource management.
Using 3,154 tokens from American English, we test whether optionality in verb–particle placement increases speech-planning cost, measured as pre-verbal silence. Tokens were coded for object properties, idiomaticity and verb frequency. We find that pre-verbal silence does not differ between split (pick the book up) and joined (pick up the book) orders. While idiomaticity favours the joined order, it does not raise planning cost. Verb frequency shortens pauses only in fast speech, suggesting predictability acts lexically, not structurally. Choice symmetry does not lengthen pauses. We therefore fail to reject the null hypothesis: the two orders are equally easy to plan. This null result, from tests designed to detect a theoretically predicted effect, aligns with other evidence that syntactic choice imposes no production cost. We conclude that variation in verb–particle constructions (VPCs) is cost-free; distributional differences reflect object properties and idiomaticity, not derivational markedness.
This study examined the association between transitions in BMI growth channel (BMI-GC) and the odds of underweight and overweight in young adulthood. Data were drawn from 2759 participants in the Young Lives study (YL) and 2782 participants in the National Longitudinal Survey of Youth 1997 (NLSY97). Normal weight subsamples, consisting of 1922 participants from YL and 1477 from NLSY97, were selected for sensitivity analyses. Individual BMI-GC trajectories were estimated using linear mixed-effects models and classified into four groups: Stable, Crossing Upwards, Crossing Downwards and Fluctuating. Associations between BMI-GC groups and underweight and overweight at age 22 were assessed using logistic regression models. Compared with the Stable group, participants in the Crossing Downwards group had higher odds of being underweight in YL (OR 2·62; 95 % CI 1·95, 3·54), whereas those in the Crossing Upwards group had higher odds of overweight in YL (OR 3·96 (95 % CI 2·61, 5·99)) and in NLSY97 (OR 2·55 (95 % CI 1·95, 3·33)). In sensitivity analysis (normal weight subsamples), Crossing Downwards remained associated with underweight in YL (OR 1·75; 95 % CI 1·23, 2·48), and Crossing Upwards remained associated with overweight in both cohorts (OR 1·95; 95 % CI 1·14, 3·34 in YL and OR 1·67; 95 % CI 1·00, 2·78 in NLSY97). Crossing BMI-GC was associated with both underweight and overweight outcomes, including among participants with normal weight during childhood and adolescence. These findings highlight the importance of BMI-GC in weight assessments, offering a more nuanced understanding of growth trajectories and emphasising the need to move beyond BMI categories alone to predict long-term nutritional risks.
We present and conduct a novel experiment on a multi-period beauty contest game. Leveraging the multi-period feature, we investigate how participants revise their forecasts in periods when new information—such as shocks or announcements—arrives and how they form their expectations in the absence of new information. We make two key contributions. First, we develop a new method based on forecast revisions to evaluate whether participants behave in a forward-looking manner. The experimental results show that participants do react to anticipated shocks: namely, the announcements of future shocks. Second, we identify a new strategic environment effect during periods without new information; only when the game exhibits strategic complementarity do participants use extrapolation and expect continuously rising prices. This finding suggests that expectation formation is endogenous to the economic environment; and policy design should thus take this endogeneity into account.
Although the shift from traditional to digital food environments has enhanced accessibility and convenience in food purchasing and delivery, emerging evidence suggests that current digital food environments tend to promote energy-dense foods rather than healthier options. Therefore, this commentary aims to highlight the challenges faced by healthcare professionals in shaping a healthier digital food environment and to offer practical recommendations for fostering such an environment in Malaysia. This commentary also emphasises that shaping a healthier digital food environment is not an individual endeavour but a collaborative effort among key stakeholders, including government ministries, platform operators, online food vendors and platform users.
Recent advances in Artificial Intelligence (AI) reveal a mismatch between the EU’s individual-centric data protection shell and automated systems’ ability to affect entire groups of people, sealed within that shell. AI routinely processes data about groups, while the GDPR still allocates rights and remedies to identifiable individuals. This design produces a structural collective redress gap where injunctions may be obtained without individual mandates (GDPR Art. 80(2), RAD Art. 8), but compensation remains tied to identifiability. Here, I show how the GDPR’s model (consent, data subjects’ rights, Art. 80) fits in and why it fails against AI’s capacity to de-anonymise and infer traits about persons whose data were never collected or volunteered. I then examine the AI Act 2024/1689. Although it repeatedly refers to “groups of persons,” trilogue negotiations removed the Parliament’s key collective remedy tools, leaving only ex‑ante risk and transparency duties. The example of online behavioural advertising or affinity profiling illustrates how AI‑designed groups fall outside the scope of meaningful GDPR or AI Act remedies. I argue for a right to group protection and propose four main revisions: a definition of groups, a mechanism for a group complaint and redress, group-level impact assessment requirements and group data protection by design.
Persistent funding shortfalls undermine protected areas (PAs) worldwide, yet few studies analyse these patterns across space and time. We examined funding deficits in 300 Brazilian federal PAs from 2014 to 2023 using spatial Durbin error models. Deficits were measured as the gap between evidence-based minimum management costs and actual spending. We analysed how PA age, size, management group, ecological region, population density and per capita GDP predict deficits, decomposing socioeconomic effects into direct and spillover components. In 2023, 72% of the PAs faced deficits totalling 958 million international dollars, despite a 30% investment increase over the decade. Larger PAs had greater shortfalls; older PAs had smaller ones. Amazon PAs averaged 79.2% deficits versus 27.6% in the Atlantic Forest. No significant difference emerged between management types. Higher population density predicted lower deficits, probably reflecting greater political visibility near urban centres. No direct local GDP effect was detected, but spillovers from neighbouring high-income regions suggest regional prosperity influences PA funding through spatial networks. Funding deteriorated in 2020–2021 amid fiscal contractions and policy shifts, then recovered in 2022–2023. These findings reveal deep structural inequities, particularly in the Amazon, highlighting the need for transparent national PA financing systems.
The drag wake of a towed inclined 6 : 1 prolate spheroid in unstratified and stratified ambients is investigated experimentally using stereoscopic particle image velocimetry. Tow speed, stratification strength and inclination angle are varied independently, resulting in a parameter space spanning Reynolds numbers $\textit{Re} = (1.25{-}20) \times 10^3$, Froude numbers $\textit{Fr}= U/\textit{ND} = 2{-}32$ and $\infty$, and inclination angles $\theta = 0^\circ$ and $20^\circ$. Measurements are repeated at each parameter combination to obtain converged wake statistics for $3 \leqslant x/D \leqslant 40$. Unstratified measurements provide a baseline experimental dataset for inclined spheroids that has not previously been reported. In the absence of stratification, inclination generates persistent wake asymmetries and a net vertical impulse that deflects the wake trajectory. Although inclined configurations exhibit larger initial wake heights than axisymmetric cases, the early wake evolution collapses when scaled by an effective body diameter, indicating that this increase is geometric in origin. Regular vertical velocity protrusions are observed in inclined wakes, with a characteristic spacing that depends on Reynolds number but shows no measurable dependence on Froude number. At sufficiently low Froude number, buoyancy influences the near-body flow, and modifies the wake trajectory and streamwise velocity profiles. For $\textit{Re} = 5000$, wake heights for both axisymmetric and inclined configurations collapse across stratification strengths when scaled by an effective diameter. In this regime, the wake trajectory exhibits oscillations with period $2\pi /N$, in agreement with previously reported stratified wake dynamics.
CAR-T cell gene therapy has advanced from an experimental concept to a standard curative treatment for selected hematologic malignancies. Substantial clinical evidence has established CAR-T therapy as a cornerstone for relapsed/refractory B-cell malignancies and multiple myeloma, demonstrating durable, long-term remissions. In 2025, the U.S. Food and Drug Administration (FDA) eliminated the Risk Evaluation and Mitigation Strategy (REMS) requirement, reflecting improved clinical management of Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS). Yet, the widespread adoption of these therapies has unveiled a new landscape of long-term and next-generation challenges.
Methods
This review critically analyzes CAR-T therapy’s clinical trajectory and the bioengineering strategies redefining its safety, scalability, and translational potential.
Results
A major hurdle is therapeutic resistance driven by antigen escape, notably through alternative splicing and lineage switching. The emergence of long-term safety signals, specifically secondary T-cell malignancies, has necessitated rigorous surveillance, exemplified by the European Medicines Agency’s (EMA) mandate for lifelong patient monitoring. The therapeutic landscape is further complicated by histopathological and immunological barriers limiting the expansion and persistence of engineered cells. These include deficient T-cell trafficking, an immunosuppressive tumor microenvironment (TME), and antigen heterogeneity, which have historically constrained efficacy in solid tumors. To address these hurdles, the field is leveraging CRISPR-enhanced allogeneic platforms, cytokine-secreting armored CARs (TRUCKs), and logic-gated systems showing early clinical promise.
Conclusion
Building on these developments, we hypothesize that CAR-T therapy is undergoing a paradigm shift from single-target cytotoxicity toward a multi-functional, programmable framework capable of overcoming resistance, enhancing safety, and enabling effective penetration of solid tumors.
Early psychological deprivation is associated with increased risk for cardiometabolic disorders, and rapid catch-up growth following improved care environments may further influence this risk. Using data from the Bucharest Early Intervention Project – a randomized longitudinal study of children institutionalized in infancy assigned to high-quality foster care, continued institutional care, or raised by biological families – we examined cardiometabolic outcomes in early adulthood. Participants were 81 women and 58 men (mean age 22.6 years), predominantly Romanian. We assessed associations between care type and cardiometabolic traits including blood pressure, lipid and glucose metabolism, and metabolic syndrome. Results indicated that adults with histories of institutionalization displayed poorer lipid metabolism compared to non-institutionalized controls. Notably, individuals randomized to foster care showed increased BMI and waist circumference in adulthood relative to those who remained in institutional care. Longitudinal latent class analyses revealed four distinct BMI trajectories from infancy to early adulthood. The accelerated BMI trajectory, predominantly comprising foster care participants, was associated with the greatest prevalence of metabolic syndrome. These findings suggest that both lipid dysregulation and persistent increases in BMI represent ongoing concerns for cardiometabolic risk following early psychosocial deprivation. Those exposed to early adverse care may benefit from ongoing cardiometabolic monitoring and lifestyle interventions.
In 1970, Ted Williams – a medical missionary who had been running a small hospital at Kuluva in the West Nile region of Uganda for decades – was approached by the International Agency for Research on Cancer (IARC) to help establish a major study on the possible role of Epstein–Barr Virus in the aetiology of Burkitt’s lymphoma (BL). At the time, there was intense global interest in BL, as the cancer promised to be the first shown to have a viral aetiology. IARC centred its project at Kuluva Hospital and in the West Nile district because of Williams’ unusually detailed and accurate records. Williams was a meticulous record-keeper, who relied on various methods of data collection, from collecting and comparing to selecting and sorting. His paper-based archives and recording practices provide a rare window onto epidemiological knowledge production in East Africa in the decades before computing reshaped medical record-keeping. By tracing the ‘sociomaterial paper trail’ of Williams’s work, this paper examines how persona, place, and paper intersected in the making of medical knowledge, and how the researcher’s persona shapes the kinds of epidemiological data that are ultimately produced.
The interaction between acoustic waves and turbulent grazing flow over an acoustic liner is investigated using lattice-Boltzmann very-large-eddy simulations. A single-degree-of-freedom liner with 11 streamwise-aligned cavities is studied in a grazing flow impedance tube. The conditions replicate reference experiments from the Federal University of Santa Catarina. The influence of grazing flow (with a centreline Mach number of 0.32), acoustic wave amplitude, frequency and propagation direction relative to the mean flow is analysed. Impedance is computed using both direct (i.e. the in situ method) and model-fitting inference (i.e. the mode-matching) methods. The former reveals strong spatial variations; however, averaged values throughout the sample show minimal differences between upstream- and downstream-propagating waves, in contrast to what is obtained with the latter method. Flow analyses reveal that the orifices displace the flow away from the face sheet, with this effect amplified by acoustic waves and dependent on the wave propagation direction. Consequently, the boundary layer displacement thickness ($\delta ^*$) increases along the streamwise direction compared with a smooth wall and exhibits localised humps downstream of each orifice. The growth of $\delta ^*$ alters the flow dynamics within the orifices by weakening the shear layer at downstream positions. This influences the acoustic-induced mass flow rate through the orifices at equal sound pressure level, suggesting that acoustic energy is dissipated differently along the liner. The asymmetry of the flow field experienced by the acoustic wave, depending on its propagation direction, highlights the need to consider a spatially evolving turbulent flow when studying the acoustic–flow interaction and measuring impedance.