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This article suggests directions and approaches for amplifying and deepening the work of the humanities in communities beyond the academy, with specific attention to public readerships and scholarship in literary studies globally. It argues that in the academic humanities, scholars work with materials that resonate with broad public audiences, but the scholarship they produce in their interpretation of those materials—in the case of literary studies, literary texts—does not often enough reach or resonate with wider audiences. Drawing upon the concept of “resonance” as distinctly theorized first by literary critic Wai Chee Dimock and more recently by sociologist Hartmut Rosa, this article describes how scholarship in literary studies might open itself up to the possibility of resonant relationships with readers who are not formally trained in the field but whose thoughtful and deeply held convictions, commitments, and articulations of experience are valuable to the exchange of ideas around which intellectual life is constructed. This article details two possible answers to the methodological question of what would be necessary for the further development of a publicly engaged literary criticism, one emphasizing interpretation as a broadly shared project in the humanities sector and the other focusing on targeted publicly engaged peer review.
Diabetes affects over 500 million people worldwide and contributes substantially to the environmental impact of health care, including carbon emissions and plastic waste. As healthcare systems globally aim to reduce their environmental footprint, there is a need to embed environmental sustainability into decision making and foster innovation in health and life sciences.
This commentary outlines the environmental sustainability challenges and opportunities across the diabetes care pathway, highlighting innovations that reduce the demand for healthcare resources and associated environmental impact. We discuss the current and potential role of health technology assessment (HTA) agencies in promoting more sustainable health systems, by incorporating environmental considerations into the value assessment of technologies. Several approaches, such as integrated and parallel evaluation, are emerging to support this aim, whereas HTA agencies increasingly consider parameters of environmental life cycle assessment (eLCA), a comprehensive framework for evaluating the environmental sustainability of technology. Although a framework is evolving, early implementation by HTA bodies, for example, in the United Kingdom, Thailand, Canada, and Italy, highlights growing momentum. Moreover, sustainability policies at government and health system levels are developing globally, signaling opportunities to incorporate environmental sustainability in HTA (ESHTA).
Given the scale of health care’s environmental footprint, large disease areas offer critical opportunities for sustainable action. Diabetes, with its growing global prevalence, presents a particularly suitable domain for piloting the integration of environmental sustainability into HTA.
This study provides quantitative evidence on UK public attitudes towards stateless people, comparing them with attitudes towards refugees and asylum seekers. A cross-sectional UK survey (n = 385) was conducted. Network analysis modelled associations between social policy attitudes and prejudice towards stateless people, refugees, and asylum seekers, alongside other variables, including political orientation and perceived threat. Social policy attitudes were more restrictive towards stateless people than refugees, but less restrictive than towards asylum seekers. Prejudice towards stateless people was not significantly different to that towards refugees or asylum seekers. Prejudice and social policy attitudes were highly interrelated between all three groups, with political orientation and perceived threat the strongest predictors. Findings demonstrate similarities in UK public attitudes towards stateless people, refugees, and asylum seekers. Awareness-raising interventions and interventions addressing political and threat-based narratives may be most effective in reducing discrimination and fostering inclusion of stateless people.
Although Franco’s dictatorship in Spain was rooted in the repression of the labor movement and the working class, the 1960s and 1970s witnessed political and social changes that enabled the anti-Franco unions to achieve better conditions for workers. However, domestic workers were denied these improvements due to their exclusion from the formal labor system. This exclusion kept domestic workers in the informal sector and ensured their continued feminization and precarity. This article contributes to debates on the level of coercion in non-productive work by examining labor discipline in the Spanish domestic service during the 1960s and 1970s. It follows Marcel van der Linden’s proposal to focus on three defining stages of labor discipline: entry, work and exit. Although the working conditions and identities of Spanish domestic workers in the 1960s and 1970s have been studied, coercion and resistance have rarely been put at the center of analysis. Doing so introduces Spanish domestic labor into the study of coerced work, showing how it was affected by global features such as migration, feminization, all-day work, and control over workers’ bodies. This paper sees labor discipline as dialectically constructed, shaped by both adherence to and negation of established norms. Therefore, it is important to study both how domestic workers complied with rules set by employers and how everyday forms of resistance challenged labor discipline and thus contributed to its refinement. Some of these forms of resistance (petty theft, change of employment) caused confrontation, while others (marriage) fell within accepted moral and legal boundaries. The article is based on a wide range of sources, including surveys and reports by Catholic working-class organizations, letters sent by domestic workers to the Elena Francis radio advice program, and court records and newspaper reports about domestic workers’ theft. These sources make it possible to analyze labor discipline from different perspectives, showing variation in mistresses’ coercive measures, domestic workers’ attitude towards coercion, and autonomous practices against household discipline. While this paper focuses specifically on the intersection between class and gender in late Franco Spain, it contributes to labor and coercion studies in other geographical and historical contexts.
This article contains editions of three new copperplate charters of the kings of Valkhā who, in the late fourth and early fifth centuries ce, ruled a territory situated to the north of the Vākāṭaka kingdom along the Narmadā river. Ramesh and Tewari, the editors of the famous Bagh hoard of plates discovered in 1982, furnished a straightforward chronology of five successive Valkhā rulers on the basis of 32 plates known to them. However, one of the plates edited here flatly contradicts the sequence they proposed. It turns out that the dating of several previously known Valkhā charters is also controversial. It has been suggested by other scholars that there were, in fact, two kings of Valkhā by the name of Rudradāsa as well as two by the name of Bhuluṇḍa. A reinvestigation of old data combined with the newly edited plates confirms the former and shows a high likelihood of the latter.
Peripartum depression (PPD) is one of the most common pregnancy complications; nevertheless, it often goes underdiagnosed. Pinpointing important correlates is crucial for early risk identification and pathophysiology understanding. We aimed to investigate the association between self-reported mood swings during oral contraceptive (OC) use and peripartum depressive symptoms (PPDS).
Methods
We used data from the Swedish longitudinal cohort study Mom2B. 3829 women who had reported previous usage of OCs were included. Self-reported mood swings during OC use were assessed through a single question, and PPDS were evaluated using established cut-offs of the Edinburgh Postnatal Depression Scale (EPDS).
Results
Self-reported mood swings during OC use were associated with PPDS at gestational weeks 12–22 (OR = 1.30, 95% CI, 1.01–1.66), 24–34 (OR = 1.37, 95% CI, 1.10–1.71) and 36–42 (OR = 1.39, 95% CI, 1.05–1.82) as well as at postpartum weeks 6–13 (OR = 1.46, 95% CI, 1.12–1.92) and 24–35 (OR = 2.07, 95% CI, 1.43–2.99). Interestingly, self-reported mood swings during OC use were associated with higher odds for newly developed PPDS in early postpartum (OR for weeks 6–13 = 1.92, 95% CI: 1.19–3.08).
Conclusions
Women with self-reported mood swings during OC use have higher risk of experiencing depressive symptoms across the peripartum period and twice the risk of newly developed PPDS during the early postpartum, adding to current evidence of a hormonal sensitive subgroup of women and the opportunity to use this simple question in future predictive efforts.
A ParasiteBlitz event offers a brief, intense opportunity to discover diverse parasite species and to reveal life cycles of heteroxenous parasite taxa. In this study, we describe Monomyxum ligophori n. sp., a hyperparasitic myxozoan (Monomyxidae) proliferating in two dactylogyrid monopisthocotylan flatworms (Ligophorus saladensis, Ligophorus mugilinus) infecting mugilid fishes (Mugil cephalus, Mugil curema) on the Atlantic coast of North America. Furthermore, we used DNA barcoding to infer the parasite’s complex life cycle, matching its hyperparasitic myxospore stages with actinospore stages infecting the polychaete Streblospio benedicti found in the same locality during the ParasiteBlitz and also reported previously from the same region. Thus we report the first life cycle of a myxozoan that most likely does not require a vertebrate host. Hyperparasitic myxozoans are rare with only five species reported worldwide to infect flatworms. This study provides more information on the previously discussed host specificity towards monopisthocotylan hosts of these monomyxid myxozoan hyperparasites. Notably, Monomyxum ligophori n. sp. was detected in two out of four gill-infecting parasitic flatworms (being absent in Ligophorus uruguayensis and Metamicrocotyla macracantha) found infecting the same fish individuals during the ParasiteBlitz. Our molecular data and phylogenetic analysis support the previously suggested common origin of Monomyxum species infecting monopisthocotylan flatworms, and contribute to understanding the life cycle and host interactions of this unique hyperparasitic myxozoan lineage.
There is an increasing number of patients with cancer and acute ischemic stroke (AIS). We aim to compare outcomes in patients treated with thrombolysis for AIS with a history of cancer to those without.
Methods:
This is a post hoc analysis of the Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT) trial, evaluating tenecteplase versus alteplase in patients with AIS within 4.5 h of onset. ICD-10 codes via administrative data linkage were used to identify a history of cancer. Primary outcome was modified Rankin Scale (mRS) 0–2 at 90 days. Other outcomes included mRS 0–1 at 90 days, return to pre-stroke function, mortality and bleeding. Analysis was done using logistic regression for binary outcomes adjusted for age, stroke severity, presence of cancer history and time from onset to needle. A generalized linear regression model was used for numeric outcomes, with effect measures reported as adjusted risk ratios (aRR).
Results:
Of the 1577 patients enrolled, 37 (2.35%) had a prior diagnosis of cancer. At 90 days, cancer patients were less likely to achieve 90-day mRS 0–2 (aOR of 0.33 [95% CI 0.15–0.75]) and had higher mortality (aOR 3.75 [95% CI 1.76–7.75]) as compared to those without cancer. Length of stay was longer in patients with cancer than those without cancer (median 11.5 days [IQR 7–24.5] vs 5 days [IQR 3–11], respectively, aRR 2.76 [95% CI 2.58–2.94]).
Conclusion:
Patients with AIS and a history of cancer had worse functional outcomes, prolonged length of stay and higher rates of mortality as compared to those with no diagnosis of cancer.
To enhance representation in LCS research, we examined associations between participant characteristics and their preferred mode of survey completion among individuals eligible for LCS.
Methods:
Between February 2023 and April 2024, prospective participants were identified using electronic healthcare records from Mass General Brigham and the University of Oklahoma Health Sciences (OUHSC). We offered three modes of survey completion: online, by mail, or by phone. Eligible participants were 50–80 years old, had smoked within the past 15 years, and spoke English or Spanish. We used multinomial logistic regression to estimate relative risk ratios (RRR).
Results:
Outreach to 2,822 individuals resulted in a sample of 315 participants. The mean age was 61.7 years (SD = 10.9). Most respondents were women (63.0%) and identified as White (63.3%), 29.8 % were Hispanic. The most common survey completion mode was mail (37.1%), followed by online (35.9%) and phone (27.0%). Characteristics associated with completion by mail were study site (RRR = 6.86, 95%CI:3.10–15.14), and race (RRR = 3.63, 95%CI:1.53–8.61); with respondents at OUHSC or who did not identify as White being more likely to choose mail over online modality. Characteristics associated with phone completion, included older age (RRR = 1.11, 95% CI: 1.03–1.20), Spanish language preference (RRR = 9.28, 95%CI:2.38–36.09), and with local government or community insurance (RRR = 9.91, 95% CI:1.92–51.3).
Conclusion:
The current trend toward online surveys may not fully account for individual preferences for LCS research engagement, and could limit the representativeness in LCS studies if offline alternatives are not offered.
In this retrospective case series, we present two patients with primary lateral sclerosis (PLS) and spasticity-related gait impairment. Both patients were assessed with 6-min walk tests (6MWT) and timed up and go (TUG) at baseline and after 4 weeks of oral levetiracetam. Following levetiracetam therapy, Patient 1 improved 27.3% (148.5 to 189 m) on 6MWT and 26.1% (23–17 s) on TUG. Patient 2 improved 18% (90 m in 4:29 min to 112 m in 6 min) on 6MWT and 10% (46–41 s) on TUG. Larger prospective trials of levetiracetam for spasticity and gait may be considered in PLS.
The burden of cancer worldwide is rising, with 20 million new cases diagnosed in 2022. In Europe, 1.2 million women are diagnosed with cancer annually and an estimated 600,000 women die from cancer each year. International research and data from Ireland demonstrate that women with cancer face a particular set of challenges, including increased psychological distress compared to men. As a result, Ireland’s Model of Care for Psycho-Oncology could usefully place greater emphasis on gender-specific provisions which address the increased psychological needs of women. To date, Ireland has made some progress in recognising the physical and mental healthcare needs of women and developing gender-informed policies. It is essential that such policies are implemented fully so as to reduce and eliminate disparities in care. A more tailored, gender-informed approach would also help ensure the provision of gender-aware psycho-oncological care for all women and men as they navigate their cancer journeys.
Major depressive disorder (MDD) is closely associated with suicide, which often begins with suicidal ideation (SI). However, the underlying neural mechanisms remain unclear.
Methods
We included 73 MDD patients with SI (MDD-SI), 44 MDD patients without SI (MDD-NSI) and 78 healthy controls (HCs), then compared the amplitude of low-frequency fluctuations (ALFF), functional connectivity (FC), and effective connectivity (EC) differences across groups and analyzed their relationship with SI severity. FC and EC analyses used brain regions with ALFF differences between MDD-SI and MDD-NSI as seed points. ALFF findings were validated using the REST-meta-MDD consortium dataset (N = 1 596, 24 sites). Additionally, we explored the trend of changes in abnormal activity and connectivity of SI and suicidal behavior (SB) in MDD-SI.
Results
Compared to MDD-NSI, MDD-SI showed increased ALFF in the right anterior cingulate cortex (ACC), validated by the REST-meta-MDD consortium dataset. MDD-SI also exhibited reduced FC between the right ACC and the left inferior frontal gyrus and decreased EC from the right ACC to the right fusiform gyrus, which were negatively correlated with the Hamilton Depression Rating Scale (HAMD)-suicidality item scores. Increased EC was observed in MDD-SI from the right ACC to the right cerebellar tonsil and from the left inferior parietal lobule (IPL) to the right ACC, following a progressive increase pattern (HC < MDD-NSI < MDD-SI without SB < MDD-SI with SB).
Conclusions
Increased activity and aberrant connectivity of the ACC may be associated with SI in MDD patients and potentially serve as biomarkers for suicide risk.
We consider nonmonotonic inferences from belief bases that contain conditionals enforcing some of the possible worlds to be infeasible and thus completely implausible. In contrast to belief bases satisfying the strong notion of consistency requiring every world to be at least somewhat plausible, we call such belief bases weakly consistent. First, we review the treatment of weakly consistent belief bases by the seminal approaches of p-entailment, which coincides with system P, and of system Z, which coincides with rational closure. Then we focus on c-inference, an inductive inference operator that has been shown to exhibit many desirable properties put forward for nonmonotonic reasoning. It is based on c-representations, which are a special kind of ranking model ordering worlds according to their plausibility. While c-representation is defined for strongly consistent belief bases only, in this article, we extend the notions of c-representation and of c-inference to cover also weakly consistent belief bases. We adapt a constraint satisfaction problem (CSP) characterizing c-representations to capture extended c-representations, and we show how this extended CSP can be used to characterize extended c-inference, providing a basis for its implementation. We show various properties of extended c-inference and in particular, we prove that also the extended notion of c-inference fully satisfies syntax splitting. Furthermore, we extend and evaluate credulous and weakly skeptical c-inference to weakly consistent belief bases and provide characterizations for them as CSPs.
This study provides the large-scale bibliometric assessment of the Journal of Management & Organization (JMO), offering insights into its intellectual trajectory and positioning within the management field. Covering 1,083 documents published between 1995 and 2024, indexed in Web of Science and Scopus, the analysis applies performance metrics, citation structures, and science mapping using VOSviewer and Bibliometrix. The study is further grounded in institutional and field-theoretic perspectives, interpreting JMO’s evolution as a process of legitimacy-building and scientific capital accumulation within a global knowledge field. The results show that JMO’s growth has been marked by cyclical expansion, with a sharp increase in productivity since the mid-2000s but uneven citation impact, heavily reliant on a small set of landmark articles. Co-citation and bibliographic coupling analyses reveal intellectual roots in organizational behavior, psychology, and strategy, while keyword and thematic mapping highlight enduring strengths in leadership, human resource management, and job satisfaction. At the same time, new research frontiers have emerged in governance, innovation, sustainability, and work-life balance, reflecting JMO’s responsiveness to global challenges such as COVID-19 and digital transformation. Collaboration networks confirm the journal’s Australasian anchoring, yet also demonstrate growing integration into international research systems, particularly through linkages with the United States, China, and Europe. This study contributes to understanding JMO’s evolving role within management and organizational scholarship, identifying both its achievements and challenges. The findings offer insights for scholars, institutions, and editors on how JMO can consolidate high-impact niches, diversify its author base, and strengthen its influence in shaping global management debates.
To address the possible occurrence of a finite-time singularity during the oblique reconnection of two vortex rings, (Moffatt and Kimura 2019, J. Fluid Mech., vol. 870, R1) developed a simplified model based on the Biot–Savart law and claimed that the vorticity amplification $\omega _{{max}}/\omega _0$ becomes very large for vortex Reynolds number $Re_{\varGamma } \geqslant 4000$. However, with direct numerical simulations (DNS), Yao and Hussain (2020a, J. Fluid Mech.vol. 888, pp. R2) were able to show that the vorticity amplification is in fact much smaller and increases slowly with $Re_{\varGamma }$. This suppression of vorticity was linked to two key factors – deformation of the vortex core during approach, and formation of hairpin-like bridge structures. In this work, a recently developed numerical technique called log-lattice (Campolina & Mailybaev, 2021, Nonlinearity, vol. 34, 4684), where interacting Fourier modes are logarithmically sampled, is applied to the same oblique vortex ring interaction problem. It is shown that the log-lattice vortex reconnection displays core compression and formation of bridge structures, similar to the actual reconnection seen with DNS. Furthermore, the sparsity of the Fourier modes allows us to probe very large $Re_{\varGamma } = 10^8$ until which the peak of the maximum norm of vorticity, while increasing with $Re_{\varGamma }$, remains finite, and a blow-up is observed only for the inviscid case.
This article investigates the organization of a transnational criminal enterprise through a detailed case study of Operation Singapore, a network producing and trafficking falsified pharmaceuticals from China to the United Kingdom. Drawing on law enforcement records, court transcripts, digital communications, and expert interviews, the study maps the structure and strategies of this criminal enterprise. It applies Peter Reuter’s theory of criminal organization, and Niles Breuer and Federico Varese’s typology of network forms to show how functional roles shape organizational structure: production was hierarchical and security-driven, while distribution was decentralized and transactional. Trust was not based on kinship or ethnicity but constructed through moral appeals and restricted information flows. The case reveals how criminal actors exploit legal frameworks and commercial infrastructures to mask illegal activity and blur boundaries between legal and illegal markets. These findings challenge static models of organized crime and call for a more dynamic, relational understanding of criminal enterprise.